CN100367869C - 压缩口香糖 - Google Patents
压缩口香糖 Download PDFInfo
- Publication number
- CN100367869C CN100367869C CNB028292499A CN02829249A CN100367869C CN 100367869 C CN100367869 C CN 100367869C CN B028292499 A CNB028292499 A CN B028292499A CN 02829249 A CN02829249 A CN 02829249A CN 100367869 C CN100367869 C CN 100367869C
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- Prior art keywords
- chewing gum
- particle
- matrix
- gum
- chewing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
本发明涉及包含口香糖芯(38)的压缩口香糖片(37),所述口香糖芯(38)包含胶基颗粒(32)和口香糖添加剂(33)的压缩物,所述口香糖添加剂包括甜味剂和香料,所述胶基颗粒(32)的至少第一部分包含引入有香料的胶基颗粒。所述胶基颗粒(32)的至少第二部分包含传统胶基颗粒。
Description
发明领域
本发明涉及口香糖制造工艺和胶基颗粒。
发明背景
本领域中公知有多种不同的口香糖制造方法。总的来说,这些不同的制法基本上可以分为两类方法,即在胶基化合物的基础上机械混合的口香糖或在不同程度分散的胶基颗粒的基础上压缩的口香糖。在几个不同的参数中,第一类口香糖通常受益于非常舒适的质感,其最可能是由机械混合聚合物以及例如香料所致的。然而,该类方法和口香糖的一个缺点为:混合过程可能会不同程度地破坏或降解不同的成分,例如包封的香料、活性成分等。
第二类口香糖通常受益于对敏感添加剂相对温和的处理,如上述香料和活性成分。然而,该类口香糖的一个缺点是形成的口香糖片通常会很容易碎裂,特别是在初始咀嚼时。
口香糖领域的人们已经意识到:由于各种不同的原因,在预处理加工的口香糖材料的基础上压缩口香糖的工艺是复杂的。
美国专利4,753,805公开了在预加工的口香糖组分基础上制造口香糖的方法。所公开口香糖制造方法的一个缺点是口香糖组分需要称作压缩助剂的不同添加剂,以便于最终的压缩工艺。显然,这种添加剂意味着更高的成本,并且添加剂是最终所获得的口香糖的固有部分,因此影响最终的质感或味道。
美国专利4,000,321公开了在预加工胶基颗粒的基础上获得压缩口香糖的另一种方法。所公开方法的一个缺点是应用的颗粒需要加热,以能够自粘在一起。这样,活性成分会变差,质感也会变得太“类似固体”。
本发明的一个目的是提供压缩口香糖组合物的口香糖,当所述口香糖组合物通过压缩的方法加工时,提供与传统混合口香糖一样的质感。
发明内容
本发明涉及含有口香糖芯的压缩口香糖片,所述口香糖芯包括胶基颗粒和口香糖添加剂的压缩物,所述口香糖添加剂包括甜味剂和香料,所述胶基颗粒的至少第一部分包含引入香料或活性成分的胶基,并且所述胶基颗粒的至少第二部分包含传统胶基颗粒。
根据本发明,传统胶基指含有不溶于水的部分的胶基,更具体地,传统胶基指未混合有香料或活性成分的胶基。
根据本发明,获得了标准口香糖和压缩口香糖的有利结合。根据本发明,可以获得预释放和后释放的有利结合。此外,可以获得良好的早期口感和后期口感的结合。
根据本发明,口香糖添加剂可泛指甜味剂、香料、酸、色素、活性成分、清凉剂、冻干水果等。此外,所用成分可以被包覆。
根据本发明,此处所使用的口香糖胶基可包括一种或多种树脂化合物,其有助于获得所需的咀嚼特征,并用作弹性体的增塑剂。
混合物中预混的和粉碎的胶基之间的平衡可随应用的不同而明显改变,这取决于最终压缩口香糖的所需稠度。
当使用多阶段(multi-string)工艺时,根据本发明的多个优点之一为:一个阶段,如称之为预混的阶段可包括产品区分(specifier),第二阶段可包括通用胶基混合,典型为可应用于全部两个阶段的颗粒。这样,例如香料和活性成分的不同预混可构成限定混合阶段的最终产品。
该特征某种意义上说是另一个优点,因为通用胶基混合物基本不含香料或其它胶基改性成分,与所得的引入了香料的预混颗粒相比,对于环境影响如水分和温度都相对稳定,可以较稳固地制造和储存。
根据本发明的另一实施方案,还有可能调节和控制最终口香糖的香料释放在早期释放和后期释放之间的平衡,所述早期释放主要通过在将混合颗粒压缩成最终口香糖时加入的香料和甜味剂来获得,而后期释放主要通过在预混阶段引入胶基弹性体中的香料来得到。
混合物中预混的和粉碎的胶基之间的平衡可随应用的不同而明显改变,这取决于最终口香糖的所需香料释放和预混物中的香料浓度。
根据本发明的另一实施方案,当将预混的胶基和第二阶段胶基联用时,可有利地调节咀嚼特性。
当所述胶基颗粒的至少第一部分包含稳定香料的树脂时,得到了本发明的更有利的实施方案。
当所述胶基颗粒的至少第一部分包含合成树脂时,得到了本发明的更有利的实施方案。
当所述合成树脂包括聚乙酸乙烯酯、乙酸乙烯酯一月桂酸乙烯酯共聚物及其混合物时,得到了本发明的更有利的实施方案。
当所述胶基颗粒的至少第一部分基本不含蜡时,得到了本发明的更有利的实施方案。
当所述口香糖片的水含量低于5重量%,优选低于3重量%时,得到了本发明的更有利的实施方案。
通常优选较低的水含量,例如因为这样获得的压缩口香糖更易于处理。此外,应用活性成分时,尤其是非包覆活性成分时,如果水含量过高可能会引起不必要的化学反应。
根据本发明,还认为:即使水含量极低、甚至低于1.0重量%时,也可以获得可接受的质感。
当所述口香糖芯基本不含压缩助剂时,得到了本发明的更有利的实施方案。
当所述胶基颗粒的至少第二部分为适度粘性时,得到了本发明的更有利的实施方案。例如,适度粘性可通过应用天然树脂或例如蜡来获得。
当所述胶基颗粒的至少第二部分包含天然树脂时,得到了本发明的更有利的实施方案。
当所述胶基颗粒的至少第二部分包含蜡时,得到了本发明的更有利的实施方案。
当其中所述适度粘性通过在至少一部分胶基颗粒中引入至少一种天然树脂的方法来得到时,得到了本发明的更有利的实施方案。
当压缩口香糖片含有约3重量%-50重量%的天然树脂,优选约5重量%-40重量%时,得到了本发明的更有利的实施方案。
当压缩口香糖片含有约0.5重量%-30重量%的弹性体,优选约5重量%-25重量%时,得到了本发明的更有利的实施方案。
当压缩口香糖片含有约0.1重量%-15重量%的香味剂,优选约0.8重量%-5重量%时,得到了本发明的更有利的实施方案。
