CN103827177B - 用于生物活性化合物的受控释放的生物可降解的、半结晶的、相分离的、热塑性多嵌段共聚物 - Google Patents
用于生物活性化合物的受控释放的生物可降解的、半结晶的、相分离的、热塑性多嵌段共聚物 Download PDFInfo
- Publication number
- CN103827177B CN103827177B CN201280040941.7A CN201280040941A CN103827177B CN 103827177 B CN103827177 B CN 103827177B CN 201280040941 A CN201280040941 A CN 201280040941A CN 103827177 B CN103827177 B CN 103827177B
- Authority
- CN
- China
- Prior art keywords
- prepolymer
- multipolymer
- block
- separated
- biodegradable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/672—Dicarboxylic acids and dihydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L101/00—Compositions of unspecified macromolecular compounds
- C08L101/16—Compositions of unspecified macromolecular compounds the macromolecular compounds being biodegradable
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L87/00—Compositions of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds
- C08L87/005—Block or graft polymers not provided for in groups C08L1/00 - C08L85/04
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
- C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11174987.5 | 2011-07-22 | ||
| EP11174987 | 2011-07-22 | ||
| PCT/NL2012/050529 WO2013015685A1 (en) | 2011-07-22 | 2012-07-23 | Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103827177A CN103827177A (zh) | 2014-05-28 |
| CN103827177B true CN103827177B (zh) | 2016-02-10 |
Family
ID=46704994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280040941.7A Active CN103827177B (zh) | 2011-07-22 | 2012-07-23 | 用于生物活性化合物的受控释放的生物可降解的、半结晶的、相分离的、热塑性多嵌段共聚物 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20140199385A1 (https=) |
| EP (1) | EP2734573B1 (https=) |
| JP (2) | JP6174023B2 (https=) |
| KR (1) | KR101889586B1 (https=) |
| CN (1) | CN103827177B (https=) |
| AU (1) | AU2012287577B2 (https=) |
| BR (1) | BR112014001441A2 (https=) |
| CA (1) | CA2842514C (https=) |
| CL (1) | CL2014000159A1 (https=) |
| CO (1) | CO7020923A2 (https=) |
| ES (1) | ES2899701T3 (https=) |
| IL (1) | IL230606B (https=) |
| MX (1) | MX362941B (https=) |
| MY (1) | MY169349A (https=) |
| PH (1) | PH12014500192A1 (https=) |
| RU (2) | RU2018125698A (https=) |
| UA (1) | UA112192C2 (https=) |
| WO (1) | WO2013015685A1 (https=) |
| ZA (1) | ZA201400846B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2018125698A (ru) * | 2011-07-22 | 2019-03-13 | Иннокор Текнолоджис Б.В. | Биоразлагаемые полукристаллические термопластичные мультиблочные сополимеры с разделенными фазами для контролируемого высвобождения биологически активных соединений |
| RU2694901C2 (ru) * | 2013-04-18 | 2019-07-18 | Шаньдун Луе Фармасьютикал Ко., Лтд | Фармацевтические композиции микросфер гозерелина с пролонгированным высвобождением |
| JO3394B1 (ar) | 2014-07-04 | 2019-10-20 | Osteo Pharma B V | تركيبات ومنتجات للاستعمال في علاج كسور وعيوب العظام |
| CN105273153A (zh) * | 2014-07-24 | 2016-01-27 | 允友成(宿迁)复合新材料有限公司 | 一种可降解生物基水性乳液及其制备方法 |
| CN105273154A (zh) * | 2014-07-24 | 2016-01-27 | 允友成(宿迁)复合新材料有限公司 | 一种可降解聚乳酸基水性乳液及其制备方法 |
| JP6910949B2 (ja) * | 2014-08-14 | 2021-07-28 | ブラウン ユニバーシティ | タンパク質を安定化させ、送達するための組成物 |
| EP3218022A1 (en) | 2014-11-14 | 2017-09-20 | University College Cork, National University Of Ireland | Delivery of igf-1 in myocardial infarction |
| KR102009972B1 (ko) * | 2015-11-25 | 2019-10-21 | 주식회사 엘지화학 | 양친성 고분자 |
