CL2015002455A1 - Terapia de combinación para el tratamiento de la neoplasia. - Google Patents
Terapia de combinación para el tratamiento de la neoplasia.Info
- Publication number
- CL2015002455A1 CL2015002455A1 CL2015002455A CL2015002455A CL2015002455A1 CL 2015002455 A1 CL2015002455 A1 CL 2015002455A1 CL 2015002455 A CL2015002455 A CL 2015002455A CL 2015002455 A CL2015002455 A CL 2015002455A CL 2015002455 A1 CL2015002455 A1 CL 2015002455A1
- Authority
- CL
- Chile
- Prior art keywords
- antagonist
- treatment
- neoplasia
- combination therapy
- cancer
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A UN ANTAGONISTA DE LOS RECEPTORES CON FACTOR DE CRECIMIENTO SIMILAR AL DE LA INSULINA (IGF) PARA USA EN EL TRATAMIENTO DE LA NEOPLASIA PROSTÁTICA QUE INCLUYE LA HIPERPLASIA PROSTÁTICA BENIGNA (HPB), CANCER DE PRÓSTATA, Y PARTICULARRNENTE CRPC, EN EL QUE EL ANTAGONISTA SE UTILIZA EN COMBINACIÓN CON UN ANTAGONISTA DE LOS RECEPTORES ANDRÓGENOS. UNA FORMA DE REALIZACIÓN DE LA INVENCIÓN ES AQUELLA EN DONDE EL ANTAGONISTA DEL RECEPTOR DE LOS ANDRÓGENOS ES LA ENZALUTAMIDA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13158228 | 2013-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015002455A1 true CL2015002455A1 (es) | 2016-05-27 |
Family
ID=47827067
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015002455A CL2015002455A1 (es) | 2013-03-07 | 2015-09-02 | Terapia de combinación para el tratamiento de la neoplasia. |
Country Status (16)
Country | Link |
---|---|
US (2) | US20140255413A1 (es) |
EP (1) | EP2964256B1 (es) |
JP (1) | JP6532828B2 (es) |
KR (1) | KR20150123859A (es) |
CN (1) | CN105007942A (es) |
AR (1) | AR095041A1 (es) |
AU (1) | AU2014224608B2 (es) |
BR (1) | BR112015020943A2 (es) |
CA (1) | CA2903645A1 (es) |
CL (1) | CL2015002455A1 (es) |
EA (1) | EA034884B1 (es) |
IL (1) | IL240599A0 (es) |
MX (1) | MX367624B (es) |
PH (1) | PH12015501852A1 (es) |
UY (1) | UY35371A (es) |
WO (1) | WO2014135611A1 (es) |
Families Citing this family (13)
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HUE026374T2 (en) | 2008-12-12 | 2016-05-30 | Boehringer Ingelheim Int | Anti-IGF antibody |
US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
WO2015018421A1 (en) | 2013-08-07 | 2015-02-12 | Rigshospitalet Copenhagen University Hospital | Antibodies, compounds and derivatives thereof for use in the treatment of male infertility |
CN106714835A (zh) * | 2014-09-17 | 2017-05-24 | 默克专利股份公司 | 治疗骨转移疾病的方法、其药物以及预测治疗骨转移疾病的临床结果的方法 |
US11415581B2 (en) | 2014-09-17 | 2022-08-16 | Merck Patent Gmbh | Method of treating solid cancers and/or metastases thereof with pan AV integrin inhibitor, medicaments therefore, and a method of predicting the clinical outcome of treating solid cancers and/or metastases thereof |
WO2016113572A1 (en) * | 2015-01-16 | 2016-07-21 | The University Of Liverpool | Insulin-like growth factor inhibitor and chemotherapeutic agent for use in cancer therapy |
US10722527B2 (en) | 2015-04-10 | 2020-07-28 | Capsugel Belgium Nv | Abiraterone acetate lipid formulations |
