CL2013003298A1 - Uso de metotrexato porque sirve para preparar un medicamento, útil en el tratamiento de enfermedades que necesiten tratamiento con un producto terapéutico que produzca autoinmunidad, administrado en un sólo ciclo. - Google Patents

Uso de metotrexato porque sirve para preparar un medicamento, útil en el tratamiento de enfermedades que necesiten tratamiento con un producto terapéutico que produzca autoinmunidad, administrado en un sólo ciclo.

Info

Publication number
CL2013003298A1
CL2013003298A1 CL2013003298A CL2013003298A CL2013003298A1 CL 2013003298 A1 CL2013003298 A1 CL 2013003298A1 CL 2013003298 A CL2013003298 A CL 2013003298A CL 2013003298 A CL2013003298 A CL 2013003298A CL 2013003298 A1 CL2013003298 A1 CL 2013003298A1
Authority
CL
Chile
Prior art keywords
treatment
methotrexate
autoimmunity
administered
diseases
Prior art date
Application number
CL2013003298A
Other languages
English (en)
Inventor
Alexandra Joseph
Susan Richard
Melanie Ruzek
Richard Garman
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47177257&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013003298(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of CL2013003298A1 publication Critical patent/CL2013003298A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La invención proporciona métodos para reducir las respuestas inmunológicas no deseadas, tales como las respuestas de anticuerpos anti-fármaco (ADA) y otras respuestas inmunológicas mediadas por células T y/o B, en pacientes, utilizando un tratamiento con metotrexato.
CL2013003298A 2011-05-16 2013-11-15 Uso de metotrexato porque sirve para preparar un medicamento, útil en el tratamiento de enfermedades que necesiten tratamiento con un producto terapéutico que produzca autoinmunidad, administrado en un sólo ciclo. CL2013003298A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161486697P 2011-05-16 2011-05-16

Publications (1)

Publication Number Publication Date
CL2013003298A1 true CL2013003298A1 (es) 2014-07-25

Family

ID=47177257

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013003298A CL2013003298A1 (es) 2011-05-16 2013-11-15 Uso de metotrexato porque sirve para preparar un medicamento, útil en el tratamiento de enfermedades que necesiten tratamiento con un producto terapéutico que produzca autoinmunidad, administrado en un sólo ciclo.

Country Status (27)

Country Link
US (3) US20140135337A1 (es)
EP (2) EP2709627B1 (es)
JP (3) JP6174572B2 (es)
KR (3) KR102316283B1 (es)
CN (4) CN109620830A (es)
AU (1) AU2012256281B2 (es)
BR (1) BR112013029501A2 (es)
CA (1) CA2835819A1 (es)
CL (1) CL2013003298A1 (es)
CO (1) CO6841993A2 (es)
DO (1) DOP2013000268A (es)
EC (1) ECSP13013081A (es)
ES (1) ES2836823T3 (es)
GT (1) GT201300278A (es)
IL (2) IL229245B (es)
MA (1) MA35165B1 (es)
MX (1) MX2013013445A (es)
MY (1) MY173304A (es)
NI (1) NI201300121A (es)
PE (1) PE20140469A1 (es)
PT (1) PT2709627T (es)
RU (1) RU2674036C2 (es)
SG (1) SG194802A1 (es)
TN (1) TN2013000472A1 (es)
UA (1) UA117556C2 (es)
WO (1) WO2012158362A1 (es)
ZA (1) ZA201308315B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3182519A1 (en) 2011-04-29 2012-11-01 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers for antigen-specific deletion of t effector cells
CN109620830A (zh) 2011-05-16 2019-04-16 建新公司 使用甲氨蝶呤诱导免疫耐受性
AU2014262163A1 (en) 2013-05-03 2015-11-19 Selecta Biosciences, Inc. Delivery of immunosuppressants having a specified pharmacodynamic effective-life and antigen for the inducation of immune tolerance
MX2015016691A (es) * 2013-06-04 2016-04-04 Selecta Biosciences Inc Administracion repetida de inmunoterapeuticos especificos de antigeno no inmunosupresores.
CN107073091A (zh) 2014-09-07 2017-08-18 西莱克塔生物科技公司 用于减弱外显子跳读抗病毒转移载体免疫应答的方法和组合物
JP2016213236A (ja) * 2015-04-30 2016-12-15 日東電工株式会社 半導体装置用フィルム、及び、半導体装置の製造方法
CN110612122A (zh) 2017-03-11 2019-12-24 西莱克塔生物科技公司 与用抗炎剂和包含免疫抑制剂之合成纳米载体进行的组合治疗相关的方法和组合物
WO2018209300A1 (en) * 2017-05-12 2018-11-15 Duke University Methods for the use of low-dose immune modulators transiently for treating patients undergoing protein replacement therapy
TWI821227B (zh) * 2017-12-22 2023-11-11 美商健臻公司 胺甲喋呤誘發的免疫耐受性之生物標記
TW202142264A (zh) 2020-02-08 2021-11-16 美商健臻公司 治療龐貝氏症的組成物及方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
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US4080325A (en) 1976-11-17 1978-03-21 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of methotrexate
US4558690A (en) 1982-01-26 1985-12-17 University Of Scranton Method of administration of chemotherapy to tumors
US5108987A (en) 1982-02-25 1992-04-28 Faulk Ward P Conjugates of proteins with anti-tumor agents
US5028697A (en) 1988-08-08 1991-07-02 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers
DE4000154A1 (de) 1990-01-04 1991-07-11 Symbiotec Gmbh Chemotherapeutisches mittel, insbesondere zur behandlung von krebserkrankungen
US6015557A (en) 1999-02-24 2000-01-18 Tobinick; Edward L. Tumor necrosis factor antagonists for the treatment of neurological disorders
US7485314B2 (en) * 2002-05-06 2009-02-03 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Induction of antigen specific immunologic tolerance
KR101234476B1 (ko) 2004-03-05 2013-02-18 덴끼 가가꾸 고교 가부시키가이샤 히알루론산/메토트렉세이트 화합물
US7884196B2 (en) 2004-10-06 2011-02-08 Oliver Lawless Vaccine composition comprising methylated DNA and immunomodulatory motifs
CN101437501B (zh) * 2006-03-02 2012-09-05 阿莱克申药物公司 通过抑制补体活性延长同种异体移植物的存活
WO2008094937A2 (en) 2007-01-29 2008-08-07 Joslin Diabetes Center, Inc. Methods of modulating angiogenesis
WO2009073146A2 (en) * 2007-11-29 2009-06-11 Celgene Corporation Use of immunomodulatory compounds for the treatment of transverse myelitis, multiple sclerosis, and other disorders
US7914785B2 (en) * 2008-01-02 2011-03-29 Bergen Teknologieverforing As B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome
EP2077281A1 (en) * 2008-01-02 2009-07-08 Bergen Teknologioverforing AS Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome
KR101825457B1 (ko) 2008-10-08 2018-02-05 캠브리지 엔터프라이즈 리미티드 다발경화증에 대한 2차 자가면역 질환의 진단 및 치료를 위한 방법 및 조성물
EA201100605A1 (ru) 2008-11-07 2012-02-28 4ЭсЦэ АГ Комбинированная терапия, включающая ингибитор dhodh и метотрексат, для лечения аутоиммунного заболевания
CN109620830A (zh) 2011-05-16 2019-04-16 建新公司 使用甲氨蝶呤诱导免疫耐受性

