JPWO2012063487A1 - アラレマイシン又はその誘導体を有効成分とする抗マラリア薬 - Google Patents
アラレマイシン又はその誘導体を有効成分とする抗マラリア薬 Download PDFInfo
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- JPWO2012063487A1 JPWO2012063487A1 JP2012542816A JP2012542816A JPWO2012063487A1 JP WO2012063487 A1 JPWO2012063487 A1 JP WO2012063487A1 JP 2012542816 A JP2012542816 A JP 2012542816A JP 2012542816 A JP2012542816 A JP 2012542816A JP WO2012063487 A1 JPWO2012063487 A1 JP WO2012063487A1
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- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical class C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000004992 toluidines Chemical class 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
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Abstract
Description
(1)式(I)
で表わされるアラレマイシン(Alaremycin)若しくはその誘導体又はその薬理学的に許容される塩を有効成分として含有するマラリアの予防及び/又は治療剤に関する。
また、本発明は、
(2)R1がヒドロキシ基、R2がメチル基、R3が水素であることを特徴とする上記(1)記載のマラリアの予防及び/又は治療剤や、
(3)R1がメトキシ基、R2がメチル基、R3が水素であることを特徴とする上記(1)記載のマラリアの予防及び/又は治療剤、及び
(4)R1がアミノ基、R2がメチル基、R3が水素であることを特徴とする上記(1)記載のマラリアの予防及び/又は治療剤に関する。
別の態様として、本発明は、式(I)
で表わされるアラレマイシン(Alaremycin)若しくはその誘導体又はその薬理学的に許容される塩を有効成分として含有する医薬を、それを必要とする患者に投与する工程を含むマラリアの予防及び/又は治療方法や、式(I)で表わされるアラレマイシン(Alaremycin)若しくはその誘導体又はその薬理学的に許容される塩をマラリアの予防及び/又は治療に使用する方法に関する。
Claims (4)
- R1がヒドロキシ基、R2がメチル基、R3が水素であることを特徴とする請求項1記載のマラリアの予防及び/又は治療剤。
- R1がメトキシ基、R2がメチル基、R3が水素であることを特徴とする請求項1記載のマラリアの予防及び/又は治療剤。
- R1がアミノ基、R2がメチル基、R3が水素であることを特徴とする請求項1記載のマラリアの予防及び/又は治療剤。
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JP2012542816A JP5669111B2 (ja) | 2010-11-10 | 2011-11-09 | アラレマイシン又はその誘導体を有効成分とする抗マラリア薬 |
Applications Claiming Priority (4)
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JP2010251562 | 2010-11-10 | ||
JP2010251562 | 2010-11-10 | ||
JP2012542816A JP5669111B2 (ja) | 2010-11-10 | 2011-11-09 | アラレマイシン又はその誘導体を有効成分とする抗マラリア薬 |
PCT/JP2011/006273 WO2012063487A1 (ja) | 2010-11-10 | 2011-11-09 | アラレマイシン又はその誘導体を有効成分とする抗マラリア薬 |
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JP5669111B2 JP5669111B2 (ja) | 2015-02-12 |
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EP (1) | EP2638902B1 (ja) |
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JP2006282577A (ja) | 2005-03-31 | 2006-10-19 | Rikogaku Shinkokai | ガン光線力学治療用新規光増感剤 |
KR20120137506A (ko) * | 2010-05-19 | 2012-12-21 | 고쿠리츠다이가쿠호징 도쿄다이가쿠 | 5-아미노레불린산 또는 그 유도체를 유효성분으로 하는 항말라리아약 |
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EP2638902A4 (en) | 2014-04-16 |
US9295660B2 (en) | 2016-03-29 |
HK1186655A1 (zh) | 2014-03-21 |
EP2638902B1 (en) | 2016-02-24 |
US20130217913A1 (en) | 2013-08-22 |
JP5669111B2 (ja) | 2015-02-12 |
EP2638902A1 (en) | 2013-09-18 |
WO2012063487A1 (ja) | 2012-05-18 |
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