RS55948B1 - Derivati n-prop-2-inil karboksamida i njihova upotreba kao antagonista trpa1 - Google Patents
Derivati n-prop-2-inil karboksamida i njihova upotreba kao antagonista trpa1Info
- Publication number
- RS55948B1 RS55948B1 RS20170429A RSP20170429A RS55948B1 RS 55948 B1 RS55948 B1 RS 55948B1 RS 20170429 A RS20170429 A RS 20170429A RS P20170429 A RSP20170429 A RS P20170429A RS 55948 B1 RS55948 B1 RS 55948B1
- Authority
- RS
- Serbia
- Prior art keywords
- ynyl
- prop
- carboxamide derivatives
- trpa1 antagonists
- trpa1
- Prior art date
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261708330P | 2012-10-01 | 2012-10-01 | |
PCT/FI2013/000034 WO2014053694A1 (en) | 2012-10-01 | 2013-09-30 | N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
RS55948B1 true RS55948B1 (sr) | 2017-09-29 |
Family
ID=49447574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20170429A RS55948B1 (sr) | 2012-10-01 | 2013-09-30 | Derivati n-prop-2-inil karboksamida i njihova upotreba kao antagonista trpa1 |
Country Status (35)
Country | Link |
---|---|
US (1) | US9533952B2 (sr) |
EP (1) | EP2903965B1 (sr) |
JP (1) | JP6226991B2 (sr) |
KR (1) | KR102164756B1 (sr) |
CN (1) | CN104822653B (sr) |
AR (1) | AR092749A1 (sr) |
AU (1) | AU2013326429B2 (sr) |
BR (1) | BR112015007422B1 (sr) |
CA (1) | CA2884922C (sr) |
CL (1) | CL2015000818A1 (sr) |
CO (1) | CO7350625A2 (sr) |
CY (1) | CY1119022T1 (sr) |
DK (1) | DK2903965T3 (sr) |
EA (1) | EA026942B1 (sr) |
ES (1) | ES2624873T3 (sr) |
HK (1) | HK1212965A1 (sr) |
HR (1) | HRP20170828T1 (sr) |
HU (1) | HUE034362T2 (sr) |
IL (1) | IL237784A (sr) |
LT (1) | LT2903965T (sr) |
ME (1) | ME02745B (sr) |
MX (1) | MX363565B (sr) |
MY (1) | MY187910A (sr) |
NZ (1) | NZ706989A (sr) |
PE (1) | PE20150598A1 (sr) |
PH (1) | PH12015500716A1 (sr) |
PL (1) | PL2903965T3 (sr) |
PT (1) | PT2903965T (sr) |
RS (1) | RS55948B1 (sr) |
SA (1) | SA515360195B1 (sr) |
SG (1) | SG11201502150PA (sr) |
SI (1) | SI2903965T1 (sr) |
TW (1) | TWI603948B (sr) |
WO (1) | WO2014053694A1 (sr) |
ZA (1) | ZA201502144B (sr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2805718B1 (en) | 2012-01-17 | 2018-04-04 | EA Pharma Co., Ltd. | Heterocyclic amide derivative and pharmaceutical product containing same |
WO2015103060A1 (en) | 2014-01-06 | 2015-07-09 | Algomedix, Inc. | Trpa1 modulators |
TW201620876A (zh) * | 2014-03-28 | 2016-06-16 | 奧利安公司 | 新的醫藥化合物 |
TW201620877A (zh) * | 2014-03-28 | 2016-06-16 | 奧利安公司 | 新的醫藥化合物 |
WO2016071485A1 (en) * | 2014-11-07 | 2016-05-12 | Danmarks Tekniske Universitet | Method for determining the composition of the sugar moiety of a sugar containing compound |
CN109952291B (zh) * | 2016-09-12 | 2022-09-23 | 纽若斯丹公司 | 与糖尿病相关的神经缺陷的改善 |
KR200488636Y1 (ko) | 2016-11-29 | 2019-05-22 | 조길연 | 점검구 일체형 욕실천장 |
WO2018109155A1 (en) | 2016-12-16 | 2018-06-21 | Galderma Research & Development | Trpa1 antagonists for use in the treatment of atopic dermatitis |
JP7323913B2 (ja) * | 2019-04-12 | 2023-08-09 | 国立大学法人 筑波大学 | 睡眠誘導剤である複素環化合物 |
EP4021449A4 (en) * | 2019-08-30 | 2023-11-01 | University of South Florida | STITCH MODULATORS, COMPOSITIONS AND METHODS OF USE |
IT202100015098A1 (it) | 2021-06-09 | 2022-12-09 | Flonext S R L | Composto antagonista del canale trpa1 per uso in patologie degenerative della retina |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS612667B2 (sr) * | 1973-11-20 | 1986-01-27 | Hisamitsu Pharmaceutical Co | |
US20040167226A1 (en) | 2002-12-16 | 2004-08-26 | Serafini Tito A. | Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same |
JP2008544982A (ja) * | 2005-06-29 | 2008-12-11 | アストラゼネカ・アクチエボラーグ | アルファ7ニコチン性受容体調節剤としてのチオフェン−2−カルボキサミド誘導体 |
WO2009118596A2 (en) | 2008-03-26 | 2009-10-01 | Glenmark Pharmaceuticals, S. A. | Phthalimide derivatives as trpa1 modulators |
WO2009144548A1 (en) | 2008-05-28 | 2009-12-03 | Glenmark Pharmaceuticals S.A. | Imidazo [2,1-b] purine derivatives as trpa1 modulators |
US20110124666A1 (en) | 2008-06-02 | 2011-05-26 | Janssen Pharmaceutica NV a corporation | 3,4-dihydropyrimidine trpa1 antagonists |
