CH674309A5 - - Google Patents
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- Publication number
- CH674309A5 CH674309A5 CH1467/86A CH146786A CH674309A5 CH 674309 A5 CH674309 A5 CH 674309A5 CH 1467/86 A CH1467/86 A CH 1467/86A CH 146786 A CH146786 A CH 146786A CH 674309 A5 CH674309 A5 CH 674309A5
- Authority
- CH
- Switzerland
- Prior art keywords
- zinc
- ionone
- weight
- preparation according
- amounts
- Prior art date
Links
- 150000003751 zinc Chemical class 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 24
- 229930002839 ionone Natural products 0.000 claims description 23
- 150000002499 ionone derivatives Chemical class 0.000 claims description 23
- 238000002360 preparation method Methods 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims description 17
- UZFLPKAIBPNNCA-UHFFFAOYSA-N alpha-ionone Natural products CC(=O)C=CC1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-UHFFFAOYSA-N 0.000 claims description 17
- 206010006326 Breath odour Diseases 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- UZFLPKAIBPNNCA-FPLPWBNLSA-N α-ionone Chemical compound CC(=O)\C=C/C1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-FPLPWBNLSA-N 0.000 claims description 16
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 14
- 239000002324 mouth wash Substances 0.000 claims description 11
- 239000000606 toothpaste Substances 0.000 claims description 11
- PSQYTAPXSHCGMF-BQYQJAHWSA-N β-ionone Chemical compound CC(=O)\C=C\C1=C(C)CCCC1(C)C PSQYTAPXSHCGMF-BQYQJAHWSA-N 0.000 claims description 10
- 229940051866 mouthwash Drugs 0.000 claims description 9
- 229940034610 toothpaste Drugs 0.000 claims description 9
- 239000010692 aromatic oil Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 239000011592 zinc chloride Substances 0.000 claims description 7
- 235000005074 zinc chloride Nutrition 0.000 claims description 7
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 6
- 235000019477 peppermint oil Nutrition 0.000 claims description 6
- 231100000252 nontoxic Toxicity 0.000 claims description 5
- 230000003000 nontoxic effect Effects 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 239000003349 gelling agent Substances 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 4
- 239000011885 synergistic combination Substances 0.000 claims description 4
- SFEOKXHPFMOVRM-UHFFFAOYSA-N (+)-(S)-gamma-ionone Natural products CC(=O)C=CC1C(=C)CCCC1(C)C SFEOKXHPFMOVRM-UHFFFAOYSA-N 0.000 claims description 3
- 239000001244 (E)-1-(2,6,6-trimethyl-1-cyclohex-2-enyl)pent-1-en-3-one Substances 0.000 claims description 3
- VPKMGDRERYMTJX-XEHSLEBBSA-N (e)-1-[(1r)-2,6,6-trimethylcyclohex-2-en-1-yl]pent-1-en-3-one Chemical compound CCC(=O)\C=C\[C@H]1C(C)=CCCC1(C)C VPKMGDRERYMTJX-XEHSLEBBSA-N 0.000 claims description 3
- YJRODKCOICMRBO-BQYQJAHWSA-N (e)-4-(2,2,6-trimethylcyclohexyl)but-3-en-2-one Chemical compound CC1CCCC(C)(C)C1\C=C\C(C)=O YJRODKCOICMRBO-BQYQJAHWSA-N 0.000 claims description 3
- 239000008365 aqueous carrier Substances 0.000 claims description 3
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 229930007090 gamma-ionone Natural products 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- SFEOKXHPFMOVRM-BQYQJAHWSA-N γ-ionone Chemical compound CC(=O)\C=C\C1C(=C)CCCC1(C)C SFEOKXHPFMOVRM-BQYQJAHWSA-N 0.000 claims description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims 1
- 239000004246 zinc acetate Substances 0.000 claims 1
- -1 ketone terpenes Chemical class 0.000 description 25
- 150000001875 compounds Chemical class 0.000 description 15
- 239000011701 zinc Substances 0.000 description 15
- 229910052725 zinc Inorganic materials 0.000 description 14
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 13
- 239000000126 substance Substances 0.000 description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 235000006679 Mentha X verticillata Nutrition 0.000 description 7
- 244000246386 Mentha pulegium Species 0.000 description 7
- 235000016257 Mentha pulegium Nutrition 0.000 description 7
- 235000002899 Mentha suaveolens Nutrition 0.000 description 7
- 235000004357 Mentha x piperita Nutrition 0.000 description 7
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 235000001050 hortel pimenta Nutrition 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 7
- 229940068196 placebo Drugs 0.000 description 7
- 239000000902 placebo Substances 0.000 description 7
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 7
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 235000014113 dietary fatty acids Nutrition 0.000 description 6
- 239000000194 fatty acid Substances 0.000 description 6
- 229930195729 fatty acid Natural products 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 4
