CL2015000563A1 - Rendimiento loci fad2 y correspondiente ubicación especifica de proteínas aglutinadoras capaces de conducir quiebres dirigidos. - Google Patents
Rendimiento loci fad2 y correspondiente ubicación especifica de proteínas aglutinadoras capaces de conducir quiebres dirigidos.Info
- Publication number
- CL2015000563A1 CL2015000563A1 CL2015000563A CL2015000563A CL2015000563A1 CL 2015000563 A1 CL2015000563 A1 CL 2015000563A1 CL 2015000563 A CL2015000563 A CL 2015000563A CL 2015000563 A CL2015000563 A CL 2015000563A CL 2015000563 A1 CL2015000563 A1 CL 2015000563A1
- Authority
- CL
- Chile
- Prior art keywords
- fad2
- breaks
- specific location
- corresponding specific
- proteins capable
- Prior art date
Links
- 230000004523 agglutinating effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 101710163270 Nuclease Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
- A01H1/06—Processes for producing mutations, e.g. treatment with chemicals or with radiation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/822—Reducing position variability, e.g. by the use of scaffold attachment region/matrix attachment region (SAR/MAR); Use of SAR/MAR to regulate gene expression
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
- A01H5/10—Seeds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
- A01H6/54—Leguminosae or Fabaceae, e.g. soybean, alfalfa or peanut
- A01H6/542—Glycine max [soybean]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
- C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261697886P | 2012-09-07 | 2012-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2015000563A1 true CL2015000563A1 (es) | 2015-10-02 |
Family
ID=50237761
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015000563A CL2015000563A1 (es) | 2012-09-07 | 2015-03-06 | Rendimiento loci fad2 y correspondiente ubicación especifica de proteínas aglutinadoras capaces de conducir quiebres dirigidos. |
| CL2015000561A CL2015000561A1 (es) | 2012-09-07 | 2015-03-06 | Rendimiento loci fad2 y correspondiente ubicación especifica de proteínas aglutinadoras capaces de inducir quiebres dirigidos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2015000561A CL2015000561A1 (es) | 2012-09-07 | 2015-03-06 | Rendimiento loci fad2 y correspondiente ubicación especifica de proteínas aglutinadoras capaces de inducir quiebres dirigidos. |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US9963711B2 (enExample) |
| EP (4) | EP2892321B1 (enExample) |
| JP (4) | JP6704251B2 (enExample) |
| KR (2) | KR102147005B1 (enExample) |
| CN (4) | CN108610408B (enExample) |
| AR (2) | AR092481A1 (enExample) |
| AU (2) | AU2013312455B2 (enExample) |
| BR (1) | BR112015004980B1 (enExample) |
| CA (2) | CA2883846C (enExample) |
| CL (2) | CL2015000563A1 (enExample) |
| HK (2) | HK1213736A1 (enExample) |
| IL (2) | IL237536B (enExample) |
| MX (2) | MX369701B (enExample) |
| NZ (1) | NZ705742A (enExample) |
| RU (2) | RU2656159C2 (enExample) |
| TW (1) | TWI667348B (enExample) |
| UA (1) | UA118090C2 (enExample) |
| UY (3) | UY35020A (enExample) |
| WO (2) | WO2014039702A2 (enExample) |
| ZA (2) | ZA201501397B (enExample) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734621B1 (en) | 2011-07-22 | 2019-09-04 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| UA116097C2 (uk) | 2011-12-11 | 2018-02-12 | Зе Стейт Оф Ізраел, Міністрі Оф Агрікалче Енд Руерал Девелопмент, Агрікалчерал Рісьоч Організейшн, (А.Р.О.), Волкані Сентре | Спосіб модуляції провідності устячка рослини |
| GB201122458D0 (en) | 2011-12-30 | 2012-02-08 | Univ Wageningen | Modified cascade ribonucleoproteins and uses thereof |