当天然树脂提供了改进的和粘性的片剂质感时,得到了本发明的更有利的实施方案。
当压缩口香糖包含含有例如润滑剂、防粘剂和助流剂的隔离层时,得到了本发明的更有利的实施方案。
当隔离层包含硬脂酸镁时,得到了本发明的更有利的实施方案。
当隔离层包含硬脂酸金属盐、氢化植物油、部分氢化植物油、聚乙二醇、聚氧乙烯单硬脂酸酯、动物脂、硅酸盐、二氧化硅、滑石、硬脂酸镁、硬脂酸钙、热解法二氧化硅及其混合物时,得到了本发明的更有利的实施方案。
当口香糖芯基本不含润滑剂、防粘剂和助流剂时,得到了本发明的更有利的实施方案。
此外,本发明涉及一种口香糖颗粒,其中至少一部分口香糖颗粒粒子引入了香料,并且包含基于合成树脂制得的胶基;和其中至少一部分口香糖颗粒粒子包含基于天然树脂所制得的胶基。
此外,本发明涉及一种提供压缩口香糖的方法,包括以下步骤
-将至少一种弹性体和至少一种增塑剂混入第一匀质胶基中,
-将一定量的香料引入所述第一胶基中,优选通过机械混合,
-将所述引入了香料的胶基造粒,
-将至少一种弹性体和至少一种增塑剂混入第二匀质胶基中,
-将所述第二胶基造粒,
-混合所述第一和所述第二胶基,期间加入其它口香糖添加剂,和
-将该混合物压缩成片。
根据本发明的一个实施方案,胶基颗粒的适度粘性应足以使压缩胶基颗粒粘在一起,特别是在初始咀嚼期间。
此外,根据本发明,已经认识到:控制粘性,优选采用天然树脂来实现控制粘性有利于更自由地选择片型。
根据本发明,现在可以通过将胶基颗粒和口香糖添加剂压缩制得口香糖片,并使其具有可接受的和改善的直接初始质感。
很明显,根据本发明,例如在混合期间或混合之后,可向胶基中加入其它添加剂。
此外,根据本发明,已经认识到当咀嚼压缩口香糖片时,天然树脂促进有利的总香料释放。这可能部分由于初始咀嚼口香糖片使香料粒子立即释放,同时使一部分溶解的香料粒子反应或引入到口香糖胶基中。
香料释放的最后部分导致总释放时间的延长。
此外,根据本发明的口香糖片的另一优点在于:在最终工艺,例如包衣和最后包装之前,该片剂可暂时储存。
当胶基颗粒不能再由传统压缩技术加工时,就达到了所需粘性的上限。
此外,根据本发明,已经认识到当咀嚼压缩口香糖片时,天然树脂促进有利的总香料释放。这可能部分由于初始咀嚼口香糖片使香料粒子立即释放,同时使一部分溶解的香料粒子反应或引入到口香糖胶基中。
此外,根据本发明的一个实施方案,所用隔离层可以形成或部分形成水分隔离层。由于根据本发明的一个实施方案优选较低的水含量,因此该片剂应该优选被保护以免于从空气中吸收太多的水分。
附图说明
下面将参照附图来说明本发明,其中
图1示出根据本发明的口香糖片,
图2示出根据本发明的一个实施方案的口香糖制造方法的流程图。
具体实施方式
图1示出根据本发明的口香糖片。
图1示出基于压缩口香糖颗粒制造的口香糖片。
基于胶基制造胶基颗粒。本文所用的表述“胶基”通常指口香糖中不溶于水的部分,其通常构成总口香糖配方的10-90重量%,包括15-50重量%。口香糖胶基配方通常包括一种或多种合成或天然来源的弹性化合物、一种或多种合成或天然来源的树脂化合物、填料、软化剂化合物和少量其它成分,例如抗氧化剂和色素等。
虽然为压缩的,但所示的最终口香糖37基本包含胶基颗粒33和口香糖添加剂32。口香糖37包括包覆有隔离层39的口香糖芯38。在本发明的范围内,口香糖添加剂可指多种口香糖添加剂,如甜味剂、香料、酸、活性成分等。
以下所限定的与口香糖添加剂混合的口香糖胶基配方的组成基本上可以根据所制备的具体产品和最终产品的所需质感或其它感官特征来变化。然而,上述胶基组分的典型范围(重量%)为:5-50重量%的弹性化合物、5-55重量%的弹性体增塑剂、0-50重量%的填料/组织形成剂、5-35重量%软化剂和0-1重量%的其它成分,例如抗氧化剂和色素等。
虽然未示出,但是优选在片剂加工之前或期间应用隔离层。隔离层例如硬脂酸镁形成口香糖片的外隔层。
例如,可将硬脂酸镁用作粉末脱模剂。
例如,可通过在压片机的压制工具的材料接触表面上沉积一定量的粉末润滑剂和脱模化合物将隔离层加至最终片剂上。
隔离层包括硬脂酸金属盐、氢化植物油、部分氢化植物油、聚乙二醇、聚氧乙烯单硬脂酸酯、动物脂、硅酸盐、二氧化硅、滑石、硬脂酸镁、硬脂酸钙、气相法二氧化硅、粉末状氢化棉花籽油、氢化植物油、氢化大豆油,及其混合物。
如果使用隔离层,那么隔离层的功能之一是防止粘附到压片机的压制工具上,从而利于提高口香糖芯的粘着性。
片剂上还可以包覆其它层,如传统包衣。
图2示出说明本发明范围内的几种适用制造工艺之一的主要步骤的典型流程。
在步骤21a和21b中,根据本发明的配方制备至少两种不同的适用胶基。
在步骤200中,至少一种胶基与香料和甜味剂预混合或剪切混合。该胶基也可指以下预混物。
一种胶基,此处该胶基在步骤21b中混合,包括适用于口香糖颗粒的传统胶基。
例如,在步骤200中的香料和甜味剂的预混合可通过传统混合机来进行,例如用Z型桨叶搅拌机进行,期间不加热或优选稍微加热,并基本在大气压力下。优选地,该纯粹机械预混合(也指剪切混合)应该充分进行以得到胶基中混入香料和/或活性成分的匀质共混物。
通常混合持续时间可在几分钟至例如30分钟之间。很明显,根据本发明,其它温度、压力、持续时间和混合方法可以用于将香料和/或活性成分混入胶基的目的,从而将胶基颗粒应用于后续压缩过程。
在步骤22a中,研磨预混合的胶基。可通过公知技术进行研磨。这些技术之一包括在造粒前首先冷却胶基。如果胶基的稠度允许,所提供的胶基可在室温下研磨。
相似地,在步骤22b中,将其它胶基分别研磨,例如通过上述同样的方法。
根据本发明的一个有利实施方案,填充型甜味剂(bulk-sweetener)可有利地用作研磨助剂。山梨糖醇可被用作非糖甜味剂。其它有用的非糖甜味剂包括,但不限于其它糖醇,如甘露醇、木糖醇、氢化淀粉水解物、麦芽糖醇、异麦芽酚、赤藻糖醇、乳糖醇等,单独或联合使用。
步骤23中,胶基颗粒与合适的口香糖添加剂共混。
所得的共混物包括来自预混合步骤21a、200、22a、预混有香料与任选的其它成分如甜味剂的胶基颗粒以及来自加工步骤21b和22b的胶基颗粒的共混物。
此外,得自步骤23的共混物含有其它口香糖添加剂。
在本说明书中,口香糖添加剂包括填充型甜味剂、高甜度甜味剂、香料、软化剂、乳化剂、色素、粘合剂、酸化剂、填料、抗氧化剂和其它成分,如药物或生物活性物质,其将期望的性质转移到最终口香糖产品中。
合适的甜味剂的实例如以下所列。
例如,合适的填充型甜味剂包括糖类和非糖类成分。填充型甜味剂通常构成口香糖重量的约5-约95重量%,更一般地为约20-约80重量%,如30-60重量%。
有用的糖类甜味剂为口香糖领域普遍公知的含糖化合物组分,包括但不限于蔗糖、葡萄糖、麦芽糖、糊精、海藻糖、D-塔格糖、干燥的转化糖、果糖、左旋糖、半乳糖、玉米糖浆固体等,单独或联合使用。
