CL2017003005A1 - Métodos de diagnóstico para tratamiento con linfocitos t - Google Patents

Métodos de diagnóstico para tratamiento con linfocitos t

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Publication number
CL2017003005A1
CL2017003005A1 CL2017003005A CL2017003005A CL2017003005A1 CL 2017003005 A1 CL2017003005 A1 CL 2017003005A1 CL 2017003005 A CL2017003005 A CL 2017003005A CL 2017003005 A CL2017003005 A CL 2017003005A CL 2017003005 A1 CL2017003005 A1 CL 2017003005A1
Authority
CL
Chile
Prior art keywords
treatment
lymphocytes
diagnostic methods
lymphocyt
conditioning
Prior art date
Application number
CL2017003005A
Other languages
English (en)
Inventor
Adrian Bot
Jeffrey S Wiezorek
William GO
Rajul JAIN
James N Kochenderfer
Steven A Rosenberg
Original Assignee
Kite Pharma Inc
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57393492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017003005(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kite Pharma Inc, Us Health filed Critical Kite Pharma Inc
Publication of CL2017003005A1 publication Critical patent/CL2017003005A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
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    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5443—IL-15

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Abstract

<p>LA INVENCIÓN PROPORCIONA MÉTODOS PARA INCREMENTAR LA EFICACIA DE UN TRATAMIENTO CON LINFOCITOS T EN UN PACIENTE EN NECESIDAD DE LOS MISMOS. LA INVENCIÓN INCLUYE UN MÉTODO PARA ACONDICIONAR UN PACIENTE ANTES DE UN TRATAMIENTO CON LINFOCITOS T, EN DONDE EL ACONDICIONAMIENTO INVOLUCRA ADMINISTRAR UNA COMBINACIÓN DE CICLOFOSFAMIDA Y FLUDARABINA.</p>
CL2017003005A 2015-05-28 2017-11-27 Métodos de diagnóstico para tratamiento con linfocitos t CL2017003005A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562167738P 2015-05-28 2015-05-28
US201562262111P 2015-12-02 2015-12-02

Publications (1)

Publication Number Publication Date
CL2017003005A1 true CL2017003005A1 (es) 2018-05-11

Family

ID=57393492

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017003005A CL2017003005A1 (es) 2015-05-28 2017-11-27 Métodos de diagnóstico para tratamiento con linfocitos t

Country Status (22)

Country Link
US (2) US11779601B2 (es)
EP (2) EP4218778A3 (es)
JP (3) JP6917903B2 (es)
KR (3) KR20230005428A (es)
CN (2) CN107921064A (es)
AU (2) AU2016268863B2 (es)
BR (2) BR112017025120A2 (es)
CA (1) CA2986793A1 (es)
CL (1) CL2017003005A1 (es)
DO (1) DOP2017000272A (es)
EA (1) EA201792642A1 (es)
ES (1) ES2944962T3 (es)
HK (2) HK1246150A1 (es)
IL (2) IL255888B2 (es)
MA (1) MA45281A (es)
MX (2) MX2017015190A (es)
PH (1) PH12017502153A1 (es)
PL (1) PL3302507T3 (es)
PT (1) PT3302507T (es)
SG (2) SG10201913620QA (es)
SI (1) SI3302507T1 (es)
WO (1) WO2016191755A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11491187B2 (en) 2015-05-28 2022-11-08 Kite Pharma, Inc. Methods of conditioning patients for T cell therapy
US11779601B2 (en) 2015-05-28 2023-10-10 Kite Pharma, Inc. Diagnostic methods for T cell therapy

