CN100422133C - 2-（α-羟基戊基）苯甲酸盐及其制法和用途 - Google Patents

2-（α-羟基戊基）苯甲酸盐及其制法和用途 Download PDF

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Publication number
CN100422133C
CN100422133C CNB03156495XA CN03156495A CN100422133C CN 100422133 C CN100422133 C CN 100422133C CN B03156495X A CNB03156495X A CN B03156495XA CN 03156495 A CN03156495 A CN 03156495A CN 100422133 C CN100422133 C CN 100422133C
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CN
China
Prior art keywords
salt
alpha
preparation
amyl group
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CNB03156495XA
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English (en)
Chinese (zh)
Other versions
CN1523003A (zh
Inventor
杨文斌
秦华
赵兴凯
马喜生
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BEIJING TIANHENG DRUG RESEARCH INSTITUTE
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BEIJING TIANHENG MEDICINE INST
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Priority to CNB03156495XA priority Critical patent/CN100422133C/zh
Priority to PCT/CN2004/000102 priority patent/WO2005021481A1/fr
Publication of CN1523003A publication Critical patent/CN1523003A/zh
Application granted granted Critical
Publication of CN100422133C publication Critical patent/CN100422133C/zh
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB03156495XA 2003-09-01 2003-09-01 2-（α-羟基戊基）苯甲酸盐及其制法和用途 Expired - Lifetime CN100422133C (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CNB03156495XA CN100422133C (zh) 2003-09-01 2003-09-01 2-（α-羟基戊基）苯甲酸盐及其制法和用途
PCT/CN2004/000102 WO2005021481A1 (fr) 2003-09-01 2004-02-09 Sel n,n'-dibenzyl ethylenediamine d'acide benzoique 2-(alpha-hydroxypentyl) et procede de preparation et utilisation correspondante

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB03156495XA CN100422133C (zh) 2003-09-01 2003-09-01 2-（α-羟基戊基）苯甲酸盐及其制法和用途

Publications (2)

Publication Number Publication Date
CN1523003A CN1523003A (zh) 2004-08-25
CN100422133C true CN100422133C (zh) 2008-10-01

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Family Applications (1)

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CNB03156495XA Expired - Lifetime CN100422133C (zh) 2003-09-01 2003-09-01 2-（α-羟基戊基）苯甲酸盐及其制法和用途

Country Status (2)

Country Link
CN (1) CN100422133C (fr)
WO (1) WO2005021481A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9475750B2 (en) * 2010-10-27 2016-10-25 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
CN103113210A (zh) * 2013-02-19 2013-05-22 石药集团中奇制药技术（石家庄）有限公司 羟戊基苯甲酸钾晶体及其制备方法
CN105616375B (zh) * 2013-03-06 2018-08-28 贵州贵安新区协生元医药科技有限公司 消旋2-(α-羟基戊基)苯甲酸盐片及其制备方法
CN103142513B (zh) * 2013-03-25 2016-01-20 石家庄鸯星科技有限公司 一种注射用消旋2-(α-羟基戊基)苯甲酸盐冻干粉针及其制备方法
CN104086399B (zh) * 2013-07-17 2016-08-24 浙江奥翔药业股份有限公司 5-溴-2-（α-羟基戊基）苯甲酸钠盐的不同晶型及其制备方法
EP4122462A4 (fr) 2020-03-20 2024-03-20 Cspc Nbp Pharmaceutical Co., Ltd. Utilisation de butylphtalide et dérivé associé
CN116262698A (zh) * 2023-03-22 2023-06-16 成都施贝康生物医药科技有限公司 一种新的2-(1-羟基戊基)苯甲酸环烷胺盐

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1382682A (zh) * 2002-05-09 2002-12-04 中国医学科学院药物研究所 2－(α－羟基戊基)苯甲酸盐及其制法和用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1382682A (zh) * 2002-05-09 2002-12-04 中国医学科学院药物研究所 2－(α－羟基戊基)苯甲酸盐及其制法和用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
苯甲酸与乙二胺反应的研究. 徐家业等人.西安石油学院学报（自然科学版），第16卷第1期. 2001
苯甲酸与乙二胺反应的研究. 徐家业等人.西安石油学院学报（自然科学版），第16卷第1期. 2001 *

Also Published As

Publication number Publication date
CN1523003A (zh) 2004-08-25
WO2005021481A1 (fr) 2005-03-10

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SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
EE01 Entry into force of recordation of patent licensing contract

Assignee: Ningbo Pharmaceutical Technology and Research Co.,Ltd.

Assignor: TEAM ACADEMY OF PHARMACEUTICAL SCIENCE

Contract fulfillment period: 2008.10.6 to 2023.8.31

Contract record no.: 2008330001467

Denomination of invention: 2- (alpha hydroxy amyl) benzoate, preparation method and use thereof

Granted publication date: 20081001

License type: Exclusive license

Record date: 20081029

LIC Patent licence contract for exploitation submitted for record

Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.10.6 TO 2023.8.31; CHANGE OF CONTRACT

Name of requester: NINGBO CITY MEDICINE TECHNOLOGY RESEARCH CO., LTD.

Effective date: 20081029

CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: 100141 Beijing city Fengtai District Xiaotun Road No. 8 purple Park office block C C510

Patentee after: Beijing Tianheng Drug Research Institute

Address before: 100039 Beijing City, Fengtai District Jiang Jia Fen Road No. 329 Beijing Tianheng Pharmaceutical Institute

Patentee before: TEAM ACADEMY OF PHARMACEUTICAL SCIENCE

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20081001