SV2017005434A - 2-amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de bace1 para el tratamiento de la enfermedad de alzheimer - Google Patents

2-amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de bace1 para el tratamiento de la enfermedad de alzheimer

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Publication number
SV2017005434A
SV2017005434A SV2017005434A SV2017005434A SV2017005434A SV 2017005434 A SV2017005434 A SV 2017005434A SV 2017005434 A SV2017005434 A SV 2017005434A SV 2017005434 A SV2017005434 A SV 2017005434A SV 2017005434 A SV2017005434 A SV 2017005434A
Authority
SV
El Salvador
Prior art keywords
alzheimer
disease
tetrahydropiridins
difluoro
phenyl
Prior art date
Application number
SV2017005434A
Other languages
English (en)
Inventor
Karsten Juhl
Lena Tagmose
Mauro Marigo
Original Assignee
H Lundbeck As
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Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of SV2017005434A publication Critical patent/SV2017005434A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA PRESENTE INVENCIÓN SE DIRIGE A COMPUESTOS DE ACUERDO CON LA FÓRMULA I: (VER FORMULA); COMPUESTOS QUE SON INHIBIDORES DE LA ENZIMA BACE1. ASPECTOS SEPARADOS DE LA INVENCIÓN SE DIRIGEN A COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN DICHOS COMPUESTOS Y A USOS DE LOS COMPUESTOS PARA TRATAR TRASTORNOS PARA LOS CUALES LA REDUCCIÓN DE DEPÓSITOS DE ABETA ES BENEFICIOSA TAL COMO LA ENFERMEDAD DE ALZHEIMER
SV2017005434A 2014-11-10 2017-05-09 2-amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de bace1 para el tratamiento de la enfermedad de alzheimer SV2017005434A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201400649 2014-11-10
DKPA201500450 2015-08-07

Publications (1)

Publication Number Publication Date
SV2017005434A true SV2017005434A (es) 2017-07-19

Family

ID=54476983

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2017005434A SV2017005434A (es) 2014-11-10 2017-05-09 2-amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de bace1 para el tratamiento de la enfermedad de alzheimer

Country Status (26)

Country Link
US (1) US10059669B2 (es)
EP (1) EP3218362B1 (es)
JP (1) JP2017533253A (es)
KR (1) KR20170082529A (es)
CN (1) CN107074809A (es)
AU (1) AU2015345257A1 (es)
BR (1) BR112017009647A2 (es)
CA (1) CA2964305A1 (es)
CL (1) CL2017001113A1 (es)
CO (1) CO2017004530A2 (es)
CR (1) CR20170187A (es)
DO (1) DOP2017000118A (es)
EA (1) EA201790817A1 (es)
EC (1) ECSP17028463A (es)
ES (1) ES2710602T3 (es)
IL (1) IL252091A0 (es)
MX (1) MX2017006048A (es)
NI (1) NI201700056A (es)
PE (1) PE20170947A1 (es)
PH (1) PH12017500829A1 (es)
RU (1) RU2017116197A (es)
SG (1) SG11201703177WA (es)
SV (1) SV2017005434A (es)
TN (1) TN2017000134A1 (es)
WO (1) WO2016075062A1 (es)
ZA (1) ZA201702799B (es)

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JO3458B1 (ar) 2014-11-10 2020-07-05 H Lundbeck As 2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1
MA40941A (fr) 2014-11-10 2017-09-19 H Lundbeck As 2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1
CR20170187A (es) 2014-11-10 2018-02-01 H Lundbeck As 2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TW201717948A (zh) 2015-08-10 2017-06-01 Ｈ 朗德貝克公司 包括給予２－胺基－３，５，５－三氟－３，４，５，６－四氫吡啶的聯合治療
TW201718543A (zh) 2015-08-12 2017-06-01 Ｈ 朗德貝克公司 作爲ｂａｃｅ１抑制劑之２－胺基－３－氟－３－（氟甲基）－６－甲基－６－苯基－３，４，５，６－四氫吡啶
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
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SI3532064T1 (sl) 2016-10-28 2020-10-30 H. Lundbeck A/S Kombinirana zdravljenja, ki obsegajo imidazopirazinone za zdravljenje psihiatričnih in/ali kognitivnih motenj
JP2020500841A (ja) 2016-10-28 2020-01-16 ハー・ルンドベック・アクチエゼルスカベット イミダゾピラジノンの投与を含む併用療法
WO2018114910A1 (en) * 2016-12-21 2018-06-28 H. Lundbeck A/S 6-amino-5-fluoro-5-(fluoromethyl)-2,3,4,5-tetrahydropyridin-2-yl-phenyl-5-(methoxy-d3)-pyrazine-2-carboxamides and fluorinated derivatives thereof as bace1 inhibitors
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
US11634416B2 (en) 2017-12-14 2023-04-25 H. Lundbeck A/S Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines
CN117447475A (zh) 2017-12-20 2024-01-26 H.隆德贝克有限公司 作为PDE1抑制剂的吡唑并[4,3-b]吡啶和咪唑并[1,5-a]嘧啶
CN109970681A (zh) * 2019-04-19 2019-07-05 安徽海康药业有限责任公司 一种瑞格列奈的合成方法
CN113720930A (zh) * 2021-07-26 2021-11-30 南京一诺医药科技有限公司 一种hplc-ms/ms联用检测人血浆中奥美拉唑的方法
CN114235985A (zh) * 2021-11-25 2022-03-25 南京海纳医药科技股份有限公司 一种hplc-ms/ms联用检测人血浆中胍法辛的方法

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MA40941A (fr) 2014-11-10 2017-09-19 H Lundbeck As 2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1
JO3458B1 (ar) 2014-11-10 2020-07-05 H Lundbeck As 2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1
CR20170187A (es) 2014-11-10 2018-02-01 H Lundbeck As 2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer
TW201717948A (zh) 2015-08-10 2017-06-01 Ｈ 朗德貝克公司 包括給予２－胺基－３，５，５－三氟－３，４，５，６－四氫吡啶的聯合治療
TW201718543A (zh) 2015-08-12 2017-06-01 Ｈ 朗德貝克公司 作爲ｂａｃｅ１抑制劑之２－胺基－３－氟－３－（氟甲基）－６－甲基－６－苯基－３，４，５，６－四氫吡啶

Also Published As

Publication number Publication date
AU2015345257A1 (en) 2017-05-04
EP3218362B1 (en) 2019-01-09
PE20170947A1 (es) 2017-07-13
US20170313658A1 (en) 2017-11-02
IL252091A0 (en) 2017-07-31
CA2964305A1 (en) 2016-05-19
ECSP17028463A (es) 2017-08-31
EP3218362A1 (en) 2017-09-20
ES2710602T3 (es) 2019-04-26
TN2017000134A1 (en) 2018-10-19
KR20170082529A (ko) 2017-07-14
PH12017500829A1 (en) 2017-10-09
RU2017116197A (ru) 2018-12-13
CO2017004530A2 (es) 2017-07-28
US10059669B2 (en) 2018-08-28
BR112017009647A2 (pt) 2017-12-19
CL2017001113A1 (es) 2017-12-01
WO2016075062A1 (en) 2016-05-19
CN107074809A (zh) 2017-08-18
JP2017533253A (ja) 2017-11-09
CR20170187A (es) 2018-02-01
EA201790817A1 (ru) 2017-09-29
ZA201702799B (en) 2018-08-29
MX2017006048A (es) 2017-06-19
NI201700056A (es) 2017-09-22
DOP2017000118A (es) 2017-07-15
SG11201703177WA (en) 2017-05-30

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