CN100464743C - 治疗和预防药物中毒的n-乙酰半胱氨酸组合物 - Google Patents

治疗和预防药物中毒的n-乙酰半胱氨酸组合物 Download PDF

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Publication number
CN100464743C
CN100464743C CNB028077334A CN02807733A CN100464743C CN 100464743 C CN100464743 C CN 100464743C CN B028077334 A CNB028077334 A CN B028077334A CN 02807733 A CN02807733 A CN 02807733A CN 100464743 C CN100464743 C CN 100464743C
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CN
China
Prior art keywords
acetylcysteine
acetaminophen
therapeutic
use according
therapeutic agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB028077334A
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English (en)
Chinese (zh)
Other versions
CN1507350A (zh
Inventor
莱纳德·A·赫泽恩伯格
S·C·德索萨
J·安德鲁斯
里奥铙雷·A·赫泽恩伯格
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Leland Stanford Junior University
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Bioadvantex Pharma Inc
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Publication of CN1507350A publication Critical patent/CN1507350A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB028077334A 2001-03-30 2002-03-28 治疗和预防药物中毒的n-乙酰半胱氨酸组合物 Expired - Fee Related CN100464743C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28060001P 2001-03-30 2001-03-30
US60/280,600 2001-03-30
US09/833,228 US6566401B2 (en) 2001-03-30 2001-04-11 N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity
US09/833,228 2001-04-11

Publications (2)

Publication Number Publication Date
CN1507350A CN1507350A (zh) 2004-06-23
CN100464743C true CN100464743C (zh) 2009-03-04

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CNB028077334A Expired - Fee Related CN100464743C (zh) 2001-03-30 2002-03-28 治疗和预防药物中毒的n-乙酰半胱氨酸组合物

Country Status (13)

Country Link
US (2) US6566401B2 (cg-RX-API-DMAC7.html)
EP (1) EP1379232B1 (cg-RX-API-DMAC7.html)
JP (3) JP2005508840A (cg-RX-API-DMAC7.html)
CN (1) CN100464743C (cg-RX-API-DMAC7.html)
AU (1) AU2002255942B2 (cg-RX-API-DMAC7.html)
BR (1) BR0208563A (cg-RX-API-DMAC7.html)
CA (1) CA2442168C (cg-RX-API-DMAC7.html)
ES (1) ES2550094T3 (cg-RX-API-DMAC7.html)
IL (2) IL158181A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA03008904A (cg-RX-API-DMAC7.html)
NZ (1) NZ528478A (cg-RX-API-DMAC7.html)
RU (1) RU2291689C2 (cg-RX-API-DMAC7.html)
WO (1) WO2002078627A2 (cg-RX-API-DMAC7.html)

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US8993627B2 (en) * 2005-04-21 2015-03-31 Sentient Lifesciences, Inc. N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress
US8148356B2 (en) 2005-08-24 2012-04-03 Cumberland Pharmaceuticals, Inc. Acetylcysteine composition and uses therefor
RU2302236C2 (ru) * 2005-09-09 2007-07-10 Государственное учреждение научно-исследовательский институт Гриппа Российской академии медицинских наук (ГУ НИИ Гриппа РАМН) Средство, обладающее антигипоксической и цитопротекторной активностями, используемое для снижения токсичности ремантадина при лечении гриппозной инфекции
US20070098790A1 (en) * 2005-10-31 2007-05-03 David Jiang Nutritional supplement for the enhancement of the health of the liver
US20080139654A1 (en) * 2006-12-09 2008-06-12 Eric Mott Soderling Acetaminophen compositions having minimized side effects including reduced hepatotoxicity
CN103251631A (zh) * 2008-05-13 2013-08-21 根梅迪卡治疗公司 用于治疗代谢性病症的水杨酸盐(酯)缀合物
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AU2010224866C1 (en) * 2009-03-16 2015-01-15 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
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WO2011006097A2 (en) * 2009-07-10 2011-01-13 The Brigham And Women's Hospital, Inc. Methods For Treating Toxicity
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EA032777B1 (ru) 2013-12-24 2019-07-31 Вирджиния Коммонвелт Юниверсити Способ предотвращения или лечения почечной недостаточности
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EP3302580B1 (en) * 2015-05-27 2021-01-20 University of Pittsburgh - Of the Commonwealth System of Higher Education Compositions and methods for reducing the risk of post-imaging pancreatitis
MX389285B (es) 2015-05-28 2025-03-20 Baylor College Medicine Beneficios de la suplementación con n-acetilcisteína y glicina para mejorar los niveles de glutatión.
CA3010915C (en) * 2016-01-11 2024-06-04 Pledpharma Ab Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions
SI3411047T1 (sl) * 2016-02-04 2021-09-30 Czap Research And Development, Llc Sredstva za nadzorovano sproščeni in stratificirani kompleks vključitve ciklodekstrina
JP2020502096A (ja) 2016-12-15 2020-01-23 ザンボン ソシエタ ペル アチオニ 抗バクテリア剤（ａｎｔｉｂａｃｔｅｒｉａｌ ａｇｅｎｔ）として使用するためのｎ−アセチルシステイン
KR101942568B1 (ko) * 2017-01-24 2019-01-30 주식회사 우성제약 아세트아미노펜을 함유하는 주사제 조성물
JPWO2020129509A1 (ja) * 2018-12-21 2021-11-04 富士フイルム株式会社 光毒性または光アレルギーの測定方法および上記測定方法において使用するための試薬
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CN113288890B (zh) * 2021-06-21 2022-02-22 南方医科大学南方医院 N-乙酰-l-半胱氨酸在制备预防和/或治疗运动损伤的药物中的应用
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Also Published As

Publication number Publication date
RU2003131876A (ru) 2005-04-10
MXPA03008904A (es) 2005-03-07
IL158181A0 (en) 2004-03-28
US7723389B2 (en) 2010-05-25
US6566401B2 (en) 2003-05-20
JP2011225610A (ja) 2011-11-10
NZ528478A (en) 2007-08-31
EP1379232B1 (en) 2015-07-29
ES2550094T3 (es) 2015-11-04
WO2002078627A2 (en) 2002-10-10
JP2015078185A (ja) 2015-04-23
RU2291689C2 (ru) 2007-01-20
EP1379232A2 (en) 2004-01-14
US20030069311A1 (en) 2003-04-10
BR0208563A (pt) 2006-02-21
CA2442168A1 (en) 2002-10-10
EP1379232A4 (en) 2008-04-23
IL158181A (en) 2012-04-30
AU2002255942B2 (en) 2007-07-05
CA2442168C (en) 2012-05-29
US20020142991A1 (en) 2002-10-03
WO2002078627A3 (en) 2003-09-18
CN1507350A (zh) 2004-06-23
JP2005508840A (ja) 2005-04-07

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