EA202090775A1 - Замещенные нуклеозиды, нуклеотиды и их аналоги - Google Patents
Замещенные нуклеозиды, нуклеотиды и их аналогиInfo
- Publication number
- EA202090775A1 EA202090775A1 EA202090775A EA202090775A EA202090775A1 EA 202090775 A1 EA202090775 A1 EA 202090775A1 EA 202090775 A EA202090775 A EA 202090775A EA 202090775 A EA202090775 A EA 202090775A EA 202090775 A1 EA202090775 A1 EA 202090775A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- analogues
- nucleotides
- substituted nucleosides
- compounds
- formula
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000711573 Coronaviridae Species 0.000 abstract 1
- 241000711950 Filoviridae Species 0.000 abstract 1
- 241000710781 Flaviviridae Species 0.000 abstract 1
- 241000709664 Picornaviridae Species 0.000 abstract 1
- 241000711904 Pneumoviridae Species 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
В изобретении раскрыты соединения формулы (I) и их фармацевтически приемлемые солигде переменные в формуле (I) описаны в этом документе. Также описаны способы синтеза таких соединений и способы их применения для лечения заболеваний и/или состояний, таких как вирусные инфекции, вызванные Picornaviridae, Flaviviridae, Filoviridae, Pneumoviridae и/или Coronaviridae.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762560110P | 2017-09-18 | 2017-09-18 | |
PCT/IB2018/057188 WO2019053696A1 (en) | 2017-09-18 | 2018-09-18 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202090775A1 true EA202090775A1 (ru) | 2020-07-06 |
Family
ID=63794555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090775A EA202090775A1 (ru) | 2017-09-18 | 2018-09-18 | Замещенные нуклеозиды, нуклеотиды и их аналоги |
Country Status (18)
Country | Link |
---|---|
US (2) | US11149049B2 (ru) |
EP (1) | EP3684782A1 (ru) |
JP (1) | JP2020534361A (ru) |
KR (1) | KR20200098483A (ru) |
CN (1) | CN111542531A (ru) |
AU (1) | AU2018332540B2 (ru) |
BR (1) | BR112020005177A2 (ru) |
CA (1) | CA3075950A1 (ru) |
CL (1) | CL2020000685A1 (ru) |
CR (1) | CR20200126A (ru) |
EA (1) | EA202090775A1 (ru) |
EC (1) | ECSP20022130A (ru) |
IL (1) | IL273341A (ru) |
MA (1) | MA50172A (ru) |
MX (1) | MX2020002925A (ru) |
PH (1) | PH12020550114A1 (ru) |
SG (1) | SG11202002295QA (ru) |
WO (1) | WO2019053696A1 (ru) |
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DK3013843T3 (en) | 2013-06-26 | 2018-09-03 | Alios Biopharma Inc | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF |
AU2015280234B2 (en) | 2014-06-24 | 2021-04-01 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
AU2018262501B2 (en) | 2017-05-01 | 2020-12-10 | Gilead Sciences, Inc. | Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
CN111093627B (zh) | 2017-07-11 | 2024-03-08 | 吉利德科学公司 | 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物 |
KR20200098483A (ko) | 2017-09-18 | 2020-08-20 | 얀센 바이오파마, 인크. | 치환된 뉴클레오시드, 뉴클레오티드 및 이들의 유사체 |
CN110724174B (zh) * | 2019-09-10 | 2021-02-05 | 广州六顺生物科技股份有限公司 | 吡咯并三嗪类化合物、组合物及其应用 |
CN110776512A (zh) * | 2019-11-28 | 2020-02-11 | 成都傲飞生物化学品有限责任公司 | 一种核苷类似物的制备方法 |
TWI789695B (zh) | 2020-01-27 | 2023-01-11 | 美商基利科學股份有限公司 | 治療sars cov-2感染之方法 |
TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
TW202245800A (zh) * | 2020-02-18 | 2022-12-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
