CL2020000685A1 - Nucleósidos sustituidos, nucleótidos y análogos de estos. - Google Patents
Nucleósidos sustituidos, nucleótidos y análogos de estos.Info
- Publication number
- CL2020000685A1 CL2020000685A1 CL2020000685A CL2020000685A CL2020000685A1 CL 2020000685 A1 CL2020000685 A1 CL 2020000685A1 CL 2020000685 A CL2020000685 A CL 2020000685A CL 2020000685 A CL2020000685 A CL 2020000685A CL 2020000685 A1 CL2020000685 A1 CL 2020000685A1
- Authority
- CL
- Chile
- Prior art keywords
- nucleotides
- analogs
- substituted nucleosides
- nucleosides
- substituted
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 title abstract 2
- 125000003835 nucleoside group Chemical group 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 241000711573 Coronaviridae Species 0.000 abstract 1
- 241000711950 Filoviridae Species 0.000 abstract 1
- 241000710781 Flaviviridae Species 0.000 abstract 1
- 241000709664 Picornaviridae Species 0.000 abstract 1
- 241000711904 Pneumoviridae Species 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762560110P | 2017-09-18 | 2017-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2020000685A1 true CL2020000685A1 (es) | 2020-10-23 |
Family
ID=63794555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020000685A CL2020000685A1 (es) | 2017-09-18 | 2020-03-16 | Nucleósidos sustituidos, nucleótidos y análogos de estos. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11149049B2 (https=) |
| EP (1) | EP3684782A1 (https=) |
| JP (1) | JP2020534361A (https=) |
| KR (1) | KR102696517B1 (https=) |
| CN (1) | CN111542531B (https=) |
| AU (1) | AU2018332540B2 (https=) |
| CA (1) | CA3075950A1 (https=) |
| CL (1) | CL2020000685A1 (https=) |
| CR (1) | CR20200126A (https=) |
| EA (1) | EA202090775A1 (https=) |
| EC (1) | ECSP20022130A (https=) |
| IL (1) | IL273341A (https=) |
| MA (1) | MA50172A (https=) |
| MX (1) | MX2020002925A (https=) |
| PH (1) | PH12020550114A1 (https=) |
| SG (1) | SG11202002295QA (https=) |
| WO (1) | WO2019053696A1 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014209983A1 (en) | 2013-06-26 | 2014-12-31 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| TN2016000566A1 (en) | 2014-06-24 | 2018-04-04 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| AU2018262501B2 (en) | 2017-05-01 | 2020-12-10 | Gilead Sciences, Inc. | Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| WO2019014247A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS |
| CR20200126A (es) * | 2017-09-18 | 2020-07-11 | Janssen Biopharma Inc | Nucleósidos sustituidos, nucleótidos y análogos de estos |
| EP3946611A2 (en) | 2019-03-31 | 2022-02-09 | Yeda Research and Development Co. Ltd | Anti-viral and anti-tumoral compounds |
| CN110724174B (zh) * | 2019-09-10 | 2021-02-05 | 广州六顺生物科技股份有限公司 | 吡咯并三嗪类化合物、组合物及其应用 |
| CN110776512A (zh) * | 2019-11-28 | 2020-02-11 | 成都傲飞生物化学品有限责任公司 | 一种核苷类似物的制备方法 |
| US11660307B2 (en) | 2020-01-27 | 2023-05-30 | Gilead Sciences, Inc. | Methods for treating SARS CoV-2 infections |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AU2021224588B2 (en) * | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI775313B (zh) * | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| CN113292565B (zh) * | 2020-02-24 | 2023-01-31 | 浙江森科建设有限公司 | 核苷类化合物及其制备方法和应用 |
| CN113387954B (zh) * | 2020-03-11 | 2024-03-19 | 上海特化医药科技有限公司 | 一种瑞德西韦中间体的制备方法 |
| JP7554841B2 (ja) | 2020-03-12 | 2024-09-20 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノヌクレオシドを調製する方法 |
