CN100335040C - 含有酸敏感型活性成分的快速崩解片剂 - Google Patents

含有酸敏感型活性成分的快速崩解片剂 Download PDF

Info

Publication number
CN100335040C
CN100335040C CNB018202594A CN01820259A CN100335040C CN 100335040 C CN100335040 C CN 100335040C CN B018202594 A CNB018202594 A CN B018202594A CN 01820259 A CN01820259 A CN 01820259A CN 100335040 C CN100335040 C CN 100335040C
Authority
CN
China
Prior art keywords
active ingredient
tablet
acid
mixture
sensitive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB018202594A
Other languages
English (en)
Chinese (zh)
Other versions
CN1479613A (zh
Inventor
R·迪特里希
R·林德
H·奈伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Langer Dietrich
Original Assignee
AUSTANA PHARMACEUTICAL GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AUSTANA PHARMACEUTICAL GmbH filed Critical AUSTANA PHARMACEUTICAL GmbH
Publication of CN1479613A publication Critical patent/CN1479613A/zh
Application granted granted Critical
Publication of CN100335040C publication Critical patent/CN100335040C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
CNB018202594A 2000-12-07 2001-12-06 含有酸敏感型活性成分的快速崩解片剂 Expired - Fee Related CN100335040C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00126807 2000-12-07
EP00126807.7 2000-12-07

Publications (2)

Publication Number Publication Date
CN1479613A CN1479613A (zh) 2004-03-03
CN100335040C true CN100335040C (zh) 2007-09-05

Family

ID=8170591

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018202594A Expired - Fee Related CN100335040C (zh) 2000-12-07 2001-12-06 含有酸敏感型活性成分的快速崩解片剂

Country Status (15)

