CN100349885C - 依他普仑氢溴酸盐及其制备方法 - Google Patents

依他普仑氢溴酸盐及其制备方法 Download PDF

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Publication number
CN100349885C
CN100349885C CNB2003801063775A CN200380106377A CN100349885C CN 100349885 C CN100349885 C CN 100349885C CN B2003801063775 A CNB2003801063775 A CN B2003801063775A CN 200380106377 A CN200380106377 A CN 200380106377A CN 100349885 C CN100349885 C CN 100349885C
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CN
China
Prior art keywords
disorder
escitalopram
escitalopram hydrobromide
treatment
hydrobromide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2003801063775A
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English (en)
Chinese (zh)
Other versions
CN1726202A (zh
Inventor
L·马特尔
R·丹塞尔
H·彼得森
P·埃勒加德
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H Lundbeck AS
Original Assignee
H Lundbeck AS
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32668635&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN100349885(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of CN1726202A publication Critical patent/CN1726202A/zh
Application granted granted Critical
Publication of CN100349885C publication Critical patent/CN100349885C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNB2003801063775A 2002-12-23 2003-12-18 依他普仑氢溴酸盐及其制备方法 Expired - Fee Related CN100349885C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200202005 2002-12-23
DKPA200202005 2002-12-23

Publications (2)

Publication Number Publication Date
CN1726202A CN1726202A (zh) 2006-01-25
CN100349885C true CN100349885C (zh) 2007-11-21

Family

ID=32668635

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2003801063775A Expired - Fee Related CN100349885C (zh) 2002-12-23 2003-12-18 依他普仑氢溴酸盐及其制备方法

Country Status (32)

Country Link
US (1) US20040167209A1 (https=)
EP (1) EP1578738B1 (https=)
JP (2) JP4658613B2 (https=)
KR (1) KR20050086933A (https=)
CN (1) CN100349885C (https=)
AR (1) AR042652A1 (https=)
AT (1) ATE388947T1 (https=)
AU (1) AU2003287919B2 (https=)
BR (1) BR0317623A (https=)
CA (1) CA2511142A1 (https=)
CY (1) CY1107451T1 (https=)
DE (1) DE60319739T2 (https=)
DK (1) DK1578738T3 (https=)
EA (1) EA013116B1 (https=)
EG (1) EG24729A (https=)
ES (1) ES2298595T3 (https=)
IL (1) IL169125A0 (https=)
IS (1) IS2654B (https=)
ME (1) MEP5808A (https=)
MX (1) MXPA05005772A (https=)
MY (1) MY135468A (https=)
NO (1) NO20053595L (https=)
NZ (1) NZ540281A (https=)
PE (1) PE20040924A1 (https=)
PL (1) PL378275A1 (https=)
PT (1) PT1578738E (https=)
RS (1) RS51092B (https=)
TW (1) TW200501943A (https=)
UA (1) UA80170C2 (https=)
UY (1) UY28148A1 (https=)
WO (1) WO2004056791A1 (https=)
ZA (1) ZA200504109B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
AU2003287919B2 (en) * 2002-12-23 2009-11-12 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
WO2005084643A1 (en) * 2004-03-05 2005-09-15 H. Lundbeck A/S Crystalline composition containing escitalopram oxalate
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI347942B (en) 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
JP2009511607A (ja) * 2005-10-14 2009-03-19 ハー・ルンドベック・アクチエゼルスカベット エスシタロプラムおよびブプロピオンを含有する安定な医薬製剤
EA200801081A1 (ru) * 2005-10-14 2008-10-30 Х. Лундбекк А/С Способы лечения расстройств центральной нервной системы комбинацией малых доз эсциталопрама и бупропиона
TW200812993A (en) * 2006-05-02 2008-03-16 Lundbeck & Co As H New uses of escitalopram
US8030303B2 (en) 2006-07-11 2011-10-04 Mitsubishi Tanabe Pharma Corporation Salt of morpholine compound
WO2008059514A2 (en) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Process for preparing escitalopram
FR3006594A1 (fr) * 2013-06-11 2014-12-12 Sorin Crm Sas Microsonde implantable de detection/stimulation incorporant un agent anti-inflammatoire
CN108976188B (zh) * 2017-06-05 2022-12-06 上海奥博生物医药股份有限公司 一种艾司西酞普兰双羟萘酸盐新的制备方法
CN111194312A (zh) * 2017-10-09 2020-05-22 提瓦制药工业公司 依地普仑的新盐和固态形式
US20240100012A1 (en) 2021-01-18 2024-03-28 Mark Hasleton Pharmaceutical dosage form

