AU2018332540B2 - Substituted nucleosides, nucleotides and analogs thereof - Google Patents

Substituted nucleosides, nucleotides and analogs thereof Download PDF

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Publication number
AU2018332540B2
AU2018332540B2 AU2018332540A AU2018332540A AU2018332540B2 AU 2018332540 B2 AU2018332540 B2 AU 2018332540B2 AU 2018332540 A AU2018332540 A AU 2018332540A AU 2018332540 A AU2018332540 A AU 2018332540A AU 2018332540 B2 AU2018332540 B2 AU 2018332540B2
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AU
Australia
Prior art keywords
optionally substituted
compound
acceptable salt
pharmaceutically acceptable
infection
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Ceased
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AU2018332540A
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English (en)
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AU2018332540A1 (en
Inventor
Leonid Beigelman
Jerome Deval
Marija Prhavc
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Janssen Biopharma Inc
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Janssen Biopharma Inc
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Publication of AU2018332540A1 publication Critical patent/AU2018332540A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2018332540A 2017-09-18 2018-09-18 Substituted nucleosides, nucleotides and analogs thereof Ceased AU2018332540B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762560110P 2017-09-18 2017-09-18
US62/560,110 2017-09-18
PCT/IB2018/057188 WO2019053696A1 (en) 2017-09-18 2018-09-18 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Publications (2)

Publication Number Publication Date
AU2018332540A1 AU2018332540A1 (en) 2020-04-30
AU2018332540B2 true AU2018332540B2 (en) 2023-10-05

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018332540A Ceased AU2018332540B2 (en) 2017-09-18 2018-09-18 Substituted nucleosides, nucleotides and analogs thereof

Country Status (17)

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US (2) US11149049B2 (https=)
EP (1) EP3684782A1 (https=)
JP (1) JP2020534361A (https=)
KR (1) KR102696517B1 (https=)
CN (1) CN111542531B (https=)
AU (1) AU2018332540B2 (https=)
CA (1) CA3075950A1 (https=)
CL (1) CL2020000685A1 (https=)
CR (1) CR20200126A (https=)
EA (1) EA202090775A1 (https=)
EC (1) ECSP20022130A (https=)
IL (1) IL273341A (https=)
MA (1) MA50172A (https=)
MX (1) MX2020002925A (https=)
PH (1) PH12020550114A1 (https=)
SG (1) SG11202002295QA (https=)
WO (1) WO2019053696A1 (https=)

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CN110776512A (zh) * 2019-11-28 2020-02-11 成都傲飞生物化学品有限责任公司 一种核苷类似物的制备方法
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KR20200098483A (ko) 2020-08-20
IL273341A (en) 2020-05-31
SG11202002295QA (en) 2020-04-29
EP3684782A1 (en) 2020-07-29
ECSP20022130A (es) 2020-07-31
US20210395288A1 (en) 2021-12-23
EA202090775A1 (ru) 2020-07-06
BR112020005177A2 (pt) 2020-09-15
CN111542531B (zh) 2024-07-19
MX2020002925A (es) 2020-10-05
CR20200126A (es) 2020-07-11
AU2018332540A1 (en) 2020-04-30
WO2019053696A1 (en) 2019-03-21
KR102696517B1 (ko) 2024-08-21
CA3075950A1 (en) 2019-03-21
CL2020000685A1 (es) 2020-10-23
US11149049B2 (en) 2021-10-19
US11773126B2 (en) 2023-10-03
US20200277321A1 (en) 2020-09-03
CN111542531A (zh) 2020-08-14
JP2020534361A (ja) 2020-11-26
PH12020550114A1 (en) 2020-12-07
MA50172A (fr) 2021-04-07

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