WO2009084037A3 - Novel process for preparation of o-desmethylvenlafaxine - Google Patents

Novel process for preparation of o-desmethylvenlafaxine Download PDF

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Publication number
WO2009084037A3
WO2009084037A3 PCT/IN2008/000850 IN2008000850W WO2009084037A3 WO 2009084037 A3 WO2009084037 A3 WO 2009084037A3 IN 2008000850 W IN2008000850 W IN 2008000850W WO 2009084037 A3 WO2009084037 A3 WO 2009084037A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
desmethylvenlafaxine
preparation
novel process
pharmaceutically acceptable
Prior art date
Application number
PCT/IN2008/000850
Other languages
French (fr)
Other versions
WO2009084037A4 (en
WO2009084037A2 (en
Inventor
Bansi Lal
Vitthal Genbhau Gund
Vijay Kannan Pandian
Original Assignee
Calyx Chemicals And Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calyx Chemicals And Pharmaceuticals Ltd. filed Critical Calyx Chemicals And Pharmaceuticals Ltd.
Publication of WO2009084037A2 publication Critical patent/WO2009084037A2/en
Publication of WO2009084037A3 publication Critical patent/WO2009084037A3/en
Publication of WO2009084037A4 publication Critical patent/WO2009084037A4/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention relates to the novel processes for the preparation of 4-(2- (dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol, commonly known as O- desmethylvenlafaxine of formula (I) and its pharmaceutically acceptable salts thereof The present invention also relates to the novel process for the preparation of O- desmethylvenlafaxine of formula (I) and its pharmaceutically acceptable salts thereof formula (V) or formula (VI) formula (I) or formula (VII) wherein, R is hydrogen, methoxyethoxymethyl (MEM), methoxymethyl (MOM), aryloyl, arylsulfonyl, tetrahydropyranyl or substituted silyl.
PCT/IN2008/000850 2007-12-20 2008-12-19 Novel process for preparation of o-desmethylvenlafaxine WO2009084037A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2504/MUM/2007 2007-12-20
IN2504MU2007 2007-12-20

Publications (3)

Publication Number Publication Date
WO2009084037A2 WO2009084037A2 (en) 2009-07-09
WO2009084037A3 true WO2009084037A3 (en) 2009-12-03
WO2009084037A4 WO2009084037A4 (en) 2010-01-21

Family

ID=40824851

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000850 WO2009084037A2 (en) 2007-12-20 2008-12-19 Novel process for preparation of o-desmethylvenlafaxine

Country Status (1)

Country Link
WO (1) WO2009084037A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018146529A1 (en) * 2017-02-09 2018-08-16 R L Finechem Private Limited A process for preparation of1-[2-(dimethylamino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof
CN108440315A (en) * 2018-03-12 2018-08-24 钦州学院 Deuterated O-DMV and its preparation method and application
CN109012737B (en) * 2018-06-19 2021-09-17 陕西蒲城万德科技有限公司 Catalytic synthesis method of antidepressant drug intermediate
CN108752235B (en) * 2018-06-19 2020-11-10 武汉普元药业有限责任公司 Method for preparing drug intermediate by hydrotalcite material catalysis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536815A (en) * 1994-03-31 1996-07-16 Research Corporation Technologies, Inc. Cyclopropyl based O- and N- and S-protecting groups
US5894074A (en) * 1997-04-01 1999-04-13 Basf Aktiengesellschaft Preparation of tertiary amines from nitriles and secondary amines
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
US20030139623A1 (en) * 2000-08-30 2003-07-24 Ekkundi Vadiraj S Process for the preparation of substituted phenylacetonitriles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536815A (en) * 1994-03-31 1996-07-16 Research Corporation Technologies, Inc. Cyclopropyl based O- and N- and S-protecting groups
US5894074A (en) * 1997-04-01 1999-04-13 Basf Aktiengesellschaft Preparation of tertiary amines from nitriles and secondary amines
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
US20030139623A1 (en) * 2000-08-30 2003-07-24 Ekkundi Vadiraj S Process for the preparation of substituted phenylacetonitriles

Also Published As

Publication number Publication date
WO2009084037A4 (en) 2010-01-21
WO2009084037A2 (en) 2009-07-09

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