CL2021002959A1 - Nuevas formas sólidas de ácido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6-(((4ar,10ar)-7- hidroxi-1-propil-1,2,3,4,4a,5,10,10a- octahidrobenzo[g]quinolin-6-il)oxi)tetrahidro2h-piran-2-carboxílico. - Google Patents

Nuevas formas sólidas de ácido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6-(((4ar,10ar)-7- hidroxi-1-propil-1,2,3,4,4a,5,10,10a- octahidrobenzo[g]quinolin-6-il)oxi)tetrahidro2h-piran-2-carboxílico.

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Publication number
CL2021002959A1
CL2021002959A1 CL2021002959A CL2021002959A CL2021002959A1 CL 2021002959 A1 CL2021002959 A1 CL 2021002959A1 CL 2021002959 A CL2021002959 A CL 2021002959A CL 2021002959 A CL2021002959 A CL 2021002959A CL 2021002959 A1 CL2021002959 A1 CL 2021002959A1
Authority
CL
Chile
Prior art keywords
acid
trihydroxy
quinolin
pyran
oxy
Prior art date
Application number
CL2021002959A
Other languages
English (en)
Inventor
Diego Heidi Lopez De
Martin Juhl
Lisbet Kværnø
Klaus Gjervig Jensen
Morten Jørgensen
Karin Fredholt
Frans Dennis Therkelsen
Tobias Gylling Frihed
Mikkel Fo Jacobsen
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of CL2021002959A1 publication Critical patent/CL2021002959A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a nuevas formas sólidas del compuesto ácido (2S,3S,4S,5R,6S)-3,4,5-trihidroxi-6-(((4aR,10aR)-7-hidroxi-1-propil-1,2,3,4,4a,5,10,10aoctahidrobenzo[g]quinolin-6-il)oxi)tetrahidro-2H-piran-2-carboxílico con la fórmula (Id) a continuación (Id). El compuesto de fórmula (Id) es un profármaco de una catecolamina para su uso en el tratamiento de trastornos y enfermedades neurodegenerativas tales como enfermedad de Parkinson.
CL2021002959A 2019-05-20 2021-11-09 Nuevas formas sólidas de ácido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6-(((4ar,10ar)-7- hidroxi-1-propil-1,2,3,4,4a,5,10,10a- octahidrobenzo[g]quinolin-6-il)oxi)tetrahidro2h-piran-2-carboxílico. CL2021002959A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA201900599 2019-05-20
DKPA201900598 2019-05-20
DKPA201900612 2019-05-21
DKPA201900636 2019-05-24

Publications (1)

Publication Number Publication Date
CL2021002959A1 true CL2021002959A1 (es) 2022-08-19

Family

ID=70847349

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2021002959A CL2021002959A1 (es) 2019-05-20 2021-11-09 Nuevas formas sólidas de ácido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6-(((4ar,10ar)-7- hidroxi-1-propil-1,2,3,4,4a,5,10,10a- octahidrobenzo[g]quinolin-6-il)oxi)tetrahidro2h-piran-2-carboxílico.

Country Status (14)

Country Link
US (2) US11130775B2 (es)
EP (1) EP3972969A1 (es)
JP (2) JP7364691B2 (es)
KR (1) KR20220010485A (es)
CN (1) CN113784965B (es)
AU (1) AU2020280970A1 (es)
BR (1) BR112021000833A2 (es)
CA (1) CA3139784A1 (es)
CL (1) CL2021002959A1 (es)
IL (1) IL287954A (es)
MX (1) MX2021013687A (es)
SG (1) SG11202111874YA (es)
WO (1) WO2020234272A1 (es)
ZA (1) ZA202108768B (es)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA50800A (fr) 2017-11-24 2020-09-30 H Lundbeck As Nouveaux promédicaments de catécholamine destinés à être utilisés dans le traitement de la maladie de parkinson
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US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol
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WO2023208865A1 (en) 2022-04-25 2023-11-02 Integrative Research Laboratories Sweden Ab NOVEL 1,2,3,4,4a,5,6,7,8,9,10,10a-DODECAHYDROBENZO[G]QUINOLIN-6-OL COMPOUNDS AND USES THEREOF
WO2023208867A1 (en) 2022-04-25 2023-11-02 Integrative Research Laboratories Sweden Ab NOVEL 1,2,3,4,4a,5,8,9,10,10a-DECAHYDROBENZO[G]QUINOLIN-6(7H)-ONE COMPOUNDS AND USES THEREOF

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Publication number Publication date
JP2023179408A (ja) 2023-12-19
MX2021013687A (es) 2021-12-10
CA3139784A1 (en) 2020-11-26
JP7364691B2 (ja) 2023-10-18
BR112021000833A2 (pt) 2021-04-13
EP3972969A1 (en) 2022-03-30
SG11202111874YA (en) 2021-12-30
US11858954B2 (en) 2024-01-02
CN113784965B (zh) 2024-05-03
IL287954A (en) 2022-01-01
ZA202108768B (en) 2023-07-26
US20220024962A1 (en) 2022-01-27
KR20220010485A (ko) 2022-01-25
US11130775B2 (en) 2021-09-28
WO2020234272A1 (en) 2020-11-26
US20200392176A1 (en) 2020-12-17
JP2022533050A (ja) 2022-07-21
CN113784965A (zh) 2021-12-10
AU2020280970A1 (en) 2021-12-09

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