TN2013000472A1 - Induction of immune tolerance by using methotrexate - Google Patents

Induction of immune tolerance by using methotrexate

Info

Publication number
TN2013000472A1
TN2013000472A1 TNP2013000472A TN2013000472A TN2013000472A1 TN 2013000472 A1 TN2013000472 A1 TN 2013000472A1 TN P2013000472 A TNP2013000472 A TN P2013000472A TN 2013000472 A TN2013000472 A TN 2013000472A TN 2013000472 A1 TN2013000472 A1 TN 2013000472A1
Authority
TN
Tunisia
Prior art keywords
methotrexate
induction
immune tolerance
immune responses
responses
Prior art date
Application number
TNP2013000472A
Other languages
English (en)
Inventor
Alexandra Joseph
Susan Richards
Melanie Ruzek
Richard Garman
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47177257&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2013000472(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of TN2013000472A1 publication Critical patent/TN2013000472A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
TNP2013000472A 2011-05-16 2013-11-13 Induction of immune tolerance by using methotrexate TN2013000472A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161486697P 2011-05-16 2011-05-16
PCT/US2012/036405 WO2012158362A1 (fr) 2011-05-16 2012-05-03 Induction de tolérance immune par utilisation de méthotrexate

Publications (1)

Publication Number Publication Date
TN2013000472A1 true TN2013000472A1 (en) 2015-03-30

Family

ID=47177257

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2013000472A TN2013000472A1 (en) 2011-05-16 2013-11-13 Induction of immune tolerance by using methotrexate

Country Status (27)

Country Link
US (3) US20140135337A1 (fr)
EP (2) EP3824890A1 (fr)
JP (3) JP6174572B2 (fr)
KR (3) KR102316283B1 (fr)
CN (4) CN110124039A (fr)
AU (1) AU2012256281B2 (fr)
BR (1) BR112013029501A2 (fr)
CA (1) CA2835819A1 (fr)
CL (1) CL2013003298A1 (fr)
CO (1) CO6841993A2 (fr)
DO (1) DOP2013000268A (fr)
EC (1) ECSP13013081A (fr)
ES (1) ES2836823T3 (fr)
GT (1) GT201300278A (fr)
IL (2) IL229245B (fr)
MA (1) MA35165B1 (fr)
MX (1) MX2013013445A (fr)
MY (1) MY173304A (fr)
NI (1) NI201300121A (fr)
PE (1) PE20140469A1 (fr)
PT (1) PT2709627T (fr)
RU (1) RU2674036C2 (fr)
SG (1) SG194802A1 (fr)
TN (1) TN2013000472A1 (fr)
UA (1) UA117556C2 (fr)
WO (1) WO2012158362A1 (fr)
ZA (1) ZA201308315B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9265815B2 (en) 2011-04-29 2016-02-23 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers
PE20140469A1 (es) 2011-05-16 2014-04-23 Genzyme Corp Induccion de tolerancia inmunologica utilizando metotrexato
JP7028556B2 (ja) 2013-05-03 2022-03-02 セレクタ バイオサイエンシーズ インコーポレーテッド 特定の薬力学的有効期間および免疫寛容の誘発のための抗原を有する免疫抑制剤の送達
CN112933218A (zh) * 2013-06-04 2021-06-11 西莱克塔生物科技公司 非免疫抑制性抗原特异性免疫治疗剂的重复施用
MX2017002933A (es) 2014-09-07 2017-05-30 Selecta Biosciences Inc Metodos y composiciones para atenuar las respuestas inmunes del vector de transferencia anti-viral de edicion del gen.
JP2016213236A (ja) * 2015-04-30 2016-12-15 日東電工株式会社 半導体装置用フィルム、及び、半導体装置の製造方法
WO2018169811A1 (fr) 2017-03-11 2018-09-20 Selecta Biosciences, Inc. Procédés et compositions associés à un traitement combiné avec anti-inflammatoires et nanovecteurs synthétiques comprenant un immunosuppresseur
WO2018209300A1 (fr) * 2017-05-12 2018-11-15 Duke University Méthodes d'utilisation de modulateurs immunitaires à faible dose de façon transitoire pour traiter des patients subissant une thérapie de remplacement de protéine
TWI821227B (zh) * 2017-12-22 2023-11-11 美商健臻公司 胺甲喋呤誘發的免疫耐受性之生物標記
WO2021159092A1 (fr) 2020-02-08 2021-08-12 Genzyme Corporation Compositions et méthodes de traitement de la maladie de pompe