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES
CN112175911B (zh) 2014-05-15 2023-10-13 新加坡国立大学 经修饰的自然杀伤细胞及其用途
WO2018182511A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
MX2019011514A (es) 2017-03-27 2020-01-27 Nat Univ Singapore Receptores quimericos nkg2d truncados y usos de los mismos en inmunoterapia con celulas asesinas naturales.
JP2020512983A (ja) 2017-04-03 2020-04-30 カイト ファーマ インコーポレイテッドＫｉｔｅ Ｐｈａｒｍａ， Ｉｎｃ 最適化された多機能性ｔ細胞を含むキメラ受容体ｔ細胞を使用する治療
CN111225675B (zh) 2017-06-02 2024-05-03 朱诺治疗学股份有限公司 使用过继细胞疗法治疗的制品和方法
WO2019207942A1 (ja) * 2018-04-27 2019-10-31 OTA Takayo 免疫チェックポイント阻害剤によるがん治療の効果を評価するためのバイオマーカー
SG11202011541SA (en) * 2018-06-01 2020-12-30 Kite Pharma Inc Chimeric antigen receptor t cell therapy
US20210155941A1 (en) 2018-06-22 2021-05-27 Kite Pharma Eu B.V. Compositions and methods for making engineered t cells
CN109207430A (zh) * 2018-09-25 2019-01-15 华东师范大学 一种嵌合抗原受体nk细胞及其制备方法和应用
CN113766956B (zh) 2019-03-05 2024-05-07 恩卡尔塔公司 Cd19定向性嵌合抗原受体及其在免疫疗法中的用途
GB201911066D0 (en) 2019-08-02 2019-09-18 Achilles Therapeutics Ltd T cell therapy
BR112022014501A2 (pt) * 2020-01-24 2022-09-20 Juno Therapeutics Inc Métodos para dosagem e tratamento de linfoma folicular e linfoma de zona marginal em terapia celular adotiva
CA3176654A1 (en) 2020-04-28 2021-11-04 Karl PEGGS T cell therapy
KR20230117383A (ko) * 2020-12-04 2023-08-08 셀진 코포레이션 염증-관련 가용성 인자의 억제제와 조합된 키메라 항원수용체 (car) t-세포 요법의 용도
WO2022214835A1 (en) 2021-04-09 2022-10-13 Achilles Therapeutics Uk Limited Batch release assay for pharmaceutical products relating to t cell therapies
GB202109886D0 (en) 2021-07-08 2021-08-25 Achilles Therapeutics Uk Ltd Assay
CN117580946A (zh) 2021-06-22 2024-02-20 阿基里斯治疗英国有限公司 用于产生抗原特异性t细胞的方法
WO2023230276A1 (en) 2022-05-27 2023-11-30 Kite Pharma, Inc. Compositions and methods for preparing engineered lymphocytes for cell therapy
US20240148790A1 (en) 2022-10-28 2024-05-09 Kite Pharma, Inc. Expedited administration of engineered lymphocytes
US20240158869A1 (en) 2022-10-28 2024-05-16 Kite Pharma, Inc. Factors for optimizing immunotherapy

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
US20030031652A1 (en) 2001-04-16 2003-02-13 Bernhard Hering Systems and methods for inducing mixed chimerism
US7718196B2 (en) 2001-07-02 2010-05-18 The United States Of America, As Represented By The Department Of Health And Human Services Rapamycin-resistant T cells and therapeutic uses thereof
WO2004021995A2 (en) 2002-09-06 2004-03-18 The Government Of The United States Of America, Represented By The Secretary, Departement Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
KR20180108886A (ko) * 2010-03-23 2018-10-04 인트렉손 코포레이션 치료적 단백질을 조건부로 발현하는 벡터，상기 벡터를 포함하는 숙주 세포 및 이의 용도
MX347078B (es) 2010-12-09 2017-04-10 Univ Pennsylvania Uso de celulas t modificadas por receptor de antigeno quimerico para tratar cancer.
US9402865B2 (en) 2011-01-18 2016-08-02 The Trustees Of The University Of Pennsylvania Compositions and methods for treating cancer
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
KR20140060541A (ko) 2011-09-16 2014-05-20 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암을 치료하기 위한 rna 조작된 t 세포
EP3144008B1 (en) * 2012-05-08 2018-01-17 The John Hopkins University Compositions for infusion of transiently engrafting, selected populations of allogeneic lymphocytes
WO2014055657A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
EP3650038A1 (en) * 2013-06-19 2020-05-13 Massachusetts Institute of Technology In vivo targeting of cells with ligand-conjugated particles
EA201690912A1 (ru) * 2013-11-05 2016-10-31 Когнейт Биосервисис, Инк. Комбинации ингибиторов контрольных точек и терапевтических средств для лечения рака
CA2986793A1 (en) 2015-05-28 2016-12-01 Kite Pharma, Inc. Diagnostic methods for t cell therapy
EP3851110A1 (en) 2015-05-28 2021-07-21 Kite Pharma, Inc. Methods of conditioning patients for t cell therapy
PL3436079T3 (pl) 2016-04-01 2021-12-20 Kite Pharma, Inc. Antygen chimeryczny i receptory komórek t oraz sposoby ich stosowania

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11491187B2 (en) 2015-05-28 2022-11-08 Kite Pharma, Inc. Methods of conditioning patients for T cell therapy
US11779601B2 (en) 2015-05-28 2023-10-10 Kite Pharma, Inc. Diagnostic methods for T cell therapy

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