| WO2021207049A1 (en) | 2020-04-06 | 2021-10-14 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
| CN112778310B (zh) | 2020-04-20 | 2025-05-30 | 中国科学院上海药物研究所 | 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用 |
| CN111961057A (zh) * | 2020-05-26 | 2020-11-20 | 李小冬 | 一种α构型核苷及其在治疗猫冠状病毒感染的应用 |
| CA3179226A1 (en) | 2020-05-29 | 2021-12-02 | Tomas Cihlar | Remdesivir treatment methods |
| AU2021296841B2 (en) * | 2020-06-24 | 2025-01-23 | Gilead Sciences, Inc. | 1'-cyano nucleoside analogs and uses thereof |
| CN111793101B (zh) * | 2020-07-17 | 2022-09-30 | 四川大学 | C-核苷化合物的合成方法 |
| MX2023001002A (es) | 2020-07-24 | 2023-03-01 | Univ California | Farmacos antivirales, composiciones farmaceuticas, y metodos. |
| WO2022038539A2 (en) * | 2020-08-18 | 2022-02-24 | Yeda Research And Development Co. Ltd. | Anti-viral and anti-tumoral compounds |
| AU2021330835B2 (en) | 2020-08-24 | 2023-12-14 | Gilead Sciences, Inc. | Phospholipid compounds and uses thereof |
| SI4204421T1 (sl) * | 2020-08-27 | 2024-07-31 | Gilead Sciences, Inc., | Spojine in postopki za zdravljenje virusnih okužb |
| JP2023541960A (ja) * | 2020-09-17 | 2023-10-04 | メレティオス セラピューティクス | ウイルス感染を治療するための化合物 |
| CN112142810A (zh) * | 2020-09-29 | 2020-12-29 | 佛山科学技术学院 | 核苷酸双氨基磷酸酯化合物、其药物组合物及其制备方法和应用 |
| TW202344257A (zh) | 2020-10-16 | 2023-11-16 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| CN112300236A (zh) * | 2020-10-21 | 2021-02-02 | 佛山科学技术学院 | 核苷酸混合氨基磷酸酯化合物、其药物组合物及其应用 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CN114588159A (zh) * | 2020-12-07 | 2022-06-07 | 成都傲科新技术有限责任公司 | 一种治疗猫冠状病毒感染的化合物及其应用 |
| CN114634529A (zh) * | 2020-12-15 | 2022-06-17 | 中国科学院大连化学物理研究所 | 一种氟代瑞德西韦及其合成方法 |
| JP2024503755A (ja) * | 2020-12-30 | 2024-01-26 | サウザン・ユニバーシティ・オブ・サイエンス・アンド・テクノロジー | ウイルス感染症治療用ヌクレオシド系化合物及びその用途 |
| US12558364B2 (en) | 2021-01-20 | 2026-02-24 | Regents Of The University Of Minnesota | Next generation remdesivir antivirals |
| WO2022166581A1 (zh) * | 2021-02-07 | 2022-08-11 | 石家庄迪斯凯威医药科技有限公司 | 一种核苷酸衍生物及其药物组合物和用途 |
| US20240166680A1 (en) * | 2021-04-15 | 2024-05-23 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Nucleoside analog and use thereof |
| EP4323362B1 (en) * | 2021-04-16 | 2025-05-07 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| EP4323361A1 (en) * | 2021-04-16 | 2024-02-21 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| AU2022328698B2 (en) | 2021-08-18 | 2025-02-20 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| IL310854A (en) * | 2021-08-20 | 2024-04-01 | Shionogi & Co | Nucleoside compounds and their drug derivatives possessing viral growth inhibitory activity |
| CN118591377A (zh) | 2022-01-26 | 2024-09-03 | 加利福尼亚大学董事会 | 抗病毒前药、中效和长效制剂和方法 |
| IL315102A (en) | 2022-03-02 | 2024-10-01 | Gilead Sciences Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS |
| PE20250419A1 (es) * | 2022-03-03 | 2025-02-14 | Gilead Sciences Inc | Compuestos antivirales y metodos de elaboracion y uso de los mismos |
| CN114573590B (zh) * | 2022-03-18 | 2023-11-14 | 苏州旺山旺水生物医药有限公司 | 一种四异丁酰基核苷类似物的制备方法及用途 |
| CN116891474A (zh) * | 2022-03-31 | 2023-10-17 | 苏州旺山旺水生物医药有限公司 | 一种单异丁酰基核苷类似物的制备方法 |
| WO2024002112A1 (zh) * | 2022-06-28 | 2024-01-04 | 苏州旺山旺水生物医药股份有限公司 | 一种治疗猫冠状或杯状病毒感染的方法 |
| CN115894498A (zh) * | 2022-10-01 | 2023-04-04 | 海化生命(厦门)科技有限公司 | 一种潜在抗病毒药物中间体bl及其合成方法 |
| CN120152976A (zh) * | 2022-10-23 | 2025-06-13 | 上海柯君医药科技有限公司 | 抗冠状病毒化合物及其组合物和用途 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| US20250090537A1 (en) * | 2023-08-31 | 2025-03-20 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| CN117509571B (zh) * | 2023-11-01 | 2025-12-05 | 乐威医药（江苏）股份有限公司 | 一种连续化制备叠氮化碘的方法及其应用 |