JP7429799B2 (ja) | 2020-02-18 | 2024-02-08 | ギリアード サイエンシーズ, インコーポレイテッド | 抗ウイルス化合物 |
CN113292565B (zh) * | 2020-02-24 | 2023-01-31 | 浙江森科建设有限公司 | 核苷类化合物及其制备方法和应用 |
CN113387954B (zh) * | 2020-03-11 | 2024-03-19 | 上海特化医药科技有限公司 | 一种瑞德西韦中间体的制备方法 |
AU2021234308C1 (en) | 2020-03-12 | 2024-02-22 | Gilead Sciences, Inc. | Methods of preparing 1'-cyano nucleosides |
WO2021207049A1 (en) | 2020-04-06 | 2021-10-14 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
CN112778310A (zh) * | 2020-04-20 | 2021-05-11 | 中国科学院上海药物研究所 | 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用 |
CN111961057A (zh) * | 2020-05-26 | 2020-11-20 | 李小冬 | 一种α构型核苷及其在治疗猫冠状病毒感染的应用 |
TW202203941A (zh) | 2020-05-29 | 2022-02-01 | 美商基利科學股份有限公司 | 瑞德西韋之治療方法 |
CN115996928A (zh) * | 2020-06-24 | 2023-04-21 | 吉利德科学公司 | 1’-氰基核苷类似物及其用途 |
CN116264827A (zh) * | 2020-07-24 | 2023-06-16 | 加利福尼亚大学董事会 | 抗病毒前药、药物制剂和方法 |
EP4228656A2 (en) * | 2020-08-18 | 2023-08-23 | Yeda Research and Development Co. Ltd | Anti-viral and anti-tumoral compounds |
WO2022046631A1 (en) | 2020-08-24 | 2022-03-03 | Gilead Sciences, Inc. | Phospholipid compounds and uses thereof |
TW202233204A (zh) * | 2020-08-27 | 2022-09-01 | 美商基利科學股份有限公司 | 用於治療病毒感染之化合物及方法 |
CN112142810A (zh) * | 2020-09-29 | 2020-12-29 | 佛山科学技术学院 | 核苷酸双氨基磷酸酯化合物、其药物组合物及其制备方法和应用 |
TWI811812B (zh) | 2020-10-16 | 2023-08-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
CN112300236A (zh) * | 2020-10-21 | 2021-02-02 | 佛山科学技术学院 | 核苷酸混合氨基磷酸酯化合物、其药物组合物及其应用 |
CN114588159A (zh) * | 2020-12-07 | 2022-06-07 | 成都傲科新技术有限责任公司 | 一种治疗猫冠状病毒感染的化合物及其应用 |
CN114634529A (zh) * | 2020-12-15 | 2022-06-17 | 中国科学院大连化学物理研究所 | 一种氟代瑞德西韦及其合成方法 |
CN116370479B (zh) * | 2020-12-30 | 2024-02-13 | 南方科技大学 | 化合物atv014在制备用于治疗新冠病毒感染的产品中的用途 |
WO2022166581A1 (zh) * | 2021-02-07 | 2022-08-11 | 石家庄迪斯凯威医药科技有限公司 | 一种核苷酸衍生物及其药物组合物和用途 |
WO2022218274A1 (zh) * | 2021-04-15 | 2022-10-20 | 中国科学院上海药物研究所 | 核苷类似物及其用途 |
EP4323362A1 (en) * | 2021-04-16 | 2024-02-21 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
PE20240654A1 (es) * | 2021-08-20 | 2024-04-04 | Shionogi & Co | Derivados de nucleosido y profarmacos de los mismos que tienen accion inhibidora del crecimiento viral |
WO2023167944A1 (en) | 2022-03-02 | 2023-09-07 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
WO2023168194A1 (en) * | 2022-03-03 | 2023-09-07 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
CN114573590B (zh) * | 2022-03-18 | 2023-11-14 | 苏州旺山旺水生物医药有限公司 | 一种四异丁酰基核苷类似物的制备方法及用途 |
CN116891474A (zh) * | 2022-03-31 | 2023-10-17 | 苏州旺山旺水生物医药有限公司 | 一种单异丁酰基核苷类似物的制备方法 |
CN115894498A (zh) * | 2022-10-01 | 2023-04-04 | 海化生命(厦门)科技有限公司 | 一种潜在抗病毒药物中间体bl及其合成方法 |
WO2024088183A1 (en) * | 2022-10-23 | 2024-05-02 | Shanghai Curegene Pharmaceutical Co., Ltd. | Anticoronviral compounds and compositions and uses thereof |
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US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
MXPA03006514A (es) | 2001-01-22 | 2004-12-02 | Merck & Co Inc | Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico. |
WO2005020884A2 (en) | 2003-05-14 | 2005-03-10 | Idenix (Cayman) Limited | Nucleosides for treatment of infection by corona viruses, toga viruses and picorna viruses |
PT2280973E (pt) * | 2008-04-23 | 2013-02-04 | Gilead Sciences Inc | Análogos de carba-nucleósido para tratamento antiviral |
WO2010002877A2 (en) * | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