| SI3401400T1 (sl) | 2012-05-25 | 2019-10-30 | Univ California | Postopki in sestavki za RNA usmerjeno modifikacijo tarčne DNA in za RNA usmerjeno modulacijo prepisovanja |
| BR112014031891A2 (pt) | 2012-06-19 | 2017-08-01 | Univ Minnesota | direcionamento genético nas plantas utilizando vírus de dna |
| UA119135C2 (uk) * | 2012-09-07 | 2019-05-10 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб отримання трансгенної рослини |
| UA118090C2 (uk) | 2012-09-07 | 2018-11-26 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив |
| HK1217732A1 (zh) * | 2012-09-07 | 2017-01-20 | 美国陶氏益农公司 | Fad3性能基因座及相應的能夠誘導靶向斷裂的靶位點特異性結合蛋白 |
| SG11201503059XA (en) * | 2012-10-23 | 2015-06-29 | Toolgen Inc | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| US20140120578A1 (en) | 2012-11-01 | 2014-05-01 | Medicago Inc. | Plants for production of therapeutic proteins |
| EP3138911B1 (en) | 2012-12-06 | 2018-12-05 | Sigma Aldrich Co. LLC | Crispr-based genome modification and regulation |
| EP2934097B1 (en) | 2012-12-21 | 2018-05-02 | Cellectis | Potatoes with reduced cold-induced sweetening |
| US20140315985A1 (en) | 2013-03-14 | 2014-10-23 | Caribou Biosciences, Inc. | Compositions and methods of nucleic acid-targeting nucleic acids |
| CN105246324B (zh) * | 2013-03-15 | 2018-08-28 | 塞尔克蒂斯股份有限公司 | 通过靶向敲除fad2-1a/1b基因来改良大豆油成分 |
| US10113162B2 (en) | 2013-03-15 | 2018-10-30 | Cellectis | Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| CA2930015A1 (en) | 2013-11-07 | 2015-05-14 | Editas Medicine, Inc. | Crispr-related methods and compositions with governing grnas |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| EP3158072B1 (en) | 2014-06-20 | 2021-01-13 | Cellectis | Potatoes with reduced granule-bound starch synthase |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| EP3186376B1 (en) | 2014-08-27 | 2019-03-20 | Caribou Biosciences, Inc. | Methods for increasing cas9-mediated engineering efficiency |
| CN107250148B (zh) | 2014-12-03 | 2021-04-16 | 安捷伦科技有限公司 | 具有化学修饰的指导rna |
| CN107406842B (zh) * | 2015-01-09 | 2021-05-11 | 生物辐射实验室股份有限公司 | 检测基因组编辑 |
| WO2016164356A1 (en) | 2015-04-06 | 2016-10-13 | The Board Of Trustees Of The Leland Stanford Junior University | Chemically modified guide rnas for crispr/cas-mediated gene regulation |
| WO2016174119A1 (en) * | 2015-04-28 | 2016-11-03 | Bayer Cropscience Nv | Brassica plants with modified seed oil composition |
| US10837024B2 (en) | 2015-09-17 | 2020-11-17 | Cellectis | Modifying messenger RNA stability in plant transformations |
| IL258821B (en) | 2015-10-23 | 2022-07-01 | Harvard College | Nucleobase editors and their uses |
| EP4646936A3 (en) | 2016-02-02 | 2025-11-19 | Cellectis | Modifying soybean oil composition through targeted knockout of the fad3a/b/c genes |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| DK3472325T3 (da) * | 2016-06-20 | 2024-05-21 | Keygene Nv | Fremgangsmåde til målrettet DNA-ændring i planteceller |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CA3033327A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CA3035229A1 (en) * | 2016-09-02 | 2018-03-08 | North Carolina State University | Methods and compositions for modification of plastid genomes |
| JP7588390B2 (ja) | 2016-10-14 | 2024-11-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸塩基エディターのaav送達 |
| WO2018081978A1 (zh) * | 2016-11-03 | 2018-05-11 | 深圳华大基因研究院 | 提高基因编辑效率的方法和系统 |
| CA3042857A1 (en) | 2016-11-16 | 2018-05-24 | Cellectis | Methods for altering amino acid content in plants through frameshift mutations |