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4080325A (en) 1976-11-17 1978-03-21 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthesis of methotrexate
US4558690A (en) 1982-01-26 1985-12-17 University Of Scranton Method of administration of chemotherapy to tumors
US5108987A (en) 1982-02-25 1992-04-28 Faulk Ward P Conjugates of proteins with anti-tumor agents
US5028697A (en) 1988-08-08 1991-07-02 Eli Lilly And Company Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers
DE4000154A1 (de) 1990-01-04 1991-07-11 Symbiotec Gmbh Chemotherapeutisches mittel, insbesondere zur behandlung von krebserkrankungen
US6015557A (en) 1999-02-24 2000-01-18 Tobinick; Edward L. Tumor necrosis factor antagonists for the treatment of neurological disorders
US7485314B2 (en) * 2002-05-06 2009-02-03 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Induction of antigen specific immunologic tolerance
KR101234476B1 (ko) 2004-03-05 2013-02-18 덴끼 가가꾸 고교 가부시키가이샤 히알루론산/메토트렉세이트 화합물
US7884196B2 (en) 2004-10-06 2011-02-08 Oliver Lawless Vaccine composition comprising methylated DNA and immunomodulatory motifs
AU2007224250B2 (en) * 2006-03-02 2012-05-03 Alexion Pharmaceuticals, Inc. Prolongation of survival of an allograft by inhibiting complement activity
WO2008094937A2 (fr) 2007-01-29 2008-08-07 Joslin Diabetes Center, Inc. Procédés de modulation de l'angiogenèse
WO2009073146A2 (fr) * 2007-11-29 2009-06-11 Celgene Corporation Utilisation de composés immunomodulateurs destinés au traitement de la myélite transverse, de la sclérose en plaques et d'autres troubles
EP2077281A1 (fr) * 2008-01-02 2009-07-08 Bergen Teknologioverforing AS Anticorps anti-CD20 ou fragments correspondants pour le traitement de syndrome de fatigue chronique
US7914785B2 (en) * 2008-01-02 2011-03-29 Bergen Teknologieverforing As B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome
SI2344677T1 (sl) 2008-10-08 2017-10-30 Cambridge Enterprise Limited Postopki in sestavki za diagnosticiranje in zdravljenje multipli sklerozi sekundarne avtoimune bolezni
US20120028985A1 (en) 2008-11-07 2012-02-02 4Sc Ag Combinational therapy for treating autoimmune disease
PE20140469A1 (es) 2011-05-16 2014-04-23 Genzyme Corp Induccion de tolerancia inmunologica utilizando metotrexato

Also Published As

Publication number Publication date
JP2014513722A (ja) 2014-06-05
CN110124039A (zh) 2019-08-16
US20230372347A1 (en) 2023-11-23
JP2017141236A (ja) 2017-08-17
ECSP13013081A (es) 2015-04-30
KR20200116543A (ko) 2020-10-12
AU2012256281A1 (en) 2013-11-28
GT201300278A (es) 2015-02-12
CO6841993A2 (es) 2014-01-20
IL229245A0 (en) 2014-01-30
ZA201308315B (en) 2014-07-30
KR102163285B1 (ko) 2020-10-08
PE20140469A1 (es) 2014-04-23
US20200360385A1 (en) 2020-11-19
JP2018184466A (ja) 2018-11-22
IL229245B (en) 2020-08-31
AU2012256281B2 (en) 2017-06-15
EP3824890A1 (fr) 2021-05-26
CL2013003298A1 (es) 2014-07-25
CN113209288A (zh) 2021-08-06
JP6381707B2 (ja) 2018-08-29
US11672802B2 (en) 2023-06-13
CA2835819A1 (fr) 2012-11-22
KR20190132551A (ko) 2019-11-27
US20140135337A1 (en) 2014-05-15
MX2013013445A (es) 2014-07-28
UA117556C2 (uk) 2018-08-27
DOP2013000268A (es) 2014-01-31
KR20140040744A (ko) 2014-04-03
RU2013155618A (ru) 2015-06-27
IL276879B (en) 2022-06-01
ES2836823T3 (es) 2021-06-28
KR102316283B1 (ko) 2021-10-21
CN103648501A (zh) 2014-03-19
MA35165B1 (fr) 2014-06-02
IL276879A (en) 2020-10-29
EP2709627A4 (fr) 2014-11-12
JP6694020B2 (ja) 2020-05-13
NI201300121A (es) 2014-02-28
NZ617575A (en) 2016-10-28
NZ716716A (en) 2018-06-29
EP2709627A1 (fr) 2014-03-26
RU2674036C2 (ru) 2018-12-04
CN109620830A (zh) 2019-04-16
PT2709627T (pt) 2020-12-24
EP2709627B1 (fr) 2020-09-23
WO2012158362A1 (fr) 2012-11-22
NZ742216A (en) 2018-10-26
JP6174572B2 (ja) 2017-08-02
BR112013029501A2 (pt) 2017-01-24
SG194802A1 (en) 2013-12-30
MY173304A (en) 2020-01-14

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