| KR102001614B1 (ko) * | 2015-11-25 | 2019-07-18 | 주식회사 엘지화학 | 양친성 고분자 |
| JP7665280B2 (ja) | 2015-12-22 | 2025-04-21 | アクセス・バスキュラー・インコーポレイテッド | 高強度生体材 |
| CN105461884B (zh) * | 2015-12-22 | 2018-05-29 | 佛山市顺德区福利来酒店傢具有限公司 | 儿童抗菌耐划伤家具及其制备方法 |
| KR101913146B1 (ko) * | 2016-06-16 | 2018-11-01 | 주식회사 엘지화학 | 양친성 트리블록 고분자 |
| WO2017217813A1 (ko) * | 2016-06-16 | 2017-12-21 | 주식회사 엘지화학 | 양친성 고분자 |
| CN109312035B (zh) * | 2016-06-16 | 2021-07-30 | 株式会社Lg化学 | 两亲性聚合物 |
| MX391306B (es) | 2017-01-31 | 2025-03-21 | Veru Inc | COMPOSICIONES PARA LA LIBERACIÓN PROLONGADA DE ANTAGONISTAS DE LA HORMONA LIBERADORA DE GONADOTROPINA (GnRH) |
| CN109876191B (zh) * | 2017-07-15 | 2020-04-03 | 深圳市立心科学有限公司 | 可吸收的生物医用复合材料及其制备方法 |
| CN111372970A (zh) | 2017-10-04 | 2020-07-03 | 时尚化学品股份有限公司 | 新的聚乳酸酯及其组合物 |
| WO2019187569A1 (ja) * | 2018-03-30 | 2019-10-03 | 東レ株式会社 | 生分解性を有するブロック共重合体 |
| CN108387664B (zh) * | 2018-07-03 | 2020-06-23 | 中国食品药品检定研究院 | 人血白蛋白分子大小分布超高效液相色谱测定方法 |
| WO2020071912A1 (en) | 2018-10-02 | 2020-04-09 | Innocore Technologies B.V. | Extended release formulations of human chorionic gonadotropin (hcg) |
| MY203238A (en) | 2018-10-29 | 2024-06-19 | Fraunhofer Ges Zur Frderung Der Angewandten Forschung E V | Tetracycline complexes with sustained activity |
| JP2022514368A (ja) * | 2018-12-19 | 2022-02-10 | アクセス・バスキュラー・インコーポレイテッド | 放出制御用高強度多孔質材料 |
| EA202192644A1 (ru) * | 2019-03-28 | 2021-12-14 | Пк Мед | Многокомпонентный термопластичный продукт |
| US20210017329A1 (en) * | 2019-07-19 | 2021-01-21 | Evonik Operations Gmbh | Multi-block shape memory bioresorbable polymers |
| CA3156256A1 (en) * | 2019-10-01 | 2021-04-08 | InnoCore Technologies Holding B.V. | Biodegradable, phase separated, thermoplastic multi-block copolymer |
| WO2021067388A1 (en) | 2019-10-01 | 2021-04-08 | Allergan Sales, Llc | Poly-dioxanone multi-block copolymer for ocular protein delivery |
| US11819576B2 (en) * | 2019-10-31 | 2023-11-21 | Evonik Operations Gmbh | Process for preparing nano-or microparticles comprising a carrier-polymer and one or more biologically active ingredients |
| US20220409730A1 (en) * | 2019-11-01 | 2022-12-29 | InnoCore Technologies Holding B.V. | Dosage form for extended release of an antibody or large protein |
| US20230055790A1 (en) * | 2019-12-12 | 2023-02-23 | Massachusetts Eye And Ear Infirmary | Melt-extrudable 3d printing inks |
| WO2021168170A1 (en) * | 2020-02-21 | 2021-08-26 | Natureworks Llc | Cosmetic compositions containing low molecular weight amorphous grade polylactic acid resin |
| CN115605248A (zh) | 2020-03-06 | 2023-01-13 | 阿塞斯血管有限公司(Us) | 用于水合制品的包装和相关方法 |
| JP2023522134A (ja) * | 2020-04-10 | 2023-05-26 | サイエンチュア, インコーポレイテッド | 長時間作用型アポモルフィン製剤、およびその治療送達用のインジェクター |
| US20240033221A1 (en) | 2020-04-22 | 2024-02-01 | Scienture, Inc. | Long-acting bupivacaine microsphere formulations |
| CN111484635B (zh) * | 2020-06-10 | 2023-09-12 | 杭州铭善生物科技有限公司 | 一种温敏性水凝胶材料的改性方法、改性温敏性水凝胶材料和生物3d打印墨水 |
| CN112336689B (zh) * | 2020-10-30 | 2022-06-28 | 浙江大学衢州研究院 | 一种结晶性嵌段共聚物胶束制备多重Pickering乳液的方法 |
| US20240082167A1 (en) * | 2021-01-22 | 2024-03-14 | University Of Connecticut | Synthetic artificial stem cells (sasc) |
| US12186722B2 (en) | 2022-02-07 | 2025-01-07 | Honeywell Federal Manufacturing & Technologies, Llc | Porous polysiloxane microspheres |