SG186830A1 (en) * | 2010-07-22 | 2013-02-28 | Gilead Sciences Inc | Methods and compounds for treating paramyxoviridae virus infections |
PE20140608A1 (es) * | 2010-09-22 | 2014-06-12 | Alios Biopharma Inc | Analogos de nucleotidos sustituidos |
WO2012040124A1 (en) * | 2010-09-22 | 2012-03-29 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
SG10201804835VA (en) * | 2013-10-11 | 2018-07-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
UA119050C2 (uk) | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
WO2015143712A1 (en) | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
AU2015280234B2 (en) * | 2014-06-24 | 2021-04-01 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
HUE051986T2 (hu) * | 2014-06-24 | 2021-04-28 | Janssen Biopharma Inc | Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra |
TWI687432B (zh) * | 2014-10-29 | 2020-03-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
MA41213A (fr) * | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
LT3785717T (lt) * | 2015-09-16 | 2022-04-11 | Gilead Sciences, Inc. | Coronaviridae infekcijų gydymo būdai |
KR20200098483A (ko) * | 2017-09-18 | 2020-08-20 | 얀센 바이오파마, 인크. | 치환된 뉴클레오시드, 뉴클레오티드 및 이들의 유사체 |
-
2018
- 2018-09-18 KR KR1020207011130A patent/KR20200098483A/ko not_active Application Discontinuation
- 2018-09-18 MX MX2020002925A patent/MX2020002925A/es unknown
- 2018-09-18 MA MA050172A patent/MA50172A/fr unknown
- 2018-09-18 EA EA202090775A patent/EA202090775A1/ru unknown
- 2018-09-18 CA CA3075950A patent/CA3075950A1/en active Pending
- 2018-09-18 CN CN201880074579.2A patent/CN111542531A/zh active Pending
- 2018-09-18 US US16/648,405 patent/US11149049B2/en active Active
- 2018-09-18 JP JP2020537296A patent/JP2020534361A/ja active Pending
- 2018-09-18 BR BR112020005177-2A patent/BR112020005177A2/pt unknown
- 2018-09-18 SG SG11202002295QA patent/SG11202002295QA/en unknown
- 2018-09-18 CR CR20200126A patent/CR20200126A/es unknown
- 2018-09-18 AU AU2018332540A patent/AU2018332540B2/en active Active
- 2018-09-18 WO PCT/IB2018/057188 patent/WO2019053696A1/en unknown
- 2018-09-18 EP EP18783113.6A patent/EP3684782A1/en active Pending
-
2020
- 2020-03-16 CL CL2020000685A patent/CL2020000685A1/es unknown
- 2020-03-17 IL IL273341A patent/IL273341A/en unknown
- 2020-03-22 PH PH12020550114A patent/PH12020550114A1/en unknown
- 2020-04-15 EC ECSENADI202022130A patent/ECSP20022130A/es unknown
-
2021
- 2021-08-26 US US17/446,007 patent/US11773126B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2018332540B2 (en) | 2023-10-05 |
CR20200126A (es) | 2020-07-11 |
CN111542531A (zh) | 2020-08-14 |
BR112020005177A2 (pt) | 2020-09-15 |
US11773126B2 (en) | 2023-10-03 |
ECSP20022130A (es) | 2020-07-31 |
US20200277321A1 (en) | 2020-09-03 |
SG11202002295QA (en) | 2020-04-29 |
EP3684782A1 (en) | 2020-07-29 |
JP2020534361A (ja) | 2020-11-26 |
WO2019053696A1 (en) | 2019-03-21 |
AU2018332540A1 (en) | 2020-04-30 |
PH12020550114A1 (en) | 2020-12-07 |
MA50172A (fr) | 2021-04-07 |
CA3075950A1 (en) | 2019-03-21 |
CL2020000685A1 (es) | 2020-10-23 |
KR20200098483A (ko) | 2020-08-20 |
US11149049B2 (en) | 2021-10-19 |
IL273341A (en) | 2020-05-31 |
MX2020002925A (es) | 2020-10-05 |
US20210395288A1 (en) | 2021-12-23 |
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