CL2021002961A1 - Un procedimiento para la fabricación de ácido(2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6-(((4ar,10ar)-7-hidroxi-1-propil-1,2,3,4,4a, 5,10,10a-octahidrobenzo[g]quinolin-6-il)oxi) tetrahidro-2h-piran-2-carboxílico. - Google Patents
Un procedimiento para la fabricación de ácido(2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6-(((4ar,10ar)-7-hidroxi-1-propil-1,2,3,4,4a, 5,10,10a-octahidrobenzo[g]quinolin-6-il)oxi) tetrahidro-2h-piran-2-carboxílico.Info
- Publication number
- CL2021002961A1 CL2021002961A1 CL2021002961A CL2021002961A CL2021002961A1 CL 2021002961 A1 CL2021002961 A1 CL 2021002961A1 CL 2021002961 A CL2021002961 A CL 2021002961A CL 2021002961 A CL2021002961 A CL 2021002961A CL 2021002961 A1 CL2021002961 A1 CL 2021002961A1
- Authority
- CL
- Chile
- Prior art keywords
- acid
- octahydrobenzo
- trihydroxy
- quinolin
- pyran
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- MQAYFGXOFCEZRW-UHFFFAOYSA-N oxane-2-carboxylic acid Chemical compound OC(=O)C1CCCCO1 MQAYFGXOFCEZRW-UHFFFAOYSA-N 0.000 title 1
- 125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- UAFMEIHFRQARQG-VFUBLZDWSA-N (2S,3S,4S,5R,6S)-6-[[(4aR,10aR)-7-hydroxy-1-propyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-6-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)OC1=C(C=CC2=C1C[C@H]1CCCN([C@@H]1C2)CCC)O)C(=O)O UAFMEIHFRQARQG-VFUBLZDWSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 150000003943 catecholamines Chemical class 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a un procedimiento para la fabricación de ácido (2S,3S,4S,5R,6S)- 3,4,5-trihidroxi-6-(((4aR,10aR)-7-hidroxi-1-propil-1,2,3,4,4a,5,10,10a-octahidrobenzo[g]quinolin-6- il)oxi)tetrahidro-2H-piran-2-carboxílico con la fórmula (Id) que figura a continuación y sales del mismo (Id). El compuesto de fórmula (Id) es un profármaco de una catecolamina para uso en el tratamiento de enfermedades y trastornos neurodegenerativos tales como la enfermedad de Parkinson. La invención también se refiere a nuevos compuestos intermedios de dicho procedimiento
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201900599 | 2019-05-20 | ||
DKPA201900636 | 2019-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021002961A1 true CL2021002961A1 (es) | 2022-08-19 |
Family
ID=73457597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021002961A CL2021002961A1 (es) | 2019-05-20 | 2021-11-09 | Un procedimiento para la fabricación de ácido(2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6-(((4ar,10ar)-7-hidroxi-1-propil-1,2,3,4,4a, 5,10,10a-octahidrobenzo[g]quinolin-6-il)oxi) tetrahidro-2h-piran-2-carboxílico. |
Country Status (14)
Country | Link |
---|---|
US (2) | US11111263B2 (es) |
EP (1) | EP3972968A1 (es) |
JP (1) | JP7509803B2 (es) |
KR (1) | KR20220010482A (es) |
CN (1) | CN113748112A (es) |
AU (1) | AU2020278140A1 (es) |
BR (1) | BR112021000896A2 (es) |
CA (1) | CA3138962A1 (es) |
CL (1) | CL2021002961A1 (es) |
IL (1) | IL287755B1 (es) |
MX (1) | MX2021013425A (es) |
SG (1) | SG11202112118RA (es) |
WO (1) | WO2020234271A1 (es) |
ZA (1) | ZA202108164B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112019014981A2 (pt) | 2017-11-24 | 2020-04-07 | H Lundbeck As | composto, sal farmaceuticamente aceitável, uso dos mesmos e composição farmacêutica |