| CN114737276B (zh) * | 2022-03-11 | 2023-02-07 | 北京朗净汇明生物科技有限公司 | 一种耐热抗水解型聚乳酸纤维及其制备方法 |
| AU2023235001A1 (en) | 2022-03-17 | 2024-10-17 | InnoCore Technologies Holding B.V. | Biodegradable thermoplastic poly(ortho ester) based multiblock copolymers |
| WO2026015019A1 (en) | 2024-07-08 | 2026-01-15 | InnoCore Technologies Holding B.V. | Biodegradable thermoplastic polyoxazoline based copolymers |
| US12514756B1 (en) | 2024-10-08 | 2026-01-06 | Covidien Lp | Dermal patch and systems, kits, and methods associated therewith |
| DE102024129442A1 (de) | 2024-10-11 | 2026-04-16 | Universität Potsdam, Körperschaft des öffentlichen Rechts | Polymer-gekoppelte antikörper und antikörperfragmente |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083076A (zh) * | 1992-07-20 | 1994-03-02 | 中国科学院化学研究所 | 热致形状可回复性多嵌段聚合物材料 |
| CN1675281A (zh) * | 2002-07-16 | 2005-09-28 | 伊诺科雷技术有限公司 | 可生物降解的相分离链段多嵌段共聚物 |
| CN1910217A (zh) * | 2004-01-15 | 2007-02-07 | 伊诺科雷技术有限公司 | 可生物降解的多嵌段共聚物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4429080A (en) | 1982-07-01 | 1984-01-31 | American Cyanamid Company | Synthetic copolymer surgical articles and method of manufacturing the same |
| US5066772A (en) | 1987-12-17 | 1991-11-19 | Allied-Signal Inc. | Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides |
| US5133739A (en) | 1990-02-06 | 1992-07-28 | Ethicon, Inc. | Segmented copolymers of ε-caprolactone and glycolide |
| US5236444A (en) | 1992-10-27 | 1993-08-17 | United States Surgical Corporation | Absorbable polymers and surgical articles made therefrom |
| NZ261250A (en) * | 1993-01-06 | 1997-08-22 | Kinerton Ltd | Ionic conjugates of polypeptides |
| US5403347A (en) | 1993-05-27 | 1995-04-04 | United States Surgical Corporation | Absorbable block copolymers and surgical articles fabricated therefrom |
| US5711958A (en) | 1996-07-11 | 1998-01-27 | Life Medical Sciences, Inc. | Methods for reducing or eliminating post-surgical adhesion formation |
| US5980948A (en) | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
| US6211249B1 (en) | 1997-07-11 | 2001-04-03 | Life Medical Sciences, Inc. | Polyester polyether block copolymers |
| US6160084A (en) | 1998-02-23 | 2000-12-12 | Massachusetts Institute Of Technology | Biodegradable shape memory polymers |
| US8158143B2 (en) | 2000-07-14 | 2012-04-17 | Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh | Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect |
| US20090004243A1 (en) * | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
| RU2018125698A (ru) * | 2011-07-22 | 2019-03-13 | Иннокор Текнолоджис Б.В. | Биоразлагаемые полукристаллические термопластичные мультиблочные сополимеры с разделенными фазами для контролируемого высвобождения биологически активных соединений |
-
2012
- 2012-07-23 RU RU2018125698A patent/RU2018125698A/ru not_active Application Discontinuation
- 2012-07-23 BR BR112014001441A patent/BR112014001441A2/pt not_active Application Discontinuation
- 2012-07-23 CN CN201280040941.7A patent/CN103827177B/zh active Active
- 2012-07-23 US US14/233,961 patent/US20140199385A1/en not_active Abandoned
- 2012-07-23 WO PCT/NL2012/050529 patent/WO2013015685A1/en not_active Ceased
- 2012-07-23 PH PH1/2014/500192A patent/PH12014500192A1/en unknown
- 2012-07-23 MX MX2014000891A patent/MX362941B/es active IP Right Grant
- 2012-07-23 AU AU2012287577A patent/AU2012287577B2/en active Active