糖醇可用作非糖类甜味剂。其它有用的非糖甜味剂包括,但不限于其它糖醇,如甘露醇、木糖醇、氢化淀粉水解物、麦芽糖醇、异麦芽酚、赤藻糖醇、乳糖醇等,单独或联合使用。
高甜度人造甜味剂也可单独使用或与上述甜味剂联合使用。优选的高甜度甜味剂包括但不限于,三氯蔗糖(sucralose)、阿斯巴甜、安赛蜜、阿力甜、糖精及其盐、neotam、环己氨基磺酸及其盐、甘草甜素、二氢查耳酮、索马甜(thaumatin)、莫内林、甜菊苷等,单独或联合使用。为了提供更长效的甜味和香味感觉,可能需要用包覆或其它方法来控制至少一部分人造甜味剂的释放。可用来得到期望释放特性的技术包括湿法造粒、蜡造粒、喷雾干燥、喷雾冷冻、流化床包覆、凝聚、酵母泡腔包覆和纤维挤出。甜味剂的包覆方法也可用作另一种口香糖组分的包覆方法,例如树脂化合物的包覆。
人造甜味剂用量的变化显著依赖于诸如甜味剂的效力、释放速度、产品的期望甜度、所用香料量和类型以及成本等因素。因此,人造甜味剂的有效用量可在约0.02重量%-约8重量%之间变化。当包括用来包覆的载体时,该包覆的甜味剂的用量比例会更高。根据本发明,可在口香糖配方中联合使用糖类和/或非糖类甜味剂。另外,软化剂也会提供额外的甜度,如糖或多羟糖醇水溶液。
如果想得到低热量的口香糖,可以采用低热量的添加剂。低热量添加剂的实施例包括:聚葡萄糖、Raftilose(低聚果糖)、Raftilin(菊粉)、Inuline、寡聚果糖(NutraFlora)、低聚帕拉金糖、水解瓜尔胶(如Sun Fiber)或不可消化的糊精(如Fibersol)。然而,也可使用其它低热量添加剂。
可以包括在本方法所加工的口香糖混合物中的其它口香糖添加剂包括表面活性剂和/或增溶剂,特别是当药物、化妆品或生物活性物质存在时。根据本发明,口香糖组合物中用作增溶剂的表面活性剂类型的例子可参考H.P.Fiedler,Lexikon derHilfstoffe für Pharmacie,Kosmetik und Angrenzende Gebiete,63-64页(1981)和各国批准的食品用乳化剂名单。可使用阴离子、阳离子、两性或非离子增溶剂。合适的增溶剂包括卵磷脂、聚氧乙烯硬脂酸酯、聚氧乙烯山梨聚糖脂肪酸酯、脂肪酸盐、食用脂肪酸单和二甘油酯的单和二乙酰基酒石酸酯、食用脂肪酸单和二甘油酯的柠檬酸酯、脂肪酸蔗糖酯、脂肪酸聚甘油酯、内酯化蓖麻油酸的聚甘油酯(E476)、硬脂酰基乳酰乳酸钠、十二烷基硫酸钠和山梨聚糖脂肪酸酯与聚氧乙烯化氢化蓖麻油(例如以商品名CREMOPHOR销售的产品)、氧化乙烯与氧化丙烯的嵌段共聚物(例如以商品名PLURONIC和POLOXAMER销售的产品)、聚氧乙烯脂肪醇醚、聚氧乙烯山梨聚糖脂肪酸酯、脂肪酸山梨聚糖酯和聚氧乙烯硬脂酸酯。
特别适用的增溶剂为聚氧乙烯硬脂酸酯,例如聚氧乙烯(8)硬脂酸酯和聚氧乙烯(40)硬脂酸酯;以商品名TWEEN销售的聚氧乙烯山梨聚糖脂肪酸酯,例如TWEEN20(单月桂酸酯)、TWEEN80(单油酸酯)、TWEEN40(单棕榈酸酯)、TWEEN60(单硬脂酸酯)或TWEEN65(三硬脂酸酯);食用脂肪酸单和二甘油酯的单和二乙酰基酒石酸酯、食用脂肪酸单和二甘油酯的柠檬酸酯;硬脂酰基乳酰乳酸钠;十二烷基硫酸钠;聚氧乙烯化氢化蓖麻油;氧化乙烯和氧化丙烯的嵌段共聚物与聚氧乙烯脂肪醇醚。所述增溶剂可为单一化合物或几种化合物的组合。本文中表述的“增溶剂”用来描述两种可能性,所用增溶剂必须适用于食品和/或药品中。
在活性成分存在时,口香糖优选还包括本领域公知的载体。
本方法的一个重要优点在于整个操作中温度能够保持在较低的水平,正如以下所将要说明的。在保持高温易分解的所添加香料组分的香味方面,这是一个重要的特性。例如,在本发明的口香糖中非常有用的香味剂和香料是冻干的天然植物成分、精油、香精、提取物、粉末形式的天然和合成香料(包括天然香料),包括能影响味道分布的酸和其它物质。液体和粉末状香料的例子包括椰子、咖啡、巧克力、香草、葡萄、橙(橘)、酸橙、薄荷醇、甘草、焦糖味、蜜糖味、花生、胡桃、腰果、榛字、杏仁、菠萝、草莓、覆盆子、热带水果、樱桃、肉桂、胡椒薄荷、冬青、留兰香、桉树和薄荷,例如来自苹果、梨、桃、草莓、杏、黑莓、樱桃、菠萝和李子的水果香精。精油包括胡椒薄荷、留兰香、薄荷醇、桉树、丁香油、月桂油、茴芹、百里香、侧柏油、肉豆蔻和上述水果的油。
在一个优选实施方案中,香料为一种或多种冻干的天然香味剂,优选形态为粉末、薄片或碎片或其组合。该试剂粒子尺寸可小于3mm,如小于2mm,更优选为小于1mm,以粒子的最长尺寸来计算。天然香料的形态也可为粒子尺寸从约3μm至2mm,例如从4μm至1mm。优选的天然香料包括来自例如,草莓、黑莓和覆盆子的水果种子。
根据本发明也可使用如混合水果香味的各种合成香料。如上所指出,该香味剂的用量小于传统用量。该香味剂和/或香料用量为最终产品重量的约0.01-约30%,这取决于期望的香味强度和/或所采用的香料。优选地,香味剂/香料的含量范围为总组合物重量的0.2-3%。
根据本发明,可在压缩前,例如在图2的步骤23中,将包覆的香料或活性成分添加到最终共混物中。
包覆香料或活性成分的不同方法可包括如喷雾干燥、喷雾冷冻、薄膜包覆、凝聚、双乳液法(挤出技术)或造粒,其中的香料或活性成分指混入胶基的香料或活性成分,以及压缩到口香糖中的香料或活性成分。
用于上述包覆方法的材料可包括,例如明胶、小麦蛋白、大豆蛋白、酪蛋白酸钠、酪蛋白、阿拉伯胶、改性淀粉、水解淀粉(麦芽糊精)、藻酸盐、果胶、角叉菜胶、黄原胶、槐豆胶、壳聚糖、蜂蜡、小烛树腊、棕榈蜡、氢化植物油、玉米蛋白和/或蔗糖。
可将活性成分添加到口香糖中。优选地,在任何重要的加热或混合过程之后加入该活性成分。换言之,优选就在压缩成最终片剂之前立即将活性成分加入。
参照图2所示的方法,在最终压缩成片前,加入的活性成分可以小心地和预先混合好的胶基颗粒与其它所需添加剂共混。
合适活性成分的实例如下所列。
在本发明的一个实施方案中,口香糖包含药学、化妆品学或生物学上的活性物质。这类活性物质实例的综合列表可在WO 00/25598中查到,其通过引用并入本文,包括药品、食品添加物、防腐剂、pH-调节剂、戒烟剂,以及护理或治疗口腔和牙齿的物质,如过氧化氢和能够在咀嚼过程中释放尿素的化合物。防腐剂形式的有用活性物质的实例包括胍和双胍的盐及衍生物(例如,乙酸氯己定),以及具有有限水溶性的下述类型的物质:季铵化合物(如ceramine、氯二甲酚、结晶紫、氯胺)、醛(如多聚甲醛)、dequaline、polynoxyline、酚类衍生物(如麝香草酚、p-氯酚和甲酚)、六氯酚、水杨酸苯胺化合物、三氯生、卤素类(碘、碘消灵、氯胺、二氯氰尿酸盐)、醇类(3,4-二氯苯甲醇、苯甲醇、苯氧乙醇、苯乙醇),还参见Martindale,The ExtraPharmacopoeia,28th edition,page 547-578;可以包括具有有限水溶性的金属盐、配位化合物和化合物,如铝盐(例如硫酸铝钾AlK(SO4)2,12H2O)和下列物质的盐、配位化合物和化合物:硼、钡、锶、铁、钙、锌、(乙酸锌、氯化锌、葡萄糖酸锌)、铜(氯化铜、硫酸铜)、铅、银、镁、钠、钾、锂、钼、钒;护理口腔和牙齿的其它组分,例如含氟(如氟化钠、单氟磷酸钠、氨基氟化物、氟化锡)、磷酸盐、碳酸盐和硒的盐、配位化合物和化合物。其它活性物质可以在J.Dent.Res.Vol.28 No.2,page 160-171,1949中查到。