Also Published As

Publication number Publication date
MX2013013445A (es) 2014-07-28
ZA201308315B (en) 2014-07-30
GT201300278A (es) 2015-02-12
US20200360385A1 (en) 2020-11-19
NI201300121A (es) 2014-02-28
KR102316283B1 (ko) 2021-10-21
KR20200116543A (ko) 2020-10-12
MY173304A (en) 2020-01-14
IL276879A (en) 2020-10-29
NZ716716A (en) 2018-06-29
JP2017141236A (ja) 2017-08-17
ES2836823T3 (es) 2021-06-28
CA2835819A1 (en) 2012-11-22
CO6841993A2 (es) 2014-01-20
KR102163285B1 (ko) 2020-10-08
CN110124039A (zh) 2019-08-16
JP6694020B2 (ja) 2020-05-13
CN113209288A (zh) 2021-08-06
JP2018184466A (ja) 2018-11-22
BR112013029501A2 (pt) 2017-01-24
IL229245A0 (en) 2014-01-30
DOP2013000268A (es) 2014-01-31
US20140135337A1 (en) 2014-05-15
PT2709627T (pt) 2020-12-24
JP6381707B2 (ja) 2018-08-29
NZ617575A (en) 2016-10-28
UA117556C2 (uk) 2018-08-27
KR20140040744A (ko) 2014-04-03
EP2709627A1 (en) 2014-03-26
EP2709627B1 (en) 2020-09-23
RU2013155618A (ru) 2015-06-27
AU2012256281A1 (en) 2013-11-28
US20230372347A1 (en) 2023-11-23
TN2013000472A1 (en) 2015-03-30
WO2012158362A1 (en) 2012-11-22
CN109620830A (zh) 2019-04-16
JP6174572B2 (ja) 2017-08-02
IL229245B (en) 2020-08-31
AU2012256281B2 (en) 2017-06-15
KR20190132551A (ko) 2019-11-27
IL276879B (en) 2022-06-01
RU2674036C2 (ru) 2018-12-04
EP2709627A4 (en) 2014-11-12
US11672802B2 (en) 2023-06-13
ECSP13013081A (es) 2015-04-30
SG194802A1 (en) 2013-12-30
PE20140469A1 (es) 2014-04-23
MA35165B1 (fr) 2014-06-02
EP3824890A1 (en) 2021-05-26
JP2014513722A (ja) 2014-06-05
CN103648501A (zh) 2014-03-19
NZ742216A (en) 2018-10-26

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