CL2016003055A1 - Sistema gastroretentivo expandible de liberación de medicamentos - Google Patents

Sistema gastroretentivo expandible de liberación de medicamentos

Info

Publication number
CL2016003055A1
CL2016003055A1 CL2016003055A CL2016003055A CL2016003055A1 CL 2016003055 A1 CL2016003055 A1 CL 2016003055A1 CL 2016003055 A CL2016003055 A CL 2016003055A CL 2016003055 A CL2016003055 A CL 2016003055A CL 2016003055 A1 CL2016003055 A1 CL 2016003055A1
Authority
CL
Chile
Prior art keywords
delivery system
drug delivery
gastroretentive drug
expandable
expandable gastroretentive
Prior art date
Application number
CL2016003055A
Other languages
English (en)
Inventor
Avshalom Ben Menachem
Ilan Zalit
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of CL2016003055A1 publication Critical patent/CL2016003055A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<p>SE PROPORCIONA UN DISPOSITIVO DE ENTREGA DE FARMACOS GASTRORRETENTIVOS ORALES, LOS CUALES SE DESPLIEGAN RAPIDAMENTE AL CONTACTO CON LOS JUGOS GÁSTRICOS, EL DISPOSITIVO ESTA CONFIGURADO EN UNA CONFIGURACION PLEGADA PARA SU INGESTA ORAL Y DESPLEGADA PARA UNA RETENCION GASTRICA DURANTE UN PERIODO DE TIEMPO PREDETERMINADO Y ASI REDUCIR EVENTUALMENTE EL TAMAÑO PARA SU PASO A TRAVES DEL RESTO DEL TRACTO GASTROINTESTINAL.</p>
CL2016003055A 2014-06-02 2016-11-28 Sistema gastroretentivo expandible de liberación de medicamentos CL2016003055A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462006541P 2014-06-02 2014-06-02
US201462093763P 2014-12-18 2014-12-18

Publications (1)

Publication Number Publication Date
CL2016003055A1 true CL2016003055A1 (es) 2017-07-28

Family

ID=54700510

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016003055A CL2016003055A1 (es) 2014-06-02 2016-11-28 Sistema gastroretentivo expandible de liberación de medicamentos

Country Status (13)

Country Link
US (7) US10485758B2 (es)
EP (1) EP3148514B1 (es)
JP (1) JP6570043B2 (es)
KR (1) KR20170015389A (es)
CN (1) CN106535878B (es)
AU (1) AU2015271808A1 (es)
BR (1) BR112016028180A2 (es)
CA (1) CA2949372C (es)
CL (1) CL2016003055A1 (es)
IL (2) IL248939B (es)
MX (1) MX2016015891A (es)
RU (1) RU2016151697A (es)
WO (1) WO2015187746A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170015389A (ko) * 2014-06-02 2017-02-08 테바 파마슈티컬 인더스트리즈 리미티드 확장 가능한 위체류 투여 형태
ES2832334T3 (es) 2014-06-11 2021-06-10 Massachusetts Inst Technology Estructuras de permanencia y métodos relacionados
WO2017070612A1 (en) 2015-10-23 2017-04-27 Lyndra, Inc. Gastric residence systems for sustained release of therapeutic agents and methods of use thereof
US11147766B2 (en) 2015-12-01 2021-10-19 Clexio Biosciences Ltd. Gastric retentive devices
CN108495622A (zh) 2015-12-02 2018-09-04 克雷西奥生物科技有限公司 用于制备胃滞留剂型的装置和方法
KR20180090881A (ko) 2015-12-08 2018-08-13 린드라 인코퍼레이티드 위 체류 시스템을 위한 기하 구성형태
WO2017205844A2 (en) * 2016-05-27 2017-11-30 Lyndra, Inc. Materials architecture for gastric residence systems
CA3038557A1 (en) 2016-09-30 2018-04-05 Lyndra, Inc. Gastric residence systems for sustained delivery of adamantane-class drugs
CN110035718B (zh) * 2016-12-02 2021-04-06 克雷西奥生物科技有限公司 胃内滞留系统
EP3720537A1 (en) 2017-12-04 2020-10-14 Clexio Biosciences Ltd. Long acting gastric residence system
EP4233978A3 (en) 2017-12-18 2023-11-15 Biograil APS Oral delivery of active drug substances
CN116270513A (zh) 2018-01-09 2023-06-23 南京三迭纪医药科技有限公司 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型
WO2020039253A2 (en) * 2018-08-20 2020-02-27 Besselink Petrus A Improved tubing for manufacturing expandable devices
WO2020230089A1 (en) 2019-05-14 2020-11-19 Clexio Biosciences Ltd. Treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease
WO2022026116A1 (en) * 2020-07-29 2022-02-03 The Secant Group, Llc Shape-guided controlled release and retention with structures including crosslinked poly(glycerol sebacate)
US20230398066A1 (en) * 2020-10-30 2023-12-14 Triastek, Inc. Drug dosage forms for stomach retention
US20230390193A1 (en) * 2020-10-30 2023-12-07 Triastek, Inc. Gastroretentive pharmaceutical dosage form
AU2021396978A1 (en) 2020-12-08 2023-02-23 Ruminant Biotech Corp Limited Improvements to devices and methods for delivery of substances to animals
WO2022195476A1 (en) 2021-03-15 2022-09-22 Clexio Biosciences Ltd. Gastroretentive devices for assessment of intragastric conditions
WO2023021480A1 (en) 2021-08-19 2023-02-23 Clexio Biosciences Ltd. Method of treating parkinson's disease
WO2023234868A1 (en) * 2022-06-03 2023-12-07 The Chloroplast Pte. Ltd A gastric residence article for oral administration
WO2024083145A1 (en) * 2022-10-18 2024-04-25 Triastek, Inc. Oral drug dosage forms for stomach retention
DK202270525A1 (en) * 2022-10-28 2024-06-14 Biograil ApS Oral drug delivery device
WO2024097572A1 (en) * 2022-11-01 2024-05-10 Merck Sharp & Dohme Llc Gastroretentive systems and methods of making and using same

