CL2014000159A1 - Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto. - Google Patents

Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto.

Info

Publication number
CL2014000159A1
CL2014000159A1 CL2014000159A CL2014000159A CL2014000159A1 CL 2014000159 A1 CL2014000159 A1 CL 2014000159A1 CL 2014000159 A CL2014000159 A CL 2014000159A CL 2014000159 A CL2014000159 A CL 2014000159A CL 2014000159 A1 CL2014000159 A1 CL 2014000159A1
Authority
CL
Chile
Prior art keywords
biologically active
compound
deliver
copolymer
host
Prior art date
Application number
CL2014000159A
Other languages
English (en)
Spanish (es)
Inventor
Rob Steendam
Theodorus Adrianus Cornelius Flipsen
Christine Hiemstra
Johan Zuidema
Original Assignee
Innocore Technologies B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innocore Technologies B V filed Critical Innocore Technologies B V
Publication of CL2014000159A1 publication Critical patent/CL2014000159A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816Wall or shell material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08Lactones or lactides
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66Polyesters containing oxygen in the form of ether groups
    • C08G63/668Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/672Dicarboxylic acids and dihydroxy compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00Compositions of unspecified macromolecular compounds
    • C08L101/16Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L87/00Compositions of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds
    • C08L87/005Block or graft polymers not provided for in groups C08L1/00 - C08L85/04
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/38Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
    • C08G2650/42Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
CL2014000159A 2011-07-22 2014-01-21 Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto. CL2014000159A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11174987 2011-07-22

Publications (1)

Publication Number Publication Date
CL2014000159A1 true CL2014000159A1 (es) 2014-08-29

Family

ID=46704994

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014000159A CL2014000159A1 (es) 2011-07-22 2014-01-21 Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto.

Country Status (19)

