CL2018000463A1 - Compuestos deuterados y usos de los mismos - Google Patents
Compuestos deuterados y usos de los mismosInfo
- Publication number
- CL2018000463A1 CL2018000463A1 CL2018000463A CL2018000463A CL2018000463A1 CL 2018000463 A1 CL2018000463 A1 CL 2018000463A1 CL 2018000463 A CL2018000463 A CL 2018000463A CL 2018000463 A CL2018000463 A CL 2018000463A CL 2018000463 A1 CL2018000463 A1 CL 2018000463A1
- Authority
- CL
- Chile
- Prior art keywords
- deuterated compounds
- hne
- mda
- pathogenesis
- implicated
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención proporciona el tratamiento, prevención y/o reducción del riesgo de una enfermedad, trastorno o condición en la que la toxicidad por aldehído está implicada en la patogénesis, incluidos trastornos oculares, trastornos de la piel, condiciones asociadas con efectos perjudiciales de los agentes ampollantes, y enfermedades autoinmunes, inflamatorias, neurológicas y cardiovasculares mediante el uso de una amina primaria para secuestrar aldehídos tóxicos, tales como MDA y HNE
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562208223P | 2015-08-21 | 2015-08-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2018000463A1 true CL2018000463A1 (es) | 2018-08-17 |
Family
ID=58100876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018000463A CL2018000463A1 (es) | 2015-08-21 | 2018-02-21 | Compuestos deuterados y usos de los mismos |
Country Status (15)
Country | Link |
---|---|
US (5) | US10550085B2 (es) |
EP (1) | EP3337486B1 (es) |
JP (2) | JP6947406B2 (es) |
KR (1) | KR102664994B1 (es) |
CN (1) | CN108135907A (es) |
AU (1) | AU2016311158A1 (es) |
BR (1) | BR112018003250A2 (es) |
CA (1) | CA2996183A1 (es) |
CL (1) | CL2018000463A1 (es) |
CO (1) | CO2018002822A2 (es) |
HK (1) | HK1256980A1 (es) |
IL (1) | IL257611A (es) |
MX (1) | MX2018002155A (es) |
WO (1) | WO2017035077A1 (es) |
ZA (1) | ZA201801678B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2325171B1 (en) | 2005-05-26 | 2013-10-09 | Aldexa Therapeutics, Inc. | Quinoline derivatives for treating retinal diseases |
KR102435676B1 (ko) | 2013-01-23 | 2022-08-24 | 알데이라 테라퓨틱스, 아이엔씨. | 독성 알데히드 관련된 질병 및 치료 |
WO2017035077A1 (en) | 2015-08-21 | 2017-03-02 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
CN109069530A (zh) | 2016-02-28 | 2018-12-21 | 奥尔德拉医疗公司 | 用环糊精治疗过敏性眼部病状 |
CA3022665A1 (en) | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
WO2018039197A1 (en) * | 2016-08-22 | 2018-03-01 | Aldeyra Therapeutics, Inc. | Aldehyde trapping compounds and methods of use thereof |
EP3500256A4 (en) * | 2016-08-22 | 2020-01-08 | Aldeyra Therapeutics, Inc. | ALDEHYDE CAPTURE CONNECTIONS AND USES THEREOF |
CA3054811A1 (en) | 2017-03-16 | 2018-09-20 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
CN111356451A (zh) | 2017-10-10 | 2020-06-30 | 奥尔德拉医疗公司 | 炎性病症的治疗 |
US20200038392A1 (en) | 2018-08-03 | 2020-02-06 | Aldeyra Therapeutics, Inc. | Topical compositions and methods of preparation and use |
WO2020033344A1 (en) | 2018-08-06 | 2020-02-13 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
US11197821B2 (en) | 2018-09-25 | 2021-12-14 | Aldeyra Therapeutics, Inc. | Formulations for treatment of dry eye disease |
US20220133697A1 (en) * | 2018-12-05 | 2022-05-05 | Aldeyra Therapeutics, Inc. | Injectable formulations |
EP3901138A4 (en) * | 2018-12-18 | 2022-10-05 | Medshine Discovery Inc. | COMPOUND FOR USE IN RETINAR DISEASES |
JP2022526917A (ja) | 2019-03-26 | 2022-05-27 | アルデイラ セラピューティクス, インコーポレイテッド | 眼科用製剤およびその使用 |
US20230021669A1 (en) * | 2019-12-30 | 2023-01-26 | The National Institutes of Pharmaceutical R&D Co., Ltd. | Tricyclic compound, and preparation method therefor and medical use thereof |
WO2022267930A1 (zh) * | 2021-06-25 | 2022-12-29 | 中国医药研究开发中心有限公司 | 三环化合物及其制备方法和医药用途 |
WO2024109905A1 (zh) * | 2022-11-26 | 2024-05-30 | 珠海联邦制药股份有限公司 | 一种含有吡啶苯基类化合物的眼用制剂及其制备方法和应用 |
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JP2017527614A (ja) * | 2014-09-02 | 2017-09-21 | ブピンダー シン | 重水素化又は非重水素化分子及び医薬製剤 |
