CL2015000818A1 - Compuestos derivados de n-prop-2-inil carboxamida, antagonistas del receptor transitorio potencial de la subfamilia 1, miembro 1 (trpa1); composicion farmaceutica que los comprende; y metodo para el tratamiento del dolor neuropatico, dolor por polineuropatia diabetica, dolor postoperatorio y dolor por cancer, entre otros. - Google Patents

Compuestos derivados de n-prop-2-inil carboxamida, antagonistas del receptor transitorio potencial de la subfamilia 1, miembro 1 (trpa1); composicion farmaceutica que los comprende; y metodo para el tratamiento del dolor neuropatico, dolor por polineuropatia diabetica, dolor postoperatorio y dolor por cancer, entre otros.

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Publication number
CL2015000818A1
CL2015000818A1 CL2015000818A CL2015000818A CL2015000818A1 CL 2015000818 A1 CL2015000818 A1 CL 2015000818A1 CL 2015000818 A CL2015000818 A CL 2015000818A CL 2015000818 A CL2015000818 A CL 2015000818A CL 2015000818 A1 CL2015000818 A1 CL 2015000818A1
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CL
Chile
Prior art keywords
pain
trpa1
inyl
subfamily
carboxamide
Prior art date
Application number
CL2015000818A
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English (en)
Inventor
Riina Arvela
Terhi Heikkinen
Patrik Holm
Peteris Prusis
Mattias Roslund
Harri Salo
Original Assignee
Orion Corp
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Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of CL2015000818A1 publication Critical patent/CL2015000818A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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CL2015000818A 2012-10-01 2015-04-01 Compuestos derivados de n-prop-2-inil carboxamida, antagonistas del receptor transitorio potencial de la subfamilia 1, miembro 1 (trpa1); composicion farmaceutica que los comprende; y metodo para el tratamiento del dolor neuropatico, dolor por polineuropatia diabetica, dolor postoperatorio y dolor por cancer, entre otros. CL2015000818A1 (es)

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TW201620876A (zh) * 2014-03-28 2016-06-16 奧利安公司 新的醫藥化合物
WO2016071485A1 (en) * 2014-11-07 2016-05-12 Danmarks Tekniske Universitet Method for determining the composition of the sugar moiety of a sugar containing compound
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EP3554500A1 (en) 2016-12-16 2019-10-23 Galderma Research & Development Trpa1 antagonists for use in the treatment of atopic dermatitis
JP7323913B2 (ja) * 2019-04-12 2023-08-09 国立大学法人 筑波大学 睡眠誘導剤である複素環化合物
US20220267270A1 (en) * 2019-08-30 2022-08-25 University Of South Florida Sting modulators, compositions, and methods of use
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