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347066A1 (en) * 1988-06-14 1989-12-20 H. Lundbeck A/S New enantiomers and their isolation
EP1152000A1 (en) * 2000-05-02 2001-11-07 SUMIKA FINE CHEMICALS Co., Ltd. Citalopram hydrobromide crystal and method for crystallization thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34712A (en) * 1862-03-18 James h
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
PL199423B1 (pl) * 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
HRP20020344B1 (hr) * 1999-10-25 2010-10-31 H. Lundbeck A/S Način priprave citaloprama
JP2002020379A (ja) * 2000-05-02 2002-01-23 Sumika Fine Chemicals Co Ltd シタロプラム臭化水素酸塩の結晶およびその結晶化方法
IES20010693A2 (en) * 2000-08-10 2002-07-10 Lundbeck & Co As H Pharmaceutical composition containing citalopram
ES2223959T3 (es) * 2000-12-04 2005-03-01 Westfalia Separator Ag Procedimiento de pretratamiento de aceites en bruto y grasas en bruto para la produccion de esteres de acidos grasos.
WO2002087566A1 (en) * 2001-05-01 2002-11-07 H. Lundbeck A/S The use of enantiomeric pure escitalopram
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AU2003287919B2 (en) * 2002-12-23 2009-11-12 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
US20050174782A1 (en) * 2003-03-25 2005-08-11 Chapman Leonard T. Flashlight

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0347066A1 (en) * 1988-06-14 1989-12-20 H. Lundbeck A/S New enantiomers and their isolation
EP1152000A1 (en) * 2000-05-02 2001-11-07 SUMIKA FINE CHEMICALS Co., Ltd. Citalopram hydrobromide crystal and method for crystallization thereof

Also Published As

Publication number Publication date
AU2003287919B2 (en) 2009-11-12
US20040167209A1 (en) 2004-08-26
PT1578738E (pt) 2008-04-11
HK1087708A1 (en) 2006-10-20
AU2003287919A1 (en) 2004-07-14
ES2298595T3 (es) 2008-05-16
MXPA05005772A (es) 2005-08-16
BR0317623A (pt) 2005-11-29
JP4658613B2 (ja) 2011-03-23
DE60319739T2 (de) 2008-07-17
IL169125A0 (en) 2009-02-11
RS51092B (sr) 2010-10-31
CA2511142A1 (en) 2004-07-08
MEP5808A (xx) 2010-02-10
UY28148A1 (es) 2004-09-30
PL378275A1 (pl) 2006-03-20
EA013116B1 (ru) 2010-02-26
MY135468A (en) 2008-04-30
DK1578738T3 (da) 2008-06-30
PE20040924A1 (es) 2004-12-11
KR20050086933A (ko) 2005-08-30
JP2006514952A (ja) 2006-05-18
TW200501943A (en) 2005-01-16
DE60319739D1 (de) 2008-04-24
IS2654B (is) 2010-08-15
CN1726202A (zh) 2006-01-25
EP1578738B1 (en) 2008-03-12
EP1578738A1 (en) 2005-09-28
ATE388947T1 (de) 2008-03-15
JP2011037893A (ja) 2011-02-24
ZA200504109B (en) 2006-08-30
IS7848A (is) 2005-05-17
CY1107451T1 (el) 2012-12-19
EG24729A (en) 2010-06-21
RS20050487A (sr) 2007-06-04
WO2004056791A1 (en) 2004-07-08
NO20053595L (no) 2005-09-05
EA200501046A1 (ru) 2005-12-29
UA80170C2 (en) 2007-08-27
NZ540281A (en) 2008-07-31
AR042652A1 (es) 2005-06-29

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