MX360665B - Nueva composición de alfentanilo para el tratamiento del dolor agudo. - Google Patents

Nueva composición de alfentanilo para el tratamiento del dolor agudo.

Info

Publication number
MX360665B
MX360665B MX2014013176A MX2014013176A MX360665B MX 360665 B MX360665 B MX 360665B MX 2014013176 A MX2014013176 A MX 2014013176A MX 2014013176 A MX2014013176 A MX 2014013176A MX 360665 B MX360665 B MX 360665B
Authority
MX
Mexico
Prior art keywords
treatment
alfentanil
acid
new
microparticles
Prior art date
Application number
MX2014013176A
Other languages
English (en)
Other versions
MX2014013176A (es
Inventor
Anders Pettersson
Emil Schwan
Barbro Johansson
Original Assignee
Orexo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48577134&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX360665(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1207701.2A external-priority patent/GB201207701D0/en
Priority claimed from GBGB1221130.6A external-priority patent/GB201221130D0/en
Application filed by Orexo Ab filed Critical Orexo Ab
Publication of MX2014013176A publication Critical patent/MX2014013176A/es
Publication of MX360665B publication Critical patent/MX360665B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporcionan composiciones farmacéuticas para el tratamiento del dolor, por ejemplo el dolor de corta duración, comprendiendo las composiciones una mezcla que comprende: (a) micropartículas de alfentanilo, o una sal farmacéuticamente aceptable del mismo, presentándose las micropartículas en las superficies de partículas vehículo más grandes; (b) una base débil soluble en agua; y (c) un compuesto que es un ácido débil, presentándose el ácido en mezcla íntima con las micropartículas de alfentanilo o la sal del mismo. La composición puede comprender además un disgregante. El ácido es, preferentemente, ácido cítrico.
MX2014013176A 2012-05-02 2013-05-01 Nueva composición de alfentanilo para el tratamiento del dolor agudo. MX360665B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1207701.2A GB201207701D0 (en) 2012-05-02 2012-05-02 New pharmaceutical composition
GBGB1221130.6A GB201221130D0 (en) 2012-11-23 2012-11-23 New pharmaceutical composition
PCT/GB2013/051131 WO2013164620A1 (en) 2012-05-02 2013-05-01 New alfentanil composition for the treatment of acute pain

Publications (2)

Publication Number Publication Date
MX2014013176A MX2014013176A (es) 2015-01-19
MX360665B true MX360665B (es) 2018-11-13

Family

ID=48577134

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014013176A MX360665B (es) 2012-05-02 2013-05-01 Nueva composición de alfentanilo para el tratamiento del dolor agudo.

Country Status (33)

Country Link
US (4) US8815911B2 (es)
EP (2) EP2849730B1 (es)
JP (1) JP6275696B2 (es)
KR (1) KR20150005695A (es)
CN (1) CN104427978B (es)
AU (1) AU2013255640B2 (es)
BR (1) BR112014027213A8 (es)
CA (1) CA2871805A1 (es)
CL (1) CL2014002979A1 (es)
CO (1) CO7170181A2 (es)
CY (2) CY1118570T1 (es)
DK (2) DK3150199T3 (es)
EA (1) EA028110B1 (es)
ES (2) ES2694644T3 (es)
HR (2) HRP20161634T1 (es)
HU (1) HUE031792T2 (es)
IL (1) IL235272B (es)
IN (1) IN2014MN02156A (es)
LT (2) LT2849730T (es)
ME (1) ME02644B (es)
MX (1) MX360665B (es)
NZ (1) NZ701428A (es)
PE (1) PE20142444A1 (es)
PH (1) PH12014502407B1 (es)
PL (2) PL2849730T3 (es)
PT (2) PT3150199T (es)
RS (2) RS57951B1 (es)
SG (1) SG11201407081PA (es)
SI (2) SI2849730T1 (es)
SM (3) SMT201800585T1 (es)
TR (1) TR201815935T4 (es)
WO (1) WO2013164620A1 (es)
ZA (1) ZA201407559B (es)

