CL2014002979A1 - Una composicion farmaceutica para administracion sublingual que comprende una mezcla de a) microparticulas de alfentanilo, presentandose en las superficies de particulas vehiculo mas grandes, b) una base debil soluble en agua, y c) un compuesto acido debil en mezcla intima con las microparticulas de alfentanilo; su procedimiento de preparacion; y su uso para el tratamiento del dolor. - Google Patents

Una composicion farmaceutica para administracion sublingual que comprende una mezcla de a) microparticulas de alfentanilo, presentandose en las superficies de particulas vehiculo mas grandes, b) una base debil soluble en agua, y c) un compuesto acido debil en mezcla intima con las microparticulas de alfentanilo; su procedimiento de preparacion; y su uso para el tratamiento del dolor.

Info

Publication number
CL2014002979A1
CL2014002979A1 CL2014002979A CL2014002979A CL2014002979A1 CL 2014002979 A1 CL2014002979 A1 CL 2014002979A1 CL 2014002979 A CL2014002979 A CL 2014002979A CL 2014002979 A CL2014002979 A CL 2014002979A CL 2014002979 A1 CL2014002979 A1 CL 2014002979A1
Authority
CL
Chile
Prior art keywords
alfentanil
microparticles
weak
pain
presenting
Prior art date
Application number
CL2014002979A
Other languages
English (en)
Spanish (es)
Inventor
Anders Pettersson
Emil Schwan
Barbro Johansson
Original Assignee
Orexo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48577134&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014002979(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1207701.2A external-priority patent/GB201207701D0/en
Priority claimed from GBGB1221130.6A external-priority patent/GB201221130D0/en
Application filed by Orexo Ab filed Critical Orexo Ab
Publication of CL2014002979A1 publication Critical patent/CL2014002979A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CL2014002979A 2012-05-02 2014-11-03 Una composicion farmaceutica para administracion sublingual que comprende una mezcla de a) microparticulas de alfentanilo, presentandose en las superficies de particulas vehiculo mas grandes, b) una base debil soluble en agua, y c) un compuesto acido debil en mezcla intima con las microparticulas de alfentanilo; su procedimiento de preparacion; y su uso para el tratamiento del dolor. CL2014002979A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1207701.2A GB201207701D0 (en) 2012-05-02 2012-05-02 New pharmaceutical composition
GBGB1221130.6A GB201221130D0 (en) 2012-11-23 2012-11-23 New pharmaceutical composition

Publications (1)

Publication Number Publication Date
CL2014002979A1 true CL2014002979A1 (es) 2014-12-05

Family

ID=48577134

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014002979A CL2014002979A1 (es) 2012-05-02 2014-11-03 Una composicion farmaceutica para administracion sublingual que comprende una mezcla de a) microparticulas de alfentanilo, presentandose en las superficies de particulas vehiculo mas grandes, b) una base debil soluble en agua, y c) un compuesto acido debil en mezcla intima con las microparticulas de alfentanilo; su procedimiento de preparacion; y su uso para el tratamiento del dolor.

Country Status (33)

Country Link
US (4) US8815911B2 (en:Method)
EP (2) EP2849730B1 (en:Method)
JP (1) JP6275696B2 (en:Method)
KR (1) KR20150005695A (en:Method)
CN (1) CN104427978B (en:Method)
AU (1) AU2013255640B2 (en:Method)
BR (1) BR112014027213A8 (en:Method)
CA (1) CA2871805A1 (en:Method)
CL (1) CL2014002979A1 (en:Method)
CO (1) CO7170181A2 (en:Method)
CY (2) CY1118570T1 (en:Method)
DK (2) DK3150199T3 (en:Method)
EA (1) EA028110B1 (en:Method)
ES (2) ES2694644T3 (en:Method)
HR (2) HRP20161634T1 (en:Method)
HU (1) HUE031792T2 (en:Method)
IL (1) IL235272B (en:Method)
IN (1) IN2014MN02156A (en:Method)
LT (2) LT2849730T (en:Method)
ME (1) ME02644B (en:Method)
MX (1) MX360665B (en:Method)
NZ (1) NZ701428A (en:Method)
PE (1) PE20142444A1 (en:Method)
PH (1) PH12014502407A1 (en:Method)
PL (2) PL2849730T3 (en:Method)
PT (2) PT3150199T (en:Method)
RS (2) RS57951B1 (en:Method)
SG (1) SG11201407081PA (en:Method)
SI (2) SI2849730T1 (en:Method)
SM (3) SMT201800585T1 (en:Method)
TR (1) TR201815935T4 (en:Method)
WO (1) WO2013164620A1 (en:Method)
ZA (1) ZA201407559B (en:Method)