Country Link
US (1) US7147869B2 (https=)
EP (1) EP1341528B1 (https=)
JP (1) JP2004514737A (https=)
KR (1) KR20030072555A (https=)
CN (1) CN100335040C (https=)
AT (1) ATE541564T1 (https=)
AU (1) AU2002221939A1 (https=)
BR (1) BR0115986A (https=)
CA (1) CA2430829C (https=)
CY (1) CY1112615T1 (https=)
DK (1) DK1341528T3 (https=)
ES (1) ES2380654T3 (https=)
PT (1) PT1341528E (https=)
SI (1) SI1341528T1 (https=)
WO (1) WO2002045694A1 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030059318A (ko) * 2000-12-07 2003-07-07 알타나 파마 아게 산 불안정성 활성 성분을 포함하는 현탁액 형태의 약학 제제
UA80393C2 (uk) * 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
CN100536844C (zh) * 2000-12-07 2009-09-09 尼科梅德有限责任公司 包含酸不稳定活性成分的糊剂形式的药物制剂
BR0211117A (pt) * 2001-07-16 2004-06-22 Astrazeneca Ab Tablete multiparticulado, processo para a manufatura e uso do mesmo, e, método e tratamento de distúrbios gastrointestinais
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
PT1606261E (pt) 2003-03-10 2010-01-11 Nycomed Gmbh Novo processo para a preparação de roflumilast
PE20050150A1 (es) 2003-05-08 2005-03-22 Altana Pharma Ag Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
CL2004000983A1 (es) 2003-05-08 2005-03-04 Altana Pharma Ag Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
US8461187B2 (en) * 2004-06-16 2013-06-11 Takeda Pharmaceuticals U.S.A., Inc. Multiple PPI dosage form
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US8057820B2 (en) * 2004-10-08 2011-11-15 Mcneil-Ppc, Inc. Enteric coated aspirin granules comingled with binder
US8758814B2 (en) 2004-10-08 2014-06-24 Mcneil-Ppc, Inc. Chewable enteric coated aspirin tablets
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
FR2885526B1 (fr) * 2005-05-13 2007-07-27 Flamel Technologies Sa Medicament oral a base d'inhibiteur de pompe a protons
CN100431526C (zh) * 2005-11-07 2008-11-12 上海艾力斯医药科技有限公司 一种酸敏感型药物的快速崩解片剂
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8425935B2 (en) * 2005-12-21 2013-04-23 Basf Se Pharmaceutical formulation for producing rapidly disintegrating tablets
CN102083410B (zh) * 2007-06-06 2013-04-17 巴斯夫欧洲公司 用于制备迅速崩解的片剂的药物制剂
KR20160083132A (ko) * 2007-06-06 2016-07-11 바스프 에스이 급속 붕해 정제의 제조를 위한 제약 제제
SG185296A1 (en) * 2007-10-12 2012-11-29 Takeda Pharmaceuticals Usa Inc Methods of treating gastrointestinal disorders independent of the intake of food
DE102010011421A1 (de) * 2009-03-19 2010-09-30 Schaeffler Technologies Gmbh & Co. Kg Schaltbarer Schlepphebel eines Ventiltriebs einer Brennkraftmaschine
WO2010122583A2 (en) 2009-04-24 2010-10-28 Rubicon Research Private Limited Oral pharmaceutical compositions of acid labile substances
US20110097401A1 (en) 2009-06-12 2011-04-28 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
WO2011112771A1 (en) * 2010-03-11 2011-09-15 Rich Vitamins Llc Quick dissolve nutritional powder
EP2441446A1 (en) * 2010-10-14 2012-04-18 Deva Holding Anonim Sirketi Using of superdisintegrants in cetyl myristate and/or cetyl palmitate formulations
EP2589378A1 (en) * 2010-10-14 2013-05-08 Deva Holding Anonim Sirketi Coating of cetyl myristate and/or cetyl palmitate particles
CN103429228B (zh) 2011-01-05 2016-10-26 赫士睿股份有限公司 万古霉素的喷雾干燥
CN104043104B (zh) 2013-03-15 2018-07-10 浙江创新生物有限公司 含盐酸万古霉素的喷雾干粉及其工业化制备方法
WO2016174664A1 (en) 2015-04-29 2016-11-03 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
CN120585773B (zh) * 2025-08-06 2025-11-07 广州仁恒医药科技股份有限公司 一种盐酸米诺环素胶囊及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065142A (en) * 1958-07-30 1962-11-20 Armour Pharma Gastric resistant medicinal preparation
US5380535A (en) * 1991-05-28 1995-01-10 Geyer; Robert P. Chewable drug-delivery compositions and methods for preparing the same
CN1139878A (zh) * 1994-01-31 1997-01-08 山之内制药株式会社 口溶性压制制剂及其制造方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006227A (en) * 1973-11-15 1977-02-01 Gallegos Alfred J Compositions and methods for fertility control
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
GB2189699A (en) 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
FI90544C (fi) 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
ES2202302T3 (es) 1991-05-28 2004-04-01 Mcneil-Ppc, Inc. Composicion masticable que libera un farmaco.
SE9402431D0 (sv) 1994-07-08 1994-07-08 Astra Ab New tablet formulation
EE03305B1 (et) 1994-07-08 2000-12-15 Astra Aktiebolag Paljuosaline tableteeritud annusvorm I
SE512835C2 (sv) 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
JP4939680B2 (ja) * 1997-05-27 2012-05-30 武田薬品工業株式会社 固形製剤
CA2315088A1 (en) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Process for manufacturing bite-dispersion tablets
SE9704869D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New pharmaceutical formulaton II
DK2263660T3 (en) * 1998-05-18 2018-01-02 Takeda Pharmaceuticals Co Orally disintegrating tablets.
ATE291418T1 (de) * 1998-07-28 2005-04-15 Takeda Pharmaceutical Leicht zerfallende feste zubereitung
SE9803240D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
DE19925710C2 (de) * 1999-06-07 2002-10-10 Byk Gulden Lomberg Chem Fab Neue Zubereitung und Darreichungsform enthaltend einen säurelabilen Protonenpumpenhemmer
CA2376202C (en) * 1999-06-07 2008-11-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel preparation and administration form comprising an acid-labile active compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065142A (en) * 1958-07-30 1962-11-20 Armour Pharma Gastric resistant medicinal preparation
US5380535A (en) * 1991-05-28 1995-01-10 Geyer; Robert P. Chewable drug-delivery compositions and methods for preparing the same
CN1139878A (zh) * 1994-01-31 1997-01-08 山之内制药株式会社 口溶性压制制剂及其制造方法