口腔中pH调节剂形式的活性物质的实例包括:酸,如己二酸、琥珀酸、延胡索酸或其盐,或柠檬酸、酒石酸、苹果酸、乙酸、乳酸、磷酸和戊二酸的盐;与可接受的碱,如碳酸盐、碳酸氢盐、磷酸盐、硫酸盐或钠、钾、铵、镁或钙的氧化物,尤其是镁和钙的氧化物。
活性成分可以包含下述的化合物或其衍生物,但不局限于这些:对乙酰氨基酚、乙酰水杨酸、丁丙诺啡、溴己新、塞来昔布、可待因、苯海拉明、双氯芬酸、依他昔布、布洛芬、吲哚美辛、酮洛芬、Luminracoxib、吗啡、奈普生、美沙酮、帕瑞昔布、吡罗昔康、伪麻黄碱(Pseudoefedrin)、罗非昔布、替诺昔康、曲马多、伐地昔布、碳酸钙、镁加铝、双硫仑、安非他酮、尼古丁、阿奇雷素、克拉霉素、克雷唑、红霉素、四环素、Gramsetron、恩丹西酮、Prometazin、托烷司琼、溴苯那敏、Ceterizin、Leco-Ceterizin、氯环利嗪、氯芬尼拉明、氯苯吡胺、二苯安明、多西拉敏、Fenofenadin、愈创甘油醚、Loratidin、des-Loratidin、苯托沙敏、异丙嗪、Pyridamine、特非那定、曲克芦丁、甲基多巴、哌醋甲酯、Benzalcon.Chloride、Benzeth.chloride、Cetylpyrid.Chlorhexidine、依卡倍特钠、氟哌啶醇、别嘌醇、Colchinine、茶碱、普萘洛尔、强的松龙、强的松、氟化物、脲、Actot、格列本脲、格列吡嗪、甲福明、米格列醇、Repaglinide、罗格列酮、阿朴吗啡、Cialis、Sildenafil、Valdenafil、氰苯哌酯、二甲硅油、西咪替丁、法莫替丁、雷尼替丁、Ratinidine、cetrizin、Loratadine、阿司匹林、苯佐卡因、右甲吗喃、苯丙醇胺、伪麻黄碱、Cisapride、多潘立酮、甲氧氯普胺、Acyclovir、Dioctylsulfosucc.、酚酞、阿莫曲坦、依来曲普坦、麦角胺、Migea、那拉曲坦、利扎曲普坦、Sumatriptan、佐米曲普坦、铝盐、钙盐、亚铁盐、银盐、锌盐、两性霉素B、氯己定、咪康唑、Triamcinolonacetonid、褪黑激素、苯巴比妥、咖啡因、Benzodiazepiner、羟嗪、甲丙氨酯、吩噻嗪、布克利嗪、Brometazine、桂利嗪、赛克利嗪、Difenhydramine、茶苯海明、丁洛地尔、安非他明、咖啡因、麻黄碱、Orlistat、phenylephedrine、苯丙醇胺、伪麻黄碱、西布曲明、酮康唑、硝酸甘油、制霉菌素、匹格列酮、黄体酮、睾酮、维生素B12、维生素C、维生素A、维生素D、维生素E、匹鲁卡品、乙酰氨铝、西咪替丁、埃索美拉唑、法莫替丁、兰索拉唑、氧化镁、尼扎替丁(Nizatide)和或Ratinidine。
本发明适于增加或加速活性剂的释放,所述活性剂选自食用添加物、口腔或牙齿组合物、防腐剂、pH调节剂、戒烟剂、甜味剂、香料、香味剂或药物。其中一些将在下文加以描述。
与本发明联用的活性剂可以是需要从口香糖中释放的任意物质。需要控制和/或加快释放速度的活性剂主要是具有有限水溶性的物质,其水溶性通常低于10g/100ml,包括完全不溶于水的物质。实例有药物、食用添加剂、口腔组合物、戒烟剂、高效甜味剂、pH-调节剂、香料等。
其它的活性成分有,例如,扑热息痛、苯佐卡因、桂利嗪、薄荷醇、香芹酮、咖啡因、乙酸氯己定、盐酸赛克利嗪、1,8-桉油醇、南诺龙、咪康唑、Mystatine、阿斯巴甜、氟化钠、尼古丁、糖精、西吡氯胺、其它季铵化合物、维生素E、维生素A、维生素D、格列苯脲或其衍生物、黄体酮、乙酰水杨酸、茶苯海明、赛克利嗪、甲硝唑、碳酸氢钠、银杏的活性组分、蜂胶的活性组分、人参的活性组分、美沙酮、薄荷油、水杨酰胺、氢化可的松或阿斯咪唑。
例如,食用添加物形式的活性成分是具有营养作用的下列盐和化合物:维生素B2(核黄素)、B12、叶酸、烟酸、生物素、水溶性差的甘油磷酸酯、氨基酸、维生素A、D、E和K、含钙、磷、镁、铁、锌、铜、碘、锰、铬、硒、钼、钾、钠或钴的盐、配位化合物和化合物形式的矿物质。
另外,还可参考不同国家权威人士所接受的营养品列表,例如美国联邦法规实施细则(US code of Federal Regulations),Title 21,Section 182.5013.182 5997和182.8013-182.8997。
用于护理或治疗口腔和牙齿的化合物形式的活性剂的实例有束缚态(bound)过氧化氢和能够在咀嚼过程中释放尿素的化合物。
防腐剂形式的活性剂的实例有胍和双胍的盐与化合物(例如乙酸氯乙定),以及下述类型的具有有限水溶性的物质:季铵化合物(例如ceramine、氯二甲酚、结晶紫、氯胺)、醛(如多聚甲醛)、dequaline、polynoxyline、酚类化合物(如麝香草酚、对氯酚和甲酚)、六氯酚、水杨酸苯胺化合物、三氯生、卤素类(碘、碘消灵、氯胺、二氯氰尿酸盐)、醇类(3,4-二氯苯甲醇、苯甲醇、苯氧乙醇、苯乙醇),还参见Martindale,The Extra Pharmacopoeia,28th edition,page 547-578;可以包括具有有限水溶性的金属盐、配位化合物和化合物,如铝盐(例如硫酸铝钾AlK(SO4)2,12H2O)和下列物质的盐、复合物与化合物:硼、钡、锶、铁、钙、锌、(乙酸锌、氯化锌、葡萄糖酸锌)、铜(氯化铜、硫酸铜)、铅、银、镁、钠、钾、锂、钼、钒;护理口腔和牙齿的其它组分,例如含氟(如氟化钠、单氟磷酸钠、氨基氟化物、氟化锡)、磷酸盐、碳酸盐和硒的盐、配位化合物和化合物。
还参见J.Dent.Res.Vol.28 No.2,Page 160-171,1949,其中提到了许多受试化合物。
调节口腔中pH的试剂形式的活性剂的例子包括:如:可接受的酸,如己二酸、琥珀酸、延胡索酸或其盐,或柠檬酸、酒石酸、苹果酸、乙酸、乳酸、磷酸和戊二酸的盐;与可接受的碱,如碳酸盐、碳酸氢盐、磷酸盐、硫酸盐或钠、钾、铵、镁或钙的氧化物,尤其是镁和钙的氧化物。
戒烟剂形式的活性剂的例子包括:如:尼古丁、烟草粉末或银盐,例如乙酸银、碳酸银和硝酸银。
