CL2022000990A1 - Combinación de un antagonista de cxcr7 con un modulador del receptor s1p1 - Google Patents
Combinación de un antagonista de cxcr7 con un modulador del receptor s1p1Info
- Publication number
- CL2022000990A1 CL2022000990A1 CL2022000990A CL2022000990A CL2022000990A1 CL 2022000990 A1 CL2022000990 A1 CL 2022000990A1 CL 2022000990 A CL2022000990 A CL 2022000990A CL 2022000990 A CL2022000990 A CL 2022000990A CL 2022000990 A1 CL2022000990 A1 CL 2022000990A1
- Authority
- CL
- Chile
- Prior art keywords
- combination
- cxcr7
- receptor modulator
- cxcr7 antagonist
- antagonist
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuesto (1-pirimidin-2-il-ciclopropil)-amida del ácido (3S,4S)-1-ciclopropilmetil-4-{[5-(2,4-difluoro-fenil)-isoxazol-3-carbonil]-amino}-piperidin-3-carboxílico y su uso como modulador del receptor de CXCL11/CXCL12, CXCR7, en combinación con otros ingredientes o agentes, en la prevención o tratamiento de enfermedades y trastornos donde tanto la expresión de CXCR7 o sus ligandos y S1P desempeñan una función. Composiciones farmacéuticas que comprenden el compuesto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2019079932 | 2019-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2022000990A1 true CL2022000990A1 (es) | 2023-01-27 |
Family
ID=75715765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2022000990A CL2022000990A1 (es) | 2019-10-31 | 2022-04-20 | Combinación de un antagonista de cxcr7 con un modulador del receptor s1p1 |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP4051250A1 (es) |
JP (1) | JP2023501217A (es) |
KR (1) | KR20220093330A (es) |
CN (1) | CN114599363A (es) |
AU (1) | AU2020372647A1 (es) |
CA (1) | CA3156298A1 (es) |
CL (1) | CL2022000990A1 (es) |
IL (1) | IL292529A (es) |
MX (1) | MX2022005014A (es) |
TW (1) | TW202131921A (es) |
WO (1) | WO2021084068A1 (es) |
Family Cites Families (44)
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MXPA04002679A (es) | 2001-09-27 | 2004-07-30 | Kyorin Seiyaku Kk | Derivados de sulfuro de diarilo, sales de los mismos y agentes inmunosupresores que utilizan los mismos. |
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
ATE483698T1 (de) | 2003-11-21 | 2010-10-15 | Actelion Pharmaceuticals Ltd | 5-(benz- (z) -yliden) -thiazolidin-4-onderivate als das immunsystem unterdrückende mittel |
KR20110136901A (ko) | 2004-02-24 | 2011-12-21 | 상꾜 가부시키가이샤 | 아미노 알코올 화합물 |
CA2589265A1 (en) | 2004-11-29 | 2006-06-01 | Novartis Ag | Dosage regimen of an s1p receptor agonist |
ES2378776T3 (es) | 2004-12-13 | 2012-04-17 | Ono Pharmaceutical Co., Ltd. | Derivado de ácido aminocarboxílico y uso medicinal del mismo |
KR101346527B1 (ko) | 2005-12-15 | 2013-12-31 | 미쓰비시 타나베 파마 코퍼레이션 | 아민 화합물 및 그 의약 용도 |
GB0612721D0 (en) | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
JP4669564B2 (ja) | 2006-11-23 | 2011-04-13 | アクテリオン ファーマシューティカルズ リミテッド | 2−イミノ−チアゾリジン−4−オン誘導体の製造のための新規な方法 |
JO2701B1 (en) | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