- 2012-07-23 EP EP12748568.8A patent/EP2734573B1/en active Active
- 2012-07-23 RU RU2014102900A patent/RU2662818C2/ru active
- 2012-07-23 UA UAA201401832A patent/UA112192C2/uk unknown
- 2012-07-23 ES ES12748568T patent/ES2899701T3/es active Active
- 2012-07-23 MY MYPI2014700136A patent/MY169349A/en unknown
- 2012-07-23 CA CA2842514A patent/CA2842514C/en active Active
- 2012-07-23 KR KR1020147004468A patent/KR101889586B1/ko not_active Expired - Fee Related
- 2012-07-23 JP JP2014521586A patent/JP6174023B2/ja active Active
-
2014
- 2014-01-21 CL CL2014000159A patent/CL2014000159A1/es unknown
- 2014-01-22 IL IL230606A patent/IL230606B/en active IP Right Grant
- 2014-01-23 CO CO14012995A patent/CO7020923A2/es unknown
- 2014-02-04 ZA ZA2014/00846A patent/ZA201400846B/en unknown
-
2017
- 2017-05-16 JP JP2017097345A patent/JP6472836B2/ja active Active
- 2017-08-15 US US15/677,442 patent/US10300019B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083076A (zh) * | 1992-07-20 | 1994-03-02 | 中国科学院化学研究所 | 热致形状可回复性多嵌段聚合物材料 |
| CN1675281A (zh) * | 2002-07-16 | 2005-09-28 | 伊诺科雷技术有限公司 | 可生物降解的相分离链段多嵌段共聚物 |
| CN1910217A (zh) * | 2004-01-15 | 2007-02-07 | 伊诺科雷技术有限公司 | 可生物降解的多嵌段共聚物 |
Also Published As
| Publication number | Publication date |
|---|---|
| MY169349A (en) | 2019-03-21 |
| BR112014001441A2 (pt) | 2019-05-14 |
| RU2018125698A (ru) | 2019-03-13 |
| UA112192C2 (uk) | 2016-08-10 |
| ZA201400846B (en) | 2016-08-31 |
| PH12014500192A1 (en) | 2014-03-24 |
| JP2017141477A (ja) | 2017-08-17 |
| ES2899701T3 (es) | 2022-03-14 |
| CN103827177A (zh) | 2014-05-28 |
| MX362941B (es) | 2019-02-27 |
| US20180085318A1 (en) | 2018-03-29 |
| US10300019B2 (en) | 2019-05-28 |
| JP6174023B2 (ja) | 2017-08-02 |
| JP6472836B2 (ja) | 2019-02-20 |
| AU2012287577B2 (en) | 2017-02-16 |
| IL230606A0 (en) | 2014-03-31 |
| NZ620392A (en) | 2016-02-26 |
| EP2734573A1 (en) | 2014-05-28 |
| EP2734573B1 (en) | 2021-09-08 |
| CA2842514C (en) | 2018-12-18 |
| CA2842514A1 (en) | 2013-01-31 |
| CL2014000159A1 (es) | 2014-08-29 |
| US20140199385A1 (en) | 2014-07-17 |
| RU2014102900A (ru) | 2015-08-27 |
| AU2012287577A1 (en) | 2014-03-13 |
| RU2662818C2 (ru) | 2018-07-31 |
| CO7020923A2 (es) | 2014-08-11 |
| KR101889586B1 (ko) | 2018-09-20 |
| IL230606B (en) | 2019-07-31 |
| MX2014000891A (es) | 2015-05-11 |
| KR20140048296A (ko) | 2014-04-23 |
| JP2014521762A (ja) | 2014-08-28 |
| WO2013015685A1 (en) | 2013-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103827177B (zh) | 用于生物活性化合物的受控释放的生物可降解的、半结晶的、相分离的、热塑性多嵌段共聚物 | |
| CN1910217B (zh) | 可生物降解的多嵌段共聚物 | |
| US12325776B2 (en) | Biodegradable, phase separated, thermoplastic multi-block copolymer | |
| JP2025509813A (ja) | 生分解性熱可塑性ポリ(オルトエステル)ベースのマルチブロック共重合体 | |
| NZ620392B2 (en) | Biodegradable, semi-crystalline, phase separated, thermoplastic multi block copolymers for controlled release of biologically active compounds | |
| WO2026015019A1 (en) | Biodegradable thermoplastic polyoxazoline based copolymers | |
| Hydrogels | Injectable Temperature-and pH| Temperature-Sensitive Block |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210809 Address after: Holland in Groningen Province Patentee after: Inokole Technology Holding Co.,Ltd. Address before: Holland in Groningen Province Patentee before: INNOCORE TECHNOLOGIES B.V. |
|
| TR01 | Transfer of patent right |