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1318259A (en) 1919-10-07 Resilient wheel
AU449029B2 (en) 1969-08-28 1974-04-17 Commonwealth Scientific And Industrial Research Organisation Device for administration to ruminants
US4220153A (en) 1978-05-08 1980-09-02 Pfizer Inc. Controlled release delivery system
CA1273872A (en) 1985-05-10 1990-09-11 Larry J. Caldwell Drug delivery device which can be retained in the stomach for a controlled period of time
JPS6226215A (ja) * 1985-05-10 1987-02-04 メルク　エンド　カムパニ−　インコ−ポレ−テツド 一定に制御した時間内胃中に保持できる薬剤移送装置
US4735804A (en) * 1985-05-10 1988-04-05 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US5002772A (en) * 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
JPH03163011A (ja) 1989-08-31 1991-07-15 Yamanouchi Pharmaceut Co Ltd 胃内滞留デバイス
IT1282650B1 (it) 1996-02-19 1998-03-31 Jagotec Ag Compressa farmaceutica,caratterizzata da elevato aumento di volume a contatto con liquidi biologici
IL133196A0 (en) 1999-11-29 2001-03-19 Yissum Res Dev Co Gastroretentive controlled release pharmaceutical dosage forms
US6753011B2 (en) 2000-01-14 2004-06-22 Osmotica Corp Combined diffusion/osmotic pumping drug delivery system
AU767812B2 (en) 2000-02-04 2003-11-27 Depomed, Inc. Shell-and-core dosage form approaching zero-order drug release
AR030557A1 (es) 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US6723340B2 (en) 2001-10-25 2004-04-20 Depomed, Inc. Optimal polymer mixtures for gastric retentive tablets
CA2409552A1 (en) 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
MXPA04006545A (es) * 2002-01-03 2004-10-04 Smithkline Beecham Corp Nuevas formas de dosificacion farmaceutica y metodo para producir las mismas.
GB0214013D0 (en) 2002-06-18 2002-07-31 Euro Celtique Sa Pharmaceutical product
US20050013863A1 (en) 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
IL166183A0 (en) 2005-01-06 2006-01-15 Yissum Res Dev Co Novel diagnostic and imaging techniques of the gi tract
BRPI0620863A8 (pt) 2005-12-29 2018-01-16 Osmotica Kereskedelmi Es Szolgaltato Kft comprimido em camadas com combinação de liberação tripla
HUE043365T2 (hu) 2006-01-18 2019-08-28 Intec Pharma Ltd Kiadóberendezés szer orális bevételéhez
WO2007093999A1 (en) 2006-02-15 2007-08-23 Intec Pharma Ltd. A gastro-retentive system for the delivery of macromolecules
WO2007106957A1 (en) 2006-03-21 2007-09-27 Laboratoires Smb S.A. Multiple units controlled-release floating dosage forms
US9579227B2 (en) * 2006-03-29 2017-02-28 Eat Little Inc. Ingestible implement for weight control
WO2008087882A1 (ja) 2007-01-15 2008-07-24 Kissei Pharmaceutical Co., Ltd. 胃内滞留型レボドパ徐放性製剤
EP2219624A2 (en) 2007-11-08 2010-08-25 Glaxo Group Limited Pharmaceutical formulations
WO2009144558A1 (en) 2008-04-18 2009-12-03 Intec Pharma Ltd. Carbidopa/lipodopa gastroretentive drug delivery
EP2133071A1 (en) 2008-06-09 2009-12-16 Université de la Méditerranée Process for making gastroretentive dosage forms
WO2010035273A2 (en) 2008-09-29 2010-04-01 Intec Pharma Ltd. Novel gastroretentive delivery system
US20110066175A1 (en) * 2009-05-07 2011-03-17 Rainbow Medical Ltd. Gastric anchor
US20120321706A1 (en) 2009-10-19 2012-12-20 Intec Pharma Ltd. Novel gastroretentive dosage forms of poorly soluble drugs
WO2011090724A2 (en) 2009-12-29 2011-07-28 Impax Laboratories, Inc. Gastroretentive solid oral dosage forms with lipid-based low-density excipient
CN101919803A (zh) 2010-07-16 2010-12-22 钟术光 一种控释制剂
WO2012006963A1 (zh) 2010-07-16 2012-01-19 Zhong Shuguang 在控释制剂中的聚合物增强剂
US20140017303A1 (en) 2010-11-01 2014-01-16 Intec Pharma Ltd. Accordion pill comprising levodopa for an improved treatment of parkinson's disease symptoms
US20130072869A1 (en) 2011-09-15 2013-03-21 The Johns Hopkins University Intra-Gastric Timed-Release Drug Delivery System
WO2013054285A1 (en) 2011-10-11 2013-04-18 Ranbaxy Laboratories Limited A gastroretentive dosage system and process of preparation thereof
KR20170015389A (ko) * 2014-06-02 2017-02-08 테바 파마슈티컬 인더스트리즈 리미티드 확장 가능한 위체류 투여 형태
ES2832334T3 (es) 2014-06-11 2021-06-10 Massachusetts Inst Technology Estructuras de permanencia y métodos relacionados
US11147766B2 (en) * 2015-12-01 2021-10-19 Clexio Biosciences Ltd. Gastric retentive devices