WO2010004390A1 (en) | 2008-06-17 | 2010-01-14 | Glenmark Pharmaceuticals, S.A. | Quinazoline dione derivatives as trpa1 modulators |
TW201026700A (en) | 2008-12-22 | 2010-07-16 | Hydra Biosciences Inc | Compositions useful for treating disorders related to TRPA1 |
KR20110132575A (ko) | 2009-03-23 | 2011-12-08 | 그렌마크 파머수티칼스 에스. 아. | Trpa1 조절자로서 융합된 피리미딘디온 유도체 |
SI2411395T1 (sl) | 2009-03-23 | 2013-07-31 | Glenmark Pharmaceuticals S.A. | Furopirimidindionski derivati kot TRPA1 modulatorji |
KR20120001746A (ko) | 2009-03-23 | 2012-01-04 | 그렌마크 파머수티칼스 에스. 아. | Trpa1 조절자로서 이소티아졸로-피리미딘디온 유도체 |
WO2010125469A1 (en) | 2009-04-29 | 2010-11-04 | Glenmark Pharmaceuticals, S.A. | Pyrimidinedione-fused heterocyclic compounds as trpa1 modulators |
WO2010132838A1 (en) | 2009-05-14 | 2010-11-18 | Hydra Biosciences, Inc. | Compounds useful for treating disorders related to trpa1 |
WO2010138879A1 (en) | 2009-05-29 | 2010-12-02 | Hydra Biosciences, Inc. | Compounds useful for treating disorders related to trpa1 |
US8614201B2 (en) | 2009-06-05 | 2013-12-24 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of TRPA1 |
WO2011043954A1 (en) | 2009-10-07 | 2011-04-14 | Merck Sharp & Dohme Corp. | Novel trpa1 antagonists |
WO2011114184A1 (en) | 2010-03-15 | 2011-09-22 | Glenmark Pharmaceuticals S.A. | Amides of heterocyclic compounds as trpa1 inhibitors |
WO2011132017A1 (en) | 2010-04-19 | 2011-10-27 | Glenmark Pharmaceuticals S.A. | Pyrido[3,4-d]pyrimidinyl acetamide derivatives as trpa1 modulators |
MY159059A (en) | 2010-12-20 | 2016-12-15 | Glenmark Pharmaceuticals Sa | 2-amino-4-arylthiazole compounds as trpa1 antagonists |
TW201620877A (zh) * | 2014-03-28 | 2016-06-16 | 奧利安公司 | 新的醫藥化合物 |
TW201620876A (zh) * | 2014-03-28 | 2016-06-16 | 奧利安公司 | 新的醫藥化合物 |
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2013
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- 2013-09-30 JP JP2015533645A patent/JP6226991B2/ja not_active Expired - Fee Related
- 2013-09-30 BR BR112015007422-7A patent/BR112015007422B1/pt not_active IP Right Cessation
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- 2013-09-30 TW TW102135240A patent/TWI603948B/zh not_active IP Right Cessation
- 2013-09-30 MY MYPI2015701008A patent/MY187910A/en unknown
- 2013-09-30 ES ES13779617.3T patent/ES2624873T3/es active Active
- 2013-09-30 AU AU2013326429A patent/AU2013326429B2/en not_active Ceased
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- 2013-09-30 CA CA2884922A patent/CA2884922C/en not_active Expired - Fee Related
- 2013-09-30 ME MEP-2017-101A patent/ME02745B/me unknown
- 2013-09-30 MX MX2015004247A patent/MX363565B/es unknown
- 2013-09-30 US US14/674,940 patent/US9533952B2/en active Active
- 2013-09-30 NZ NZ706989A patent/NZ706989A/en not_active IP Right Cessation
- 2013-09-30 WO PCT/FI2013/000034 patent/WO2014053694A1/en active Application Filing
- 2013-09-30 PL PL13779617T patent/PL2903965T3/pl unknown
- 2013-09-30 PE PE2015000449A patent/PE20150598A1/es active IP Right Grant
- 2013-09-30 HU HUE13779617A patent/HUE034362T2/en unknown
- 2013-09-30 AR ARP130103538A patent/AR092749A1/es active IP Right Grant
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- 2013-09-30 EA EA201590688A patent/EA026942B1/ru not_active IP Right Cessation
- 2013-09-30 CN CN201380062519.6A patent/CN104822653B/zh not_active Expired - Fee Related
- 2013-09-30 KR KR1020157011603A patent/KR102164756B1/ko active IP Right Grant
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2015
- 2015-03-16 IL IL237784A patent/IL237784A/en active IP Right Grant
- 2015-03-26 SA SA515360195A patent/SA515360195B1/ar unknown
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- 2015-04-01 CL CL2015000818A patent/CL2015000818A1/es unknown
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2016
- 2016-01-26 HK HK16100863.6A patent/HK1212965A1/zh not_active IP Right Cessation
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2017
- 2017-05-31 HR HRP20170828TT patent/HRP20170828T1/hr unknown
- 2017-05-31 CY CY20171100576T patent/CY1119022T1/el unknown
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