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PT2706986E (pt) 2011-09-19 2015-07-07 Orexo Ab Nova composição farmacêutica resistente ao abuso para o tratamento da dependência de opiáceos
EP2849730B1 (en) * 2012-05-02 2016-11-09 Orexo AB New alfentanil composition for the treatment of acute pain
US10766925B2 (en) * 2016-04-11 2020-09-08 Arizona Board Of Regents On Behalf Of The University Of Arizona Opioid receptor modulators
JP7023054B2 (ja) * 2017-04-05 2022-02-21 東和薬品株式会社 レベチラセタム含有医薬組成物及びその製造方法
CN115047109B (zh) * 2022-06-17 2024-05-31 三明海关综合技术服务中心 一种检测食品中芬太尼类新精神活性物质的方法

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Also Published As

Publication number Publication date
MX2014013176A (es) 2015-01-19
HUE031792T2 (en) 2017-07-28
KR20150005695A (ko) 2015-01-14
PE20142444A1 (es) 2015-01-09
SI2849730T1 (sl) 2017-02-28
PH12014502407B1 (en) 2015-01-12
EA028110B1 (ru) 2017-10-31
US9345698B2 (en) 2016-05-24
PL3150199T3 (pl) 2019-03-29
PT3150199T (pt) 2018-11-21
EA201401200A1 (ru) 2015-02-27
BR112014027213A8 (pt) 2018-01-16
US20140005223A1 (en) 2014-01-02
WO2013164620A1 (en) 2013-11-07
JP2015515974A (ja) 2015-06-04
PT2849730T (pt) 2017-02-15
LT3150199T (lt) 2018-11-12
NZ701428A (en) 2016-10-28
US20170071927A1 (en) 2017-03-16
EP3150199A1 (en) 2017-04-05
US20150133501A1 (en) 2015-05-14
SG11201407081PA (en) 2014-11-27
EP3150199B1 (en) 2018-08-08
CN104427978B (zh) 2017-03-01
PH12014502407A1 (en) 2015-01-12
CO7170181A2 (es) 2015-01-28
BR112014027213A2 (pt) 2017-06-27
AU2013255640A1 (en) 2014-11-20
TR201815935T4 (tr) 2018-11-21
ME02644B (me) 2017-06-20
ZA201407559B (en) 2016-05-25
JP6275696B2 (ja) 2018-02-14
PL2849730T3 (pl) 2017-05-31
CY1118570T1 (el) 2017-07-12
HK1203399A1 (en) 2015-10-30
RS57951B1 (sr) 2019-01-31
ES2614757T3 (es) 2017-06-01
IL235272B (en) 2018-10-31
EP2849730B1 (en) 2016-11-09
CY1120820T1 (el) 2019-12-11
HRP20161634T1 (hr) 2017-01-13
RS55489B1 (sr) 2017-04-28
EP2849730A1 (en) 2015-03-25
LT2849730T (lt) 2016-12-27
DK2849730T3 (en) 2017-02-13
CN104427978A (zh) 2015-03-18
HRP20181761T1 (hr) 2018-12-28
SMT201700086T1 (it) 2017-03-08
CA2871805A1 (en) 2013-11-07
AU2013255640B2 (en) 2017-06-15
SI3150199T1 (sl) 2018-12-31
US20180214437A1 (en) 2018-08-02
SMT201700086B (it) 2017-03-08
MX360665B (es) 2018-11-13
SMT201800585T1 (it) 2019-01-11
US9782396B2 (en) 2017-10-10
US8815911B2 (en) 2014-08-26
IN2014MN02156A (en:Method) 2015-08-28
ES2694644T3 (es) 2018-12-26
DK3150199T3 (en) 2018-11-12

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