PE20140469A1 - Induccion de tolerancia inmunologica utilizando metotrexato - Google Patents
Induccion de tolerancia inmunologica utilizando metotrexatoInfo
- Publication number
- PE20140469A1 PE20140469A1 PE2013002499A PE2013002499A PE20140469A1 PE 20140469 A1 PE20140469 A1 PE 20140469A1 PE 2013002499 A PE2013002499 A PE 2013002499A PE 2013002499 A PE2013002499 A PE 2013002499A PE 20140469 A1 PE20140469 A1 PE 20140469A1
- Authority
- PE
- Peru
- Prior art keywords
- subject
- enzyme
- immunological tolerance
- cells
- alpha
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Abstract
SE REFIERE A UN METODO PARA AUMENTAR LA EFICACIA DE UN PRODUCTO TERAPEUTICO TAL COMO LA ENZIMA ALFA-GALACTOSIDASA A HUMANA O ALFA-GLUCOSIDASA ACIDA HUMANA EN UN SUJETO, EL CUAL COMPRENDE ADMINISTRAR AL SUJETO UNA CANTIDAD EFICAZ DE METOTREXATO EN UN UNICO CICLO PARA i) INDUCIR UNA TOLERANCIA INMUNOLOGICA HACIA LA ENZIMA; ii) INHIBIR LAS RESPUESTAS DE ANTICUERPOS A LA ENZIMA; iii) ALIVIAR UNA REACCION DE INFUSION CONTRA LA ENZIMA; iv) REDUCIR LA AUTOINMUNIDAD SECUNDARIA EN EL SUJETO; v) AUMENTAR EL PORCENTAJE DE CELULAS B REGULADORAS EN LA POBLACION DE CELULAS B EN EL SUJETO; O vi) INHIBIR LAS RESPUESTAS DE CELULAS T EN EL SUJETO. DICHO SUJETO ES UN PACIENTE CON ESCLEROSIS MULTIPLE, QUE NECESITA UN TRANSPLANTE DE TEJIDOS, TRANSPLANTE DE ORGANOS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486697P | 2011-05-16 | 2011-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20140469A1 true PE20140469A1 (es) | 2014-04-23 |
Family
ID=47177257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013002499A PE20140469A1 (es) | 2011-05-16 | 2012-05-03 | Induccion de tolerancia inmunologica utilizando metotrexato |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US20140135337A1 (es) |
| EP (2) | EP2709627B1 (es) |
| JP (3) | JP6174572B2 (es) |
| KR (3) | KR102316283B1 (es) |
| CN (4) | CN109620830A (es) |
| AU (1) | AU2012256281B2 (es) |
| BR (1) | BR112013029501A2 (es) |
| CA (1) | CA2835819A1 (es) |
| CL (1) | CL2013003298A1 (es) |
| CO (1) | CO6841993A2 (es) |
| DO (1) | DOP2013000268A (es) |
| EC (1) | ECSP13013081A (es) |
| ES (1) | ES2836823T3 (es) |
| GT (1) | GT201300278A (es) |
| IL (2) | IL229245B (es) |
| MA (1) | MA35165B1 (es) |
| MX (1) | MX2013013445A (es) |
| MY (1) | MY173304A (es) |
| NI (1) | NI201300121A (es) |
| PE (1) | PE20140469A1 (es) |
| PT (1) | PT2709627T (es) |
| RU (1) | RU2674036C2 (es) |
| SG (1) | SG194802A1 (es) |
| TN (1) | TN2013000472A1 (es) |
| UA (1) | UA117556C2 (es) |
| WO (1) | WO2012158362A1 (es) |
| ZA (1) | ZA201308315B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3182519A1 (en) | 2011-04-29 | 2012-11-01 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers for antigen-specific deletion of t effector cells |
| CN109620830A (zh) | 2011-05-16 | 2019-04-16 | 建新公司 | 使用甲氨蝶呤诱导免疫耐受性 |
| AU2014262163A1 (en) | 2013-05-03 | 2015-11-19 | Selecta Biosciences, Inc. | Delivery of immunosuppressants having a specified pharmacodynamic effective-life and antigen for the inducation of immune tolerance |
