TWI735681B - 化合物 - Google Patents

化合物 Download PDF

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Publication number
TWI735681B
TWI735681B TW106135012A TW106135012A TWI735681B TW I735681 B TWI735681 B TW I735681B TW 106135012 A TW106135012 A TW 106135012A TW 106135012 A TW106135012 A TW 106135012A TW I735681 B TWI735681 B TW I735681B
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TW
Taiwan
Prior art keywords
compound
formula
methyl
pharmaceutically acceptable
tetrahydro
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TW106135012A
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English (en)
Chinese (zh)
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TW201829403A (zh
Inventor
詹姆士 史都華 史考特
湯瑪士 安德魯 摩斯
莎曼沙 潔恩 休斯
伯納德 克里斯多夫 巴蘭
喬翰思 威爾漢默斯 瑪利亞 尼斯克
丹尼爾 希爾布萊登 歐登諾凡
楊斌
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瑞典商阿斯特捷利康公司
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW106135012A 2016-10-24 2017-10-13 化合物 TWI735681B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662411799P 2016-10-24 2016-10-24
US62/411,799 2016-10-24
US201662435159P 2016-12-16 2016-12-16
US62/435,159 2016-12-16

Publications (2)

Publication Number Publication Date
TW201829403A TW201829403A (zh) 2018-08-16
TWI735681B true TWI735681B (zh) 2021-08-11

Family

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TW106135012A TWI735681B (zh) 2016-10-24 2017-10-13 化合物

