ATE387198T1 - Verfahren zur herstellung von 17-allyl-amino- geldanamycin (17-aag) und anderer ansamycine - Google Patents

Verfahren zur herstellung von 17-allyl-amino- geldanamycin (17-aag) und anderer ansamycine

Info

Publication number
ATE387198T1
ATE387198T1 AT02761732T AT02761732T ATE387198T1 AT E387198 T1 ATE387198 T1 AT E387198T1 AT 02761732 T AT02761732 T AT 02761732T AT 02761732 T AT02761732 T AT 02761732T AT E387198 T1 ATE387198 T1 AT E387198T1
Authority
AT
Austria
Prior art keywords
ansamycins
aag
allyl
moneyanamycin
amino
Prior art date
Application number
AT02761732T
Other languages
German (de)
English (en)
Inventor
Lin Zhang
Marcus F Boehm
Siead Zegar
Original Assignee
Conforma Therapeutic Corp
Lin Zhang
Marcus F Boehm
Siead Zegar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conforma Therapeutic Corp, Lin Zhang, Marcus F Boehm, Siead Zegar filed Critical Conforma Therapeutic Corp
Application granted granted Critical
Publication of ATE387198T1 publication Critical patent/ATE387198T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02761732T 2001-09-24 2002-09-18 Verfahren zur herstellung von 17-allyl-amino- geldanamycin (17-aag) und anderer ansamycine ATE387198T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32663901P 2001-09-24 2001-09-24
US33189301P 2001-11-21 2001-11-21

Publications (1)

Publication Number Publication Date
ATE387198T1 true ATE387198T1 (de) 2008-03-15

Family

ID=26985493

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02761732T ATE387198T1 (de) 2001-09-24 2002-09-18 Verfahren zur herstellung von 17-allyl-amino- geldanamycin (17-aag) und anderer ansamycine

Country Status (9)

Country Link
US (1) US7579462B2 (https=)
EP (1) EP1435939B1 (https=)
JP (1) JP2005504086A (https=)
KR (1) KR20040054692A (https=)
CN (1) CN100378079C (https=)
AT (1) ATE387198T1 (https=)
CA (1) CA2460498A1 (https=)
DE (1) DE60225307T2 (https=)
WO (1) WO2003026571A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
EP1435939B1 (en) 2001-09-24 2008-02-27 Conforma Therapeutic Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
US7241890B2 (en) 2001-10-30 2007-07-10 Conforma Therapeutics Corporation Purine analogs having HSP90-inhibiting activity
EP1472230B1 (en) 2002-02-08 2009-06-17 Conforma Therapeutic Corporation Ansamycins having improved pharmacological and biological properties
KR20060070572A (ko) 2003-09-18 2006-06-23 콘포마 세러퓨틱스 코포레이션 Ｈｓｐ90-저해제로서의 신규 헤테로시클릭 화합물
BRPI0418147A (pt) 2003-12-23 2007-04-17 Infinity Pharmaceuticals Inc análogos de ansamicinas contendo benzoquinona e seus métodos de uso
KR101045324B1 (ko) * 2004-08-11 2011-06-30 한국생명공학연구원 젤다나마이신 유도체 및 그 생합성 방법
US7371906B2 (en) 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
CN105879114A (zh) * 2005-02-18 2016-08-24 阿布拉西斯生物科学公司 用于整合入医疗装置的疏水性改善的药物
CA2602257A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as hsp90-inhibitors
BRPI0608661A2 (pt) * 2005-04-07 2010-01-19 Conforma Therapeutics Corp formulaÇço farmacÊutica, uso de formulaÇço farmacÊutica, e, mÉtodo de preparaÇço de uma formulaÇço farmacÊutica
US7648976B2 (en) * 2005-11-23 2010-01-19 Bristol-Myers Squibb Company 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
US20090042847A1 (en) * 2005-11-23 2009-02-12 Kosan Biosciences Incorporated 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
JP2009518302A (ja) * 2005-12-01 2009-05-07 コンフォーマ・セラピューティクス・コーポレイション アンサマイシン含有組成物
KR100796637B1 (ko) * 2006-09-29 2008-01-22 한국생명공학연구원 젤다나마이신 유도체, 이의 약학적으로 허용가능한 염,이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 및치료제
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
PE20081506A1 (es) * 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
KR100861697B1 (ko) * 2007-01-30 2008-10-07 한국생명공학연구원 Ａｈｂａ 생합성 유전자 변이주를 이용한 안사마이신유도체의 생산 방법 및 신규한 안사마이신 유도체
WO2010045442A1 (en) 2008-10-15 2010-04-22 Infinity Discovery, Inc. Ansamycin hydroquinone compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
FI943207A0 (fi) 1992-01-06 1994-07-05 Pfizer 4,5-dihydrogeldanamysiinin ja sen hydrokinonin valmistusmenetelmä ja käyttö
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
CA2166320A1 (en) 1993-06-29 1995-01-12 Randall James Gallaschun Ansamycin derivatives as antioncogene and anticancer agents
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5883236A (en) * 1997-11-19 1999-03-16 Abbott Laboratories Process for N-desmethylating erythromycins and derivatives thereof
WO2000061578A1 (en) 1999-04-09 2000-10-19 Sloan-Kettering Institute For Cancer Research Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
EP1435939B1 (en) 2001-09-24 2008-02-27 Conforma Therapeutic Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins

Also Published As

Publication number Publication date
CN100378079C (zh) 2008-04-02
WO2003026571A2 (en) 2003-04-03
EP1435939A4 (en) 2004-12-29
US20050176695A1 (en) 2005-08-11
CN1558757A (zh) 2004-12-29
US7579462B2 (en) 2009-08-25
CA2460498A1 (en) 2003-04-03
DE60225307D1 (de) 2008-04-10
EP1435939A2 (en) 2004-07-14
EP1435939B1 (en) 2008-02-27
JP2005504086A (ja) 2005-02-10
DE60225307T2 (de) 2009-03-19
KR20040054692A (ko) 2004-06-25
WO2003026571A3 (en) 2003-10-02

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