Also Published As

Publication number Publication date
PT1341528E (pt) 2012-03-20
EP1341528A1 (en) 2003-09-10
US20040110661A1 (en) 2004-06-10
KR20030072555A (ko) 2003-09-15
BR0115986A (pt) 2003-12-23
US7147869B2 (en) 2006-12-12
SI1341528T1 (sl) 2012-05-31
CA2430829A1 (en) 2002-06-13
DK1341528T3 (da) 2012-03-26
CY1112615T1 (el) 2016-02-10
CA2430829C (en) 2010-06-22
HK1062264A1 (zh) 2004-10-29
ES2380654T3 (es) 2012-05-17
CN1479613A (zh) 2004-03-03
AU2002221939A1 (en) 2002-06-18
EP1341528B1 (en) 2012-01-18
WO2002045694A1 (en) 2002-06-13
JP2004514737A (ja) 2004-05-20
ATE541564T1 (de) 2012-02-15

Similar Documents

Publication Publication Date Title
CN100335040C (zh) 含有酸敏感型活性成分的快速崩解片剂
CN1171582C (zh) 口服药用延释剂型
CN1212833C (zh) 苯并咪唑衍生物的口服给药的药物制剂及其制备方法
EP2112920B1 (en) Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
CN1126533C (zh) 有机组合物的改进或有关有机组合物的改进
EP1371361B1 (en) Novel suppository form comprising an acid-labile active compound
CN100536844C (zh) 包含酸不稳定活性成分的糊剂形式的药物制剂
CN1913876A (zh) 含药物的颗粒和包含这种颗粒的固体制剂
CN1134668A (zh) 含有质子泵抑制剂的多单元药物制剂
CN1407884A (zh) 控释氢可酮制剂
CN1251035A (zh) 胃肠粘膜粘附性药物组合物
CN1091634A (zh) 含有一种β-羟基-β-甲基戊二酸单酰辅酶还原酶抑制剂的稳定的药物组合物
EA005803B1 (ru) Новый препарат и форма для введения, включающие неустойчивое в кислой среде действующее вещество
CN1146720A (zh) 新的药物制剂及其制备方法
CN1874767A (zh) 包含aplindore和其衍生物的缓释药物组合物
CN1633281A (zh) 口内崩解的伐地考昔组合物
JP5009482B2 (ja) 酸に不安定な活性成分を含有する懸濁液の形の製薬製剤
CN1139382A (zh) 改性释放2-甲基-5-硝基-1-咪唑基-乙醇组合物及其制备和使用方法
HK1062264B (en) Rapidly disintegrating tablet comprising an acid-labile active ingredient
JP3597823B2 (ja) 固形製剤
CN1767817A (zh) 用于质子泵拮抗剂的口服药物制剂
WO2006111853A2 (en) Stable solid dosage forms of acid labile drug
HK1068557A (en) Pharmaceutical preparation in the form of a suspension comprising an acid-labile active ingredient
HK1060529A (en) Pharmaceutical preparation in the form of a paste comprising an acid-labile active ingredient
HK1034455B (en) Oral pharmaceutical extended release dosage form

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1062264

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1062264

Country of ref document: HK

C56 Change in the name or address of the patentee

Owner name: NICOMEDES LIMITED LIABILITY COMPANY

Free format text: FORMER NAME OR ADDRESS: OTANA MEDICINE AG

CP01 Change in the name or title of a patent holder

Address after: Konstanz

Patentee after: NYCOMED GmbH

Address before: Konstanz

Patentee before: ALTANA PHARMA AG

ASS Succession or assignment of patent right

Owner name: LANGA DIETRICH

Free format text: FORMER OWNER: NICOMEDES LIMITED LIABILITY COMPANY

Effective date: 20090821

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20090821

Address after: Konstanz

Patentee after: Langer Dietrich

Address before: Konstanz

Patentee before: Nycomed GmbH

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070905

Termination date: 20101206