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US (5) US10131663B2 (enExample)
EP (2) EP3640251B1 (enExample)
JP (2) JP6744489B2 (enExample)
KR (1) KR102178692B1 (enExample)
CN (2) CN109843888B (enExample)
AU (1) AU2017349797B2 (enExample)
CA (1) CA3040040A1 (enExample)
CL (1) CL2019001077A1 (enExample)
CO (1) CO2019003950A2 (enExample)
CR (1) CR20190204A (enExample)
CY (2) CY1122566T1 (enExample)
DK (2) DK3640251T3 (enExample)
DO (1) DOP2019000104A (enExample)
EC (1) ECSP19028657A (enExample)
ES (2) ES2907759T3 (enExample)
HR (1) HRP20220255T1 (enExample)
HU (2) HUE057524T2 (enExample)
IL (1) IL266245B (enExample)
JO (1) JOP20190090B1 (enExample)
LT (2) LT3640251T (enExample)
ME (1) ME03547B (enExample)
MX (1) MX382331B (enExample)
MY (1) MY205300A (enExample)
NI (1) NI201900039A (enExample)
NZ (1) NZ753459A (enExample)
PE (1) PE20191078A1 (enExample)
PH (1) PH12019500830A1 (enExample)
PL (2) PL3433256T3 (enExample)
PT (2) PT3433256T (enExample)
RS (1) RS59445B1 (enExample)
SG (1) SG11201903182XA (enExample)
SI (2) SI3433256T1 (enExample)
SM (2) SMT201900602T1 (enExample)
TW (1) TWI735681B (enExample)
UA (1) UA125824C2 (enExample)
WO (1) WO2018077630A1 (enExample)
ZA (1) ZA201900694B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122023020677A2 (pt) 2015-10-01 2023-12-12 Olema Pharmaceuticals, Inc. Compostos de tetra-hidro-1h-pirido[3,4-b]indol, composições compreendendo os referidos compostos e usos dos mesmos
EP3440067B1 (en) * 2016-04-08 2021-05-26 F. Hoffmann-La Roche AG Tetrahydroisoquinoline estrogen receptor modulators and uses thereof
US10125135B2 (en) 2016-04-20 2018-11-13 Astrazeneca Ab Chemical compounds
WO2018019793A1 (en) 2016-07-25 2018-02-01 Astrazeneca Ab N-(2-(4-((1r,3r)-3-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)phenoxy)ethyl)propan-1-amine derivatives and related compounds as selective down-regulators of the estrogen receptor for treating cancer
WO2018077630A1 (en) 2016-10-24 2018-05-03 Astrazeneca Ab 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
LT3555097T (lt) 2016-12-16 2022-08-25 Janssen Pharmaceutica Nv Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai
ES2766249T3 (es) 2017-01-30 2020-06-12 Astrazeneca Ab Moduladores del receptor de estrógeno
WO2019002442A1 (en) * 2017-06-29 2019-01-03 Astrazeneca Ab CHEMICAL COMPOUNDS
WO2019002441A1 (en) * 2017-06-29 2019-01-03 Astrazeneca Ab CHEMICAL COMPOUNDS
ES2912740T3 (es) * 2017-11-14 2022-05-27 Kind Pharmaceutical Compuesto heterocíclico y aplicación del mismo en medicina
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Jak激酶家族之小分子抑制劑
CN119552120A (zh) 2018-06-15 2025-03-04 里亚塔医药公司 用于抑制IL-17和RORγ的吡唑和咪唑化合物
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
AU2019321588A1 (en) 2018-08-17 2021-03-04 Genentech, Inc. Diagnostic and therapeutic methods for the treatment of breast cancer
CN109053524A (zh) * 2018-09-11 2018-12-21 山东谛爱生物技术有限公司 一种N-Boc-3-羟基氮杂环丁烷的制备方法
EP3993785A4 (en) 2019-07-07 2023-08-02 Olema Pharmaceuticals, Inc. ESTROGEN RECEPTOR ANTAGONIST SCHEMES
JP2023508327A (ja) * 2019-12-20 2023-03-02 リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー 組み合わせ
BR112022013322A2 (pt) 2020-01-10 2022-09-20 Jiangsu Hengrui Medicine Co Derivado de tetra-hidroisoquinolina tricíclico, método de preparação para o mesmo e aplicação do mesmo em medicina
EP4138834A1 (en) 2020-04-24 2023-03-01 Astrazeneca AB Dosage regimen for the treatment of cancer
AU2021260109B2 (en) 2020-04-24 2024-07-11 Astrazeneca Ab Pharmaceutical formulations