Country Link
US (2) US20140199385A1 (https=)
EP (1) EP2734573B1 (https=)
JP (2) JP6174023B2 (https=)
KR (1) KR101889586B1 (https=)
CN (1) CN103827177B (https=)
AU (1) AU2012287577B2 (https=)
BR (1) BR112014001441A2 (https=)
CA (1) CA2842514C (https=)
CL (1) CL2014000159A1 (https=)
CO (1) CO7020923A2 (https=)
ES (1) ES2899701T3 (https=)
IL (1) IL230606B (https=)
MX (1) MX362941B (https=)
MY (1) MY169349A (https=)
PH (1) PH12014500192A1 (https=)
RU (2) RU2018125698A (https=)
UA (1) UA112192C2 (https=)
WO (1) WO2013015685A1 (https=)
ZA (1) ZA201400846B (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2018125698A (ru) * 2011-07-22 2019-03-13 Иннокор Текнолоджис Б.В. Биоразлагаемые полукристаллические термопластичные мультиблочные сополимеры с разделенными фазами для контролируемого высвобождения биологически активных соединений
RU2694901C2 (ru) * 2013-04-18 2019-07-18 Шаньдун Луе Фармасьютикал Ко., Лтд Фармацевтические композиции микросфер гозерелина с пролонгированным высвобождением
JO3394B1 (ar) 2014-07-04 2019-10-20 Osteo Pharma B V تركيبات ومنتجات للاستعمال في علاج كسور وعيوب العظام
CN105273153A (zh) * 2014-07-24 2016-01-27 允友成(宿迁)复合新材料有限公司 一种可降解生物基水性乳液及其制备方法
CN105273154A (zh) * 2014-07-24 2016-01-27 允友成(宿迁)复合新材料有限公司 一种可降解聚乳酸基水性乳液及其制备方法
JP6910949B2 (ja) * 2014-08-14 2021-07-28 ブラウン ユニバーシティ タンパク質を安定化させ、送達するための組成物
EP3218022A1 (en) 2014-11-14 2017-09-20 University College Cork, National University Of Ireland Delivery of igf-1 in myocardial infarction
KR102009972B1 (ko) * 2015-11-25 2019-10-21 주식회사 엘지화학 양친성 고분자
KR102001614B1 (ko) * 2015-11-25 2019-07-18 주식회사 엘지화학 양친성 고분자
JP7665280B2 (ja) 2015-12-22 2025-04-21 アクセス・バスキュラー・インコーポレイテッド 高強度生体材
CN105461884B (zh) * 2015-12-22 2018-05-29 佛山市顺德区福利来酒店傢具有限公司 儿童抗菌耐划伤家具及其制备方法
KR101913146B1 (ko) * 2016-06-16 2018-11-01 주식회사 엘지화학 양친성 트리블록 고분자
WO2017217813A1 (ko) * 2016-06-16 2017-12-21 주식회사 엘지화학 양친성 고분자
CN109312035B (zh) * 2016-06-16 2021-07-30 株式会社Lg化学 两亲性聚合物
MX391306B (es) 2017-01-31 2025-03-21 Veru Inc COMPOSICIONES PARA LA LIBERACIÓN PROLONGADA DE ANTAGONISTAS DE LA HORMONA LIBERADORA DE GONADOTROPINA (GnRH)
CN109876191B (zh) * 2017-07-15 2020-04-03 深圳市立心科学有限公司 可吸收的生物医用复合材料及其制备方法
CN111372970A (zh) 2017-10-04 2020-07-03 时尚化学品股份有限公司 新的聚乳酸酯及其组合物
WO2019187569A1 (ja) * 2018-03-30 2019-10-03 東レ株式会社 生分解性を有するブロック共重合体
CN108387664B (zh) * 2018-07-03 2020-06-23 中国食品药品检定研究院 人血白蛋白分子大小分布超高效液相色谱测定方法
WO2020071912A1 (en) 2018-10-02 2020-04-09 Innocore Technologies B.V. Extended release formulations of human chorionic gonadotropin (hcg)
MY203238A (en) 2018-10-29 2024-06-19 Fraunhofer Ges Zur Frderung Der Angewandten Forschung E V Tetracycline complexes with sustained activity
JP2022514368A (ja) * 2018-12-19 2022-02-10 アクセス・バスキュラー・インコーポレイテッド 放出制御用高強度多孔質材料
EA202192644A1 (ru) * 2019-03-28 2021-12-14 Пк Мед Многокомпонентный термопластичный продукт
US20210017329A1 (en) * 2019-07-19 2021-01-21 Evonik Operations Gmbh Multi-block shape memory bioresorbable polymers
CA3156256A1 (en) * 2019-10-01 2021-04-08 InnoCore Technologies Holding B.V. Biodegradable, phase separated, thermoplastic multi-block copolymer
WO2021067388A1 (en) 2019-10-01 2021-04-08 Allergan Sales, Llc Poly-dioxanone multi-block copolymer for ocular protein delivery
US11819576B2 (en) * 2019-10-31 2023-11-21 Evonik Operations Gmbh Process for preparing nano-or microparticles comprising a carrier-polymer and one or more biologically active ingredients
US20220409730A1 (en) * 2019-11-01 2022-12-29 InnoCore Technologies Holding B.V. Dosage form for extended release of an antibody or large protein
US20230055790A1 (en) * 2019-12-12 2023-02-23 Massachusetts Eye And Ear Infirmary Melt-extrudable 3d printing inks
WO2021168170A1 (en) * 2020-02-21 2021-08-26 Natureworks Llc Cosmetic compositions containing low molecular weight amorphous grade polylactic acid resin
CN115605248A (zh) 2020-03-06 2023-01-13 阿塞斯血管有限公司(Us) 用于水合制品的包装和相关方法
JP2023522134A (ja) * 2020-04-10 2023-05-26 サイエンチュア, インコーポレイテッド 長時間作用型アポモルフィン製剤、およびその治療送達用のインジェクター
US20240033221A1 (en) 2020-04-22 2024-02-01 Scienture, Inc. Long-acting bupivacaine microsphere formulations
CN111484635B (zh) * 2020-06-10 2023-09-12 杭州铭善生物科技有限公司 一种温敏性水凝胶材料的改性方法、改性温敏性水凝胶材料和生物3d打印墨水
CN112336689B (zh) * 2020-10-30 2022-06-28 浙江大学衢州研究院 一种结晶性嵌段共聚物胶束制备多重Pickering乳液的方法
US20240082167A1 (en) * 2021-01-22 2024-03-14 University Of Connecticut Synthetic artificial stem cells (sasc)
US12186722B2 (en) 2022-02-07 2025-01-07 Honeywell Federal Manufacturing & Technologies, Llc Porous polysiloxane microspheres
CN114737276B (zh) * 2022-03-11 2023-02-07 北京朗净汇明生物科技有限公司 一种耐热抗水解型聚乳酸纤维及其制备方法
AU2023235001A1 (en) 2022-03-17 2024-10-17 InnoCore Technologies Holding B.V. Biodegradable thermoplastic poly(ortho ester) based multiblock copolymers
WO2026015019A1 (en) 2024-07-08 2026-01-15 InnoCore Technologies Holding B.V. Biodegradable thermoplastic polyoxazoline based copolymers
US12514756B1 (en) 2024-10-08 2026-01-06 Covidien Lp Dermal patch and systems, kits, and methods associated therewith
DE102024129442A1 (de) 2024-10-11 2026-04-16 Universität Potsdam, Körperschaft des öffentlichen Rechts Polymer-gekoppelte antikörper und antikörperfragmente

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4429080A (en) 1982-07-01 1984-01-31 American Cyanamid Company Synthetic copolymer surgical articles and method of manufacturing the same
US5066772A (en) 1987-12-17 1991-11-19 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5133739A (en) 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
CN1037612C (zh) * 1992-07-20 1998-03-04 中国科学院化学研究所 热致形状可回复性多嵌段聚合物材料
US5236444A (en) 1992-10-27 1993-08-17 United States Surgical Corporation Absorbable polymers and surgical articles made therefrom
NZ261250A (en) * 1993-01-06 1997-08-22 Kinerton Ltd Ionic conjugates of polypeptides
US5403347A (en) 1993-05-27 1995-04-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5711958A (en) 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5980948A (en) 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US6211249B1 (en) 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
US6160084A (en) 1998-02-23 2000-12-12 Massachusetts Institute Of Technology Biodegradable shape memory polymers
US8158143B2 (en) 2000-07-14 2012-04-17 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
EP1382628A1 (en) * 2002-07-16 2004-01-21 Polyganics B.V. Biodegradable phase separated segmented/block co-polyesters
EP1555278A1 (en) * 2004-01-15 2005-07-20 Innocore Technologies B.V. Biodegradable multi-block co-polymers
US20090004243A1 (en) * 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
RU2018125698A (ru) * 2011-07-22 2019-03-13 Иннокор Текнолоджис Б.В. Биоразлагаемые полукристаллические термопластичные мультиблочные сополимеры с разделенными фазами для контролируемого высвобождения биологически активных соединений