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MY185284A (en) 2011-09-19 2021-04-30 Orexo Ab New abuse-resistant pharmaceutical composition for the treatment of opioid dependence
KR20150005695A (ko) * 2012-05-02 2015-01-14 오렉쏘 에이비 급성 통증을 치료하기 위한 신규한 알펜타닐 조성물
US10766925B2 (en) * 2016-04-11 2020-09-08 Arizona Board Of Regents On Behalf Of The University Of Arizona Opioid receptor modulators
JP7023054B2 (ja) * 2017-04-05 2022-02-21 東和薬品株式会社 レベチラセタム含有医薬組成物及びその製造方法
CN115047109B (zh) * 2022-06-17 2024-05-31 三明海关综合技术服务中心 一种检测食品中芬太尼类新精神活性物质的方法

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SE9803240D0 (sv) 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
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Also Published As

Publication number Publication date
BR112014027213A2 (pt) 2017-06-27
DK2849730T3 (en) 2017-02-13
CN104427978B (zh) 2017-03-01
CY1118570T1 (el) 2017-07-12
CY1120820T1 (el) 2019-12-11
PE20142444A1 (es) 2015-01-09
EP3150199B1 (en) 2018-08-08
CO7170181A2 (es) 2015-01-28
PH12014502407A1 (en) 2015-01-12
US20150133501A1 (en) 2015-05-14
RS57951B1 (sr) 2019-01-31
SMT201700086T1 (it) 2017-03-08
SG11201407081PA (en) 2014-11-27
DK3150199T3 (en) 2018-11-12
IL235272B (en) 2018-10-31
EP2849730B1 (en) 2016-11-09
JP6275696B2 (ja) 2018-02-14
MX2014013176A (es) 2015-01-19
CN104427978A (zh) 2015-03-18
PT3150199T (pt) 2018-11-21
EA028110B1 (ru) 2017-10-31
NZ701428A (en) 2016-10-28
SMT201700086B (it) 2017-03-08
KR20150005695A (ko) 2015-01-14
WO2013164620A1 (en) 2013-11-07
HUE031792T2 (en) 2017-07-28
LT2849730T (lt) 2016-12-27
EA201401200A1 (ru) 2015-02-27
ES2694644T3 (es) 2018-12-26
PT2849730T (pt) 2017-02-15
SI2849730T1 (sl) 2017-02-28
ME02644B (me) 2017-06-20
SMT201800585T1 (it) 2019-01-11
CA2871805A1 (en) 2013-11-07
ES2614757T3 (es) 2017-06-01
SI3150199T1 (sl) 2018-12-31
JP2015515974A (ja) 2015-06-04
EP2849730A1 (en) 2015-03-25
TR201815935T4 (tr) 2018-11-21
PH12014502407B1 (en) 2015-01-12
BR112014027213A8 (pt) 2018-01-16
AU2013255640B2 (en) 2017-06-15
HRP20181761T1 (hr) 2018-12-28
US9782396B2 (en) 2017-10-10
US20170071927A1 (en) 2017-03-16
US8815911B2 (en) 2014-08-26
US20140005223A1 (en) 2014-01-02
US20180214437A1 (en) 2018-08-02
EP3150199A1 (en) 2017-04-05
HRP20161634T1 (hr) 2017-01-13
CL2014002979A1 (es) 2014-12-05
RS55489B1 (sr) 2017-04-28
ZA201407559B (en) 2016-05-25
US9345698B2 (en) 2016-05-24
IN2014MN02156A (es) 2015-08-28
AU2013255640A1 (en) 2014-11-20
PL2849730T3 (pl) 2017-05-31
LT3150199T (lt) 2018-11-12
HK1203399A1 (en) 2015-10-30
PL3150199T3 (pl) 2019-03-29

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