AU2009227629B2 (en) | 2008-03-17 | 2014-09-04 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective S1P1 receptor agonist |
BRPI0910236A2 (pt) | 2008-03-24 | 2019-09-24 | Kyorin Seiyaku Kk | método para cristalização de composto |
KR20190132565A (ko) | 2008-07-23 | 2019-11-27 | 아레나 파마슈티칼스, 인크. | 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[b]인돌-3-일)아세트산 유도체 |
GB0819182D0 (en) | 2008-10-20 | 2008-11-26 | Actelion Pharmaceuticals Ltd | Crystalline forms |
KR20130109254A (ko) | 2008-11-11 | 2013-10-07 | 노파르티스 아게 | 핑골리모드 hcl의 결정질 형태 |
CN105198760A (zh) | 2008-11-11 | 2015-12-30 | 诺华股份有限公司 | 芬戈莫德的盐 |
KR20110096584A (ko) | 2008-12-18 | 2011-08-30 | 노파르티스 아게 | 1-[4-[1-(4-시클로헥실-3-트리플루오로메틸-벤질옥시이미노)-에틸]-2-에틸-벤질]-아제티딘-3-카르복실산의 헤미푸마레이트 염 |
CN103204794A (zh) | 2008-12-18 | 2013-07-17 | 诺瓦提斯公司 | 新的盐 |
RU2011129230A (ru) | 2008-12-18 | 2013-01-27 | Новартис Аг | Новая полиморфная форма 1-[4-[1-(4-циклогексил-3-трифторметилбензилоксиимино)этил]-2-этилбензил]азетидин-3-карбоновой кислоты |
NZ593427A (en) | 2008-12-22 | 2013-11-29 | Novartis Ag | Dosage regimen of an s1p receptor agonist |
UY32352A (es) | 2008-12-22 | 2010-07-30 | Novartis Ag | Régimen de dosificación para un agonista de los receptores de s1p |
BR112012000763B8 (pt) | 2009-07-16 | 2021-05-25 | Actelion Pharmaceuticals Ltd | compostos derivados de piridin-4-il, composição farmacêutica, e, usos de um composto |
MX2012003752A (es) | 2009-09-29 | 2012-06-01 | Novartis Ag | Metodo y sistema para accesar datos de pacientes. |
TR201807912T4 (tr) | 2009-11-13 | 2018-06-21 | Celgene Int Ii Sarl | Seçi̇ci̇ sfi̇ngozi̇n 1 fosfat reseptör düzenleyi̇ci̇leri̇ ve ki̇ral sentez yöntemleri̇. |
ES2937386T3 (es) | 2010-01-27 | 2023-03-28 | Arena Pharm Inc | Procesos para la preparación de ácido (R)-2-(7-(4-ciclopentil-3-(trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclopenta[b]indol-3-il)acético y sales del mismo |
TW201320994A (zh) | 2011-10-11 | 2013-06-01 | Novartis Ag | 投藥療程 |
US20150218090A1 (en) | 2011-10-21 | 2015-08-06 | Novartis Ag | Dosage regimen for an s1p receptor modulator or agonist |
US20150133669A1 (en) | 2012-05-22 | 2015-05-14 | Actelion Pharmaceuticals Ltd. | New process for the preparation of 2-cyclopentyl-6-methoxy-isonicotinic acid |
PT2885266T (pt) | 2012-08-17 | 2020-05-29 | Actelion Pharmaceuticals Ltd | Processo para a preparação de (2z,5z)-5-(3-cloro-4-((r)-2,3-di-hidropropoxi)benzilideno)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona e intermediário utilizado no referido processo |
EP3062792A1 (en) | 2013-11-01 | 2016-09-07 | Celgene International II Sarl | Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith |
TW201622721A (zh) | 2014-04-10 | 2016-07-01 | 諾華公司 | S1p調節劑之立即釋放劑量療法 |
CN117137912A (zh) | 2014-12-11 | 2023-12-01 | 埃科特莱茵药品有限公司 | 选择性s1p1受体激动剂的给药方案 |
WO2016112075A1 (en) | 2015-01-06 | 2016-07-14 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
EA035133B1 (ru) | 2015-05-20 | 2020-04-30 | Идорсия Фармасьютиклз Лтд | Кристаллическая форма соединения (s)-3-{4-[5-(2-циклопентил-6-метоксипиридин-4-ил)-[1,2,4]оксадиазол-3-ил]-2-этил-6-метилфенокси}пропан-1,2-диола |
SI3310760T1 (sl) | 2015-06-22 | 2023-02-28 | Arena Pharmaceuticals, Inc. | Kristalinična L-argininska sol (R)-2-(7-(4-ciklopentil-3-(trifluorometil)benziloksi)-1,2,3,4- tetrahidrociklo-penta(b)indol-3-il)ocetne kisline za uporabo pri motnjah, povezanih z receptorjem S1P1 |
PT3798217T (pt) | 2016-07-28 | 2023-05-23 | Idorsia Pharmaceuticals Ltd | Moduladores do recetor de piperidina cxcr7 |
ES2925280T3 (es) | 2016-07-29 | 2022-10-14 | Mitsubishi Tanabe Pharma Corp | Método de producción de alcohol 4-alcoxi-3-(trifluorometil)bencílico |
US20200031784A1 (en) | 2017-04-07 | 2020-01-30 | Solipharma Llc | Ozanimod addition salt crystal, preparation method, pharmaceutical composition, and uses |
US11207301B2 (en) | 2017-05-08 | 2021-12-28 | Receptos Llc | Sphingosine 1 phosphate receptor agonists for neuroprotection |
PL3630738T3 (pl) | 2017-05-22 | 2024-04-08 | Egis Gyógyszergyár Zrt. | Sposób wytwarzania ozanimodu |
WO2019058290A1 (en) | 2017-09-20 | 2019-03-28 | Suven Life Sciences Limited | IMPROVED PROCESS FOR THE PREPARATION OF AZANIMOD A-AMINO COMPOUND |
JP2020535175A (ja) | 2017-09-27 | 2020-12-03 | ドクター レディズ ラボラトリーズ リミテッド | シポニモド、その塩およびその固体状態フォームの調製のためのプロセス |
WO2019094409A1 (en) | 2017-11-07 | 2019-05-16 | Teva Pharmaceuticals International Gmbh | Salts and solid state forms of ozanimod |
MA51664A (fr) | 2018-01-26 | 2021-05-05 | Idorsia Pharmaceuticals Ltd | Formes cristallines de l'antagoniste du récepteur cxcr7 d'acide (3s,4s)-1-cyclopropylméthyl-4-([5-(2,4-difluoro-phényl)-isoxazole-3-carbonyl]-amino)-pipéridine-3-carboxylique (1-pyrimidin-2-yl-cyclopropyl)-amide |
-
2020
- 2020-10-30 TW TW109137814A patent/TW202131921A/zh unknown
- 2020-10-30 KR KR1020227017728A patent/KR20220093330A/ko unknown
- 2020-10-30 MX MX2022005014A patent/MX2022005014A/es unknown
- 2020-10-30 JP JP2022525279A patent/JP2023501217A/ja active Pending
- 2020-10-30 EP EP20800836.7A patent/EP4051250A1/en active Pending
- 2020-10-30 WO PCT/EP2020/080510 patent/WO2021084068A1/en active Application Filing
- 2020-10-30 IL IL292529A patent/IL292529A/en unknown
- 2020-10-30 CN CN202080074623.7A patent/CN114599363A/zh active Pending
- 2020-10-30 CA CA3156298A patent/CA3156298A1/en active Pending
- 2020-10-30 AU AU2020372647A patent/AU2020372647A1/en active Pending
-
2022
- 2022-04-20 CL CL2022000990A patent/CL2022000990A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA3156298A1 (en) | 2021-05-06 |
KR20220093330A (ko) | 2022-07-05 |
IL292529A (en) | 2022-06-01 |
TW202131921A (zh) | 2021-09-01 |
MX2022005014A (es) | 2022-05-16 |
AU2020372647A1 (en) | 2022-06-16 |
JP2023501217A (ja) | 2023-01-18 |
EP4051250A1 (en) | 2022-09-07 |
WO2021084068A1 (en) | 2021-05-06 |
CN114599363A (zh) | 2022-06-07 |
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