CN106892930B - 银杏内酯b衍生物及其制备方法与应用 - Google Patents
银杏内酯b衍生物及其制备方法与应用 Download PDFInfo
- Publication number
- CN106892930B CN106892930B CN201611177538.5A CN201611177538A CN106892930B CN 106892930 B CN106892930 B CN 106892930B CN 201611177538 A CN201611177538 A CN 201611177538A CN 106892930 B CN106892930 B CN 106892930B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- ginkgolide
- preparation
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
化合物 | 水中的溶解性(mg/mL) |
银杏内酯B(GB) | 0.11 |
BM | 0.25 |
BM甲磺酸盐 | 4.20 |
BM盐酸盐 | 4.65 |
BZ | 0.30 |
BZ甲磺酸盐 | 5.02 |
BZ盐酸盐 | 5.10 |
BA | 0.22 |
BL | 0.20 |
BD | 0.25 |
Claims (9)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510961751 | 2015-12-18 | ||
CN2015109617514 | 2015-12-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106892930A CN106892930A (zh) | 2017-06-27 |
CN106892930B true CN106892930B (zh) | 2020-02-18 |
Family
ID=59055789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201611177538.5A Active CN106892930B (zh) | 2015-12-18 | 2016-12-19 | 银杏内酯b衍生物及其制备方法与应用 |
Country Status (7)
Country | Link |
---|---|
US (1) | US10875874B2 (zh) |
EP (1) | EP3381921B1 (zh) |
JP (1) | JP6767498B2 (zh) |
KR (1) | KR102105451B1 (zh) |
CN (1) | CN106892930B (zh) |
CA (1) | CA3008698C (zh) |
WO (1) | WO2017101881A1 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109988182B (zh) * | 2018-01-02 | 2021-02-19 | 澳门大学 | 银杏内酯b衍生物及其应用 |
CN109464450B (zh) * | 2019-01-08 | 2020-03-31 | 佳木斯大学附属第一医院 | 一种预防和治疗脑卒中的药物及其制备方法 |
CN115109068B (zh) * | 2021-03-19 | 2024-05-24 | 澳门科技大学 | 用于预防或治疗心脑血管疾病的化合物及其制备方法和应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1050132C (zh) * | 1993-12-31 | 2000-03-08 | 鲜京工业股份有限公司 | 银杏苦内酯类衍生物 |
CN101880286A (zh) * | 2009-05-08 | 2010-11-10 | 北京美倍他药物研究有限公司 | 银杏内酯b的水溶性氨基酸酯衍生物 |
CN103242337A (zh) * | 2013-04-12 | 2013-08-14 | 合肥工业大学 | 一种基于paf/ros双靶点的银杏内酯b衍生物及其制备方法 |
CN103508981A (zh) * | 2012-06-18 | 2014-01-15 | 北京美倍他药物研究有限公司 | 新的哌嗪衍生物及其医药用途 |
CN104098584A (zh) * | 2013-04-03 | 2014-10-15 | 广东东阳光药业有限公司 | 银杏内酯b衍生物及其在药物中的应用 |
CN105367582A (zh) * | 2014-08-11 | 2016-03-02 | 广东东阳光药业有限公司 | 银杏内酯b衍生物及其在药物中的应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8725871D0 (en) * | 1987-11-04 | 1987-12-09 | Scras | Ginkgolide derivatives |
GB9107425D0 (en) | 1991-04-09 | 1991-05-22 | Scras | Preparation of ginkgolide b |
WO1993006107A1 (en) | 1991-09-18 | 1993-04-01 | Sunkyong Industries Co., Ltd. | New ginkgolide derivatives and a process for preparing them |
US6693091B2 (en) * | 2002-03-29 | 2004-02-17 | The Trustees Of Columbia University In The City Of New York | Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies |
AU2003243158A1 (en) | 2002-03-29 | 2003-10-13 | The Trustees Of Columbia University In The City Of New York | Analogs of terpene trilactones from ginkgo biloba and related compounds and uses thereof |
CN100445288C (zh) | 2006-04-26 | 2008-12-24 | 秦引林 | 银杏内酯b衍生物及其在制药中的应用 |
-
2016
- 2016-12-19 CN CN201611177538.5A patent/CN106892930B/zh active Active
- 2016-12-19 WO PCT/CN2016/110802 patent/WO2017101881A1/zh active Application Filing
- 2016-12-19 JP JP2018550641A patent/JP6767498B2/ja active Active
- 2016-12-19 EP EP16874938.0A patent/EP3381921B1/en active Active
- 2016-12-19 US US16/063,615 patent/US10875874B2/en active Active
- 2016-12-19 CA CA3008698A patent/CA3008698C/en active Active
- 2016-12-19 KR KR1020187020564A patent/KR102105451B1/ko active IP Right Grant
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1050132C (zh) * | 1993-12-31 | 2000-03-08 | 鲜京工业股份有限公司 | 银杏苦内酯类衍生物 |
CN101880286A (zh) * | 2009-05-08 | 2010-11-10 | 北京美倍他药物研究有限公司 | 银杏内酯b的水溶性氨基酸酯衍生物 |
CN103508981A (zh) * | 2012-06-18 | 2014-01-15 | 北京美倍他药物研究有限公司 | 新的哌嗪衍生物及其医药用途 |
CN104098584A (zh) * | 2013-04-03 | 2014-10-15 | 广东东阳光药业有限公司 | 银杏内酯b衍生物及其在药物中的应用 |
