CN100378079C - 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法 - Google Patents

用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法 Download PDF

Info

Publication number
CN100378079C
CN100378079C CNB028187180A CN02818718A CN100378079C CN 100378079 C CN100378079 C CN 100378079C CN B028187180 A CNB028187180 A CN B028187180A CN 02818718 A CN02818718 A CN 02818718A CN 100378079 C CN100378079 C CN 100378079C
Authority
CN
China
Prior art keywords
allylaminogeldanamycin
solvent
ansamycins
volatile
aag
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028187180A
Other languages
English (en)
Chinese (zh)
Other versions
CN1558757A (zh
Inventor
张琳
马库斯·F·贝姆
西埃德·塞加
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Conforma Therapeutics Corp
Original Assignee
Conforma Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conforma Therapeutics Corp filed Critical Conforma Therapeutics Corp
Publication of CN1558757A publication Critical patent/CN1558757A/zh
Application granted granted Critical
Publication of CN100378079C publication Critical patent/CN100378079C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CNB028187180A 2001-09-24 2002-09-18 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法 Expired - Fee Related CN100378079C (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32663901P 2001-09-24 2001-09-24
US60/326,639 2001-09-24
US33189301P 2001-11-21 2001-11-21
US60/331,893 2001-11-21
PCT/US2002/029715 WO2003026571A2 (en) 2001-09-24 2002-09-18 Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2008100062587A Division CN101230040A (zh) 2001-09-24 2002-09-18 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法

Publications (2)

Publication Number Publication Date
CN1558757A CN1558757A (zh) 2004-12-29
CN100378079C true CN100378079C (zh) 2008-04-02

Family

ID=26985493

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028187180A Expired - Fee Related CN100378079C (zh) 2001-09-24 2002-09-18 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法

Country Status (9)

Country Link
US (1) US7579462B2 (https=)
EP (1) EP1435939B1 (https=)
JP (1) JP2005504086A (https=)
KR (1) KR20040054692A (https=)
CN (1) CN100378079C (https=)
AT (1) ATE387198T1 (https=)
CA (1) CA2460498A1 (https=)
DE (1) DE60225307T2 (https=)
WO (1) WO2003026571A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
EP1435939B1 (en) 2001-09-24 2008-02-27 Conforma Therapeutic Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
US7241890B2 (en) 2001-10-30 2007-07-10 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
EP1472230B1 (en) 2002-02-08 2009-06-17 Conforma Therapeutic Corporation Ansamycins having improved pharmacological and biological properties
KR20060070572A (ko) 2003-09-18 2006-06-23 콘포마 세러퓨틱스 코포레이션 Ｈｓｐ90-저해제로서의 신규 헤테로시클릭 화합물
BRPI0418147A (pt) 2003-12-23 2007-04-17 Infinity Pharmaceuticals Inc análogos de ansamicinas contendo benzoquinona e seus métodos de uso
KR101045324B1 (ko) * 2004-08-11 2011-06-30 한국생명공학연구원 젤다나마이신 유도체 및 그 생합성 방법
US7371906B2 (en) 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
CN105879114A (zh) * 2005-02-18 2016-08-24 阿布拉西斯生物科学公司 用于整合入医疗装置的疏水性改善的药物
CA2602257A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
BRPI0608661A2 (pt) * 2005-04-07 2010-01-19 Conforma Therapeutics Corp formulaÇço farmacÊutica, uso de formulaÇço farmacÊutica, e, mÉtodo de preparaÇço de uma formulaÇço farmacÊutica
US7648976B2 (en) * 2005-11-23 2010-01-19 Bristol-Myers Squibb Company 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
US20090042847A1 (en) * 2005-11-23 2009-02-12 Kosan Biosciences Incorporated 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
JP2009518302A (ja) * 2005-12-01 2009-05-07 コンフォーマ・セラピューティクス・コーポレイション アンサマイシン含有組成物
KR100796637B1 (ko) * 2006-09-29 2008-01-22 한국생명공학연구원 젤다나마이신 유도체, 이의 약학적으로 허용가능한 염,이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 및치료제
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
PE20081506A1 (es) * 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
KR100861697B1 (ko) * 2007-01-30 2008-10-07 한국생명공학연구원 Ａｈｂａ 생합성 유전자 변이주를 이용한 안사마이신유도체의 생산 방법 및 신규한 안사마이신 유도체
WO2010045442A1 (en) 2008-10-15 2010-04-22 Infinity Discovery, Inc. Ansamycin hydroquinone compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
WO1995001342A1 (en) * 1993-06-29 1995-01-12 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same
FI943207A0 (fi) 1992-01-06 1994-07-05 Pfizer 4,5-dihydrogeldanamysiinin ja sen hydrokinonin valmistusmenetelmä ja käyttö
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5883236A (en) * 1997-11-19 1999-03-16 Abbott Laboratories Process for N-desmethylating erythromycins and derivatives thereof
WO2000061578A1 (en) 1999-04-09 2000-10-19 Sloan-Kettering Institute For Cancer Research Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
EP1435939B1 (en) 2001-09-24 2008-02-27 Conforma Therapeutic Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
WO1995001342A1 (en) * 1993-06-29 1995-01-12 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents

