CA2521678A1 - Inhibitors of serine proteases, particularly hcv ns3-ns4a protease - Google Patents
Inhibitors of serine proteases, particularly hcv ns3-ns4a protease Download PDFInfo
- Publication number
- CA2521678A1 CA2521678A1 CA002521678A CA2521678A CA2521678A1 CA 2521678 A1 CA2521678 A1 CA 2521678A1 CA 002521678 A CA002521678 A CA 002521678A CA 2521678 A CA2521678 A CA 2521678A CA 2521678 A1 CA2521678 A1 CA 2521678A1
- Authority
- CA
- Canada
- Prior art keywords
- aliphatic
- cycloalkyl
- aryl
- heteroaryl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 208000037918 transfusion-transmitted disease Diseases 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000006514 viral protein processing Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 229940051021 yellow-fever virus Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- HGPHQCSSTFBAML-UHFFFAOYSA-M zinc;2-methylpropane;bromide Chemical compound Br[Zn+].C[C-](C)C HGPHQCSSTFBAML-UHFFFAOYSA-M 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/412,600 | 2003-04-11 | ||
| US10/412,600 US7273885B2 (en) | 2002-04-11 | 2003-04-11 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease |
| US51376503P | 2003-10-23 | 2003-10-23 | |
| US60/513,765 | 2003-10-23 | ||
| PCT/US2004/011012 WO2004092162A1 (en) | 2003-04-11 | 2004-04-09 | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2521678A1 true CA2521678A1 (en) | 2004-10-28 |
Family
ID=33302781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002521678A Abandoned CA2521678A1 (en) | 2003-04-11 | 2004-04-09 | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20050090450A1 (https=) |
| EP (2) | EP2332935A1 (https=) |
| JP (2) | JP2006526011A (https=) |
| CN (1) | CN100453553C (https=) |
| AR (1) | AR044513A1 (https=) |
| AT (1) | ATE547412T1 (https=) |
| AU (1) | AU2004230946A1 (https=) |
| CA (1) | CA2521678A1 (https=) |
| ES (1) | ES2381548T3 (https=) |
| WO (1) | WO2004092162A1 (https=) |
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| KR100509388B1 (ko) * | 1996-10-18 | 2005-08-23 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 |
| ES2240446T3 (es) * | 2000-04-03 | 2005-10-16 | Vertex Pharma | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| KR20040099425A (ko) * | 2002-04-11 | 2004-11-26 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 ｃ형 간염 바이러스 ｎｓ3-ｎｓ4프로테아제의 억제제 |
| WO2004092161A1 (en) * | 2003-04-11 | 2004-10-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| CN1852920B (zh) * | 2003-07-18 | 2010-12-15 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶抑制剂、特别是hcv ns3-ns4a蛋白酶抑制剂 |
| TWI359147B (en) * | 2003-09-05 | 2012-03-01 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv n |
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| WO2005037860A2 (en) * | 2003-10-10 | 2005-04-28 | Vertex Pharmaceuticals Incoporated | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| CN1938332B (zh) * | 2004-02-04 | 2011-10-19 | 沃泰克斯药物股份有限公司 | 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 |
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| AR029851A1 (es) * | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
| SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| KR20040099425A (ko) | 2002-04-11 | 2004-11-26 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 ｃ형 간염 바이러스 ｎｓ3-ｎｓ4프로테아제의 억제제 |
-
2004
- 2004-04-09 JP JP2006509873A patent/JP2006526011A/ja active Pending
- 2004-04-09 CA CA002521678A patent/CA2521678A1/en not_active Abandoned
- 2004-04-09 CN CNB2004800140478A patent/CN100453553C/zh not_active Expired - Fee Related
- 2004-04-09 AT AT04759362T patent/ATE547412T1/de active
- 2004-04-09 EP EP10178023A patent/EP2332935A1/en not_active Withdrawn
- 2004-04-09 AU AU2004230946A patent/AU2004230946A1/en not_active Abandoned
- 2004-04-09 WO PCT/US2004/011012 patent/WO2004092162A1/en not_active Ceased
- 2004-04-09 ES ES04759362T patent/ES2381548T3/es not_active Expired - Lifetime
- 2004-04-09 US US10/821,793 patent/US20050090450A1/en not_active Abandoned
- 2004-04-09 EP EP04759362A patent/EP1636208B1/en not_active Expired - Lifetime
- 2004-04-12 AR ARP040101227A patent/AR044513A1/es unknown
-
2008
- 2008-07-08 US US12/169,209 patent/US20090022688A1/en not_active Abandoned
-
2010
- 2010-10-29 JP JP2010243570A patent/JP2011068655A/ja active Pending
-
2011
- 2011-09-21 US US13/238,386 patent/US8618152B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011068655A (ja) | 2011-04-07 |
| CN100453553C (zh) | 2009-01-21 |
| US20120014914A1 (en) | 2012-01-19 |
| HK1090644A1 (zh) | 2006-12-29 |
| US20090022688A1 (en) | 2009-01-22 |
| EP2332935A1 (en) | 2011-06-15 |
| ES2381548T3 (es) | 2012-05-29 |
| AR044513A1 (es) | 2005-09-14 |
| CN1795188A (zh) | 2006-06-28 |
| EP1636208A1 (en) | 2006-03-22 |
| US20050090450A1 (en) | 2005-04-28 |
| JP2006526011A (ja) | 2006-11-16 |
| US8618152B2 (en) | 2013-12-31 |
| AU2004230946A1 (en) | 2004-10-28 |
| ATE547412T1 (de) | 2012-03-15 |
| WO2004092162A1 (en) | 2004-10-28 |
| EP1636208B1 (en) | 2012-02-29 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |