AU2002255942B2 - N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity - Google Patents

N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity Download PDF

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Publication number
AU2002255942B2
AU2002255942B2 AU2002255942A AU2002255942A AU2002255942B2 AU 2002255942 B2 AU2002255942 B2 AU 2002255942B2 AU 2002255942 A AU2002255942 A AU 2002255942A AU 2002255942 A AU2002255942 A AU 2002255942A AU 2002255942 B2 AU2002255942 B2 AU 2002255942B2
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AU
Australia
Prior art keywords
acetylcysteine
therapeutic
acetaminophen
combination
administered
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Expired
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AU2002255942A
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English (en)
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AU2002255942A1 (en
Inventor
James Andrus
Stephen C. De Rosa
Leonard A. Herzenberg
Leonore A. Herzenberg
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Leland Stanford Junior University
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Leland Stanford Junior University
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26960383&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2002255942(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of AU2002255942A1 publication Critical patent/AU2002255942A1/en
Assigned to THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY reassignment THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Request for Assignment Assignors: BioAdvantex Pharma, Inc.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • AIDS & HIV (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2002255942A 2001-03-30 2002-03-28 N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity Expired AU2002255942B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28060001P 2001-03-30 2001-03-30
US60/280,600 2001-03-30
US09/833,228 US6566401B2 (en) 2001-03-30 2001-04-11 N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity
US09/833,228 2001-04-11
PCT/US2002/009442 WO2002078627A2 (en) 2001-03-30 2002-03-28 N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity

Publications (2)

Publication Number Publication Date
AU2002255942A1 AU2002255942A1 (en) 2003-04-03
AU2002255942B2 true AU2002255942B2 (en) 2007-07-05

Family

ID=26960383

Family Applications (1)

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AU2002255942A Expired AU2002255942B2 (en) 2001-03-30 2002-03-28 N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity

Country Status (13)

Country Link
US (2) US6566401B2 (cg-RX-API-DMAC7.html)
EP (1) EP1379232B1 (cg-RX-API-DMAC7.html)
JP (3) JP2005508840A (cg-RX-API-DMAC7.html)
CN (1) CN100464743C (cg-RX-API-DMAC7.html)
AU (1) AU2002255942B2 (cg-RX-API-DMAC7.html)
BR (1) BR0208563A (cg-RX-API-DMAC7.html)
CA (1) CA2442168C (cg-RX-API-DMAC7.html)
ES (1) ES2550094T3 (cg-RX-API-DMAC7.html)
IL (2) IL158181A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA03008904A (cg-RX-API-DMAC7.html)
NZ (1) NZ528478A (cg-RX-API-DMAC7.html)
RU (1) RU2291689C2 (cg-RX-API-DMAC7.html)
WO (1) WO2002078627A2 (cg-RX-API-DMAC7.html)