| AU2017379402B2 (en) * | 2016-12-22 | 2022-03-10 | Toolgen Incorporated | Oleic acid-enriched plant body having genetically modified FAD2 and production method therefor |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| BR112019019655A2 (pt) | 2017-03-23 | 2020-04-22 | Harvard College | editores de nucleobase que compreendem proteínas de ligação a dna programáveis por ácido nucleico |
| HUE067206T2 (hu) | 2017-04-25 | 2024-10-28 | Cellectis | Csökkent ligninösszetételû lucerna |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CN107217070A (zh) * | 2017-05-22 | 2017-09-29 | 广东省农业科学院作物研究所 | 一种基于TALENs基因编辑花生育种方法 |
| JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物 |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| CN107502621B (zh) * | 2017-09-22 | 2021-04-13 | 福建农林大学 | 一种快速检测体内dna末端连接的方法 |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US11390876B2 (en) * | 2018-03-09 | 2022-07-19 | Pioneer Hi-Bred International, Inc. | Compositions and methods for modification of fatty acids in soybean |
| US20210010013A1 (en) | 2018-04-04 | 2021-01-14 | Cibus Us Llc | Fad2 genes and mutations |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| AU2019277388A1 (en) * | 2018-06-01 | 2020-12-03 | Pioneer Hi-Bred International, Inc. | Systems and methods for editing brassica genome |
| EP3836786A1 (en) | 2018-08-17 | 2021-06-23 | AMSilk GmbH | Use of a structural polypeptide for plant coating |
| CN109182373B (zh) * | 2018-09-18 | 2020-10-09 | 武汉市农业科学院 | 一种利用基因编辑技术获得高油酸油菜的方法 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| AU2019369418A1 (en) * | 2018-10-31 | 2021-03-18 | Pioneer Hi-Bred International, Inc. | Compositions and methods for Ochrobactrum-mediated gene editing |
| US20220007607A1 (en) * | 2018-11-05 | 2022-01-13 | University Of Tennessee Research Foundation | High throughput protoplast isolation and transformation of plant cells from a novel leaf-based cell culture-derived system |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| EP3942042A1 (en) | 2019-03-19 | 2022-01-26 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| CN110004173B (zh) * | 2019-04-08 | 2023-03-14 | 天津吉诺沃生物科技有限公司 | 一种获得非转基因耐储存鲜食枸杞的方法 |
| EP3956349A1 (en) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| WO2021226558A1 (en) | 2020-05-08 | 2021-11-11 | The Broad Institute, Inc. | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| US11884915B2 (en) | 2021-09-10 | 2024-01-30 | Agilent Technologies, Inc. | Guide RNAs with chemical modification for prime editing |
| EP4482855A1 (en) * | 2022-02-22 | 2025-01-01 | Peter Biotherapeutics, Inc. | Technologies for genetic modification |
Family Cites Families (171)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US789538A (en) | 1904-11-11 | 1905-05-09 | Colin E Ham | Dumb-bell. |
| US1173508A (en) | 1913-10-27 | 1916-02-29 | Oscar F Heartwell Jr | Ironing-board. |
| US4178330A (en) | 1977-08-29 | 1979-12-11 | Velsicol Chemical Corporation | Haloaryl halobenzenesulfonate flame retardants |
| US4179475A (en) | 1978-05-11 | 1979-12-18 | Phillips Petroleum Company | Olefin feed in HF alkylation of isoparaffin with olefin |
| US4727028A (en) | 1981-06-22 | 1988-02-23 | Eli Lilly And Company | Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transformants thereof |
| US4693977A (en) | 1982-08-23 | 1987-09-15 | Queen's University At Kingston | Enzyme immobilization for producing cephalosporin antibiotics |
| US4536475A (en) | 1982-10-05 | 1985-08-20 | Phytogen | Plant vector |
| US4535060A (en) | 1983-01-05 | 1985-08-13 | Calgene, Inc. | Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthetase, production and use |
| US5352605A (en) | 1983-01-17 | 1994-10-04 | Monsanto Company | Chimeric genes for transforming plant cells using viral promoters |
| NL8300698A (nl) | 1983-02-24 | 1984-09-17 | Univ Leiden | Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten. |
| NZ207765A (en) | 1983-04-15 | 1987-03-06 | Lubrizol Genetics Inc | Plant expression of transferred dna(t-dna)from plasmids associated with agrobacterium sp |
| US5428147A (en) | 1983-04-15 | 1995-06-27 | Mycogen Plant Science, Inc. | Octopine T-DNA promoters |
| US5447858A (en) | 1984-04-13 | 1995-09-05 | Mycogen Plant Sciences, Inc. | Heat shock promoter and gene |
| US5420034A (en) | 1986-07-31 | 1995-05-30 | Calgene, Inc. | Seed-specific transcriptional regulation |
| US5753475A (en) | 1985-01-17 | 1998-05-19 | Calgene, Inc. | Methods and compositions for regulated transcription and expression of heterologous genes |
| US4943674A (en) | 1987-05-26 | 1990-07-24 | Calgene, Inc. | Fruit specific transcriptional factors |
| US4886937A (en) | 1985-05-20 | 1989-12-12 | North Carolina State University | Method for transforming pine |
| US4940835A (en) | 1985-10-29 | 1990-07-10 | Monsanto Company | Glyphosate-resistant plants |
| US4810648A (en) | 1986-01-08 | 1989-03-07 | Rhone Poulenc Agrochimie | Haloarylnitrile degrading gene, its use, and cells containing the gene |
| ATE57390T1 (de) | 1986-03-11 | 1990-10-15 | Plant Genetic Systems Nv | Durch gentechnologie erhaltene und gegen glutaminsynthetase-inhibitoren resistente pflanzenzellen. |
| US4975374A (en) | 1986-03-18 | 1990-12-04 | The General Hospital Corporation | Expression of wild type and mutant glutamine synthetase in foreign hosts |
| US5015580A (en) | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
| DE3784860D1 (de) | 1986-12-05 | 1993-04-22 | Ciba Geigy Ag | Verbessertes verfahren zur transformation von pflanzlichen protoplasten. |
| US5322938A (en) | 1987-01-13 | 1994-06-21 | Monsanto Company | DNA sequence for enhancing the efficiency of transcription |
| US5359142A (en) | 1987-01-13 | 1994-10-25 | Monsanto Company | Method for enhanced expression of a protein |
| EP0333033A1 (en) | 1988-03-09 | 1989-09-20 | Meiji Seika Kaisha Ltd. | Glutamine synthesis gene and glutamine synthetase |
| US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US5501967A (en) | 1989-07-26 | 1996-03-26 | Mogen International, N.V./Rijksuniversiteit Te Leiden | Process for the site-directed integration of DNA into the genome of plants |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US6051753A (en) | 1989-09-07 | 2000-04-18 | Calgene, Inc. | Figwort mosaic virus promoter and uses |
| ES2150900T3 (es) | 1989-10-31 | 2000-12-16 | Monsanto Co | Promotor para plantas transgenicas. |
| US5641876A (en) | 1990-01-05 | 1997-06-24 | Cornell Research Foundation, Inc. | Rice actin gene and promoter |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| JP3209744B2 (ja) | 1990-01-22 | 2001-09-17 | デカルブ・ジェネティクス・コーポレーション | 結実能力のある遺伝子変換コーン |
| US6403865B1 (en) | 1990-08-24 | 2002-06-11 | Syngenta Investment Corp. | Method of producing transgenic maize using direct transformation of commercially important genotypes |
| US5633435A (en) | 1990-08-31 | 1997-05-27 | Monsanto Company | Glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthases |
| US5266317A (en) | 1990-10-04 | 1993-11-30 | University Of Georgia Research Foundation, Inc. | Insect-specific paralytic neurotoxin genes for use in biological insect control: methods and compositions |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| GB9104617D0 (en) | 1991-03-05 | 1991-04-17 | Nickerson Int Seed | Pest control |
| GB9115909D0 (en) | 1991-07-23 | 1991-09-04 | Nickerson Int Seed | Recombinant dna |
| DK39692D0 (da) | 1992-03-25 | 1992-03-25 | Danisco | Biologisk materiale |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5356802A (en) | 1992-04-03 | 1994-10-18 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease |
| US5487994A (en) | 1992-04-03 | 1996-01-30 | The Johns Hopkins University | Insertion and deletion mutants of FokI restriction endonuclease |
| US5591616A (en) | 1992-07-07 | 1997-01-07 | Japan Tobacco, Inc. | Method for transforming monocotyledons |
| WO1994002620A2 (en) | 1992-07-27 | 1994-02-03 | Pioneer Hi-Bred International, Inc. | An improved method of agrobacterium-mediated transformation of cultured soybean cells |
| US5607914A (en) | 1993-01-13 | 1997-03-04 | Pioneer Hi-Bred International, Inc. | Synthetic antimicrobial peptides |
| US6118047A (en) | 1993-08-25 | 2000-09-12 | Dekalb Genetic Corporation | Anthranilate synthase gene and method of use thereof for conferring tryptophan overproduction |
| US5362865A (en) | 1993-09-02 | 1994-11-08 | Monsanto Company | Enhanced expression in plants using non-translated leader sequences |
| US5580852A (en) | 1993-12-17 | 1996-12-03 | Pioneer Hi-Bred International, Inc. | Derivatives of tachyplesin having inhibitory activity towards plant pathogenic fungi |
| CA2681922C (en) | 1994-01-18 | 2012-05-15 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| JP4118327B2 (ja) | 1994-08-20 | 2008-07-16 | ゲンダック・リミテッド | Dna認識のための結合タンパク質におけるまたはそれに関連する改良 |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5994627A (en) | 1995-03-31 | 1999-11-30 | Common Wealth Scientific And Industrial Research Organisation | Genetic sequences conferring nematode resistance in plants and uses therefor |
| US5639463A (en) | 1995-05-23 | 1997-06-17 | The Mennen Company | Clear cosmetic stick composition |
| AU750363B2 (en) | 1997-06-12 | 2002-07-18 | Cargill Incorporated | Fatty acid desaturases and mutant sequences thereof |
| US5693512A (en) | 1996-03-01 | 1997-12-02 | The Ohio State Research Foundation | Method for transforming plant tissue by sonication |
| US5850019A (en) | 1996-08-06 | 1998-12-15 | University Of Kentucky Research Foundation | Promoter (FLt) for the full-length transcript of peanut chlorotic streak caulimovirus (PCLSV) and expression of chimeric genes in plants |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| CA2236770A1 (en) | 1996-09-05 | 1998-03-12 | Unilever Plc | Salt-inducible promoter derivable from a lactic acid bacterium, and its use in a lactic acid bacterium for production of a desired protein |
| WO1998027878A1 (en) | 1996-12-20 | 1998-07-02 | Fundação E.J. Zerbini | A prosthesis for thoracostomy and method for its implantation |
| CA2275491A1 (en) | 1997-01-20 | 1998-07-23 | Plant Genetic Systems, N.V. | Pathogen-induced plant promoters |
| US5981840A (en) | 1997-01-24 | 1999-11-09 | Pioneer Hi-Bred International, Inc. | Methods for agrobacterium-mediated transformation |
| GB2338237B (en) | 1997-02-18 | 2001-02-28 | Actinova Ltd | In vitro peptide or protein expression library |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| US5922564A (en) | 1997-02-24 | 1999-07-13 | Performance Plants, Inc. | Phosphate-deficiency inducible promoter |
| US5925521A (en) | 1997-03-31 | 1999-07-20 | Incyte Pharmaceuticals, Inc. | Human serine carboxypeptidase |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US6087166A (en) | 1997-07-03 | 2000-07-11 | Basf Aktiengesellschaft | Transcriptional activators with graded transactivation potential |
| US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
| KR20010041129A (ko) | 1998-02-20 | 2001-05-15 | 돈 리사 로얄 | 화분 특이적 프로모터 |
| WO1999043797A2 (en) | 1998-02-26 | 1999-09-02 | Pioneer Hi-Bred International, Inc. | Constitutive maize promoters |
| EP1056862A1 (en) | 1998-02-26 | 2000-12-06 | Pioneer Hi-Bred International, Inc. | Family of maize pr-1 genes and promoters |
| ATE466952T1 (de) | 1998-03-02 | 2010-05-15 | Massachusetts Inst Technology | Poly-zinkfinger-proteine mit verbesserten linkern |
| US6635806B1 (en) | 1998-05-14 | 2003-10-21 | Dekalb Genetics Corporation | Methods and compositions for expression of transgenes in plants |
| US6307123B1 (en) | 1998-05-18 | 2001-10-23 | Dekalb Genetics Corporation | Methods and compositions for transgene identification |
| US6140815A (en) | 1998-06-17 | 2000-10-31 | Dover Instrument Corporation | High stability spin stand platform |
| JP2000083680A (ja) | 1998-07-16 | 2000-03-28 | Nippon Paper Industries Co Ltd | 光誘導型プロモ―タ―の制御下に置かれた不定芽再分化遺伝子を選抜マ―カ―遺伝子とする植物への遺伝子導入方法及びこれに用いる植物への遺伝子導入用ベクタ― |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US7070934B2 (en) | 1999-01-12 | 2006-07-04 | Sangamo Biosciences, Inc. | Ligand-controlled regulation of endogenous gene expression |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| WO2000042207A2 (en) | 1999-01-14 | 2000-07-20 | Monsanto Technology Llc | Soybean transformation method |
| US7030215B2 (en) | 1999-03-24 | 2006-04-18 | Sangamo Biosciences, Inc. | Position dependent recognition of GNN nucleotide triplets by zinc fingers |
| US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| US6429357B1 (en) | 1999-05-14 | 2002-08-06 | Dekalb Genetics Corp. | Rice actin 2 promoter and intron and methods for use thereof |
| US6194636B1 (en) | 1999-05-14 | 2001-02-27 | Dekalb Genetics Corp. | Maize RS324 promoter and methods for use thereof |
| US6207879B1 (en) | 1999-05-14 | 2001-03-27 | Dekalb Genetics Corporation | Maize RS81 promoter and methods for use thereof |
| US6232526B1 (en) | 1999-05-14 | 2001-05-15 | Dekalb Genetics Corp. | Maize A3 promoter and methods for use thereof |
| US6677503B1 (en) | 1999-06-23 | 2004-01-13 | Pioneer Hi-Bred International, Inc. | Sunflower anti-pathogene proteins and genes and their uses |
| DE60023936T2 (de) | 1999-12-06 | 2006-05-24 | Sangamo Biosciences Inc., Richmond | Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen |
| AU3289601A (en) | 2000-01-21 | 2001-07-31 | Pioneer Hi-Bred International, Inc. | Novel root-preferred promoter elements and methods of use |
| US6689558B2 (en) | 2000-02-08 | 2004-02-10 | Sangamo Biosciences, Inc. | Cells for drug discovery |
| US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| US6388170B1 (en) | 2000-04-07 | 2002-05-14 | University Of Kentucky Research Foundation | Bidirectional promoters and methods related thereto |
| US20030044787A1 (en) | 2000-05-16 | 2003-03-06 | Joung J. Keith | Methods and compositions for interaction trap assays |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| US6586251B2 (en) * | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| US7022826B2 (en) | 2001-02-26 | 2006-04-04 | The Regents Of The University Of California | Non-oligomerizing fluorescent proteins |
| GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
| US20040224385A1 (en) | 2001-08-20 | 2004-11-11 | Barbas Carlos F | Zinc finger binding domains for cnn |
| AU2003235589A1 (en) * | 2002-01-14 | 2003-07-30 | Brookhaven Science Associates, Llc | Modified fatty acid hydroxylase protein and genes |
| US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
| EP1476547B1 (en) * | 2002-01-23 | 2006-12-06 | The University of Utah Research Foundation | Targeted chromosomal mutagenesis using zinc finger nucleases |
| AR039113A1 (es) | 2002-03-21 | 2005-02-09 | Monsanto Technology Llc | Construcciones de acidos nucleicos y metodos para producir composiciones de aceites de semillas alteradas |