Also Published As

Publication number Publication date
US20190365646A1 (en) 2019-12-05
JP6570043B2 (ja) 2019-09-04
US11648198B2 (en) 2023-05-16
US20220160630A1 (en) 2022-05-26
KR20170015389A (ko) 2017-02-08
US20220202709A1 (en) 2022-06-30
EP3148514A4 (en) 2018-02-07
IL281584A (en) 2021-05-31
JP2017518308A (ja) 2017-07-06
US20220211617A1 (en) 2022-07-07
IL281584B (en) 2022-05-01
IL248939A0 (en) 2017-01-31
CN106535878B (zh) 2022-11-01
US10485758B2 (en) 2019-11-26
MX2016015891A (es) 2017-07-11
US11285102B2 (en) 2022-03-29
CN106535878A (zh) 2017-03-22
US20200405635A1 (en) 2020-12-31
IL248939B (en) 2021-06-30
EP3148514B1 (en) 2024-04-17
CA2949372A1 (en) 2015-12-10
US20220202708A1 (en) 2022-06-30
BR112016028180A2 (pt) 2017-08-22
RU2016151697A (ru) 2018-07-10
US20150342877A1 (en) 2015-12-03
CA2949372C (en) 2023-08-22
EP3148514A1 (en) 2017-04-05
WO2015187746A1 (en) 2015-12-10
AU2015271808A1 (en) 2016-12-08

Similar Documents

Publication Publication Date Title
CL2016003055A1 (es) Sistema gastroretentivo expandible de liberación de medicamentos
DK3755384T3 (da) Bærbar fjern-uvc-indretning
CO6870010A2 (es) Sistema y método para regular el límite del ancho de banda proporcionado a un dispositivo móvil
ES2972692T3 (es) Dispositivo de administración de fármacos
EP3445162A4 (en) MOBILE SHELTER DEVICE FOR ANIMALS
DK3235342T3 (da) Belysningsindretning, belysningssystem og anvendelse deraf
EP3156836A4 (en) Lens holder driving device and mobile terminal with camera
EP3144710A4 (en) Lens drive device, camera module, and mobile terminal with camera
ES1160036Y (es) Dispositivo luminoso movil de emergencia
DK3211416T3 (da) Batteridrevet, trådløs gasdetekteringsenhed
BR112016018487A2 (pt) dispositivo e sistema de fixação de aparelho para equipamento de cabeça
TWI799414B (zh) 氣液反應裝置、反應管及成膜裝置
DK3410412T3 (da) Mobil alarmanordning
FR3003402B1 (fr) Dispositif monolithique emetteur de lumiere.
EP3130195A4 (en) Internal signal diversion with optional camera shuttering for mobile communication devices
FR3026316B1 (fr) Dispositif compact de melange de fluides
ES2973152T3 (es) Dispositivo de transporte
FR3044099B1 (fr) Dispositif de diagnostic de batterie
DE112019002579A5 (de) Ringpendeleinrichtung
TWI799514B (zh) 內視鏡攝影裝置以及內視鏡攝影系統
DK3395767T3 (da) Omvendt-osmose-modul med koaksialt indre rør
BR112015016741A2 (pt) composição, dispositivo e sistema
ES1090031Y (es) Dispositivo terapéutico y anticonceptivo de uso vaginal
EP3517525A4 (en) NON-TTEROID ANTIPHLOGISTIUM BASED ON NAPROXES WITH LOW MAGENTOXICITY
ES1194233Y (es) Sistema portatil de evaluacion de la calidad del agua