WO2008087882A1 - 胃内滞留型レボドパ徐放性製剤 - Google Patents
胃内滞留型レボドパ徐放性製剤 Download PDFInfo
- Publication number
- WO2008087882A1 WO2008087882A1 PCT/JP2008/050159 JP2008050159W WO2008087882A1 WO 2008087882 A1 WO2008087882 A1 WO 2008087882A1 JP 2008050159 W JP2008050159 W JP 2008050159W WO 2008087882 A1 WO2008087882 A1 WO 2008087882A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- levodopa
- sustained
- intragastric floating
- floating
- type
- Prior art date
Links
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title abstract 6
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title abstract 6
- 229960004502 levodopa Drugs 0.000 title abstract 6
- 239000003405 delayed action preparation Substances 0.000 title 1
- 210000002784 stomach Anatomy 0.000 abstract 2
- 230000036765 blood level Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/523,117 US20100112053A1 (en) | 2007-01-15 | 2008-01-10 | Gastric retention-type sustained-release levodopa preparation |
CA002673485A CA2673485A1 (en) | 2007-01-15 | 2008-01-10 | Gastric retention-type sustained-release levodopa preparation |
EP08703030A EP2105133A1 (en) | 2007-01-15 | 2008-01-10 | Intragastric floating-type levodopa sustained-release preparation |
JP2008554012A JPWO2008087882A1 (ja) | 2007-01-15 | 2008-01-10 | 胃内滞留型レボドパ徐放性製剤 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-005438 | 2007-01-15 | ||
JP2007005438 | 2007-01-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008087882A1 true WO2008087882A1 (ja) | 2008-07-24 |
Family
ID=39635886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/050159 WO2008087882A1 (ja) | 2007-01-15 | 2008-01-10 | 胃内滞留型レボドパ徐放性製剤 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100112053A1 (ja) |
EP (1) | EP2105133A1 (ja) |
JP (1) | JPWO2008087882A1 (ja) |
CA (1) | CA2673485A1 (ja) |
WO (1) | WO2008087882A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008280251A (ja) * | 2007-05-08 | 2008-11-20 | Shin Etsu Chem Co Ltd | 多層錠及びその製造方法 |
WO2010019915A1 (en) * | 2008-08-15 | 2010-02-18 | Depomed Inc. | Gastric retentive pharmaceutical compositions for treatment and prevention of cns disorders |
JP2019523305A (ja) * | 2016-07-29 | 2019-08-22 | ソム イノベーション バイオテク エス.エル.Som Innovation Biotech,S.L. | 微粒子化トルカポンを含む徐放性錠剤 |
WO2020230089A1 (en) | 2019-05-14 | 2020-11-19 | Clexio Biosciences Ltd. | Treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease |
WO2022195476A1 (en) | 2021-03-15 | 2022-09-22 | Clexio Biosciences Ltd. | Gastroretentive devices for assessment of intragastric conditions |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9750702B2 (en) * | 2009-12-25 | 2017-09-05 | Innopharmax, Inc. | Pharmaceutical composition for treating parkinson's disease and preparation method thereof |
ES2706880T3 (es) | 2010-02-22 | 2019-04-01 | Daiichi Sankyo Co Ltd | Preparación sólida de liberación sostenida para uso oral |
KR102127625B1 (ko) | 2012-09-03 | 2020-06-29 | 다이이찌 산쿄 가부시키가이샤 | 하이드로모르폰염산염 함유의 경구용 서방성 의약 조성물 |
RU2016151697A (ru) | 2014-06-02 | 2018-07-10 | Тева Фармасьютикал Индастриз Лтд. | Расправляемая удерживаемая в желудке лекарственная форма |
CN110035718B (zh) | 2016-12-02 | 2021-04-06 | 克雷西奥生物科技有限公司 | 胃内滞留系统 |
DK3648747T3 (da) | 2017-06-16 | 2022-11-28 | Amneal Complex Products Res Llc | Gastroretentive doseringsformer til vedvarende frigivelse af lægemidler |
US10588863B2 (en) | 2017-06-16 | 2020-03-17 | Kashiv Biosciences, Llc | Extended release compositions comprising pyridostigmine |
US10987311B2 (en) | 2017-06-16 | 2021-04-27 | Kashiv Specialty Pharmaceuticals, Llc | Extended release compositions comprising pyridostigmine |
JP7296084B2 (ja) | 2017-12-04 | 2023-06-22 | クレキシオ バイオサイエンシーズ エルティーディー. | 長時間作用型胃滞留システム |
JP7048770B2 (ja) | 2018-06-18 | 2022-04-05 | アムニール コンプレックス プロダクツ リサーチ エルエルシー | ピリドスチグミンを含む持続放出組成物 |
IT202100006776A1 (it) * | 2021-03-22 | 2022-09-22 | Univ Degli Studi Genova | Metodo di produzione di matrici compatte gastroritentive per il rilascio controllato di sostanze attive e matrici compatte così ottenute |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991006281A1 (en) * | 1989-10-26 | 1991-05-16 | Nippon Shinyaku Co., Ltd. | Gastric preparation |
JPH0667830B2 (ja) | 1987-12-11 | 1994-08-31 | メルク エンド カムパニーインコーポレーテツド | カルビドパ/レボドパの制御放出配合剤 |
JPH07247222A (ja) * | 1994-03-11 | 1995-09-26 | Tanabe Seiyaku Co Ltd | 消化管内適所放出型製剤 |
WO1999007342A1 (en) | 1997-08-11 | 1999-02-18 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