CN115836068B (zh) * 2020-05-15 2025-06-03 南京再明医药有限公司 吡咯烷类化合物及其应用
TW202214626A (zh) * 2020-06-12 2022-04-16 大陸商江蘇先聲藥業有限公司 雌激素受體調節劑化合物及其用途
CN115916769B (zh) * 2020-06-28 2024-09-10 深圳扬厉医药技术有限公司 并环吲唑类化合物
CN114105977B (zh) * 2020-08-28 2023-09-01 先声再明医药有限公司 雌激素受体调节剂化合物及其用途
KR20220107752A (ko) 2021-01-26 2022-08-02 충북대학교 산학협력단 피라졸로퀴놀린 유도체 및 이의 항암제로서의 용도
CN116669729A (zh) * 2021-02-08 2023-08-29 贝达药业股份有限公司 杂芳基并哌啶类衍生物及其药物组合物和应用
US12390451B2 (en) 2021-03-11 2025-08-19 Janssen Pharmaceutica Nv Small molecule inhibitor of the JAK family of kinases
JP2024546191A (ja) * 2021-12-28 2024-12-17 深▲セン▼揚歴医薬技術有限公司 テトラヒドロシクロヘプタインダゾール化合物の塩形、結晶
JP2025535154A (ja) 2022-10-17 2025-10-22 アストラゼネカ・アクチエボラーグ 癌を治療するためのserdの併用
EP4615431A1 (en) 2022-11-11 2025-09-17 Astrazeneca AB Combination therapies for the treatment of cancer
US20240180893A1 (en) 2022-11-17 2024-06-06 Astrazeneca Ab Methods of treatment of breast cancer
TW202508573A (zh) 2023-05-11 2025-03-01 瑞典商阿斯特捷利康公司 用於治療癌症之組合療法
WO2025175249A1 (en) * 2024-02-14 2025-08-21 Olema Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016097072A1 (en) * 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
SK1882003A3 (en) 2000-08-10 2003-06-03 Pharmacia Italia Spa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
WO2006101434A1 (en) 2005-03-22 2006-09-28 Astrazeneca Ab NOVEL TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLE DERIVATIVES AS CB1’ RECEPTOR LIGANDS
FR2884252B1 (fr) 2005-04-08 2007-05-18 Aventis Pharma Sa Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90
AR058223A1 (es) 2005-11-25 2008-01-23 Palau Pharma Sa Un comuesto de derivados de pirazoloisoquinolina, un procedimiento para l a preparacion de dicho compuesto y una composicion farmaceutica que comprende dicho compuesto
JP2010505961A (ja) 2006-10-09 2010-02-25 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
US20120157401A1 (en) 2009-05-27 2012-06-21 Ptc Therapeutics, Inc. Methods for treating neurofibromatosis
MX373926B (es) 2009-05-27 2020-07-10 Ptc Therapeutics Inc Metodos para tratar cancer y estados no neoplasicos.
WO2010138659A1 (en) 2009-05-27 2010-12-02 Ptc Therapeutics, Inc. Methods for treating brain tumors
PH12012502419A1 (en) 2010-06-10 2022-03-21 Seragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
US8853423B2 (en) 2010-06-17 2014-10-07 Seragon Pharmaceuticals, Inc. Indane estrogen receptor modulators and uses thereof
US9540361B2 (en) * 2010-12-24 2017-01-10 Merck Sharp & Dohme B.V. N-substituted azetidine derivatives
JP2015500346A (ja) 2011-12-14 2015-01-05 セラゴン ファーマシューティカルズ,インク. エストロゲン受容体モジュレーターおよびその使用
TWI653235B (zh) 2013-05-28 2019-03-11 阿斯特捷利康公司 作為抗癌劑之吲哚衍生物
BR112015031903A8 (pt) 2013-06-19 2019-12-31 Seragon Pharmaceuticals Inc composto, sal farmaceuticamente aceitável, composição farmacêutica e uso de um composto
WO2014205136A1 (en) 2013-06-19 2014-12-24 Seragon Pharmaceuticals, Inc. Azetidine estrogen receptor modulators and uses thereof
WO2015092634A1 (en) 2013-12-16 2015-06-25 Novartis Ag 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders
JP6807841B2 (ja) 2014-12-18 2021-01-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト エストロゲン受容体モジュレーター及びその使用
CN107406433A (zh) 2014-12-18 2017-11-28 豪夫迈·罗氏有限公司 用于治疗癌症的2,3‑二苯基色烯的衍生物
WO2016174551A1 (en) 2015-04-27 2016-11-03 Pfizer Inc. Anti-estrogenic compounds
US10053451B2 (en) 2015-05-26 2018-08-21 Genentech, Inc. Heterocyclic estrogen receptor modulators and uses thereof
EP3312184A4 (en) * 2015-06-16 2019-02-27 Jiangsu Hengrui Medicine Co., Ltd. PIPERIDINE DERIVATIVE AND ITS PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
