CN100453553C - 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 - Google Patents

丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 Download PDF

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Publication number
CN100453553C
CN100453553C CNB2004800140478A CN200480014047A CN100453553C CN 100453553 C CN100453553 C CN 100453553C CN B2004800140478 A CNB2004800140478 A CN B2004800140478A CN 200480014047 A CN200480014047 A CN 200480014047A CN 100453553 C CN100453553 C CN 100453553C
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aliphatic
aliphatic group
cycloalkyl
aryl
compound according
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Expired - Fee Related
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CNB2004800140478A
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English (en)
Chinese (zh)
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CN1795188A (zh
Inventor
L·J·法默
R·P·珀尼
G·R·比瑟蒂
K·P·威尔逊
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Priority claimed from US10/412,600 external-priority patent/US7273885B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CNB2004800140478A 2003-04-11 2004-04-09 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 Expired - Fee Related CN100453553C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/412,600 US7273885B2 (en) 2002-04-11 2003-04-11 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
US10/412,600 2003-04-11
US51376503P 2003-10-23 2003-10-23
US60/513,765 2003-10-23

Publications (2)

Publication Number Publication Date
CN1795188A CN1795188A (zh) 2006-06-28
CN100453553C true CN100453553C (zh) 2009-01-21

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CNB2004800140478A Expired - Fee Related CN100453553C (zh) 2003-04-11 2004-04-09 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂

Country Status (10)

Country Link
US (3) US20050090450A1 (https=)
EP (2) EP1636208B1 (https=)
JP (2) JP2006526011A (https=)
CN (1) CN100453553C (https=)
AR (1) AR044513A1 (https=)
AT (1) ATE547412T1 (https=)
AU (1) AU2004230946A1 (https=)
CA (1) CA2521678A1 (https=)
ES (1) ES2381548T3 (https=)
WO (1) WO2004092162A1 (https=)

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α-Ketoamides,α-Ketoesters and α-Diketones as HCV NS3Protease Inhibitors. Wei Han et al.Bioorganic ＆ Medicinal Chemistry Letters,Vol.10 . 2000
α-Ketoamides,α-Ketoesters and α-Diketones as HCV NS3Protease Inhibitors. Wei Han et al.Bioorganic ＆ Medicinal Chemistry Letters,Vol.10. 2000 *

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AR044513A1 (es) 2005-09-14
EP2332935A1 (en) 2011-06-15
ATE547412T1 (de) 2012-03-15
EP1636208A1 (en) 2006-03-22
AU2004230946A1 (en) 2004-10-28
ES2381548T3 (es) 2012-05-29
US8618152B2 (en) 2013-12-31
WO2004092162A1 (en) 2004-10-28
US20090022688A1 (en) 2009-01-22
EP1636208B1 (en) 2012-02-29
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JP2011068655A (ja) 2011-04-07
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