Also Published As

Publication number Publication date
MY169349A (en) 2019-03-21
BR112014001441A2 (pt) 2019-05-14
RU2018125698A (ru) 2019-03-13
UA112192C2 (uk) 2016-08-10
ZA201400846B (en) 2016-08-31
PH12014500192A1 (en) 2014-03-24
JP2017141477A (ja) 2017-08-17
ES2899701T3 (es) 2022-03-14
CN103827177A (zh) 2014-05-28
MX362941B (es) 2019-02-27
US20180085318A1 (en) 2018-03-29
US10300019B2 (en) 2019-05-28
JP6174023B2 (ja) 2017-08-02
JP6472836B2 (ja) 2019-02-20
AU2012287577B2 (en) 2017-02-16
IL230606A0 (en) 2014-03-31
NZ620392A (en) 2016-02-26
CN103827177B (zh) 2016-02-10
EP2734573A1 (en) 2014-05-28
EP2734573B1 (en) 2021-09-08
CA2842514C (en) 2018-12-18
CA2842514A1 (en) 2013-01-31
US20140199385A1 (en) 2014-07-17
RU2014102900A (ru) 2015-08-27
AU2012287577A1 (en) 2014-03-13
RU2662818C2 (ru) 2018-07-31
CO7020923A2 (es) 2014-08-11
KR101889586B1 (ko) 2018-09-20
IL230606B (en) 2019-07-31
MX2014000891A (es) 2015-05-11
KR20140048296A (ko) 2014-04-23
JP2014521762A (ja) 2014-08-28
WO2013015685A1 (en) 2013-01-31

Similar Documents

Publication Publication Date Title
CL2014000159A1 (es) Copolimeros multibloque termoplasticos biodegradables para la liberacion controlada de compuestos biologicamente activos; proceso de preparacion de dicho copolimero; composicion para suministro de compuesto biologicamente activo a un hospedero; y metodo para suministrar dicho compuesto.
CO6940430A2 (es) Nuevos portadores recubiertos para la liberación controlada de agente activo
DK2691079T3 (da) Bionedbrydelige sammensætninger, der er egnet til kontrolleret udløsning
BR112013031819A2 (pt) suporte polimérico, composição farmacêutica, composto, métodos de tratar um distúrbio, e, de preparar um suporte
PL2701687T3 (pl) Kompozycja mikrosfery rysperydonu o przedłużonym uwalnianiu
EP2668966A4 (en) BIODEGRADABLE IMPLANT MATERIAL AND METHOD FOR THE PRODUCTION THEREOF
EP2538988A4 (en) METHOD FOR TISSUE-DECELULARIZATION
PL2672966T3 (pl) Kompozycja farmaceutyczna, sposoby leczenia i jej zastosowania
EP2719714A4 (en) LACTID COPOLYMER, METHOD FOR ITS PREPARATION AND RESIN COMPOSITION THEREWITH
SG10201707535PA (en) Process for producing a particulate composition comprising crystalline alpha, alpha-trehalose di-hydrate
EP2697662A4 (en) BIO-CATALYTIC PROCESS FOR THE PREPARATION OF ESLICARBAZEPINE AND ANALOGUE THEREOF
PL2554168T3 (pl) Kompozycja farmaceutyczna do kontrolowanego uwalniania
SG11201401770YA (en) Polymeric drug-delivery material, method for manufacturing thereof and method for delivery of a drug-delivery composition
BR112014003996A2 (pt) polímero, composição e partícula para deposição de um agente de benefício
IL228462A0 (en) The film-forming composition for sustained release depends on the ph of an active ingredient
PT2704698T (pt) Forma farmacêutica para a libertação controlada de princípios activos
PL2707032T3 (pl) Wszczepialne urządzenie polimerowe do przedłużonego uwalniania sufentanylu
ZA201308195B (en) Improved polymeric composition for cement based substructures
EP2718076A4 (en) POLYMER COMPOSITION FOR THE PRODUCTION OF BIODEGRADABLE ARTICLES AND CORRESPONDING METHOD
ES1076294Y (es) Articulo absorbente multipieza para la incontinencia urinaria
PL392512A1 (pl) Sposób wytwarzania polimeru typu superabsorbent, polimer typu superabsorbent oraz kompozycja zawierająca polimer typu superabsorbent
PT3539540T (pt) Inibidor de sglt2 1-cloro-4-(beta-d-glucopiranos-1-il)-2-[4-((s)-tetra-hidrofurano-3-iloxi)-benzil]-benzeno em combinação com insulina para utilização num método para redução do risco de hipoglicemia
AU2011903135A0 (en) Active Material Compositions for Energy Storage Devices
PL395212A1 (pl) Biodegradowalny implant kostny