| CN118304315B (zh) * | 2024-04-12 | 2025-03-25 | 深圳安泰维生物医药有限公司 | 一种核苷类化合物在制备抗呼吸道合胞病毒感染相关产品上的用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| WO2002057425A2 (en) | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| WO2005020884A2 (en) | 2003-05-14 | 2005-03-10 | Idenix (Cayman) Limited | Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses |
| ES2398684T3 (es) * | 2008-04-23 | 2013-03-21 | Gilead Sciences, Inc. | Análogos de carbanucleósido para el tratamiento antiviral |
| AU2013216595B2 (en) * | 2008-04-23 | 2016-07-28 | Gilead Sciences, Inc. | 1' -substituted carba-nucleoside analogs for antiviral treatment |
| EP2313102A2 (en) * | 2008-07-03 | 2011-04-27 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| PE20120995A1 (es) * | 2009-09-21 | 2012-08-01 | Gilead Sciences Inc | Analogos de carba-nucleosidos sustituidos con 2'-fluoro para tratamiento antiviral |
| BR122020020745B8 (pt) * | 2010-07-22 | 2023-10-31 | Gilead Sciences Inc | Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende |
| BR112013005872A2 (pt) | 2010-09-22 | 2019-09-24 | Alios Biopharma Inc | compostos, composição farmacêutica e respectivos usos |
| EP2619215B1 (en) * | 2010-09-22 | 2018-09-05 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| AU2011349278C1 (en) * | 2010-12-22 | 2017-01-19 | Alios Biopharma, Inc. | Cyclic nucleotide analogs |
| EP2794630A4 (en) * | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE |
| EP3055319A4 (en) * | 2013-10-11 | 2018-01-10 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| WO2015143712A1 (en) * | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
| LT3160476T (lt) * | 2014-06-24 | 2021-04-12 | Janssen Biopharma, Inc. | Pakeistieji nukleozidai, nukleotidai ir jų analogai, skirti naudoti virusinių infekcijų gydyme |
| TN2016000566A1 (en) * | 2014-06-24 | 2018-04-04 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| MA41213A (fr) * | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
| SI3349758T1 (sl) * | 2015-09-16 | 2022-08-31 | Gilead Sciences, Inc. | Postopki za zdravljenje okužb z virusom arenaviridae |
| CR20200126A (es) * | 2017-09-18 | 2020-07-11 | Janssen Biopharma Inc | Nucleósidos sustituidos, nucleótidos y análogos de estos |
-
2018
- 2018-09-18 CR CR20200126A patent/CR20200126A/es unknown
- 2018-09-18 AU AU2018332540A patent/AU2018332540B2/en not_active Ceased
- 2018-09-18 CA CA3075950A patent/CA3075950A1/en active Pending
- 2018-09-18 WO PCT/IB2018/057188 patent/WO2019053696A1/en not_active Ceased
- 2018-09-18 EA EA202090775A patent/EA202090775A1/ru unknown
- 2018-09-18 CN CN201880074579.2A patent/CN111542531B/zh active Active
- 2018-09-18 JP JP2020537296A patent/JP2020534361A/ja active Pending
- 2018-09-18 US US16/648,405 patent/US11149049B2/en not_active Expired - Fee Related
- 2018-09-18 EP EP18783113.6A patent/EP3684782A1/en not_active Withdrawn
- 2018-09-18 MA MA050172A patent/MA50172A/fr unknown
- 2018-09-18 SG SG11202002295QA patent/SG11202002295QA/en unknown
- 2018-09-18 KR KR1020207011130A patent/KR102696517B1/ko active Active
- 2018-09-18 MX MX2020002925A patent/MX2020002925A/es unknown
-
2020
- 2020-03-16 CL CL2020000685A patent/CL2020000685A1/es unknown
- 2020-03-17 IL IL273341A patent/IL273341A/en unknown
- 2020-03-22 PH PH12020550114A patent/PH12020550114A1/en unknown
- 2020-04-15 EC ECSENADI202022130A patent/ECSP20022130A/es unknown
-
2021
