CL2019001077A1 - Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer. - Google Patents
Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer.Info
- Publication number
- CL2019001077A1 CL2019001077A1 CL2019001077A CL2019001077A CL2019001077A1 CL 2019001077 A1 CL2019001077 A1 CL 2019001077A1 CL 2019001077 A CL2019001077 A CL 2019001077A CL 2019001077 A CL2019001077 A CL 2019001077A CL 2019001077 A1 CL2019001077 A1 CL 2019001077A1
- Authority
- CL
- Chile
- Prior art keywords
- pyrazolo
- tetrahydro
- cancer
- treatment
- derivatives useful
- Prior art date
Links
- RMHAAZORBZSYHX-UHFFFAOYSA-N 6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline Chemical class C1=NNC=2C1=C1CCNCC1=CC=2 RMHAAZORBZSYHX-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662411799P | 2016-10-24 | 2016-10-24 | |
| US201662435159P | 2016-12-16 | 2016-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019001077A1 true CL2019001077A1 (es) | 2019-06-21 |
Family
ID=60083331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019001077A CL2019001077A1 (es) | 2016-10-24 | 2019-04-18 | Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f] isoquinolina útiles en el tratamiento del cáncer. |
Country Status (37)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10981911B2 (en) | 2016-12-16 | 2021-04-20 | Janssen Pharmaceutica Nv | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases |
| US11059823B2 (en) | 2016-12-16 | 2021-07-13 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US11066406B2 (en) | 2018-06-15 | 2021-07-20 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US12390451B2 (en) | 2021-03-11 | 2025-08-19 | Janssen Pharmaceutica Nv | Small molecule inhibitor of the JAK family of kinases |
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| US9969732B2 (en) * | 2016-04-08 | 2018-05-15 | Genentech, Inc. | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof |
| TW201803870A (zh) | 2016-04-20 | 2018-02-01 | 阿斯特捷利康公司 | 化學化合物 |
| US10149839B2 (en) | 2016-07-25 | 2018-12-11 | Astrazeneca Ab | Chemical compounds |
| PT3433256T (pt) | 2016-10-24 | 2019-10-31 | Astrazeneca | Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]isoquinolina úteis no tratamento do cancro |
| TWI831738B (zh) | 2016-12-16 | 2024-02-11 | 美商瑞塔醫藥有限責任公司 | 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物 |
| KR102246668B1 (ko) | 2017-01-30 | 2021-04-29 | 아스트라제네카 아베 | 에스트로겐 수용체 조절인자 |
| WO2019002442A1 (en) * | 2017-06-29 | 2019-01-03 | Astrazeneca Ab | CHEMICAL COMPOUNDS |
| WO2019002441A1 (en) * | 2017-06-29 | 2019-01-03 | Astrazeneca Ab | CHEMICAL COMPOUNDS |
| CA3082276C (en) * | 2017-11-14 | 2022-08-16 | Anlin Pharmaceuticals, Llc | Heterocyclic compounds and their application in medicine |
| BR112020025605A2 (pt) | 2018-06-15 | 2021-03-23 | Reata Pharmaceuticals, Inc. | compostos de pirazol e imidazol para inibição de il-17 e rorgama |
| EP3810141A1 (en) | 2018-06-20 | 2021-04-28 | Reata Pharmaceuticals, Inc. | Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith |
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| CN109053524A (zh) * | 2018-09-11 | 2018-12-21 | 山东谛爱生物技术有限公司 | 一种N-Boc-3-羟基氮杂环丁烷的制备方法 |
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| CN114105977B (zh) * | 2020-08-28 | 2023-09-01 | 先声再明医药有限公司 | 雌激素受体调节剂化合物及其用途 |
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| US20240180893A1 (en) | 2022-11-17 | 2024-06-06 | Astrazeneca Ab | Methods of treatment of breast cancer |
| CN121079090A (zh) | 2023-05-11 | 2025-12-05 | 阿斯利康(瑞典)有限公司 | 用于治疗癌症的parp1抑制剂和选择性雌激素降解剂的组合 |