US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
EP3972970A1 (en) * | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
WO2023208867A1 (en) | 2022-04-25 | 2023-11-02 | Integrative Research Laboratories Sweden Ab | NOVEL 1,2,3,4,4a,5,8,9,10,10a-DECAHYDROBENZO[G]QUINOLIN-6(7H)-ONE COMPOUNDS AND USES THEREOF |
WO2023208869A1 (en) | 2022-04-25 | 2023-11-02 | Integrative Research Laboratories Sweden Ab | NOVEL ESTERS OF 1,2,3,4,4a,5,6,7,8,9,10,10a-DODECAHYDROBENZO[G]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF |
WO2023208865A1 (en) | 2022-04-25 | 2023-11-02 | Integrative Research Laboratories Sweden Ab | NOVEL 1,2,3,4,4a,5,6,7,8,9,10,10a-DODECAHYDROBENZO[G]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF |
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BR112019014981A2 (pt) | 2017-11-24 | 2020-04-07 | H Lundbeck As | composto, sal farmaceuticamente aceitável, uso dos mesmos e composição farmacêutica |
US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
JP7514859B2 (ja) | 2019-05-21 | 2024-07-11 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するための新規なカテコールアミンプロドラッグ |
US20220220077A1 (en) | 2019-05-21 | 2022-07-14 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
JP2022533914A (ja) | 2019-05-21 | 2022-07-27 | ハー・ルンドベック・アクチエゼルスカベット | パーキンソン病の治療に使用するためのカテコールアミンカルバメートプロドラッグ |
EP3972970A1 (en) | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
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2020
- 2020-05-18 US US16/876,878 patent/US11111263B2/en active Active
- 2020-05-19 MX MX2021013425A patent/MX2021013425A/es unknown
- 2020-05-19 AU AU2020278140A patent/AU2020278140A1/en active Pending
- 2020-05-19 SG SG11202112118RA patent/SG11202112118RA/en unknown
- 2020-05-19 WO PCT/EP2020/063909 patent/WO2020234271A1/en active Application Filing
- 2020-05-19 KR KR1020217035286A patent/KR20220010482A/ko unknown
- 2020-05-19 CA CA3138962A patent/CA3138962A1/en active Pending
- 2020-05-19 BR BR112021000896-9A patent/BR112021000896A2/pt unknown
- 2020-05-19 IL IL287755A patent/IL287755B1/en unknown
- 2020-05-19 EP EP20727959.7A patent/EP3972968A1/en active Pending
- 2020-05-19 CN CN202080029161.7A patent/CN113748112A/zh active Pending
- 2020-05-19 JP JP2021564943A patent/JP7509803B2/ja active Active
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2021
- 2021-08-02 US US17/391,439 patent/US11851456B2/en active Active
- 2021-10-22 ZA ZA2021/08164A patent/ZA202108164B/en unknown
- 2021-11-09 CL CL2021002961A patent/CL2021002961A1/es unknown
Also Published As
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IL287755A (en) | 2022-01-01 |
US11851456B2 (en) | 2023-12-26 |
EP3972968A1 (en) | 2022-03-30 |
US20200369706A1 (en) | 2020-11-26 |
MX2021013425A (es) | 2021-12-10 |
CN113748112A (zh) | 2021-12-03 |
US20220194978A1 (en) | 2022-06-23 |
JP7509803B2 (ja) | 2024-07-02 |
AU2020278140A1 (en) | 2021-12-02 |
KR20220010482A (ko) | 2022-01-25 |
WO2020234271A1 (en) | 2020-11-26 |
US11111263B2 (en) | 2021-09-07 |
JP2022534664A (ja) | 2022-08-03 |
BR112021000896A2 (pt) | 2021-04-13 |
SG11202112118RA (en) | 2021-12-30 |
ZA202108164B (en) | 2023-11-29 |
IL287755B1 (en) | 2024-06-01 |
CA3138962A1 (en) | 2020-11-26 |
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