- 2021-08-26 US US17/446,007 patent/US11773126B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20200098483A (ko) | 2020-08-20 |
| IL273341A (en) | 2020-05-31 |
| SG11202002295QA (en) | 2020-04-29 |
| EP3684782A1 (en) | 2020-07-29 |
| ECSP20022130A (es) | 2020-07-31 |
| US20210395288A1 (en) | 2021-12-23 |
| EA202090775A1 (ru) | 2020-07-06 |
| BR112020005177A2 (pt) | 2020-09-15 |
| CN111542531B (zh) | 2024-07-19 |
| MX2020002925A (es) | 2020-10-05 |
| CR20200126A (es) | 2020-07-11 |
| AU2018332540A1 (en) | 2020-04-30 |
| WO2019053696A1 (en) | 2019-03-21 |
| KR102696517B1 (ko) | 2024-08-21 |
| CA3075950A1 (en) | 2019-03-21 |
| US11149049B2 (en) | 2021-10-19 |
| US11773126B2 (en) | 2023-10-03 |
| US20200277321A1 (en) | 2020-09-03 |
| CN111542531A (zh) | 2020-08-14 |
| AU2018332540B2 (en) | 2023-10-05 |
| JP2020534361A (ja) | 2020-11-26 |
| PH12020550114A1 (en) | 2020-12-07 |
| MA50172A (fr) | 2021-04-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2020000685A1 (es) | Nucleósidos sustituidos, nucleótidos y análogos de estos. | |
| CL2016000805A1 (es) | Nucleósidos sustituidos, nucleótidos y análogos de los mismos. | |
| CL2015003615A1 (es) | Nucleósidos sustituidos, nucleótidos y análogos de los mismos. | |
| CL2016000493A1 (es) | Inhibidores de polimerasa hcv. | |
| EA201692535A1 (ru) | Замещенные нуклеозиды, нуклеотиды и их аналоги | |
| CL2018001207A1 (es) | Compuesto de 7-(tiazol-5-il)pirrolopirimidina como agonista de tlr7 | |
| CO2019009215A2 (es) | Sal hemi-sulfato de nucleótido para el tratamiento del virus de la hepatitis c | |
| CL2016000381A1 (es) | Compuestos antivirales | |
| EA201890494A1 (ru) | Способы лечения вирусных инфекций arenaviridae и coronaviridae | |
| MX2022000453A (es) | Compuestos útiles para tratar infecciones por virus de influenza. | |
| UY37961A (es) | Nuevas y altamente activas indolo-2-carboxamidas sustituidas con pirazolo-pirimidina activas contra el virus de la hepatitis b (vhb) | |
| CL2015001916A1 (es) | Derivados de pirimidona y su uso en el tratamiento, mejora o prevención de una enfermedad viral. | |
| GT201500020A (es) | Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b | |
| UY35732A (es) | Composiciones terapéuticas de nucleótidos y nucleósidos y usos relacionados con las mismas | |
| CL2014003634A1 (es) | Inhibidores del virus de la hepatitis c | |
| ECSP16085206A (es) | Derivados de nucleósido 4'-sustituidos como inihbidores de la transcriptasa reversa de vih | |
| CL2015003370A1 (es) | Derivados de sulfamoilpirrolamiday su uso como medicamentos para el tratamiento de la hepatitis b | |
| EA201592184A1 (ru) | 4'-фтор-2'-метилзамещенные нуклеозидные производные | |
| ECSP11011310A (es) | Análogos carba - nucleósido para tratamiento antiviral | |
| GT201300093A (es) | Compuestos antivirales | |
| UY37962A (es) | Nuevas y altamente activas indol-2-carboxamidas sustituidas con amino-tiazol activas contra el virus de la hepatitis b (vhb) | |
| CL2012001959A1 (es) | Compuestos derivados del acido tiofeno-2-carboxilico, inhibidores de virus flaviviridae; composicion farmaceutica que los comprende; y su uso para el tratamiento de una infeccion viral por flaviviridae. | |
| EA201791903A1 (ru) | β-D-2'-ДЕЗОКСИ-2'-α-ФТОР-2'-β-C-ЗАМЕЩЕННЫЕ-2-МОДИФИЦИРОВАННЫЕ-N6-ЗАМЕЩЕННЫЕ ПУРИНОВЫЕ НУКЛЕОТИДЫ ДЛЯ ЛЕЧЕНИЯ ВЫЗВАННЫХ HCV ЗАБОЛЕВАНИЙ | |
| CL2016001973A1 (es) | Derivados de nucleosido sustituidos con 4' -difluorometilo como inhibidores de la replicación de arn de la influenza. | |
| MX2015011473A (es) | Compuesto de fosforamidato de nucleosido novedoso y su uso. |