在本发明的另一个实施方案中,蔗糖脂肪酸酯也可以用于增加甜味剂的释放,所述甜味剂如糖精、环己氨基磺酸盐、阿斯巴甜、索马甜、二氢查耳酮、甜菊苷、甘草甜素或其盐或化合物。对于增加甜味剂的释放来说,蔗糖脂肪酸酯优选具有至少40%,如50%的棕榈酸酯含量。
活性剂的其它实例是任意类型的药物。
药物形式的活性剂的例子包括咖啡因、水杨酸、水杨酰胺和相关物质(乙酰水杨酸、水杨酸胆碱、水杨酸镁、水杨酸钠)、扑热息痛、戊唑辛盐(盐酸戊唑辛和乙酸戊唑辛)、盐酸似普罗啡、盐酸可待因和磷酸可待因、吗啡和吗啡盐(盐酸盐、硫酸盐和酒石酸盐)、盐酸美沙酮、酚派丙酮与酚派丙酮的盐(盐酸盐)、β阻断剂(普萘洛尔)、钙拮抗剂、盐酸维拉帕米、硝苯地平,以及Pharm.Int.,Nov.85,pages 267-271,Barney H.Hunter and Robert L.Talbert中提到的物质及其盐,硝酸甘油、丁四硝酯、马钱子碱及其盐、利多卡因、盐酸丁卡因、盐酸埃托啡、阿托品、胰岛素、酶(例如木瓜蛋白酶、胰蛋白酶、淀粉葡萄糖苷酶、葡萄糖氧化酶、链激酶、链道酶、葡聚糖酶、α-淀粉酶)、多肽(催产素、促性腺激素释放因子(LH.RH)、乙酸去氨加压素(DDAVP)、盐酸异克舒令、麦角胺化合物、氯喹(磷酸盐、硫酸盐)、异山梨酯、去氨缩宫素、肝素。
其它成分包括β-羽扇醇、Letigen、Sildenafil柠檬酸酯及其衍生物。
牙科产品包括尿素、CPP酪蛋白磷酸肽;氯己定;乙酸氯己定;盐酸氯己定、葡萄糖酸氯己定;Hexetedine、氯化锶、氯化钾、碳酸氢钠、碳酸钠、含氟成分、氟化物、氟化钠、氟化铝、氟化铵、氟化钙、氟化锡、其它含氟成分氟硅酸铵、氟硅酸钾、氟硅酸钠、单氟磷酸铵、单氟磷酸钙、单氟磷酸钾、单氟磷酸钠、octadecentyl氟化铵、硬脂基三羟乙基丙烯二胺二羟基氟化物、维生素,包括A、B1、B2、B6、B12、叶酸、烟酸、Pantothensyre、生物素、C、D、E、K,矿物质,包括钙、磷、镁、铁、锌、铜、碘、锰、Crom、硒、钼。其它的活性成分包括:Q10、酶、天然药物,包括银杏、姜和鱼油。
本发明还涉及使用抗偏头痛药物,如诸如Sumatriptan、佐米曲普坦、那拉曲坦、利扎曲普坦、依来曲普坦的5-羟色胺拮抗剂;抗晕动药物,如赛克利嗪、桂利嗪、茶苯海明、苯海拉明;抗花粉热药物,如Cetrizin、Loratidin;疼痛缓解药物,如似普罗啡、Tramadol;抗口腔疾病药物,如米康唑、两性霉素B、Triamcinolonaceton;和药物Cisapid、多潘立酮、甲氧氯普胺。在本发明的优选实施方案中,涉及尼古丁及其盐的释放。
上述的活性成分和/或香料可以预混在胶基中。
当胶基颗粒包含预混的活性成分时,活性成分的控释可以借助至少双活性成分缓冲剂获得,第一缓冲剂包含在压缩之前直接共混到最终混合物中的活性成分,第二缓冲剂包含在将胶基和胶基添加剂共混之前共混到胶基中的活性成分。
一般说来,当小心地共混胶基颗粒和剩余的所需口香糖添加剂时,香料和/或活性成分的释放可以通过调整预混成分和压缩之前加入的口香糖添加剂之间的平衡来调节。
在步骤24中,所得的共混物通过筛分法制备成片。
筛分程度主要取决于当口香糖添加剂共混在一起时胶基颗粒如何“反应”。
如果需要隔离层,可以主要通过两种方式进行。
如果合适,颗粒的最初预成型可以通过在预形成的颗粒表面或至少部分表面上喷涂隔离层来进行。该技术和其变换方式可以称作显性隔离层沉积。
但是,优选的是,隔离层以一种更隐含的方式形成。该技术和其变换方式可以称作隐式隔离层沉积。该技术指隔离层化合物首先喷或沉积在压缩机中压制工具的接触表面上。
US专利5,643,630中公开了适于隐式隔离层沉积的包覆技术。
例如,任选的隔离层可包含润滑剂、防粘剂和助流剂。
例如,硬脂酸镁可以用作粉状脱模剂。
例如可以通过将一定量粉状润滑剂和脱模剂沉积在压片机中压制工具的材料接触表面上来将隔离层加在最终的片上。
例如可以采用硬脂酸金属盐、氢化植物油、部分氢化植物油、聚乙二醇、聚氧乙烯单硬脂酸酯、动物油脂、硅酸盐、二氧化硅、滑石、硬脂酸镁、硬脂酸钙、气相法二氧化桂、粉末状氢化棉籽油、氢化植物油、氢化大豆油及其化合物来建立隔离层。
如果不应用隔离层,那么本领域公知的压缩助剂就应该被引入最终共混物中,以避免粘附到压片机上。
在步骤25中,将磨碎的共混物应用到压片机的压制工具中并且压制成口香糖片。
在任选、但优选的步骤26中,制成片的口香糖具有适当的包衣。应该指出根据本发明的实施方案,口香糖片优选含有极低的水含量。因此,为了使口香糖芯对于主要是潮湿形式的环境影响保持稳定,应该包覆包衣。
根据本发明,口香糖组分包括约1-约75重量%的、包覆在口香糖芯上的外包衣。在本说明书中,适当的外包衣是相对于未包覆的同样组分口香糖来说能够延长以上限定的压缩口香糖产品的存储稳定性的任意包衣。因此,适当的包衣类型包括目前用于包覆口香糖、药品和糖果的任意组分硬包衣、膜包衣和软包衣。
根据本发明的一个优选实施方案,将膜包衣应用在压缩的口香糖片上。
一个目前优选的外包衣类型是硬包衣,其术语使用其常规含义,包括糖包衣和无糖包衣及其组合。硬包衣的目的是获得甜而易碎的层,其为消费者所欣赏,并出于各种原因保护口香糖芯。在为口香糖芯提供保护性糖包衣的典型过程中,在具有可结晶糖如蔗糖或葡萄糖的水溶液的适当包覆设备中对芯进行连续处理,依赖于所达到的包覆阶段,可以包含其它的功能成分,例如填料、色素等。在本说明书中,糖包衣可以包含其它的功能性或活性化合物,包括香料化合物、药学上的活性化合物和/或聚合物降解物质。
在口香糖的生产中,优选将包衣中的生龋的糖化合物替换成其它可结晶的、不具有生龋效应的甜味化合物。在本领域中,这类包衣通常指无糖包衣。目前优选的非生龋性硬包衣物质包括多元醇,如山梨醇、麦芽糖醇、甘露醇、木糖醇、赤藻糖醇、乳糖醇、isomalt、塔格糖,其通过工业方法分别将D-葡萄糖、麦芽糖、果糖、木糖、赤藻糖、乳糖、isomaltulose和D-半乳糖氢化而获得。
在典型的硬包衣加工过程中,如下文将详细描述的,将包含可结晶糖和/或多元醇的糖浆涂到胶芯上,通过吹暖而干燥的空气将其中所含的水分蒸发。该循环可以重复数次,典型为10~80次,以达到所需的膨胀。术语“膨胀”指在包衣操作结束时和开始时相比产品重量的增加,和包覆产品的终重量相关。根据本发明,包衣层占最终口香糖组分的约1至约75重量%,如约10至约60重量%,包括约15至50重量%。
在本发明的另一个有用实施方案中,口香糖组分的外包衣是经历膜包衣加工过程的组分,因此包含一种或多种成膜聚合物试剂和任选的一种或多种辅助化合物,例如增塑剂、颜料和遮光剂。膜包衣是包覆在任意上述形式的口香糖芯上的一层薄的聚合物基包衣。这种包衣的厚度通常在20和100μm之间。一般来说,使口香糖芯通过喷涂区而获得膜包衣,所述喷涂区具有溶于适当液体或有机溶媒中的包衣材料的雾化滴,随后将附着在芯上的材料干燥,再接受另一部分的包衣。重复该循环,直至完成包覆。