CN106518768B (zh) 2015-09-15 2021-07-02 江苏恒瑞医药股份有限公司 丙烯酸类衍生物、其制备方法及其在医药上的应用
BR122023020677A2 (pt) 2015-10-01 2023-12-12 Olema Pharmaceuticals, Inc. Compostos de tetra-hidro-1h-pirido[3,4-b]indol, composições compreendendo os referidos compostos e usos dos mesmos
JP6920295B2 (ja) 2015-11-09 2021-08-18 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト テトラヒドロナフタレンエストロゲン受容体モジュレーター及びその使用
WO2017080338A1 (zh) 2015-11-12 2017-05-18 浙江海正药业股份有限公司 丙烯酸类衍生物、其制备方法及其在医药上的用途
JP2019503346A (ja) 2015-12-22 2019-02-07 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. ベンゾピペリジン誘導体、その製造方法及びその医薬用途
EP3440067B1 (en) * 2016-04-08 2021-05-26 F. Hoffmann-La Roche AG Tetrahydroisoquinoline estrogen receptor modulators and uses thereof
US10125135B2 (en) * 2016-04-20 2018-11-13 Astrazeneca Ab Chemical compounds
WO2017182495A1 (en) * 2016-04-20 2017-10-26 Astrazeneca Ab Indazole derivatives that down-regulate the estrogen receptor and possess anti-cancer activity
CN109415388A (zh) 2016-05-06 2019-03-01 路易斯安那泽维尔大学 选择性雌激素受体下调剂(serds)
WO2018001232A1 (zh) 2016-06-29 2018-01-04 浙江海正药业股份有限公司 丙烯酸类衍生物及其制备方法和其在医药上的用途
WO2018019793A1 (en) 2016-07-25 2018-02-01 Astrazeneca Ab N-(2-(4-((1r,3r)-3-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indol-1-yl)phenoxy)ethyl)propan-1-amine derivatives and related compounds as selective down-regulators of the estrogen receptor for treating cancer
CN107814798B (zh) 2016-09-14 2020-11-03 四川科伦博泰生物医药股份有限公司 3-取代丙烯酸类化合物及其制备方法和用途
ES2975558T3 (es) 2016-09-15 2024-07-09 Arvinas Inc Derivados de indol como degradantes de receptor de estrógeno
WO2018077630A1 (en) * 2016-10-24 2018-05-03 Astrazeneca Ab 6,7,8,9-tetrahydro-3h-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer
BR102016024814A2 (pt) 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono
PL3555064T3 (pl) 2016-12-16 2023-03-06 Pfizer Inc. Agoności receptora GLP-1 i ich zastosowania
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制RORγ及其他用途的嘧啶三環烯酮衍生物
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
LT3555097T (lt) 2016-12-16 2022-08-25 Janssen Pharmaceutica Nv Imidazo[4,5-d]pirolo[2,3-b]piridino junginiai kaip janus kinazės inhibitoriai
MA53881A (fr) 2016-12-16 2022-04-27 Lilly Co Eli Dérivés de pyrido[4,3-d][1,3]oxazin-2-one en tant qu'inhibiteurs de la forme mutée des protéines idh1 et idh2
CN110291072A (zh) 2016-12-16 2019-09-27 巴斯夫欧洲公司 农药化合物
EA039783B1 (ru) 2017-01-30 2022-03-14 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. ПРОИЗВОДНЫЕ ТИРОЗИНАМИДА В КАЧЕСТВЕ ИНГИБИТОРОВ Rho-КИНАЗЫ

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016097072A1 (en) * 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

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RS59445B1 (sr) 2019-11-29
SI3640251T1 (sl) 2022-04-29
CN114656464A (zh) 2022-06-24
CN114656464B (zh) 2024-10-15
MX382331B (es) 2025-03-13
LT3640251T (lt) 2022-03-10
ES2751902T3 (es) 2020-04-02
JP6993477B2 (ja) 2022-01-13
DK3640251T3 (da) 2022-03-07
US10590130B2 (en) 2020-03-17
US10961241B2 (en) 2021-03-30
LT3433256T (lt) 2019-11-11
KR20190066054A (ko) 2019-06-12
CA3040040A1 (en) 2018-05-03
IL266245B (en) 2021-05-31
CR20190204A (es) 2019-06-11
CY1122566T1 (el) 2021-01-27
NZ753459A (en) 2023-01-27
DK3433256T3 (da) 2019-10-28
PH12019500830A1 (en) 2019-07-24
DOP2019000104A (es) 2019-05-15
CN109843888A (zh) 2019-06-04
EP3433256B1 (en) 2019-08-07
ECSP19028657A (es) 2019-04-30
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