ES2721180T3 - Productos terapéuticos usando células adiposas y secreciones celulares - Google Patents

Productos terapéuticos usando células adiposas y secreciones celulares Download PDF

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Publication number
ES2721180T3
ES2721180T3 ES12833860T ES12833860T ES2721180T3 ES 2721180 T3 ES2721180 T3 ES 2721180T3 ES 12833860 T ES12833860 T ES 12833860T ES 12833860 T ES12833860 T ES 12833860T ES 2721180 T3 ES2721180 T3 ES 2721180T3
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Prior art keywords
cells
adipose tissue
composition
tissue derived
secretions
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ES12833860T
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English (en)
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Graham Vesey
Rebecca Anne Webster
Richard Lilischkis
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Cell Ideas Pty Ltd
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Cell Ideas Pty Ltd
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Priority claimed from AU2011903938A external-priority patent/AU2011903938A0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)

Abstract

Una composición congelada que comprende células de la progenie de cultivo de células sometidas a múltiples pases de una suspensión de células derivadas de tejido adiposo y secreciones de células derivadas de tejido adiposo, en la que dichas secreciones comprenden medios clarificados y/o concentrados de cultivo de células derivadas de tejido adiposo que han surgido como células de la progenie o una línea celular de cultivo anterior para su uso en el tratamiento de una afección seleccionada del grupo que consiste en un trastorno inflamatorio, una lesión de ligamentos y una lesión de tendón, o alivio del dolor asociado con un trastorno inflamatorio, una lesión de ligamentos o una lesión de tendón, en un sujeto mamífero, en el que la composición se administra a un sujeto después de descongelar la composición.
ES12833860T 2011-09-23 2012-09-21 Productos terapéuticos usando células adiposas y secreciones celulares Active ES2721180T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AU2011903938A AU2011903938A0 (en) 2011-09-23 Therapeutic methods and compositions
AU2012901350A AU2012901350A0 (en) 2012-04-04 Therapeutic methods and compositions
AU2012903646A AU2012903646A0 (en) 2012-08-23 Therapeutic methods and compositions
PCT/AU2012/001140 WO2013040649A1 (en) 2011-09-23 2012-09-21 Therapeutics using adipose cells and cell secretions

Publications (1)

Publication Number Publication Date
ES2721180T3 true ES2721180T3 (es) 2019-07-29

Family

ID=47913679

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12833860T Active ES2721180T3 (es) 2011-09-23 2012-09-21 Productos terapéuticos usando células adiposas y secreciones celulares
ES19153401T Active ES2880084T3 (es) 2011-09-23 2012-09-21 Terapias que usan células adiposas y secreciones celulares

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES19153401T Active ES2880084T3 (es) 2011-09-23 2012-09-21 Terapias que usan células adiposas y secreciones celulares

Country Status (9)

Country Link
US (3) US10111909B2 (es)
EP (3) EP2744892B1 (es)
JP (5) JP6162123B2 (es)
AU (1) AU2012313352B2 (es)
CA (1) CA2885487C (es)
DK (2) DK3546569T3 (es)
ES (2) ES2721180T3 (es)
SG (2) SG10201606745XA (es)
WO (1) WO2013040649A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US20140286911A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
ES2721180T3 (es) * 2011-09-23 2019-07-29 Cell Ideas Pty Ltd Productos terapéuticos usando células adiposas y secreciones celulares
JP2023002772A (ja) * 2011-09-23 2023-01-10 レジニアス リミテッド 脂肪細胞および細胞分泌物を使用する治療
AU2013204930C1 (en) * 2012-09-26 2015-01-22 Cell Ideas Pty Ltd Therapeutics using multiple injections of cells
CA2891272C (en) 2012-11-15 2022-11-22 Allosource Minced cartilage systems and methods
WO2014100857A1 (en) 2012-12-24 2014-07-03 Cell Ideas Pty Ltd Vaccines for the treatment of cancer and compositions for enhancing vaccine efficacy
EP2958523B1 (en) 2013-02-22 2020-04-22 AlloSource Cartilage mosaic compositions and methods
US9168140B2 (en) 2013-03-15 2015-10-27 Allosource Perforated osteochondral allograft compositions
ES2870558T3 (es) * 2013-06-19 2021-10-27 Spinalcyte Llc Adipocitos para aplicaciones de condrocitos
CN106255884B (zh) * 2013-10-04 2019-01-11 赛尔爱迪尔私人有限公司 用于细胞治疗的生物标志物
EP3233097A4 (en) * 2014-12-19 2018-08-08 Cell Ideas Pty Ltd. Improved cell therapies
TWI760313B (zh) 2015-09-08 2022-04-11 澳大利亞商愛迪雅股份有限公司 細胞擴增方法及治療組成物
CN108289915A (zh) * 2015-11-24 2018-07-17 日本乐敦制药株式会社 包含脂肪组织来源基质细胞的肝病治疗剂及其制造方法
WO2018211498A1 (en) 2017-05-15 2018-11-22 Stem Cell Medicine Ltd. Treatment of multiple sclerosis with adipose-derived stem cells
CN110709091A (zh) 2017-05-15 2020-01-17 干细胞医药有限公司 使用长效格拉替雷和脂肪源性干细胞治疗多发性硬化症
CA3059319A1 (en) * 2017-10-02 2019-04-11 Hirotaro Fukuoka Pharmaceutical composition for use in improving quality of scalp or skin, wound healing, or improving quality of hair
MA52883A (fr) * 2018-06-15 2021-05-26 Prieto Manuel Hermida Composition pharmaceutique pour dermatologie et ses utilisations
JP7465506B2 (ja) * 2018-08-14 2024-04-11 国立研究開発法人国立国際医療研究センター 褐色脂肪細胞上清、その調製法、及び、使用
JP7429032B2 (ja) * 2019-12-24 2024-02-07 学校法人順天堂 間質性肺炎モデル非ヒト動物の作製方法
JP6826744B1 (ja) * 2020-07-17 2021-02-10 医療法人Ｙａｎａｇａ ＣＬｉｎｉｃ 成熟脂肪細胞含有組成物の製造方法
CN114452303A (zh) * 2020-11-10 2022-05-10 上海萨美细胞技术有限公司 无细胞脂肪提取液对关节炎的治疗用途
IT202100003062A1 (it) * 2021-02-11 2022-08-11 Gaia Margiotta "processo di crioconservazione di tessuto adiposo"
CN115521908A (zh) * 2022-10-24 2022-12-27 潍坊天创生物科技有限公司 一种脂肪间充质干细胞的体外培养及外泌体的分离纯化方法