在本说明书中,适当的成膜聚合物包括食用纤维素衍生物,例如纤维素醚,包括甲基纤维素(MC)、羟乙基纤维素(HEC)、羟丙基纤维素(HPC)和羟丙基甲基纤维素(HPMC)。其它有用的成膜试剂是丙烯酸聚合物和共聚物,如甲基丙烯酸酯一氨基酯共聚物或纤维素衍生物与丙烯酸聚合物的混合物。一类特别的成膜聚合物,还称为功能性聚合物,是除了具有成膜特性之外,还赋予口香糖配方中的活性成分以不同释放性能的聚合物。该释放改进聚合物包括甲基丙烯酸酯共聚物、乙基纤维素(EC)和设计用来对抗酸性胃环境使易溶于十二指肠的肠溶性聚合物。后者的聚合物包括:邻苯二甲酸纤维素乙酸酯(CAP)、邻苯二甲酸聚乙酸乙烯酯(PVAP)、虫胶、甲基丙烯酸共聚物、偏苯三酸纤维素乙酸酯(CAT)和HPMC。应该理解根据本发明的外膜包衣可以含有上述成膜聚合物的任意组合。
在其它实施方案中,根据本发明的口香糖组分的膜包衣层包含能改变聚合物的物理性质、使其更有效作为成膜材料行使功能的增塑剂。通常,由于增塑剂分子进入各个聚合物链之间,阻断聚合物-聚合物相互作用,增塑剂的作用是使聚合物更软更韧。用于膜包衣的增塑剂大部分为无定形的或具有极低结晶度。在本说明书中,适合的增塑剂包括如:丙三醇、丙二醇、聚乙二醇,例如其200-6000的级分、有机酯,如磷酸酯、癸二酸二丁酯、柠檬酸酯、和thiacetin,油/甘油酯包括蓖麻油、乙酰单甘油酯和分级椰油。
用于本发明口香糖组分的膜包衣的成膜聚合物和增塑剂的选择应考虑透过膜的水分和气体的溶解和扩散,以获得最佳可能的包衣隔离性质。
口香糖组分的膜包衣还可以含有一种或多种着色剂或遮光剂。除了提供期望的色调之外,这些试剂还可以保护该压缩口香糖不进行咀嚼前反应,特别是通过形成隔离层来隔绝水分和气体。合适的着色剂/遮光剂包括有机染料和其色淀颜料、无机染料,例如二氧化钛和天然颜料,如β-胡罗卜素。
此外,膜包衣可以含有一种或多种辅助物质,如香料和蜡或糖类化合物如聚葡萄糖、糊精包括麦芽糊精、乳糖、改性淀粉、蛋白质如明胶或玉米蛋白、植物胶以及其任意组合。
在一个特定的实施方案中,口香糖芯呈条状,在其一侧或两侧具有可食用膜,包含水溶性成膜剂组成的交替包衣层,所述水溶性成膜剂例如纤维素衍生物、改性淀粉、糊精、明胶、玉米蛋白、植物胶、合成聚合物及其任意组合,和蜡,例如蜂蜡、小烛树腊、微晶蜡、石蜡及其组合。
本发明还有一个方面是口香糖组分的外包衣可含有一种或多种药用或化妆品用成分,包括在上文中所提及的成分。
因此,在其它实施方案中,上述带有硬包衣或膜包衣的口香糖组分为这样一种组分,其中外包衣包括选自粘合剂、吸湿成分、成膜剂、分散剂、防粘剂成分、填料、香味剂、着色剂、药用或化妆品用活性成分、脂类成分、蜡成分、糖和酸的至少一种添加剂成分。如果希望直到咀嚼口香糖时外包衣中的任意此种添加剂成分的效果才显现,那么根据本发明该成分可以采用任意传统包覆剂进行包覆,例如,蛋白质包括明胶和大豆蛋白、纤维素衍生物包括任意的上述纤维素衍生物、淀粉衍生物、食用合成聚合物和脂类物质,后者可选是脂质体包覆形式。
在本发明的其它实施方案中,口香糖组分具有本领域通常所述形式的外包衣,即软包衣。这种软包衣采用传统方法应用并且可以有利地包含糖或任意上述非生龋齿性无糖甜味化合物和淀粉水解物的混合物。
再次应该注意的是上述包衣为可选的,或可以推迟到其适合制造工艺的最后部分,这是由于该应用的隔离层还起到阻止环境中水分进入片剂的全部或至少部分屏障的作用。
通常对于适用在本发明范围内的胶基配方来说,有用的合成弹性体包括,但不限于,列于食品与药品管理局,CFR,Title 21,Section 172,615,the MasticatorySubstances,Synthetic中的合成弹性体,如聚异丁烯,例如气相压力色谱(GPC)平均分子量为约10,000-约1,000,000,包括50,000-80,000的聚异丁烯;异丁烯-异戊二烯共聚物(丁基弹性体);苯乙烯-丁二烯共聚物,例如具有苯乙烯-丁二烯比例为约1∶3-3∶1;聚乙酸乙烯酯(PVA),例如GPC平均分子量范围为约2,000-约90,000,如3,000-80,000,包括30,000-50,000的聚乙酸乙烯酯,其中高分子量的聚乙酸乙烯酯通常用于泡泡糖胶基中;聚异戊二烯、聚乙烯、乙酸乙烯酯-月桂酸乙烯酯共聚物,例如月桂酸乙烯酯含量为共聚物重量的约5-约50%,如10-45%的共聚物,及其组合。
工业上,通常在胶基中混合高分子量和低分子量合成弹性体。目前优选的合成弹性体组合包括但不限于:聚异丁烯和苯乙烯-丁二烯;聚异丁烯和聚异戊二烯;聚异丁烯和异丁烯-异戊二烯共聚物(丁基橡胶);和聚异丁烯、苯乙烯-丁二烯共聚物和异丁烯-异戊二烯共聚物的组合;上述各合成聚合物分别与聚乙酸乙烯酯、乙酸乙烯酯-月桂酸乙烯酯共聚物的组合,及其混合物。
能够有利地应用到根据本发明工艺中的特别令人感兴趣的弹性体或树脂聚合物包括与目前所用的弹性体和树脂不同的聚合物,其能够使得用过的口香糖在环境中物理、化学或酶法降解,从而比基于非降解聚合物的口香糖产生更少的环境污染,因为用过的可降解口香糖残渣将最终分解和/或可通过物理或化学手段从其被丢弃的位置轻易地清除。
根据本发明,此处所用的口香糖胶基组分可以包括一种或多种有助于获得所需咀嚼性质并用作胶基组分中弹性体增塑剂的树脂化合物。在本说明书中,有用的弹性体增塑剂包括,但不限于天然松香树脂,通常称为脂胶,包括例如部分氢化的松香甘油酯、聚合松香甘油酯、部分二聚化的松香甘油酯、塔罗油松香甘油酯、部分氢化的松香季戊四醇酯、松香甲酯、部分氢化的松香甲酯或松香季戊四醇酯。其它有用的树脂化合物包括合成树脂,如衍生自α-蒎烯、β-蒎烯、和/或d-苎烯的萜烯树脂,以及天然萜烯树脂;以及上述树脂的任意适当组合。弹性体增塑剂的选择将随特定应用和所用聚合物类型而变化。
如有必要,口香糖胶基配方可包括一种或多种填料/组织形成剂,例如包括碳酸镁和碳酸钙、硫酸钠、重质碳酸钙、硅酸盐化合物如硅酸镁和硅酸铝、高岭土和粘土、氧化铝、二氧化硅、滑石、氧化钛、磷酸钙、磷酸二钙和磷酸三钙、纤维素聚合物如木材,以及其组合物。
填料/组织形成剂还可包括天然有机纤维如水果植物纤维、谷类、稻米、纤维素及其组合。
根据本发明,胶基配方包括一种或多种软化剂,例如蔗糖聚酯,包括WO00/25598所公开的蔗糖聚酯,通过引用并入本文;牛脂;氢化脂肪,包括动物脂;氢化或部分氢化植物油、可可油、单硬脂酸甘油酯、三乙酸甘油酯、卵磷脂、甘油一、二和三酸酯、乙酰化甘油单酯、脂肪酸(例如硬脂酸、棕榈酸、油酸和亚油酸),以及其组合。此处所用术语“软化剂”指软化胶基和口香糖配方并且包含蜡、脂肪、油、乳化剂、表面活性剂和增溶剂的成分。