| MX2015016691A (es) * | 2013-06-04 | 2016-04-04 | Selecta Biosciences Inc | Administracion repetida de inmunoterapeuticos especificos de antigeno no inmunosupresores. |
| CN107073091A (zh) | 2014-09-07 | 2017-08-18 | 西莱克塔生物科技公司 | 用于减弱外显子跳读抗病毒转移载体免疫应答的方法和组合物 |
| JP2016213236A (ja) * | 2015-04-30 | 2016-12-15 | 日東電工株式会社 | 半導体装置用フィルム、及び、半導体装置の製造方法 |
| CN110612122A (zh) | 2017-03-11 | 2019-12-24 | 西莱克塔生物科技公司 | 与用抗炎剂和包含免疫抑制剂之合成纳米载体进行的组合治疗相关的方法和组合物 |
| WO2018209300A1 (en) * | 2017-05-12 | 2018-11-15 | Duke University | Methods for the use of low-dose immune modulators transiently for treating patients undergoing protein replacement therapy |
| TWI821227B (zh) * | 2017-12-22 | 2023-11-11 | 美商健臻公司 | 胺甲喋呤誘發的免疫耐受性之生物標記 |
| TW202142264A (zh) | 2020-02-08 | 2021-11-16 | 美商健臻公司 | 治療龐貝氏症的組成物及方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4080325A (en) | 1976-11-17 | 1978-03-21 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of methotrexate |
| US4558690A (en) | 1982-01-26 | 1985-12-17 | University Of Scranton | Method of administration of chemotherapy to tumors |
| US5108987A (en) | 1982-02-25 | 1992-04-28 | Faulk Ward P | Conjugates of proteins with anti-tumor agents |
| US5028697A (en) | 1988-08-08 | 1991-07-02 | Eli Lilly And Company | Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers |
| DE4000154A1 (de) | 1990-01-04 | 1991-07-11 | Symbiotec Gmbh | Chemotherapeutisches mittel, insbesondere zur behandlung von krebserkrankungen |
| US6015557A (en) | 1999-02-24 | 2000-01-18 | Tobinick; Edward L. | Tumor necrosis factor antagonists for the treatment of neurological disorders |
| US7485314B2 (en) * | 2002-05-06 | 2009-02-03 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Induction of antigen specific immunologic tolerance |
| KR101234476B1 (ko) | 2004-03-05 | 2013-02-18 | 덴끼 가가꾸 고교 가부시키가이샤 | 히알루론산/메토트렉세이트 화합물 |
| US7884196B2 (en) | 2004-10-06 | 2011-02-08 | Oliver Lawless | Vaccine composition comprising methylated DNA and immunomodulatory motifs |
| CN101437501B (zh) * | 2006-03-02 | 2012-09-05 | 阿莱克申药物公司 | 通过抑制补体活性延长同种异体移植物的存活 |
| WO2008094937A2 (en) | 2007-01-29 | 2008-08-07 | Joslin Diabetes Center, Inc. | Methods of modulating angiogenesis |
| WO2009073146A2 (en) * | 2007-11-29 | 2009-06-11 | Celgene Corporation | Use of immunomodulatory compounds for the treatment of transverse myelitis, multiple sclerosis, and other disorders |
| US7914785B2 (en) * | 2008-01-02 | 2011-03-29 | Bergen Teknologieverforing As | B-cell depleting agents, like anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome |
| EP2077281A1 (en) * | 2008-01-02 | 2009-07-08 | Bergen Teknologioverforing AS | Anti-CD20 antibodies or fragments thereof for the treatment of chronic fatigue syndrome |
| KR101825457B1 (ko) | 2008-10-08 | 2018-02-05 | 캠브리지 엔터프라이즈 리미티드 | 다발경화증에 대한 2차 자가면역 질환의 진단 및 치료를 위한 방법 및 조성물 |
| EA201100605A1 (ru) | 2008-11-07 | 2012-02-28 | 4ЭсЦэ АГ | Комбинированная терапия, включающая ингибитор dhodh и метотрексат, для лечения аутоиммунного заболевания |
| CN109620830A (zh) | 2011-05-16 | 2019-04-16 | 建新公司 | 使用甲氨蝶呤诱导免疫耐受性 |