Also Published As

Publication number Publication date
WO2003026571A2 (en) 2003-04-03
EP1435939A4 (en) 2004-12-29
US20050176695A1 (en) 2005-08-11
CN1558757A (zh) 2004-12-29
US7579462B2 (en) 2009-08-25
CA2460498A1 (en) 2003-04-03
DE60225307D1 (de) 2008-04-10
EP1435939A2 (en) 2004-07-14
EP1435939B1 (en) 2008-02-27
JP2005504086A (ja) 2005-02-10
DE60225307T2 (de) 2009-03-19
KR20040054692A (ko) 2004-06-25
ATE387198T1 (de) 2008-03-15
WO2003026571A3 (en) 2003-10-02

Similar Documents

Publication Publication Date Title
CN100378079C (zh) 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法
EP1380576B1 (en) 1h-indazole compounds inhibiting jnk
KR100207802B1 (ko) N-[4-(5-시클로펜틸옥시카르보닐)아미노-1-메틸인돌-3-일-메틸]-3-메톡시벤조일]-2-메틸벤젠설폰아미드 화합물 및 이것의 제조 방법
US20080214617A1 (en) Carbamate compounds
UA124708C2 (uk) Модулятор муковісцидозного регулятора трансмембранної провідності, фармацевтичні композиції, способи лікування та спосіб отримання модулятора
EP1841762A1 (fr) Indoles substitues, compositions les contenant, procede de fabrication et utilisation
CN101230040A (zh) 用于制备17-烯丙基氨基格尔德霉素(17-aag)以及其它袢霉素的方法
FR3092581A1 (fr) Formes cristallines d'un inhibiteur de jak2
US12048700B2 (en) Crystalline monosodium salt of 5-methyl-(6S)-tetrahydrofolic acid
CN102020640A (zh) 四氢吲哚酮和四氢吲唑酮衍生物、其制备方法及其在医药上的应用
EP1923061A1 (en) Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins
HK1120411A (en) Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
AU2002326973A1 (en) Process for preparing 17-allyl amino geldanamycin (17-AAG) and other ansamycins
EP2507250A1 (en) Solid state forms of fosamprenavir calcium salt and process for preparation thereof
CN111848580B (zh) 含1,2,4-三嗪-3,5-二酮的喹啉类化合物的晶型及其制备方法和应用
RU2803290C2 (ru) Ингибирование creb-связывающего белка (cbp)
EP2183214A1 (en) Crystalline teglicar
WO2025114404A1 (en) Solid forms of a pharmaceutically active compound
WO1991017172A1 (en) Novel mycalamides with antitumor and antiviral activity
IES83541Y1 (en) Paroxetine methanesulfonate

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20080402

Termination date: 20091019