| AU2003218382B2 (en) | 2002-03-21 | 2007-12-13 | Sangamo Therapeutics, Inc. | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| US7361635B2 (en) | 2002-08-29 | 2008-04-22 | Sangamo Biosciences, Inc. | Simultaneous modulation of multiple genes |
| EP1581610A4 (en) | 2002-09-05 | 2009-05-27 | California Inst Of Techn | USE OF CHIMERIC NUCLEASES TO STIMULATE GEN-TARGETING |
| AU2003304087A1 (en) * | 2002-10-23 | 2004-11-26 | The General Hospital Corporation | Methods for producing zinc finger proteins that bind to extended dna target sequences |
| WO2004070035A2 (en) * | 2003-02-03 | 2004-08-19 | Sungene Gmbh & Co. Kgaa | Method for increasing efficiency of homologous recombination in plants |
| EP2457922A1 (en) | 2003-02-11 | 2012-05-30 | Dow AgroSciences, LLC | Altered FAD2 and FAD3 genes in brassica and the molecular marker-assisted detection thereof |
| EP1620557A2 (en) | 2003-04-29 | 2006-02-01 | Pioneer Hi-Bred International, Inc. | Novel glyphosate-n-acetyltransferase (gat) genes |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| WO2005028620A2 (en) | 2003-09-16 | 2005-03-31 | The Rockefeller University | Histone modifications as binary switches controlling gene expression |
| AU2004274957B2 (en) | 2003-09-19 | 2009-02-05 | Sangamo Therapeutics, Inc. | Engineered zinc finger proteins for regulation of gene expression |
| KR100537955B1 (ko) | 2003-10-29 | 2005-12-20 | 학교법인고려중앙학원 | 꽃가루 특이적 유전자 발현 프로모터 |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| DE602005011943D1 (de) | 2004-04-08 | 2009-02-05 | Sangamo Biosciences Inc | Zusammensetzungen zur behandlung von neuropathischen und neurodegenerativen erkrankungen |
| AU2005233550B2 (en) | 2004-04-08 | 2010-11-18 | Sangamo Therapeutics, Inc. | Treatment of neuropathic pain with zinc finger proteins |
| ES2406809T5 (es) | 2004-04-30 | 2017-09-20 | Dow Agrosciences, Llc | Nuevos genes de resistencia a los herbicidas |
| CA2592335A1 (en) * | 2005-01-28 | 2006-08-03 | Bayer Bioscience N.V. | Brassica plant comprising a mutant fatty acid desaturase |
| EP1877583A2 (en) | 2005-05-05 | 2008-01-16 | Arizona Board of Regents on behalf of the Unversity of Arizona | Sequence enabled reassembly (seer) - a novel method for visualizing specific dna sequences |
| WO2007014275A2 (en) | 2005-07-26 | 2007-02-01 | Sangamo Biosciences, Inc. | Targeted integration and expression of exogenous nucleic acid sequences |
| DK1947926T3 (en) | 2005-10-28 | 2015-01-26 | Dow Agrosciences Llc | new herbicide resistant genes |
| EP1806398A1 (en) | 2006-01-04 | 2007-07-11 | Monsanto S.A.S. | Fad-2 mutants and high oleic plants |
| JP5266210B2 (ja) | 2006-05-25 | 2013-08-21 | サンガモ バイオサイエンシズ インコーポレイテッド | 改変開裂ハーフドメイン |
| EP1862551A1 (en) * | 2006-05-29 | 2007-12-05 | Institut National De La Recherche Agronomique (Inra) | Genetic markers for high oleic acid content in plants |
| US9428756B2 (en) | 2006-08-11 | 2016-08-30 | Dow Agrosciences Llc | Zinc finger nuclease-mediated homologous recombination |
| MX2009006303A (es) | 2006-12-14 | 2009-10-21 | Dow Agrosciences Llc | Proteinas de dedo de zinc no canonicas optimizadas. |
| EP1944375A1 (en) | 2007-01-11 | 2008-07-16 | Monsanto S.A.S. | FAD2 mutants and high oleic acid plants |
| EP2171052B1 (en) | 2007-07-12 | 2014-08-27 | Sangamo BioSciences, Inc. | Methods and compositions for inactivating alpha 1,6 fucosyltransferase (fut 8) gene expression |
| HRP20161004T1 (hr) | 2007-09-27 | 2016-10-21 | Dow Agrosciences Llc | Tehnološki konstruirani proteini cinkovi prsti koji imaju kao cilj gene za sintazu 5-enolpiruvilshikimat-3-fosfata |
| US9506120B2 (en) | 2007-09-27 | 2016-11-29 | Sangamo Biosciences, Inc. | Rapid in vivo identification of biologically active nucleases |