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2012
- 2012-05-03 CN CN201811398468.5A patent/CN109620830A/zh active Pending
- 2012-05-03 EP EP12785624.3A patent/EP2709627B1/en active Active
- 2012-05-03 JP JP2014511390A patent/JP6174572B2/ja active Active
- 2012-05-03 CN CN201910138372.3A patent/CN110124039A/zh active Pending
- 2012-05-03 EP EP20197579.4A patent/EP3824890A1/en active Pending
- 2012-05-03 KR KR1020207027913A patent/KR102316283B1/ko active IP Right Grant
- 2012-05-03 PE PE2013002499A patent/PE20140469A1/es not_active Application Discontinuation
- 2012-05-03 MX MX2013013445A patent/MX2013013445A/es unknown
- 2012-05-03 UA UAA201314626A patent/UA117556C2/uk unknown
- 2012-05-03 BR BR112013029501A patent/BR112013029501A2/pt not_active Application Discontinuation
- 2012-05-03 CA CA2835819A patent/CA2835819A1/en not_active Abandoned
- 2012-05-03 CN CN201280035299.3A patent/CN103648501A/zh active Pending
- 2012-05-03 PT PT127856243T patent/PT2709627T/pt unknown
- 2012-05-03 ES ES12785624T patent/ES2836823T3/es active Active
- 2012-05-03 AU AU2012256281A patent/AU2012256281B2/en active Active
- 2012-05-03 RU RU2013155618A patent/RU2674036C2/ru active
- 2012-05-03 KR KR1020197033979A patent/KR102163285B1/ko active IP Right Grant
- 2012-05-03 CN CN202011422509.7A patent/CN113209288A/zh active Pending
- 2012-05-03 KR KR1020137032882A patent/KR20140040744A/ko active Application Filing
- 2012-05-03 MY MYPI2013003998A patent/MY173304A/en unknown
- 2012-05-03 SG SG2013082003A patent/SG194802A1/en unknown
- 2012-05-03 US US14/116,486 patent/US20140135337A1/en not_active Abandoned
- 2012-05-03 WO PCT/US2012/036405 patent/WO2012158362A1/en active Application Filing
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2013
- 2013-11-04 IL IL229245A patent/IL229245B/en active IP Right Grant
- 2013-11-06 ZA ZA2013/08315A patent/ZA201308315B/en unknown
- 2013-11-13 TN TNP2013000472A patent/TN2013000472A1/fr unknown
- 2013-11-14 NI NI201300121A patent/NI201300121A/es unknown
- 2013-11-14 GT GT201300278A patent/GT201300278A/es unknown
- 2013-11-15 DO DO2013000268A patent/DOP2013000268A/es unknown
- 2013-11-15 CL CL2013003298A patent/CL2013003298A1/es unknown
- 2013-12-04 MA MA36522A patent/MA35165B1/fr unknown
- 2013-12-05 CO CO13286019A patent/CO6841993A2/es not_active Application Discontinuation
- 2013-12-13 EC ECSP13013081 patent/ECSP13013081A/es unknown
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2017
- 2017-03-03 JP JP2017040046A patent/JP6381707B2/ja active Active
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2018
- 2018-08-02 JP JP2018145564A patent/JP6694020B2/ja active Active
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2020
- 2020-03-24 US US16/828,407 patent/US11672802B2/en active Active
- 2020-08-23 IL IL276879A patent/IL276879B/en unknown
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2023
- 2023-04-28 US US18/141,128 patent/US20230372347A1/en active Pending
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Legal Events
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