MX2021014047A - Metodos de diagnostico para tratamiento con linfocitos t. - Google Patents

Metodos de diagnostico para tratamiento con linfocitos t.

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Publication number
MX2021014047A
MX2021014047A MX2021014047A MX2021014047A MX2021014047A MX 2021014047 A MX2021014047 A MX 2021014047A MX 2021014047 A MX2021014047 A MX 2021014047A MX 2021014047 A MX2021014047 A MX 2021014047A MX 2021014047 A MX2021014047 A MX 2021014047A
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MX
Mexico
Prior art keywords
cell therapy
patient
diagnostic methods
prior
identifying
Prior art date
Application number
MX2021014047A
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English (en)
Inventor
Steven A Rosenberg
James N Kochenderfer
Adrian Bot
Jeffrey S Wiezorek
William GO
Rajul JAIN
Original Assignee
Kite Pharma Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57393492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2021014047(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kite Pharma Inc filed Critical Kite Pharma Inc
Publication of MX2021014047A publication Critical patent/MX2021014047A/es

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    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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Abstract

La invención proporciona métodos para incrementar la eficacia de un tratamiento con linfocitos T en un paciente en necesidad de los mismos. La invención incluye un método para acondicionar un paciente antes de un tratamiento con linfocitos T, en donde el acondicionamiento involucra administrar una combinación de ciclofosfamida y fludarabina.
MX2021014047A 2015-05-28 2017-11-27 Metodos de diagnostico para tratamiento con linfocitos t. MX2021014047A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562167738P 2015-05-28 2015-05-28
US201562262111P 2015-12-02 2015-12-02

Publications (1)

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MX2021014047A true MX2021014047A (es) 2021-12-10

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ID=57393492

Family Applications (2)

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MX2017015190A MX2017015190A (es) 2015-05-28 2016-05-27 Metodos de diagnostico para tratamiento con linfocitos t.
MX2021014047A MX2021014047A (es) 2015-05-28 2017-11-27 Metodos de diagnostico para tratamiento con linfocitos t.

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US (2) US11779601B2 (es)
EP (2) EP3302507B1 (es)
JP (3) JP6917903B2 (es)
KR (3) KR20230005428A (es)
CN (2) CN107921064A (es)
AU (2) AU2016268863B2 (es)
BR (1) BR122023022076A2 (es)
CA (1) CA2986793A1 (es)
CL (1) CL2017003005A1 (es)
DO (1) DOP2017000272A (es)
EA (1) EA201792642A1 (es)
ES (1) ES2944962T3 (es)
HK (2) HK1246150A1 (es)
IL (2) IL255888B2 (es)
MA (1) MA45281A (es)
MX (2) MX2017015190A (es)
PH (1) PH12017502153A1 (es)
PL (1) PL3302507T3 (es)
PT (1) PT3302507T (es)
SG (2) SG10201913623PA (es)
SI (1) SI3302507T1 (es)
WO (1) WO2016191755A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201505858VA (en) 2013-01-28 2015-09-29 St Jude Childrens Res Hospital A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
EP3851110A1 (en) 2015-05-28 2021-07-21 Kite Pharma, Inc. Methods of conditioning patients for t cell therapy
PT3302507T (pt) 2015-05-28 2023-05-23 Kite Pharma Inc Métodos de diagnóstico para terapia com células t
WO2018182511A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
CN117384929A (zh) 2017-03-27 2024-01-12 新加坡国立大学 一种编码由细胞表达的嵌合受体的多核苷酸
CN110494158A (zh) 2017-04-03 2019-11-22 凯德药业股份有限公司 使用包含优化的多功能t细胞的嵌合受体t细胞进行治疗
EP3630132A1 (en) 2017-06-02 2020-04-08 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
US12031975B2 (en) 2017-11-01 2024-07-09 Juno Therapeutics, Inc. Methods of assessing or monitoring a response to a cell therapy
WO2019207942A1 (ja) * 2018-04-27 2019-10-31 OTA Takayo 免疫チェックポイント阻害剤によるがん治療の効果を評価するためのバイオマーカー
KR102544086B1 (ko) * 2018-06-01 2023-06-16 카이트 파마 인코포레이티드 키메라 항원 수용체 t 세포 요법
WO2019243888A1 (en) 2018-06-22 2019-12-26 Kite Pharma Eu B.V. Compositions and methods for making engineered t cells
CN109207430A (zh) * 2018-09-25 2019-01-15 华东师范大学 一种嵌合抗原受体nk细胞及其制备方法和应用
CN113766956B (zh) 2019-03-05 2024-05-07 恩卡尔塔公司 Cd19定向性嵌合抗原受体及其在免疫疗法中的用途
ES2972011T3 (es) * 2019-04-23 2024-06-10 Inst Nat Sante Rech Med Usos médicos para inducir o restablecer la inmunotolerancia
GB201911066D0 (en) 2019-08-02 2019-09-18 Achilles Therapeutics Ltd T cell therapy
IL292665A (en) * 2019-11-06 2022-07-01 Kite Pharma Inc Chimeric t-cell antigen receptor therapy
AU2021209940A1 (en) * 2020-01-24 2022-08-04 Juno Therapeutics, Inc. Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy
IL297594A (en) 2020-04-28 2022-12-01 Achilles Therapeutics Uk Ltd t cell therapy
JP2023552773A (ja) * 2020-12-04 2023-12-19 セルジーン コーポレーション 炎症関連可溶性因子の阻害剤と組み合わせたキメラ抗原受容体(car)t細胞療法の使用
US20220323500A1 (en) 2021-04-09 2022-10-13 Achilles Therapeutics Uk Limited Cancer immunotherapy
GB202109886D0 (en) 2021-07-08 2021-08-25 Achilles Therapeutics Uk Ltd Assay
KR20240023426A (ko) 2021-06-22 2024-02-21 아킬레스 테라퓨틱스 유케이 리미티드 항원-특이적 t 세포를 생산하는 방법
US20230392119A1 (en) 2022-05-27 2023-12-07 Kite Pharma, Inc. Compositions and methods for preparing engineered lymphocytes for cell therapy
TW202417643A (zh) 2022-10-28 2024-05-01 美商凱特製藥公司 用於將免疫療法最佳化之因素
WO2024092145A1 (en) 2022-10-28 2024-05-02 Kite Pharma, Inc. Expedited administration of engineered lymphocytes
WO2024196689A1 (en) 2023-03-17 2024-09-26 Kite Pharma, Inc. Impact of tumor microenvironment on efficacy of immunotherapy