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2017
- 2017-10-13 PT PT177838570T patent/PT3433256T/pt unknown
- 2017-10-13 SI SI201731087T patent/SI3640251T1/sl unknown
- 2017-10-13 RS RSP20191371 patent/RS59445B1/sr unknown
- 2017-10-13 CR CR20190204A patent/CR20190204A/es unknown
- 2017-10-13 ES ES17783857T patent/ES2751902T3/es active Active
- 2017-10-13 MX MX2019004685A patent/MX382331B/es unknown
- 2017-10-13 ME MEP-2019-306A patent/ME03547B/me unknown
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- 2017-10-13 PE PE2019000845A patent/PE20191078A1/es unknown
- 2017-10-13 EP EP17783857.0A patent/EP3433256B1/en active Active
- 2017-10-13 PL PL19189010T patent/PL3640251T3/pl unknown
- 2017-10-13 PT PT191890102T patent/PT3640251T/pt unknown
- 2017-10-13 TW TW106135012A patent/TWI735681B/zh active
- 2017-10-13 WO PCT/EP2017/076191 patent/WO2018077630A1/en not_active Ceased
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- 2017-10-13 ES ES19189010T patent/ES2907759T3/es active Active
- 2017-10-13 CN CN201780064567.7A patent/CN109843888B/zh active Active
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- 2017-10-13 AU AU2017349797A patent/AU2017349797B2/en active Active
- 2017-10-13 CA CA3040040A patent/CA3040040A1/en active Pending
- 2017-10-13 CN CN202210381693.8A patent/CN114656464B/zh active Active
- 2017-10-13 JO JOP/2019/0090A patent/JOP20190090B1/ar active
- 2017-10-13 US US15/782,904 patent/US10131663B2/en active Active
- 2017-10-13 JP JP2019520525A patent/JP6744489B2/ja active Active
- 2017-10-13 DK DK17783857T patent/DK3433256T3/da active
- 2017-10-13 SM SM20190602T patent/SMT201900602T1/it unknown
- 2017-10-13 SI SI201730111T patent/SI3433256T1/sl unknown
- 2017-10-13 LT LTEP19189010.2T patent/LT3640251T/lt unknown
- 2017-10-13 KR KR1020197014062A patent/KR102178692B1/ko active Active
- 2017-10-13 PL PL17783857T patent/PL3433256T3/pl unknown
- 2017-10-13 HU HUE17783857A patent/HUE045714T2/hu unknown
- 2017-10-13 DK DK19189010.2T patent/DK3640251T3/da active
- 2017-10-13 SM SM20220098T patent/SMT202200098T1/it unknown
- 2017-10-13 HR HRP20220255TT patent/HRP20220255T1/hr unknown
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2018
- 2018-10-09 US US16/155,041 patent/US10590130B2/en active Active
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2019
- 2019-02-01 ZA ZA2019/00694A patent/ZA201900694B/en unknown
- 2019-04-16 PH PH12019500830A patent/PH12019500830A1/en unknown
- 2019-04-18 CL CL2019001077A patent/CL2019001077A1/es unknown
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2020
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10981911B2 (en) | 2016-12-16 | 2021-04-20 | Janssen Pharmaceutica Nv | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases |
| US11059823B2 (en) | 2016-12-16 | 2021-07-13 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US11827638B2 (en) | 2016-12-16 | 2023-11-28 | Janssen Pharmaceutica Nv | Imidazopyrrolopyridine as inhibitors of the JAK family of kinases |
| US12202831B2 (en) | 2016-12-16 | 2025-01-21 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US11066406B2 (en) | 2018-06-15 | 2021-07-20 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US11787807B2 (en) | 2018-06-15 | 2023-10-17 | Janssen Pharmaceutica Nv | Small molecule inhibitors of the JAK family of kinases |
| US12390451B2 (en) | 2021-03-11 | 2025-08-19 | Janssen Pharmaceutica Nv | Small molecule inhibitor of the JAK family of kinases |
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