ATE387198T1 - Verfahren zur herstellung von 17-allyl-amino- geldanamycin (17-aag) und anderer ansamycine - Google Patents

Verfahren zur herstellung von 17-allyl-amino- geldanamycin (17-aag) und anderer ansamycine

Info

Publication number
ATE387198T1
ATE387198T1 AT02761732T AT02761732T ATE387198T1 AT E387198 T1 ATE387198 T1 AT E387198T1 AT 02761732 T AT02761732 T AT 02761732T AT 02761732 T AT02761732 T AT 02761732T AT E387198 T1 ATE387198 T1 AT E387198T1
Authority
AT
Austria
Prior art keywords
ansamycins
aag
allyl
moneyanamycin
amino
Prior art date
Application number
AT02761732T
Other languages
German (de)
English (en)
Inventor
Lin Zhang
Marcus F Boehm
Siead Zegar
Original Assignee
Conforma Therapeutic Corp
Lin Zhang
Marcus F Boehm
Siead Zegar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Conforma Therapeutic Corp, Lin Zhang, Marcus F Boehm, Siead Zegar filed Critical Conforma Therapeutic Corp
Application granted granted Critical
Publication of ATE387198T1 publication Critical patent/ATE387198T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02761732T 2001-09-24 2002-09-18 Verfahren zur herstellung von 17-allyl-amino- geldanamycin (17-aag) und anderer ansamycine ATE387198T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32663901P 2001-09-24 2001-09-24
US33189301P 2001-11-21 2001-11-21

Publications (1)

Publication Number Publication Date
ATE387198T1 true ATE387198T1 (de) 2008-03-15

Family

ID=26985493

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02761732T ATE387198T1 (de) 2001-09-24 2002-09-18 Verfahren zur herstellung von 17-allyl-amino- geldanamycin (17-aag) und anderer ansamycine

Country Status (9)

Country Link
US (1) US7579462B2 (https=)
EP (1) EP1435939B1 (https=)
JP (1) JP2005504086A (https=)
KR (1) KR20040054692A (https=)
CN (1) CN100378079C (https=)
AT (1) ATE387198T1 (https=)
CA (1) CA2460498A1 (https=)
DE (1) DE60225307T2 (https=)
WO (1) WO2003026571A2 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
CA2460498A1 (en) 2001-09-24 2003-04-03 Conforma Therapeutics Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
WO2003037860A2 (en) 2001-10-30 2003-05-08 Conforma Therapeutics Corporation Purine analogs having hsp90-inhibiting activity
WO2003066005A2 (en) 2002-02-08 2003-08-14 Conforma Therapeutics Corporation Ansamycins having improved pharmacological and biological properties
MXPA06002997A (es) 2003-09-18 2007-02-08 Conforma Therapeutics Corp Novedosos compuestos heterociclicos como inhibidores- hsp90.
AU2004309395C1 (en) 2003-12-23 2012-10-04 Infinity Discovery, Inc. Analogs of benzoquinone-containing ansamycins for the treatment of cancer
KR101045324B1 (ko) * 2004-08-11 2011-06-30 한국생명공학연구원 젤다나마이신 유도체 및 그 생합성 방법
US7371906B2 (en) * 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
US20090130163A1 (en) * 2005-02-18 2009-05-21 Abraxis Bio Scoence, Inc. Drugs With Improved Hydrophobicity For Incorporation in Medical Devices
AU2006230447A1 (en) 2005-03-30 2006-10-05 Conforma Therapeutics Corporation Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors
BRPI0608661A2 (pt) * 2005-04-07 2010-01-19 Conforma Therapeutics Corp formulaÇço farmacÊutica, uso de formulaÇço farmacÊutica, e, mÉtodo de preparaÇço de uma formulaÇço farmacÊutica
US7648976B2 (en) * 2005-11-23 2010-01-19 Bristol-Myers Squibb Company 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
US20090042847A1 (en) * 2005-11-23 2009-02-12 Kosan Biosciences Incorporated 17-allylamino-17-demethoxygeldanamycin polymorphs and formulations
JP2009518302A (ja) * 2005-12-01 2009-05-07 コンフォーマ・セラピューティクス・コーポレイション アンサマイシン含有組成物
KR100796637B1 (ko) * 2006-09-29 2008-01-22 한국생명공학연구원 젤다나마이신 유도체, 이의 약학적으로 허용가능한 염,이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 및치료제
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
PE20081506A1 (es) * 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
KR100861697B1 (ko) * 2007-01-30 2008-10-07 한국생명공학연구원 Ａｈｂａ 생합성 유전자 변이주를 이용한 안사마이신유도체의 생산 방법 및 신규한 안사마이신 유도체
KR20110090925A (ko) 2008-10-15 2011-08-10 인피니티 파마슈티컬스, 인코포레이티드 안사마이신 하이드로퀴논 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3595955A (en) * 1969-03-26 1971-07-27 Upjohn Co Geldanamycin and process for producing same
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug
CA2127457A1 (en) 1992-01-06 1993-07-22 Walter P. Cullen Process and uses for 4,5-dihydrogeldanamycin and its hydroquinone
US5387584A (en) 1993-04-07 1995-02-07 Pfizer Inc. Bicyclic ansamycins
JP2794342B2 (ja) * 1993-06-29 1998-09-03 ファイザー・インク． 抗癌遺伝子剤および抗癌剤としてのアンサマイシン誘導体
US5932566A (en) * 1994-06-16 1999-08-03 Pfizer Inc. Ansamycin derivatives as antioncogene and anticancer agents
US5883236A (en) * 1997-11-19 1999-03-16 Abbott Laboratories Process for N-desmethylating erythromycins and derivatives thereof
JP2002541255A (ja) 1999-04-09 2002-12-03 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ Ｈｅｒ族チロシンキナーゼの分解および／または阻害方法および組成物
CA2460498A1 (en) 2001-09-24 2003-04-03 Conforma Therapeutics Corporation Process for preparing 17-allyl amino geldanamycin (17-aag) and other ansamycins
EP1923061A1 (en) 2001-09-24 2008-05-21 Conforma Therapeutic Corporation Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins

Also Published As

Publication number Publication date
CA2460498A1 (en) 2003-04-03
US20050176695A1 (en) 2005-08-11
DE60225307D1 (de) 2008-04-10
DE60225307T2 (de) 2009-03-19
EP1435939B1 (en) 2008-02-27
EP1435939A4 (en) 2004-12-29
EP1435939A2 (en) 2004-07-14
WO2003026571A2 (en) 2003-04-03
JP2005504086A (ja) 2005-02-10
WO2003026571A3 (en) 2003-10-02
CN1558757A (zh) 2004-12-29
CN100378079C (zh) 2008-04-02
US7579462B2 (en) 2009-08-25
KR20040054692A (ko) 2004-06-25

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