CN103242337A (zh) * | 2013-04-12 | 2013-08-14 | 合肥工业大学 | 一种基于paf/ros双靶点的银杏内酯b衍生物及其制备方法 |
CN105367582A (zh) * | 2014-08-11 | 2016-03-02 | 广东东阳光药业有限公司 | 银杏内酯b衍生物及其在药物中的应用 |
Non-Patent Citations (3)
Title |
---|
Brain-targeting research of 10-O-nicotinate ginkgolide B:a new prodrug of ginkgolide B;Ze-Yu Wu et al.;《Med Chem Res》;20111224;第21卷;第4028-4036页 * |
银杏内酯B 的1,4- 二氢吡啶酸酯衍生物的合成研究;周小健等;《安微化工》;20130228;第39卷(第1期);第48-49,56页 * |
银杏内酯B及其前药脂水分配系数的测定;潘见等;《时珍国医国药》;20111231;第22卷(第10期);第2397-2400页 * |
Also Published As
Publication number | Publication date |
---|---|
EP3381921A4 (en) | 2019-10-30 |
US20190077811A1 (en) | 2019-03-14 |
JP6767498B2 (ja) | 2020-10-14 |
CA3008698C (en) | 2020-12-15 |
KR20180095665A (ko) | 2018-08-27 |
JP2019506446A (ja) | 2019-03-07 |
EP3381921A1 (en) | 2018-10-03 |
WO2017101881A1 (zh) | 2017-06-22 |
CN106892930A (zh) | 2017-06-27 |
US10875874B2 (en) | 2020-12-29 |
KR102105451B1 (ko) | 2020-04-28 |
EP3381921B1 (en) | 2021-02-03 |
CA3008698A1 (en) | 2017-06-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106892930B (zh) | 银杏内酯b衍生物及其制备方法与应用 | |
KR102563378B1 (ko) | 2-(1-아실옥시-n-펜틸)벤조산 및 염기성 아미노산 또는 아미노구아니딘이 형성하는 염, 이의 제조 방법 및 용도 | |
KR20160058098A (ko) | 티에노피페리딘 유도체 및 이의 용도 | |
CN104892628A (zh) | 银杏内酯k衍生物及其制备方法和用途 | |
JP2008506722A (ja) | シス−1,2−置換スチルベン誘導体、および糖尿病の治療および/または予防のための薬剤の製造におけるそれらの使用 | |
CN114349745B (zh) | 一种用于治疗心肌缺血的药物及其制备方法 | |
NO179515B (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive 3,4-dihydroisokinolinderivater | |
JP2018520128A (ja) | 重水素化チエノピペリジン誘導体、調製方法、及びその使用 | |
WO2019232662A1 (zh) | 一类具有抗癌活性的吲嗪类化合物及其衍生物 | |
CN107325052A (zh) | 一类具有抗癌活性的咪唑酯类化合物及其衍生物 | |
US4851414A (en) | Anti-dementia agent | |
RU2593203C2 (ru) | Пантенола докозагексаеноат и его применение для лечения и предупреждения сердечно-сосудистых заболеваний | |
CN108069980A (zh) | 银杏内酯k新型衍生物及其制备方法和用途 | |
WO2005021481A1 (en) | N, n’-dibenzyl ethylenediamine salt pf 2-(alpha-hidroxypentyl) benzoic acid and its preparing process and usage | |
WO2023104201A1 (zh) | 芳基c-葡萄糖苷衍生物、其制备方法及其用途 | |
CN116444482B (zh) | 噻吩-2-羧酸衍生物、其制备方法及医药用途 | |
CN104873482B (zh) | 一种抗慢性心力衰竭的药物组合物 | |
CN112094255B (zh) | 一种灯盏花乙素苷元衍生物、其制备方法与应用 | |
CN113105391B (zh) | 一种具有镇痛活性的高乌甲素衍生物及其制备方法和应用 | |
JP7473554B2 (ja) | Par4阻害剤の結晶体 | |
CA1040202A (en) | Papaverine thienyl-carboxylates and medicaments containing them | |
WO2023001268A1 (zh) | 一种白杨素衍生物及其制备方法和应用 | |
WO2013083014A1 (zh) | 黄豆苷元衍生物、其药学上可接受的盐、制备方法以及包含其的药物组合物 | |
EA006245B1 (ru) | Гидрохлорид 4-[4-(2-пирролилкарбонил)-1-пиперазинил]-3-трифторметилбензоилгуанидина | |
CN111269222B (zh) | 一种化合物及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: No. 1002, Building 11, No. 88, South Keyuan Road, High tech Zone, Chengdu, Sichuan 610041 Patentee after: Sichuan Hongming Bosi Pharmaceutical Co.,Ltd. Address before: No. 1002, Building 11, No. 88, South Keyuan Road, High tech Zone, Chengdu, Sichuan 610041 Patentee before: CHENGDU BAIYU GINKGOLIDE PHARMACEUTICALS Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20221201 Address after: 10/F, Building B7, Tianfu Life Science Park, No. 88, South Keyuan Road, Hi tech Zone, Chengdu, Sichuan 610000 Patentee after: CHENGDU BAIYU PHARMACEUTICAL Co.,Ltd. Address before: No. 1002, Building 11, No. 88, South Keyuan Road, High tech Zone, Chengdu, Sichuan 610041 Patentee before: Sichuan Hongming Bosi Pharmaceutical Co.,Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Ginkgolide B derivatives and their preparation methods and applications Effective date of registration: 20230721 Granted publication date: 20200218 Pledgee: Bank of Shanghai Limited by Share Ltd. Chengdu branch Pledgor: CHENGDU BAIYU PHARMACEUTICAL Co.,Ltd. Registration number: Y2023980049267 |