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US8993627B2 (en) * 2005-04-21 2015-03-31 Sentient Lifesciences, Inc. N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress
US8148356B2 (en) 2005-08-24 2012-04-03 Cumberland Pharmaceuticals, Inc. Acetylcysteine composition and uses therefor
RU2302236C2 (ru) * 2005-09-09 2007-07-10 Государственное учреждение научно-исследовательский институт Гриппа Российской академии медицинских наук (ГУ НИИ Гриппа РАМН) Средство, обладающее антигипоксической и цитопротекторной активностями, используемое для снижения токсичности ремантадина при лечении гриппозной инфекции
US20070098790A1 (en) * 2005-10-31 2007-05-03 David Jiang Nutritional supplement for the enhancement of the health of the liver
US20080139654A1 (en) * 2006-12-09 2008-06-12 Eric Mott Soderling Acetaminophen compositions having minimized side effects including reduced hepatotoxicity
CN103251631A (zh) * 2008-05-13 2013-08-21 根梅迪卡治疗公司 用于治疗代谢性病症的水杨酸盐(酯)缀合物
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AU2010224866C1 (en) * 2009-03-16 2015-01-15 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
SG176053A1 (en) * 2009-05-15 2011-12-29 Intermune Inc Methods of treating hiv patients with anti-fibrotics
WO2011006097A2 (en) * 2009-07-10 2011-01-13 The Brigham And Women's Hospital, Inc. Methods For Treating Toxicity
CN102573463A (zh) * 2009-07-15 2012-07-11 小利兰·斯坦福大学托管委员会 N-乙酰半胱氨酸组合物以及改善对乙酰氨基酚的治疗效能的方法
DE102011006425A1 (de) 2010-03-31 2011-10-06 Awd.Pharma Gmbh & Co. Kg Pharmazeutische Zubereitung und deren Verwendung
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
WO2013006658A1 (en) * 2011-07-05 2013-01-10 The Brigham And Women's Hospital, Inc. Treatment of acetaminophen-induced liver damage by the administration of modulators of nitric oxide
US8747894B2 (en) 2012-05-08 2014-06-10 Alpex Pharma S.A. Effervescent compositions containing N-acetylcysteine
EP2854798A4 (en) 2012-05-24 2016-05-11 Mograbi Josef COMPOSITIONS WITH ISOSILYBIN B FOR THE TREATMENT AND PREVENTION OF ACTIVE-INDUCED TOXICITY
EA032777B1 (ru) 2013-12-24 2019-07-31 Вирджиния Коммонвелт Юниверсити Способ предотвращения или лечения почечной недостаточности
WO2016123223A1 (en) * 2015-01-27 2016-08-04 Florengale, Llc Healing topical composition
EP3302580B1 (en) * 2015-05-27 2021-01-20 University of Pittsburgh - Of the Commonwealth System of Higher Education Compositions and methods for reducing the risk of post-imaging pancreatitis
MX389285B (es) 2015-05-28 2025-03-20 Baylor College Medicine Beneficios de la suplementación con n-acetilcisteína y glicina para mejorar los niveles de glutatión.
CA3010915C (en) * 2016-01-11 2024-06-04 Pledpharma Ab Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions
SI3411047T1 (sl) * 2016-02-04 2021-09-30 Czap Research And Development, Llc Sredstva za nadzorovano sproščeni in stratificirani kompleks vključitve ciklodekstrina
JP2020502096A (ja) 2016-12-15 2020-01-23 ザンボン ソシエタ ペル アチオニ 抗バクテリア剤（ａｎｔｉｂａｃｔｅｒｉａｌ ａｇｅｎｔ）として使用するためのｎ−アセチルシステイン
KR101942568B1 (ko) * 2017-01-24 2019-01-30 주식회사 우성제약 아세트아미노펜을 함유하는 주사제 조성물
JPWO2020129509A1 (ja) * 2018-12-21 2021-11-04 富士フイルム株式会社 光毒性または光アレルギーの測定方法および上記測定方法において使用するための試薬
US11590090B2 (en) 2019-09-14 2023-02-28 Anzen Pharmaceuticals, LLC Acetaminophen formulation with protection against toxic effects of overdose
GB2588172B (en) * 2019-10-11 2023-05-24 Blackhawk Partners Ltd A pharmaceutical composition comprising cannabinoid
CN113288890B (zh) * 2021-06-21 2022-02-22 南方医科大学南方医院 N-乙酰-l-半胱氨酸在制备预防和/或治疗运动损伤的药物中的应用
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Also Published As

Publication number Publication date
RU2003131876A (ru) 2005-04-10
MXPA03008904A (es) 2005-03-07
IL158181A0 (en) 2004-03-28
CN100464743C (zh) 2009-03-04
US7723389B2 (en) 2010-05-25
US6566401B2 (en) 2003-05-20
JP2011225610A (ja) 2011-11-10
NZ528478A (en) 2007-08-31
EP1379232B1 (en) 2015-07-29
ES2550094T3 (es) 2015-11-04
WO2002078627A2 (en) 2002-10-10
JP2015078185A (ja) 2015-04-23
RU2291689C2 (ru) 2007-01-20
EP1379232A2 (en) 2004-01-14
US20030069311A1 (en) 2003-04-10
BR0208563A (pt) 2006-02-21
CA2442168A1 (en) 2002-10-10
EP1379232A4 (en) 2008-04-23
IL158181A (en) 2012-04-30
CA2442168C (en) 2012-05-29
US20020142991A1 (en) 2002-10-03
WO2002078627A3 (en) 2003-09-18
CN1507350A (zh) 2004-06-23
JP2005508840A (ja) 2005-04-07

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired