EA202192118A1 - Фармацевтическая композиция, содержащая ацетаминофен и ибупрофен - Google Patents

Фармацевтическая композиция, содержащая ацетаминофен и ибупрофен

Info

Publication number
EA202192118A1
EA202192118A1 EA202192118A EA202192118A EA202192118A1 EA 202192118 A1 EA202192118 A1 EA 202192118A1 EA 202192118 A EA202192118 A EA 202192118A EA 202192118 A EA202192118 A EA 202192118A EA 202192118 A1 EA202192118 A1 EA 202192118A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ibuprofen
pharmaceutical composition
composition containing
containing acetaminophen
acetaminophen
Prior art date
Application number
EA202192118A
Other languages
English (en)
Inventor
Маура Мёрфи
Мэтт Каллахан
Original Assignee
АФТ Фармасьютикалз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by АФТ Фармасьютикалз Лимитед filed Critical АФТ Фармасьютикалз Лимитед
Publication of EA202192118A1 publication Critical patent/EA202192118A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Раскрываются твердые пероральные дозированные формы, содержащие 325 мг ацетаминофена и 97,5 мг ибупрофена или 500 мг ацетаминофена и 150 мг ибупрофена, где ибупрофен характеризуется D50 от 1 до 9 мкм.
EA202192118A 2019-02-27 2020-02-27 Фармацевтическая композиция, содержащая ацетаминофен и ибупрофен EA202192118A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16/287,836 US11197830B2 (en) 2019-02-27 2019-02-27 Pharmaceutical composition containing acetaminophen and ibuprofen
PCT/US2020/020112 WO2020176736A1 (en) 2019-02-27 2020-02-27 Pharmaceutical composition containing acetominophen and ibuprofen

Publications (1)

Publication Number Publication Date
EA202192118A1 true EA202192118A1 (ru) 2021-11-18

Family

ID=72140141

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202192118A EA202192118A1 (ru) 2019-02-27 2020-02-27 Фармацевтическая композиция, содержащая ацетаминофен и ибупрофен

Country Status (23)

Country Link
US (4) US11197830B2 (ru)
EP (1) EP3930691A4 (ru)
CN (1) CN113795243A (ru)
AU (4) AU2019268077B2 (ru)
BR (1) BR112021017037A2 (ru)
CA (1) CA3131917A1 (ru)
CL (1) CL2021002252A1 (ru)
CO (1) CO2021011525A2 (ru)
CR (1) CR20210451A (ru)
EA (1) EA202192118A1 (ru)
EC (1) ECSP21072036A (ru)
GB (1) GB2595406B (ru)
IL (1) IL285866A (ru)
JO (1) JOP20210235A1 (ru)
MA (2) MA62176A1 (ru)
MX (1) MX2021010338A (ru)
NZ (1) NZ759337A (ru)
PE (1) PE20220591A1 (ru)
SG (1) SG11202109258WA (ru)
TN (1) TN2021000176A1 (ru)
TW (1) TW202045148A (ru)
UA (1) UA127775C2 (ru)
WO (1) WO2020176736A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11197830B2 (en) 2019-02-27 2021-12-14 Aft Pharmaceuticals Limited Pharmaceutical composition containing acetaminophen and ibuprofen
US11918693B2 (en) * 2019-06-27 2024-03-05 Haleon Us Holdings Llc Ibuprofen and acetaminophen tablet

Family Cites Families (26)

* Cited by examiner, † Cited by third party
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JPS5148139B2 (ru) 1972-09-30 1976-12-18
AU605538B2 (en) 1988-01-19 1991-01-17 Adcock Ingram Limited Pharmaceutical unit
CA1336687C (en) 1989-08-23 1995-08-15 Thomas M. Tencza Process for preparing tablets containing ibuprofen, apap and caffeine, the products of this process and the use of such products
US5409709A (en) * 1991-11-29 1995-04-25 Lion Corporation Antipyretic analgesic preparation containing ibuprofen
US5260337A (en) 1992-07-29 1993-11-09 Merck & Co., Inc. Ibuprofen-muscle relaxant combinations
ZA959469B (en) 1994-11-15 1996-05-15 South African Druggists Ltd Pharmaceutical composition
JP3982889B2 (ja) 1997-11-28 2007-09-26 あすか製薬株式会社 イブプロフェン含有医薬製剤
US6440983B1 (en) 2000-12-21 2002-08-27 Mary Theresa Frank-Kollman Compositions and methods for relieving headache symptoms in aspirin-sensitive headache sufferers
CN100360117C (zh) * 2002-06-21 2008-01-09 转化医药公司 具有提高的溶出度的药物组合物
GB0414442D0 (en) 2004-06-28 2004-07-28 Borealis As Zeolite catalysts
US20080275125A1 (en) * 2004-07-07 2008-11-06 Aft Pharmaceuticals Limited Combination Composition
KR20060072839A (ko) 2004-12-23 2006-06-28 김경태 아세트아미노펜과 이부프로펜을 이용하여 통증조절과 해열작용을 하는 주사제
GB0519350D0 (en) 2005-09-22 2005-11-02 Boots Healthcare Int Ltd Therapeutic agents
WO2008079818A2 (en) 2006-12-21 2008-07-03 Soluprin Pharmaceuticals, Inc. Intravenous administration of water soluble analgesic formulations
JP5148139B2 (ja) 2007-03-12 2013-02-20 パナソニック株式会社 半導体装置及びその製造方法
WO2009012590A1 (en) * 2007-07-23 2009-01-29 Kingsway Pharmaceuticals Inc. Therapeutic formulations for the treatment of cold and flu-like symptoms
US20090264530A1 (en) 2008-04-16 2009-10-22 Nickell Robert P Combined nsaid and acetaminophen formulation and method
JP2012505830A (ja) 2008-10-14 2012-03-08 エイエフティ ファーマスーティカルズ リミテッド 医薬品及び医薬品治療
KR101873500B1 (ko) 2009-04-24 2018-08-02 아이슈티카 피티와이 리미티드 생물학적 활성 물질의 용해 프로파일 개선방법
CA2759125C (en) 2009-04-24 2017-08-15 Iceutica Pty Ltd A novel formulation of indomethacin
US11135188B2 (en) 2009-05-11 2021-10-05 Bayer Healthcare Llc Method and composition to improve absorption of therapeutic agents
SG186388A1 (en) 2010-07-07 2013-01-30 Aft Pharmaceuticals Ltd A combination composition comprising ibuprofen and paracetamol
CL2010000738A1 (es) 2010-07-08 2011-03-25 Wockhardt Res Centre Suspension farmaceutica oral que comprende desde 100 hasta 500 mg/5ml de paracetamol, desde 40 hasta 80 mg/5ml de ibuprofeno o desde 200 hasta 400 mg/5ml de paracetamol, desde 100 hasta 200 mg/5ml de ibuprofeno y uno o mas excipientes farmaceuticamente aceptables, util para tratar el dolor pre, peri o postoperatorio.
CA2814057C (en) * 2010-11-04 2022-02-01 Aft Pharmaceuticals Limited Intravenous composition comprising paracetamol and ibuprofen
JP5830412B2 (ja) 2011-03-02 2015-12-09 ライオン株式会社 水難溶性薬物と賦形剤との粉砕物の製造方法、造粒粒子の製造方法、錠剤の製造方法
US11197830B2 (en) 2019-02-27 2021-12-14 Aft Pharmaceuticals Limited Pharmaceutical composition containing acetaminophen and ibuprofen

Also Published As

Publication number Publication date
GB2595406B (en) 2023-05-10
AU2019268077A1 (en) 2020-09-10
TN2021000176A1 (en) 2023-04-04
BR112021017037A2 (pt) 2021-11-09
EP3930691A1 (en) 2022-01-05
US20220175680A1 (en) 2022-06-09
AU2022201196A1 (en) 2022-03-17
UA127775C2 (uk) 2023-12-27
EP3930691A4 (en) 2022-11-30
MA62176A1 (fr) 2024-01-31
CN113795243A (zh) 2021-12-14
US11197830B2 (en) 2021-12-14
CO2021011525A2 (es) 2021-09-20
US20200268673A1 (en) 2020-08-27
ECSP21072036A (es) 2021-11-30
PE20220591A1 (es) 2022-04-22
AU2024203208A1 (en) 2024-05-30
MA54028B2 (fr) 2023-10-31
TW202045148A (zh) 2020-12-16
WO2020176736A1 (en) 2020-09-03
MA54028A1 (fr) 2022-06-30
CL2021002252A1 (es) 2022-04-29
CR20210451A (es) 2021-12-02
AU2021200634B2 (en) 2022-03-10
GB202112205D0 (en) 2021-10-13
MX2021010338A (es) 2022-01-07
US11872317B2 (en) 2024-01-16
AU2019268077B2 (en) 2021-02-25
US20240091160A1 (en) 2024-03-21
US20230201125A1 (en) 2023-06-29
SG11202109258WA (en) 2021-09-29
GB2595406A (en) 2021-11-24
JOP20210235A1 (ar) 2023-01-30
AU2021200634A1 (en) 2021-03-04
IL285866A (en) 2021-10-31
NZ759337A (en) 2023-06-30
US11534407B2 (en) 2022-12-27
CA3131917A1 (en) 2020-09-03

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