| US8936936B2 (en) | 2007-10-25 | 2015-01-20 | Sangamo Biosciences, Inc. | Methods and compositions for targeted integration |
| US9418219B2 (en) | 2008-04-11 | 2016-08-16 | Microsoft Technology Licensing, Llc | Inter-process message security |
| EP2281050B1 (en) | 2008-04-14 | 2014-04-02 | Sangamo BioSciences, Inc. | Linear donor constructs for targeted integration |
| AU2009241351A1 (en) * | 2008-04-28 | 2009-11-05 | Precision Biosciences, Inc. | Fusion molecules of rationally-designed DNA-binding proteins and effector domains |
| CA2734235C (en) | 2008-08-22 | 2019-03-26 | Sangamo Biosciences, Inc. | Methods and compositions for targeted single-stranded cleavage and targeted integration |
| EP2370575B1 (en) | 2008-12-17 | 2017-11-01 | Dow AgroSciences LLC | Targeted integration into the zp15 locus |
| US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| BRPI1015426A2 (pt) * | 2009-06-22 | 2016-06-28 | Univ Saga | planta de soja não-modificada geneticamente, composição farmacêutica, produto alimentício, ou ração, óleo de soja, combustível, métodos para fabricar e para selecionar uma planta de soja não-modificada geneticamente, e para produzir óleo de soja, oligonucleotídeo, microconjunto, e, kit. |
| US9035129B2 (en) | 2009-07-08 | 2015-05-19 | The Curators Of The University Of Missouri | Method to develop high oleic acid soybeans using conventional soybean breeding techniques |
| KR20120038020A (ko) | 2009-08-11 | 2012-04-20 | 상가모 바이오사이언스 인코포레이티드 | 표적화 변형에 대한 동형접합성 유기체 |
| US10340778B2 (en) | 2009-10-19 | 2019-07-02 | Qm Power, Inc. | Parallel magnetic circuit motor |
| KR101813981B1 (ko) | 2009-10-22 | 2018-01-04 | 다우 아그로사이언시즈 엘엘씨 | 지방산 생합성에 포함된 식물 유전자를 표적하는 조작된 징크 핑거 단백질 |
| NO2510096T3 (enExample) | 2009-12-10 | 2015-03-21 | ||
| JP5902631B2 (ja) | 2010-01-22 | 2016-04-13 | ダウ アグロサイエンシィズ エルエルシー | 標的化ゲノム変更 |
| WO2011091317A2 (en) | 2010-01-22 | 2011-07-28 | Dow Agrosciences Llc | Engineered landing pads for gene targeting in plants |
| CA2788560A1 (en) | 2010-02-08 | 2011-08-11 | Sangamo Biosciences, Inc. | Engineered cleavage half-domains |
| WO2011100058A1 (en) | 2010-02-09 | 2011-08-18 | Sangamo Biosciences, Inc. | Targeted genomic modification with partially single-stranded donor molecules |
| CN103025344B (zh) | 2010-05-17 | 2016-06-29 | 桑格摩生物科学股份有限公司 | 新型dna-结合蛋白及其用途 |
| CA2799750A1 (en) | 2010-05-17 | 2011-11-24 | The Uab Research Foundation | A general mass spectrometry assay using continuously eluting co-fractionating reporters of mass spectrometry detection efficiency |
| JP5996527B2 (ja) | 2010-05-28 | 2016-09-21 | テラヴィア ホールディングス, インコーポレイテッド | 用途に応じた油を含む食品成分 |
| CA2863201A1 (en) | 2012-02-01 | 2013-08-08 | Dow Agrosciences Llc | Glyphosate resistant plants and associated methods |
| CA2871524C (en) | 2012-05-07 | 2021-07-27 | Sangamo Biosciences, Inc. | Methods and compositions for nuclease-mediated targeted integration of transgenes |
| US8897552B2 (en) * | 2012-08-01 | 2014-11-25 | Microsoft Corporation | Setting an operating-system color using a photograph |
| EP3447958B1 (en) * | 2012-08-03 | 2020-06-17 | Telefonaktiebolaget LM Ericsson (publ) | Epdcch search space design |
| UA118090C2 (uk) * | 2012-09-07 | 2018-11-26 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив |
| CN105246324B (zh) * | 2013-03-15 | 2018-08-28 | 塞尔克蒂斯股份有限公司 | 通过靶向敲除fad2-1a/1b基因来改良大豆油成分 |
| US9417070B1 (en) | 2013-04-01 | 2016-08-16 | Nextgen Aerosciences, Inc. | Systems and methods for continuous replanning of vehicle trajectories |
| JP5937635B2 (ja) | 2014-03-28 | 2016-06-22 | ファナック株式会社 | 電磁接触器の溶着検出機能を有するモータ駆動装置 |
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