US20170088609A1 (en) | 2015-09-28 | 2017-03-30 | Boehringer Ingelheim International Gmbh | Anticancer combination therapy |
CN108114271B (zh) * | 2016-11-29 | 2021-07-02 | 中国科学院上海营养与健康研究所 | 含胰岛素样生长因子-2的药物组合物及其应用 |
CN111148534A (zh) | 2017-09-29 | 2020-05-12 | 勃林格殷格翰国际有限公司 | 抗igf和抗pd-1抗癌组合疗法 |
EP3773565A4 (en) * | 2018-03-29 | 2021-12-15 | Hinova Pharmaceuticals Inc. | DEUTERCED IMIDAZOLIDINDIONE COMPOUNDS AND THEIR USES |
US20210332392A1 (en) * | 2020-04-24 | 2021-10-28 | Lawrence Livermore National Security, Llc | Compositions and methods of use thereof for scandium separation from rare earth containing material |
CN115721629B (zh) * | 2022-10-31 | 2024-02-20 | 西安交通大学 | 多西他赛与恩杂鲁胺联合用药pH响应型铁-铜磁性纳米载药系统及其制备和应用 |
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2014
- 2014-03-04 US US14/196,231 patent/US20140255413A1/en not_active Abandoned
- 2014-03-06 WO PCT/EP2014/054300 patent/WO2014135611A1/en active Application Filing
- 2014-03-06 KR KR1020157026215A patent/KR20150123859A/ko not_active Application Discontinuation
- 2014-03-06 MX MX2015011579A patent/MX367624B/es active IP Right Grant
- 2014-03-06 BR BR112015020943A patent/BR112015020943A2/pt not_active IP Right Cessation
- 2014-03-06 JP JP2015560682A patent/JP6532828B2/ja not_active Expired - Fee Related
- 2014-03-06 CN CN201480010868.8A patent/CN105007942A/zh active Pending
- 2014-03-06 EP EP14709911.3A patent/EP2964256B1/en active Active
- 2014-03-06 CA CA2903645A patent/CA2903645A1/en not_active Abandoned
- 2014-03-06 AR ARP140100739A patent/AR095041A1/es unknown
- 2014-03-06 AU AU2014224608A patent/AU2014224608B2/en not_active Ceased
- 2014-03-06 EA EA201500906A patent/EA034884B1/ru not_active IP Right Cessation
- 2014-03-07 UY UY0001035371A patent/UY35371A/es unknown
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2015
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- 2015-08-24 PH PH12015501852A patent/PH12015501852A1/en unknown
- 2015-09-02 CL CL2015002455A patent/CL2015002455A1/es unknown
- 2015-11-19 US US14/946,067 patent/US10377828B2/en active Active
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US20140255413A1 (en) | 2014-09-11 |
CN105007942A (zh) | 2015-10-28 |
NZ711210A (en) | 2020-11-27 |
EP2964256B1 (en) | 2020-11-11 |
AU2014224608B2 (en) | 2018-08-09 |
WO2014135611A1 (en) | 2014-09-12 |
US20160199488A1 (en) | 2016-07-14 |
EA034884B1 (ru) | 2020-04-01 |
PH12015501852B1 (en) | 2016-01-18 |
MX2015011579A (es) | 2015-12-09 |
EP2964256A1 (en) | 2016-01-13 |
US10377828B2 (en) | 2019-08-13 |
JP6532828B2 (ja) | 2019-06-19 |
BR112015020943A2 (pt) | 2017-10-10 |
IL240599A0 (en) | 2015-09-24 |
CA2903645A1 (en) | 2014-09-12 |
UY35371A (es) | 2014-09-30 |
AU2014224608A1 (en) | 2015-09-10 |
JP2016511265A (ja) | 2016-04-14 |
MX367624B (es) | 2019-08-29 |
EA201500906A1 (ru) | 2016-03-31 |
PH12015501852A1 (en) | 2016-01-18 |
AR095041A1 (es) | 2015-09-16 |
KR20150123859A (ko) | 2015-11-04 |
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