Family Cites Families (16)

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US6037175A (en) 1996-03-12 2000-03-14 The University Of South Florida Method and media for enhancing cryopreservation of cells
US7078232B2 (en) * 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
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EP1451300A4 (en) * 2001-11-09 2007-01-10 Artecel Sciences Inc METHODS AND COMPOSITIONS IN WHICH STROMAL CELLS ARE USED TO SUPPORT EMBRYONIC AND ADULT STEM CELLS
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EP1678295B1 (en) * 2003-10-08 2013-03-06 Vet-Stem Inc Methods of preparing and using stem cell compositions and kits comprising the same
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WO2008018450A1 (fr) * 2006-08-08 2008-02-14 National University Corporation Nagoya University Préparation cellulaire contenant des cellules souches multipotentes provenant d'un tissu adipeux
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WO2009115581A2 (en) * 2008-03-19 2009-09-24 Cryo-Save Ag Improved cryopreservation of adipose tissue for the isolation of mesenchymal stem cells
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WO2012122604A1 (en) * 2011-03-15 2012-09-20 Cell Ideas Pty Ltd Pharmaceutical compositions and topical use thereof
ES2721180T3 (es) * 2011-09-23 2019-07-29 Cell Ideas Pty Ltd Productos terapéuticos usando células adiposas y secreciones celulares

Also Published As

Publication number Publication date
JP2017193566A (ja) 2017-10-26
JP2022033865A (ja) 2022-03-02
ES2880084T3 (es) 2021-11-23
JP7022863B2 (ja) 2022-02-18
US10111909B2 (en) 2018-10-30
EP2744892B1 (en) 2019-03-20
CA2885487A1 (en) 2013-03-28
JP6839038B2 (ja) 2021-03-03
WO2013040649A1 (en) 2013-03-28
US20140234272A1 (en) 2014-08-21
AU2012313352A1 (en) 2013-05-02
EP3546569B1 (en) 2021-06-16
EP2744892A1 (en) 2014-06-25
EP3868871A1 (en) 2021-08-25
JP2014527821A (ja) 2014-10-23
JP6912512B2 (ja) 2021-08-04
JP2021155461A (ja) 2021-10-07
US20190015455A1 (en) 2019-01-17
SG2014013676A (en) 2014-05-29
US10660921B2 (en) 2020-05-26
SG10201606745XA (en) 2016-10-28
JP6162123B2 (ja) 2017-07-12
US20200261510A1 (en) 2020-08-20
EP3546569A1 (en) 2019-10-02
EP2744892A4 (en) 2015-05-20
AU2012313352B2 (en) 2015-07-02
CA2885487C (en) 2021-11-16
DK2744892T3 (en) 2019-04-23
JP2019142971A (ja) 2019-08-29
DK3546569T3 (da) 2021-07-12
AU2012313352A9 (en) 2013-09-26

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