为了进一步软化胶基,并使其具有结合水的性质,使胶基具有令人愉悦的平滑表面并降低其粘附性质,通常在组合物中加入一种或多种乳化剂,典型用量为胶基的0-18重量%,优选为0-12重量%。可加入口香糖胶基的常用乳化剂的实例有食用脂肪酸的甘油单酯和二酯、食用脂肪酸甘油单酯和二酯的乳酸酯和乙酸酯、乙酰化甘油单酯和二酯、食用脂肪酸的糖酯、硬脂酸Na、K、Mg和Ca、卵磷脂、羟基化卵磷脂等。存在以下所限定的生物或药物活性物质时,配方可包含某些特定的乳化剂和/或增溶剂,以增强活性成分的分散和释放。
制备口香糖胶基时,通常使用蜡和脂肪来调节稠度并软化口香糖胶基。本发明中,可使用任意常用和适用类型的蜡和脂肪,例如米糠蜡、聚乙烯蜡、石油蜡(精制石蜡和微晶蜡)、石蜡、蜂蜡、棕榈蜡、小烛树腊、可可油、脱脂可可粉和任何合适的油或脂肪,例如完全或部分氢化的植物油或完全或部分氢化的动物脂肪。
此外,根据本发明,胶基配方可以包括色素和增白剂,如FD&C-型染料和色淀颜料、水果和植物提取物、二氧化钛及其组合。其它有用的口香糖组分包括抗氧化剂,例如丁基化羟基甲苯(BHT)、丁基羟基茴香醚(BHA)、丙基没食子酸和维生素E,以及防腐剂。
实施例1
参考图2制备所公开的口香糖。
应该强调的是还可应用本发明范围内的其它几种胶基组合物。
在步骤21a中机械混合的第一胶基包括
弹性体: 17重量%
合成树脂: 28重量%
脂肪/填料: 55重量%
蜡: 0重量%
步骤200中,第一胶基与薄荷醇香料预混合。
第一胶基占步骤23中所得共混物的约10.3重量%。
步骤22a中第一胶基颗粒的造粒期间,加入50∶50的甜味剂山梨糖醇。换句话说,山梨糖醇占步骤23中所得共混物的约10.3重量%。在冷却期间造粒。
步骤21b中机械混合的第二胶基包括
弹性体: 19重量%
天然树脂: 20重量%
合成树脂 20重量%
脂肪/填料: 26重量%
蜡: 15重量%
第二胶基占步骤23中所得共混物的约25.6重量%。
步骤22b中第二胶基颗粒的造粒期间,加入50∶50的甜味剂山梨糖醇。换句话说,山梨糖醇占步骤23中所得共混物的约25.6重量%。在冷却期间造粒。
步骤23中,两种颗粒与一定量的其它甜味剂共混,再混入山梨糖醇,约为步骤23中所得成品共混物的18.6重量%;然后混入香料添加剂,约为步骤23中所得成品共混物的1.4重量%;最后加入所谓的香珠和高甜度甜味剂。高甜度甜味剂包括约0.15重量%的阿斯巴甜+0.15重量%的安赛蜜(acesulfame K)=共0.3重量%。
最后,将磨碎的共混物压缩成口香糖。所得的口香糖具有两个明显的特征,即双重香料释放缓冲和双重质感功能。
此外,可以用同样的方法建立同样的双重活性成分缓冲,即在胶基中引入一部分活性成分并且在压缩前立即加入其余的活性成分。
当咀嚼口香糖时,测试所得口香糖的测试小组马上就注意到了双重释放缓冲,确定获得双重释放。初始释放由步骤23中所添加的添加剂控制,随后的释放由引入到第一胶基颗粒中的香料控制。
此外,与传统压缩口香糖相比,口香糖的质感确认为惊人地令人印象深刻。特别是初始咀嚼质感令人印象深刻。
最后,应该提及的是:虽然以上仅描述了两种胶基,但是在本发明范围内几乎可应用任意数量的不同胶基。
应该指出第一工艺阶段,此处为步骤21a、200、22a,限定引入香料的胶基颗粒的混合和制备,其优选基于不含天然树脂的胶基,还优选不含蜡。
通常,根据本发明,第一胶基应该优选能够引入较大量的不溶解的香料。这相对易于获得,例如通过在胶基中应用合成树脂并避免使用蜡。
在步骤200中预混入胶基的较大量香料形成口香糖的两种基本不同的香料释放缓冲之一。这样,预混的香料引入部分颗粒中,并倾向于提供较迟的释放,而在步骤23中加入的香料添加剂倾向于在口香糖的初始咀嚼期间非常早地释放。
与传统混合口香糖相比,至少在温度方面,胶基颗粒与口香糖添加剂的压缩是最终口香糖的较温和聚集。然而,根据传统口香糖,省略彻底剪切混合颗粒和所需添加剂将导致碎裂和分解的风险,特别是在初始咀嚼期间。
根据本发明,以粘性颗粒为特征的所得口香糖可在一定程度上抵消初始咀嚼所引起的分解,在咀嚼口香糖期间,口香糖保持不碎裂直到颗粒最终混合。
根据本发明,包覆的香料,在本领域内也称为微珠,可在压缩前加入到最终共混物中,例如在图2的步骤23中加入。
当使用多阶段(multi-string)工艺时,根据本发明的多个优点之一为:一个阶段,如称之为预混的阶段可包括产品区分(specifier),第二阶段可包括通用胶基混合,典型为可应用于全部两个阶段的颗粒。这样,例如香料和活性成分的不同预混可构成限定混合阶段的最终产品。
该特征某种意义上说是另一个优点,因为通用胶基混合物基本不含香料或其它胶基改性成分,与所得的引入了香料的预混颗粒相比,对于环境影响如水分和温度都相对稳定,可以较稳固地制造和储存。
根据本发明的另一实施方案,还有可能调节和控制最终口香糖的香料释放在早期释放和后期释放之间的平衡,所述早期释放主要通过在将混合颗粒压缩成最终口香糖时加入香料和甜味剂来获得,而后期释放主要通过在预混阶段引入胶基中的香料来得到。
混合物中预混的和粉碎的胶基之间的平衡可随应用的不同而明显改变,这取决于最终口香糖的所需香料释放和预混物中的香料浓度。
根据本发明的另一实施方案,当将预混的胶基和第二阶段胶基联用时,可有利地调节咀嚼特性。
预混阶段不仅可以包括传统意义上的香料,还包括包封或未包封的活性成分。当胶基颗粒包含预混的活性成分时,活性成分的控释可以借助至少双活性成分缓冲剂获得,第一缓冲剂包含在压缩之前直接共混到最终混合物中的活性成分,第二缓冲剂包含在将胶基和胶基添加剂共混之前共混到胶基中的活性成分。
这样,可以获得预混成分和正常压缩成分之间的平衡,获得活性成分的早期和后期释放之间的某种所需的平衡。
应该注意的是活性成分的早期和后期释放之间的平衡有利地与香料的早期和后期释放相关,从而促进和优化遮蔽。
Claims (32)
1.压缩口香糖片(37),包括口香糖芯(38),
所述口香糖芯(38)包括胶基颗粒(32)和口香糖添加剂(33)的压缩物,
所述口香糖添加剂包括甜味剂和香料,
所述胶基颗粒(32)的至少第一部分包含引入香料或活性成分的胶基,
所述胶基颗粒(32)的至少第二部分包含传统胶基颗粒。
2.根据权利要求1的压缩口香糖片,其中所述胶基颗粒(32)的所述至少第一部分包含稳定香料的树脂。
3.根据权利要求1或2的压缩口香糖片,其中所述胶基颗粒(32)的所述至少第一部分包含合成树脂。
4.根据权利要求3的压缩口香糖片,其中所述合成树脂包括聚乙酸乙烯酯、乙酸乙烯酯-月桂酸乙烯酯共聚物及其混合物。
5.根据权利要求1的压缩口香糖片,其中所述胶基颗粒(32)的所述至少第一部分不含蜡。
6.根据权利要求1的压缩口香糖片,其中所述口香糖片的含水量低于5重量%。
