MX2021013687A - Nuevas formas solidas de acido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6 -(((4ar,10ar)-7-hidroxi-1-propil-1,2,3,4,4a,5,10,10a-octahidroben zo[g]quinolin-6-il)oxi)tetrahidro-2h-piran-2-carboxilico. - Google Patents

Nuevas formas solidas de acido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6 -(((4ar,10ar)-7-hidroxi-1-propil-1,2,3,4,4a,5,10,10a-octahidroben zo[g]quinolin-6-il)oxi)tetrahidro-2h-piran-2-carboxilico.

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Publication number
MX2021013687A
MX2021013687A MX2021013687A MX2021013687A MX2021013687A MX 2021013687 A MX2021013687 A MX 2021013687A MX 2021013687 A MX2021013687 A MX 2021013687A MX 2021013687 A MX2021013687 A MX 2021013687A MX 2021013687 A MX2021013687 A MX 2021013687A
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MX
Mexico
Prior art keywords
octahydrobenzo
trihydroxy
pyran
tetrahydro
oxy
Prior art date
Application number
MX2021013687A
Other languages
English (en)
Inventor
Morten Jørgensen
De Diego Heidi Lopez
Klaus Gjervig Jensen
Mikkel Fog Jacobsen
Frans Dennis Therkelsen
Martin Juhl
Lisbet Kværnø
Tobias Gylling Frihed
Karin Fredholt
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of MX2021013687A publication Critical patent/MX2021013687A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a nuevas formas sólidas del compuesto ácido (2S,3S,4S,5R,6S)-3,4,5-trihidroxi-6-(((4aR,10aR)-7 -hidroxi-1-propil-1,2,3,4,4a,5,10,10a-octahidrobenzo[g]quinolin-6 -il)oxi)tetrahidro-2H-piran-2-carboxílico con la fórmula (Id) a continuación (ver Fórmula) El compuesto de fórmula (Id) es un profármaco de una catecolamina para su uso en el tratamiento de trastornos y enfermedades neurodegenerativas tales como enfermedad de Parkinson.
MX2021013687A 2019-05-20 2020-05-19 Nuevas formas solidas de acido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6 -(((4ar,10ar)-7-hidroxi-1-propil-1,2,3,4,4a,5,10,10a-octahidroben zo[g]quinolin-6-il)oxi)tetrahidro-2h-piran-2-carboxilico. MX2021013687A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201900599 2019-05-20
DKPA201900598 2019-05-20
DKPA201900612 2019-05-21
DKPA201900636 2019-05-24
PCT/EP2020/063910 WO2020234272A1 (en) 2019-05-20 2020-05-19 New solid forms of (2s,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(((4ar,10ar)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2h-pyran-2-carboxylic acid

Publications (1)

Publication Number Publication Date
MX2021013687A true MX2021013687A (es) 2021-12-10

Family

ID=70847349

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021013687A MX2021013687A (es) 2019-05-20 2020-05-19 Nuevas formas solidas de acido (2s,3s,4s,5r,6s)-3,4,5-trihidroxi-6 -(((4ar,10ar)-7-hidroxi-1-propil-1,2,3,4,4a,5,10,10a-octahidroben zo[g]quinolin-6-il)oxi)tetrahidro-2h-piran-2-carboxilico.

Country Status (14)

Country Link
US (3) US11130775B2 (es)
EP (1) EP3972969A1 (es)
JP (2) JP7364691B2 (es)
KR (1) KR20220010485A (es)
CN (1) CN113784965B (es)
AU (1) AU2020280970A1 (es)
BR (1) BR112021000833A2 (es)
CA (1) CA3139784A1 (es)
CL (1) CL2021002959A1 (es)
IL (1) IL287954A (es)
MX (1) MX2021013687A (es)
SG (1) SG11202111874YA (es)
WO (1) WO2020234272A1 (es)
ZA (1) ZA202108768B (es)

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US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
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Publication number Publication date
KR20220010485A (ko) 2022-01-25
CN113784965B (zh) 2024-05-03
BR112021000833A2 (pt) 2021-04-13
IL287954A (en) 2022-01-01
EP3972969A1 (en) 2022-03-30
CN113784965A (zh) 2021-12-10
ZA202108768B (en) 2023-07-26
US11858954B2 (en) 2024-01-02
JP7364691B2 (ja) 2023-10-18
AU2020280970A1 (en) 2021-12-09
US20220024962A1 (en) 2022-01-27
CL2021002959A1 (es) 2022-08-19
CA3139784A1 (en) 2020-11-26
SG11202111874YA (en) 2021-12-30
US20200392176A1 (en) 2020-12-17
JP2023179408A (ja) 2023-12-19
WO2020234272A1 (en) 2020-11-26
JP2022533050A (ja) 2022-07-21
US11130775B2 (en) 2021-09-28
US20240190909A1 (en) 2024-06-13

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