CN100392099C - 将生物分子高密度固定到表面具有活化羧基的固体基质上的方法及用该方法制备的微阵列 - Google Patents

将生物分子高密度固定到表面具有活化羧基的固体基质上的方法及用该方法制备的微阵列 Download PDF

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CN100392099C
CN100392099C CNB2005100044744A CN200510004474A CN100392099C CN 100392099 C CN100392099 C CN 100392099C CN B2005100044744 A CNB2005100044744 A CN B2005100044744A CN 200510004474 A CN200510004474 A CN 200510004474A CN 100392099 C CN100392099 C CN 100392099C
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solid substrate
tetracarboxylic dianhydride
biomolecules
matrix
carboxyl
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CN1661114A (zh
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黄奎渊
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Samsung Electronics Co Ltd
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Samsung Electronics Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier

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  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
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  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Food Science & Technology (AREA)
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  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB2005100044744A 2004-01-12 2005-01-12 将生物分子高密度固定到表面具有活化羧基的固体基质上的方法及用该方法制备的微阵列 Expired - Fee Related CN100392099C (zh)

Applications Claiming Priority (3)

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KR0001963/04 2004-01-12
KR1020040001963A KR100580642B1 (ko) 2004-01-12 2004-01-12 표면에 활성화된 카르복실기를 갖는 기판을 이용하여 생물분자를 고체 기판상에 고밀도로 고정화하는 방법 및 그에 의하여 제조되는 마이크로어레이
KR0001963/2004 2004-01-12

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CN1661114A CN1661114A (zh) 2005-08-31
CN100392099C true CN100392099C (zh) 2008-06-04

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US (2) US7195924B2 (enExample)
EP (1) EP1553415B1 (enExample)
JP (1) JP4045276B2 (enExample)
KR (1) KR100580642B1 (enExample)
CN (1) CN100392099C (enExample)
DE (1) DE602005000189T2 (enExample)

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KR100657907B1 (ko) * 2004-11-03 2006-12-14 삼성전자주식회사 신규한 링커 화합물, 상기 화합물이 코팅되어 있는 기판,상기 화합물을 이용하여 마이크로어레이를 제조하는 방법및 그에 의하여 제조된 마이크로어레이
GB2420849B (en) * 2004-12-02 2007-06-27 Schlumberger Holdings Optical pH sensor
KR100738083B1 (ko) * 2005-12-20 2007-07-12 삼성전자주식회사 마이크로어레이용 기판 및 그의 제조방법
KR100829574B1 (ko) 2006-01-03 2008-05-14 삼성전자주식회사 마이크로어레이용 기판, 그 마이크로어레이용 기판을이용하여 생분자를 분석하는 방법, 및 그 마이크로어레이용기판을 포함하는 랩온어칩
US7493199B2 (en) * 2006-10-17 2009-02-17 Trw Automotive U.S. Llc Method of controlling a roll control system for improved vehicle dynamic control
KR100843147B1 (ko) * 2007-02-12 2008-07-03 삼성전자주식회사 올리고머 프로브 어레이용 기판과 올리고머 프로브 어레이및 이들의 제조 방법
JP4805283B2 (ja) * 2007-03-22 2011-11-02 信越化学工業株式会社 マイクロアレイ作製用基板の製造方法
JP5344835B2 (ja) * 2008-03-24 2013-11-20 富士フイルム株式会社 固定化方法、生理活性物質固定化担体及び固定用担体
JP5388462B2 (ja) * 2008-03-24 2014-01-15 富士フイルム株式会社 担体及びその製造方法
US8404621B2 (en) * 2008-03-24 2013-03-26 Fujifilm Corporation Method for immobilization, physiologically active substance-immobilized carrier, carrier for immobilization, carrier, and process for producing carrier
DE102010049807A1 (de) 2010-10-27 2012-05-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Immobilisierung mindestens einer Substanz auf Oberflächen
JP5462919B2 (ja) 2011-10-31 2014-04-02 アークレイ株式会社 基材の修飾方法
CN104027852B (zh) * 2014-06-26 2015-09-23 淮阴工学院 生物材料的表面改性方法
KR101603602B1 (ko) 2014-07-09 2016-03-16 한국원자력연구원 방사선 조사를 이용한 폴리도파민 코팅 고분자 기질 및 이의 제조 방법
CN105854962B (zh) * 2016-03-28 2018-01-19 北京瑞联安科技有限公司 一种生物识别分子固定到生物芯片的方法
EP3543338B1 (en) * 2016-11-18 2025-10-22 Toyo Seikan Group Holdings, Ltd. Carrier for biologically relevant molecule immobilization
JP6931181B2 (ja) * 2016-12-20 2021-09-01 東洋製罐グループホールディングス株式会社 生体関連分子固定化用担体
JP2018078864A (ja) * 2016-11-18 2018-05-24 東洋製罐グループホールディングス株式会社 生体関連分子固定化用担体

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US5760130A (en) * 1997-05-13 1998-06-02 Molecular Dynamics, Inc. Aminosilane/carbodiimide coupling of DNA to glass substrate

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JPH0637609B2 (ja) * 1986-01-24 1994-05-18 マサチユ−セツツ インスチチユ−ト オブ テクノロジ− 接着促進剤
FR2630329B1 (fr) * 1988-04-20 1991-07-05 Merieux Inst Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
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US5350800A (en) * 1993-01-19 1994-09-27 Medtronic, Inc. Method for improving the biocompatibility of solid surfaces
US5760130A (en) * 1997-05-13 1998-06-02 Molecular Dynamics, Inc. Aminosilane/carbodiimide coupling of DNA to glass substrate

Also Published As

Publication number Publication date
CN1661114A (zh) 2005-08-31
EP1553415B1 (en) 2006-10-25
DE602005000189D1 (de) 2006-12-07
KR20050073856A (ko) 2005-07-18
KR100580642B1 (ko) 2006-05-16
JP2005201901A (ja) 2005-07-28
US7195924B2 (en) 2007-03-27
DE602005000189T2 (de) 2007-02-08
JP4045276B2 (ja) 2008-02-13
US20070141556A1 (en) 2007-06-21
EP1553415A1 (en) 2005-07-13
US20050153350A1 (en) 2005-07-14

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