US10363231B2 (en) | 2014-11-24 | 2019-07-30 | Case Western Reserve University | Compounds and methods of treating ocular disorders |
WO2017035077A1 (en) | 2015-08-21 | 2017-03-02 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
KR20180073553A (ko) * | 2015-08-21 | 2018-07-02 | 알데이라 테라퓨틱스, 아이엔씨. | 알데히드 접합체 및 이의 용도 |
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EP3500256A4 (en) | 2016-08-22 | 2020-01-08 | Aldeyra Therapeutics, Inc. | ALDEHYDE CAPTURE CONNECTIONS AND USES THEREOF |
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CN111356451A (zh) | 2017-10-10 | 2020-06-30 | 奥尔德拉医疗公司 | 炎性病症的治疗 |
WO2020018498A1 (en) | 2018-07-16 | 2020-01-23 | Aldeyra Therapeutics, Inc. | Cyclodextrin formulations |
US20200038392A1 (en) | 2018-08-03 | 2020-02-06 | Aldeyra Therapeutics, Inc. | Topical compositions and methods of preparation and use |
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US11197821B2 (en) | 2018-09-25 | 2021-12-14 | Aldeyra Therapeutics, Inc. | Formulations for treatment of dry eye disease |
WO2020072621A1 (en) | 2018-10-02 | 2020-04-09 | Aldeyra Therapeutics, Inc. | Contact lens solutions and kits |
JP2022526917A (ja) | 2019-03-26 | 2022-05-27 | アルデイラ セラピューティクス, インコーポレイテッド | 眼科用製剤およびその使用 |
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US20220089542A1 (en) | 2019-05-02 | 2022-03-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
-
2016
- 2016-08-22 WO PCT/US2016/048054 patent/WO2017035077A1/en active Application Filing
- 2016-08-22 MX MX2018002155A patent/MX2018002155A/es unknown
- 2016-08-22 CN CN201680059219.6A patent/CN108135907A/zh active Pending
- 2016-08-22 KR KR1020187008122A patent/KR102664994B1/ko active IP Right Grant
- 2016-08-22 AU AU2016311158A patent/AU2016311158A1/en not_active Abandoned
- 2016-08-22 BR BR112018003250A patent/BR112018003250A2/pt not_active Application Discontinuation
- 2016-08-22 EP EP16839942.6A patent/EP3337486B1/en active Active
- 2016-08-22 CA CA2996183A patent/CA2996183A1/en not_active Abandoned
- 2016-08-22 JP JP2018509769A patent/JP6947406B2/ja active Active
- 2016-08-22 US US15/754,065 patent/US10550085B2/en active Active
-
2018
- 2018-02-19 IL IL257611A patent/IL257611A/en unknown
- 2018-02-21 CL CL2018000463A patent/CL2018000463A1/es unknown
- 2018-03-12 ZA ZA2018/01678A patent/ZA201801678B/en unknown
- 2018-03-16 CO CONC2018/0002822A patent/CO2018002822A2/es unknown
- 2018-12-12 HK HK18115949.0A patent/HK1256980A1/zh unknown
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2019
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2021
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- 2021-07-29 JP JP2021124487A patent/JP2021167358A/ja not_active Withdrawn
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2022
- 2022-09-02 US US17/929,505 patent/US11845722B2/en active Active
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2023
- 2023-11-08 US US18/504,672 patent/US20240132451A1/en active Pending
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WO2017035077A1 (en) | 2017-03-02 |
US10550085B2 (en) | 2020-02-04 |
EP3337486B1 (en) | 2024-04-03 |
US20240132451A1 (en) | 2024-04-25 |
IL257611A (en) | 2018-04-30 |
JP6947406B2 (ja) | 2021-10-13 |
EP3337486A4 (en) | 2019-03-06 |
EP3337486A1 (en) | 2018-06-27 |
CO2018002822A2 (es) | 2018-05-31 |
US11046650B2 (en) | 2021-06-29 |
MX2018002155A (es) | 2018-06-08 |
CA2996183A1 (en) | 2017-03-02 |
KR102664994B1 (ko) | 2024-05-13 |
US20200199075A1 (en) | 2020-06-25 |
KR20180073554A (ko) | 2018-07-02 |
BR112018003250A2 (pt) | 2018-09-25 |
US20180354905A1 (en) | 2018-12-13 |
HK1256980A1 (zh) | 2019-10-11 |
JP2021167358A (ja) | 2021-10-21 |
US20230174491A1 (en) | 2023-06-08 |
CN108135907A (zh) | 2018-06-08 |
US20210347735A1 (en) | 2021-11-11 |
US11459300B2 (en) | 2022-10-04 |
AU2016311158A1 (en) | 2018-04-05 |
ZA201801678B (en) | 2019-01-30 |
US11845722B2 (en) | 2023-12-19 |
JP2018523700A (ja) | 2018-08-23 |
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