WO2000015197A1 (en) | 1998-09-14 | 2000-03-23 | Rubin Alan A | Improvement in treatment of parkinson's disease and related disorders by novel formulations of the combination carbidopa-levodopa |
WO2002000213A1 (en) | 2000-06-23 | 2002-01-03 | Teva Pharmaceutical Industries Ltd. | Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition |
WO2004032906A1 (en) | 2002-10-11 | 2004-04-22 | Depomed Development, Ltd. | Gastro-retentive levodopa delivery form |
JP2005132803A (ja) | 2003-10-31 | 2005-05-26 | Ono Pharmaceut Co Ltd | 胃内滞留固形剤 |
JP2006523633A (ja) * | 2003-04-18 | 2006-10-19 | ユニハート コーポレーション | レボドーパ及びカルビドーパを含む医薬組成物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080118556A1 (en) * | 1998-11-02 | 2008-05-22 | Elan Corporation, Plc | Modified Release of Compositions Containing a Combination of Carbidopa, Levodopa and Entacapone |
EA200700158A1 (ru) * | 2004-07-26 | 2007-08-31 | Тева Фармасьютикал Индастриес Лтд. | Лекарственные формы с ядром таблетки, покрытым энтеросолюбильной оболочкой |
-
2008
- 2008-01-10 EP EP08703030A patent/EP2105133A1/en not_active Withdrawn
- 2008-01-10 WO PCT/JP2008/050159 patent/WO2008087882A1/ja active Application Filing
- 2008-01-10 JP JP2008554012A patent/JPWO2008087882A1/ja active Pending
- 2008-01-10 US US12/523,117 patent/US20100112053A1/en not_active Abandoned
- 2008-01-10 CA CA002673485A patent/CA2673485A1/en not_active Abandoned
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0667830B2 (ja) | 1987-12-11 | 1994-08-31 | メルク エンド カムパニーインコーポレーテツド | カルビドパ/レボドパの制御放出配合剤 |
WO1991006281A1 (en) * | 1989-10-26 | 1991-05-16 | Nippon Shinyaku Co., Ltd. | Gastric preparation |
JPH07247222A (ja) * | 1994-03-11 | 1995-09-26 | Tanabe Seiyaku Co Ltd | 消化管内適所放出型製剤 |
WO1999007342A1 (en) | 1997-08-11 | 1999-02-18 | Alza Corporation | Prolonged release active agent dosage form adapted for gastric retention |
WO2000015197A1 (en) | 1998-09-14 | 2000-03-23 | Rubin Alan A | Improvement in treatment of parkinson's disease and related disorders by novel formulations of the combination carbidopa-levodopa |
WO2002000213A1 (en) | 2000-06-23 | 2002-01-03 | Teva Pharmaceutical Industries Ltd. | Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition |
WO2004032906A1 (en) | 2002-10-11 | 2004-04-22 | Depomed Development, Ltd. | Gastro-retentive levodopa delivery form |
JP2006523633A (ja) * | 2003-04-18 | 2006-10-19 | ユニハート コーポレーション | レボドーパ及びカルビドーパを含む医薬組成物 |
JP2005132803A (ja) | 2003-10-31 | 2005-05-26 | Ono Pharmaceut Co Ltd | 胃内滞留固形剤 |
Non-Patent Citations (1)
Title |
---|
KLAUSNER, E. A. ET AL., PHARMACEUTICAL RESEARCH, vol. 20, no. 9, 2003, pages 1466 - 1473 |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008280251A (ja) * | 2007-05-08 | 2008-11-20 | Shin Etsu Chem Co Ltd | 多層錠及びその製造方法 |
WO2010019915A1 (en) * | 2008-08-15 | 2010-02-18 | Depomed Inc. | Gastric retentive pharmaceutical compositions for treatment and prevention of cns disorders |
JP2012500221A (ja) * | 2008-08-15 | 2012-01-05 | ディポメド,インコーポレイティド | Cns障害の処理及び予防のための胃保持性医薬組成物 |
US9161911B2 (en) | 2008-08-15 | 2015-10-20 | Depomed, Inc. | Gastric retentive pharmaceutical compositions for treatment and prevention of CNS disorders |
US9566258B2 (en) | 2008-08-15 | 2017-02-14 | Depomed, Inc. | Gastric retentive pharmaceutical compositions for treatment and prevention of CNS disorders |
US9937142B2 (en) | 2008-08-15 | 2018-04-10 | Depomed, Inc. | Gastric retentive pharmaceutical compositions for treatment and prevention of CNS disorders |
JP2019523305A (ja) * | 2016-07-29 | 2019-08-22 | ソム イノベーション バイオテク エス.エル.Som Innovation Biotech,S.L. | 微粒子化トルカポンを含む徐放性錠剤 |
JP7047236B2 (ja) | 2016-07-29 | 2022-04-05 | ソム イノベーション バイオテク ソシエダッド アノニマ | 微粒子化トルカポンを含む徐放性錠剤 |
WO2020230089A1 (en) | 2019-05-14 | 2020-11-19 | Clexio Biosciences Ltd. | Treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease |
US11389398B2 (en) | 2019-05-14 | 2022-07-19 | Clexio Biosciences Ltd. | Gastroretentive treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease |
WO2022195476A1 (en) | 2021-03-15 | 2022-09-22 | Clexio Biosciences Ltd. | Gastroretentive devices for assessment of intragastric conditions |
Also Published As
Publication number | Publication date |
---|---|
JPWO2008087882A1 (ja) | 2010-05-06 |
CA2673485A1 (en) | 2008-07-24 |
EP2105133A1 (en) | 2009-09-30 |
US20100112053A1 (en) | 2010-05-06 |
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