CN100390164C - 异喹啉化合物及其医药用途 - Google Patents

异喹啉化合物及其医药用途 Download PDF

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Publication number
CN100390164C
CN100390164C CNB200380100827XA CN200380100827A CN100390164C CN 100390164 C CN100390164 C CN 100390164C CN B200380100827X A CNB200380100827X A CN B200380100827XA CN 200380100827 A CN200380100827 A CN 200380100827A CN 100390164 C CN100390164 C CN 100390164C
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CN
China
Prior art keywords
isoquinolin
methyl
group
ethyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB200380100827XA
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English (en)
Chinese (zh)
Other versions
CN1703410A (zh
Inventor
藤尾雅和
佐藤裕行
井上伸哉
松本寿史
江木康阳
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Tanabe Pharma Corp
Original Assignee
Mitsubishi Pharma Corp
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Publication of CN1703410A publication Critical patent/CN1703410A/zh
Application granted granted Critical
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CNB200380100827XA 2002-10-01 2003-10-01 异喹啉化合物及其医药用途 Expired - Fee Related CN100390164C (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2002288833 2002-10-01
JP288833/2002 2002-10-01
JP340175/2002 2002-11-22
JP2002340175 2002-11-22
JP109160/2003 2003-04-14
JP2003109160 2003-04-14
PCT/JP2003/012608 WO2004031171A1 (ja) 2002-10-01 2003-10-01 イソキノリン化合物及びその医薬用途

Publications (2)

Publication Number Publication Date
CN1703410A CN1703410A (zh) 2005-11-30
CN100390164C true CN100390164C (zh) 2008-05-28

Family

ID=32074144

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB200380100827XA Expired - Fee Related CN100390164C (zh) 2002-10-01 2003-10-01 异喹啉化合物及其医药用途

Country Status (12)

Country Link
US (3) US7220759B2 (https=)
EP (1) EP1557414B1 (https=)
JP (1) JP4520406B2 (https=)
KR (1) KR100735781B1 (https=)
CN (1) CN100390164C (https=)
AT (1) ATE552252T1 (https=)
CA (1) CA2500888C (https=)
DK (1) DK1557414T3 (https=)
ES (1) ES2380917T3 (https=)
PT (1) PT1557414E (https=)
TW (1) TW200424188A (https=)
WO (1) WO2004031171A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4520406B2 (ja) * 2002-10-01 2010-08-04 田辺三菱製薬株式会社 イソキノリン化合物及びその医薬用途
US7501412B2 (en) * 2002-11-22 2009-03-10 Mitsubishi Tanabe Pharma Corporation Isoquinoline compounds and medicinal use thereof
JP5282037B2 (ja) * 2007-08-10 2013-09-04 田辺三菱製薬株式会社 新規なイソキノリン化合物の塩及びその結晶
TWI499418B (zh) * 2009-05-21 2015-09-11 Nerviano Medical Sciences Srl 異喹啉－１（２ｈ）－酮衍生物
EP2729007A1 (de) 2011-07-04 2014-05-14 Bayer Intellectual Property GmbH Verwendung substituierter isochinolinone, isochinolindione, isochinolintrione und dihydroisochinolinone oder jeweils deren salze als wirkstoffe gegen abiotischen pflanzenstress
CN103130723B (zh) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 一种多聚(adp-核糖)聚合酶抑制剂
CA2865511A1 (en) * 2012-03-07 2013-09-12 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
US9611223B2 (en) 2013-09-11 2017-04-04 Institute Of Cancer Research: Royal Cancer Hospital (The) 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
TWI672297B (zh) * 2013-12-18 2019-09-21 義大利商吉斯藥品公司 作為磷脂肌醇－３－激酶抑制劑之異唏衍生物
US12459899B2 (en) 2019-10-30 2025-11-04 DIGMBIO, Inc. Isoquinolinone derivatives, method for preparing the same, and pharmaceutical composition for preventing or treating poly(ADP-ribose) polymerase-1-related diseases, comprising the same as active ingredient
US12496297B1 (en) * 2020-10-23 2025-12-16 Washington University Compositions of autophagy modulating agents and uses thereof
CN113636970B (zh) * 2021-09-13 2023-05-23 河北康泰药业有限公司 一种异吲哚酮的化合物、制备方法及其应用

Citations (5)

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JPS4612454Y1 (https=) * 1968-07-26 1971-04-30
WO1999011628A1 (en) * 1997-09-03 1999-03-11 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhi biting parp activity
WO1999059973A1 (en) * 1998-05-15 1999-11-25 Guilford Pharmaceuticals Inc. Carboxamide compounds, compositions, and methods for inhibiting parp activity
CN1278797A (zh) * 1997-09-03 2001-01-03 吉尔福特药品有限公司 氧代化合物、其制备方法和组合物及抑制parp活性的方法
WO2002048117A1 (en) * 2000-12-11 2002-06-20 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivatives

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GB1062357A (en) 1965-03-23 1967-03-22 Pfizer & Co C Quinazolone derivatives
DE2121031A1 (en) 1971-04-29 1972-11-02 Dr. Karl Thomae Gmbh, 7950 Biberach Base-substd quinazolines - thrombocyte aggregation inhibitors
IT1054655B (it) * 1975-08-27 1981-11-30 Lepetit Spa Derivati condensati del l isochinolina
JPS52156875A (en) 1976-06-23 1977-12-27 Mitsui Toatsu Chem Inc Preparation of novel isoquinolone derivatives
JPS5484597A (en) 1977-12-15 1979-07-05 Yamanouchi Pharmaceut Co Ltd Novel heterocyclic compound and its preparation
JPS6442472U (https=) 1986-06-14 1989-03-14
US4808595A (en) 1986-12-24 1989-02-28 Merck & Co., Inc. Furopyridine sulfonamides and their opthalmological compositions
JPS6442472A (en) 1987-08-10 1989-02-14 Kanebo Ltd Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient
CA1334969C (en) 1988-08-19 1995-03-28 Mark James Suto Substituted dihydroisoquinoline and phthalazine derivatives as potentiators of the lethal effects of radiation and certain chemotherapeutic agents, selected compounds, analogs andprocess
AU8784698A (en) 1997-08-15 1999-03-08 Johns Hopkins University, The Method of using selective parp inhibitors to prevent or treat neurotoxicity
US6635642B1 (en) 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6514983B1 (en) 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
AU2004200A (en) 1999-01-14 2000-08-01 Meiji Seika Kaisha Ltd. Poly(adp-ribose) polymerase inhibitors consisting of pyrimidine derivatives
US6677333B1 (en) 1999-01-26 2004-01-13 Ono Pharmaceutical Co., Ltd. 2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient
DE19918211A1 (de) 1999-04-22 2000-10-26 Basf Ag Cycloalkylsubstituierte Benzimidazole, deren Herstellung und Anwendung
DE19920936A1 (de) 1999-05-07 2000-11-09 Basf Ag Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung
DE19921567A1 (de) 1999-05-11 2000-11-16 Basf Ag Verwendung von Phthalazine-Derivaten
JPWO2001079184A1 (ja) 2000-04-18 2004-03-18 住友製薬株式会社 置換ピペラジン類
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DE60218458T2 (de) 2001-05-08 2007-11-15 Kudos Pharmaceuticals Ltd. Isochinolinon derivate als parp inhibitoren
JPWO2002094790A1 (ja) * 2001-05-23 2004-09-09 三菱ウェルファーマ株式会社 縮合ヘテロ環化合物およびその医薬用途
AUPS019702A0 (en) 2002-01-29 2002-02-21 Fujisawa Pharmaceutical Co., Ltd. Condensed heterocyclic compounds
JP4520406B2 (ja) * 2002-10-01 2010-08-04 田辺三菱製薬株式会社 イソキノリン化合物及びその医薬用途
US7501412B2 (en) 2002-11-22 2009-03-10 Mitsubishi Tanabe Pharma Corporation Isoquinoline compounds and medicinal use thereof
JP4612454B2 (ja) 2005-03-31 2011-01-12 本田技研工業株式会社 ブレーキ制御装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4612454Y1 (https=) * 1968-07-26 1971-04-30
WO1999011628A1 (en) * 1997-09-03 1999-03-11 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhi biting parp activity
CN1278797A (zh) * 1997-09-03 2001-01-03 吉尔福特药品有限公司 氧代化合物、其制备方法和组合物及抑制parp活性的方法
WO1999059973A1 (en) * 1998-05-15 1999-11-25 Guilford Pharmaceuticals Inc. Carboxamide compounds, compositions, and methods for inhibiting parp activity
WO2002048117A1 (en) * 2000-12-11 2002-06-20 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivatives

Also Published As

Publication number Publication date
JP4520406B2 (ja) 2010-08-04
US20040248931A1 (en) 2004-12-09
WO2004031171A1 (ja) 2004-04-15
ATE552252T1 (de) 2012-04-15
EP1557414B1 (en) 2012-04-04
US20070161620A1 (en) 2007-07-12
CA2500888C (en) 2010-07-13
JPWO2004031171A1 (ja) 2006-02-02
TW200424188A (en) 2004-11-16
DK1557414T3 (da) 2012-05-29
US20090076276A1 (en) 2009-03-19
EP1557414A1 (en) 2005-07-27
KR100735781B1 (ko) 2007-07-06
US7220759B2 (en) 2007-05-22
CA2500888A1 (en) 2004-04-15
CN1703410A (zh) 2005-11-30
EP1557414A4 (en) 2007-10-31
US7812178B2 (en) 2010-10-12
US7459465B2 (en) 2008-12-02
TWI338687B (https=) 2011-03-11
KR20050070024A (ko) 2005-07-05
AU2003268724A1 (en) 2004-04-23
ES2380917T3 (es) 2012-05-21
PT1557414E (pt) 2012-04-17

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Owner name: TANADE SEIYAKU CO., LTD.

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