7.根据权利要求1的压缩口香糖片,其中所述口香糖芯(38)不含压缩助剂。
8.根据权利要求1的压缩口香糖片,其中所述胶基颗粒(32)的所述至少第二部分具有受控粘性。
9.根据权利要求1的压缩口香糖片,其中所述胶基颗粒(32)的所述至少第二部分包含天然树脂。
10.根据权利要求1的压缩口香糖片,其中所述胶基颗粒(32)的所述至少第二部分包含蜡。
11.根据权利要求8的压缩口香糖片,其中所述受控粘性通过将至少一种天然树脂引入到至少一部分胶基颗粒(32)中而得到。
12.根据权利要求1的压缩口香糖片,其中压缩口香糖片包含3-50重量%的天然树脂。
13.根据权利要求1的压缩口香糖片,其中压缩口香糖片包含0.5-30重量%的弹性体。
14.根据权利要求1的压缩口香糖片,其中压缩口香糖片包含0.1-15重量%的香味剂。
15.根据权利要求9的压缩口香糖片,其中天然树脂提供改进的和粘性的片剂质感。
16.根据权利要求1的压缩口香糖片,其中所述压缩口香糖包含含有润滑剂、防粘剂和助流剂的隔离层。
17.根据权利要求16的压缩口香糖片,其中所述隔离层包含硬脂酸镁。
18.根据权利要求16的压缩口香糖片,其中所述隔离层包含硬脂酸金属盐、氢化植物油、部分氢化植物油、聚乙二醇、聚氧乙烯单硬脂酸酯、动物脂、硅酸盐、二氧化硅、滑石、硬脂酸镁、硬脂酸钙、热解法二氧化硅及其混合物。
19.根据权利要求1的压缩口香糖片,其中口香糖芯不含润滑剂、防粘剂和助流剂。
20.根据权利要求1的压缩口香糖片,其中所述口香糖添加剂包括甜味剂,其含量为口香糖的5-95重量%。
21.提供压缩口香糖的方法,包括以下步骤
-将至少一种弹性体和至少一种增塑剂混入第一匀质胶基中,
-将一定量的香料引入所述第一胶基中,
-将所述引入了香料的胶基造粒,
-将至少一种弹性体和至少一种增塑剂混入第二匀质胶基中,
-将所述第二胶基造粒,
-混合所述第一和所述第二胶基,期间加入其它口香糖添加剂,和
-将该混合物压缩成片。
22.根据权利要求21的方法,其中造粒在加入至少一种填充型甜味剂的过程中进行。
23.口香糖颗粒,其中
口香糖颗粒的第一部分包含引入有香料和/或活性成分的颗粒,
口香糖颗粒的第二部分包含传统胶基颗粒。
24.根据权利要求23的口香糖颗粒,其中口香糖颗粒的第一部分包含合成树脂。
25.根据权利要求23或24的口香糖颗粒,其中口香糖颗粒的第二部分包含基于天然树脂制造的胶基。
26.根据权利要求23的口香糖颗粒,其中口香糖颗粒的第一部分不含天然树脂。
27.根据权利要求23的口香糖颗粒,其中口香糖颗粒的第一部分不含蜡。
28.根据权利要求23的口香糖颗粒,其中口香糖颗粒含有研磨助剂。
29.根据权利要求28的口香糖颗粒,其中所述研磨助剂包括填充型甜味剂。
30.根据权利要求28的口香糖颗粒,其中所述研磨助剂包括山梨糖醇。
31.根据权利要求23的口香糖颗粒,其中所述合成树脂包括聚乙酸乙烯酯、乙酸乙烯酯-月桂酸乙烯酯共聚物及其混合物。
32.根据权利要求23的口香糖颗粒,其中所述颗粒不含润滑剂、防粘剂和助流剂。
Applications Claiming Priority (1)
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PCT/DK2002/000462 WO2004004479A1 (en) | 2002-07-02 | 2002-07-02 | Compressed chewing gum |
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CN1633242A CN1633242A (zh) | 2005-06-29 |
CN100367869C true CN100367869C (zh) | 2008-02-13 |
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US (2) | US20060115433A1 (zh) |
EP (1) | EP1517617B1 (zh) |
JP (1) | JP4481816B2 (zh) |
CN (1) | CN100367869C (zh) |
AU (1) | AU2002320960B2 (zh) |
CA (1) | CA2491295C (zh) |
DE (1) | DE60217731T2 (zh) |
DK (1) | DK1517617T3 (zh) |
EA (1) | EA008858B1 (zh) |
ES (1) | ES2280557T3 (zh) |
MX (1) | MXPA04012407A (zh) |
WO (1) | WO2004004479A1 (zh) |
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Also Published As
Publication number | Publication date |
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CA2491295A1 (en) | 2004-01-15 |
WO2004004479A1 (en) | 2004-01-15 |
DE60217731T2 (de) | 2007-10-18 |
CN1633242A (zh) | 2005-06-29 |
US20060115433A1 (en) | 2006-06-01 |
EA200500129A1 (ru) | 2005-06-30 |
EP1517617A1 (en) | 2005-03-30 |
DE60217731D1 (de) | 2007-03-08 |
ES2280557T3 (es) | 2007-09-16 |
EP1517617B1 (en) | 2007-01-17 |
EA008858B1 (ru) | 2007-08-31 |
AU2002320960B2 (en) | 2008-09-11 |
MXPA04012407A (es) | 2005-06-17 |
JP2005531317A (ja) | 2005-10-20 |
CA2491295C (en) | 2010-10-12 |
DK1517617T3 (da) | 2007-05-21 |
US20130129640A1 (en) | 2013-05-23 |
AU2002320960A1 (en) | 2004-01-23 |
JP4481816B2 (ja) | 2010-06-16 |
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