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728388A (en) 1989-10-03 1998-03-17 Terman; David S. Method of cancer treatment
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
US6406699B1 (en) 1999-10-05 2002-06-18 Gary W. Wood Composition and method of cancer antigen immunotherapy
US20030031652A1 (en) 2001-04-16 2003-02-13 Bernhard Hering Systems and methods for inducing mixed chimerism
US7718196B2 (en) 2001-07-02 2010-05-18 The United States Of America, As Represented By The Department Of Health And Human Services Rapamycin-resistant T cells and therapeutic uses thereof
AU2003265948B8 (en) 2002-09-06 2009-09-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
GB0700058D0 (en) 2007-01-03 2007-02-07 Scancell Aps Anti-tumor vaccine based on normal cells
CN103038343A (zh) 2010-03-23 2013-04-10 英特瑞克斯顿股份有限公司 条件表达治疗蛋白的载体,包含所述载体的宿主细胞,及其应用
KR102243575B1 (ko) 2010-12-09 2021-04-22 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 암을 치료하기 위한 키메릭 항원 수용체 변형 t 세포의 용도
BR112013018311A2 (pt) 2011-01-18 2017-03-21 Univ Pennsylvania sequência de ácido nucleico isolada, receptor de antígeno quimérico isolado, célula t geneticamente modificada, vetor, e, uso de uma célula t geneticamente modificada.
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
AU2012308205A1 (en) 2011-09-16 2014-03-13 The Trustees Of The University Of Pennsylvania RNA engineered T cells for the treatment of cancer
WO2013169386A1 (en) 2012-05-08 2013-11-14 The Johns Hopkins University Methods and compositions for infusion of transiently engrafting, selected populations of allogeneic lymphocytes to treat cancer
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
WO2014204762A1 (en) 2013-06-19 2014-12-24 Massachusetts Institute Of Technology In vivo targeting of cells with ligand-conjugated particles
BR112016010224A2 (pt) * 2013-11-05 2018-05-02 Cognate Bioservices, Inc. combinações de inibidores do ponto de verificação e produtos terapêuticos para tratar o câncer.
PT3302507T (pt) 2015-05-28 2023-05-23 Kite Pharma Inc Métodos de diagnóstico para terapia com células t
EP3851110A1 (en) 2015-05-28 2021-07-21 Kite Pharma, Inc. Methods of conditioning patients for t cell therapy
EP3984559A1 (en) 2016-04-01 2022-04-20 Kite Pharma, Inc. Chimeric antigen and t cell receptors and methods of use

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