- 239000003599 detergent Substances 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical class CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 4
- 238000005498 polishing Methods 0.000 description 4
- 210000003296 saliva Anatomy 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical group COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 4
- 229940123208 Biguanide Drugs 0.000 description 3
- 208000006558 Dental Calculus Diseases 0.000 description 3
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 239000011737 fluorine Substances 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 235000007586 terpenes Nutrition 0.000 description 3
- 150000003752 zinc compounds Chemical class 0.000 description 3
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 description 2
- 229940011037 anethole Drugs 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000007859 condensation product Substances 0.000 description 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000001282 iso-butane Chemical class 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 2
- 230000007505 plaque formation Effects 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- 239000011698 potassium fluoride Substances 0.000 description 2
- 159000000001 potassium salts Chemical class 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 2
- 229960002799 stannous fluoride Drugs 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 150000003464 sulfur compounds Chemical class 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 2
- 239000011746 zinc citrate Substances 0.000 description 2
- 235000006076 zinc citrate Nutrition 0.000 description 2
- 229940068475 zinc citrate Drugs 0.000 description 2
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 2
- UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 description 2
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 2
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- HTYFFCPFVMJTKM-UHFFFAOYSA-N 2-(4-chlorophenyl)-1-(diaminomethylidene)guanidine Chemical compound NC(N)=NC(N)=NC1=CC=C(Cl)C=C1 HTYFFCPFVMJTKM-UHFFFAOYSA-N 0.000 description 1
- XLMXUUQMSMKFMH-UZRURVBFSA-N 2-hydroxyethyl (z,12r)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCC[C@@H](O)C\C=C/CCCCCCCC(=O)OCCO XLMXUUQMSMKFMH-UZRURVBFSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 239000004604 Blowing Agent Substances 0.000 description 1
- ICFJTPJPQNKNBN-UHFFFAOYSA-N C1(=CC=CC=C1)O.[Zn+2].[Cr](=O)(=O)([O-])[O-].[Zn+2].[Cr](=O)(=O)([O-])[O-] Chemical compound C1(=CC=CC=C1)O.[Zn+2].[Cr](=O)(=O)([O-])[O-].[Zn+2].[Cr](=O)(=O)([O-])[O-] ICFJTPJPQNKNBN-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- DQFBYFPFKXHELB-UHFFFAOYSA-N Chalcone Natural products C=1C=CC=CC=1C(=O)C=CC1=CC=CC=C1 DQFBYFPFKXHELB-UHFFFAOYSA-N 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- 239000005696 Diammonium phosphate Substances 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 244000166124 Eucalyptus globulus Species 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 239000004201 L-cysteine Substances 0.000 description 1
- 235000013878 L-cysteine Nutrition 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
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- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
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- AMCPECLBZPXAPB-UHFFFAOYSA-N propane-1,2,3-triol;sodium Chemical compound [Na].OCC(O)CO AMCPECLBZPXAPB-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
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- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 description 1
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- 230000002195 synergetic effect Effects 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 230000036367 tooth discoloration Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- YZYKBQUWMPUVEN-UHFFFAOYSA-N zafuleptine Chemical compound OC(=O)CCCCCC(C(C)C)NCC1=CC=C(F)C=C1 YZYKBQUWMPUVEN-UHFFFAOYSA-N 0.000 description 1
- DJWUNCQRNNEAKC-UHFFFAOYSA-L zinc acetate Chemical class [Zn+2].CC([O-])=O.CC([O-])=O DJWUNCQRNNEAKC-UHFFFAOYSA-L 0.000 description 1
- 235000013904 zinc acetate Nutrition 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- XLMCDAMBOROREP-UHFFFAOYSA-N zinc;3-phosphonooxypropane-1,2-diolate Chemical compound [Zn+2].OP(O)(=O)OCC([O-])C[O-] XLMCDAMBOROREP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72378685A | 1985-04-16 | 1985-04-16 | |
| US06/836,671 US4689214A (en) | 1985-04-16 | 1986-03-10 | Composition to counter breath odor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH674309A5 true CH674309A5 (en, 2012) | 1990-05-31 |
Family
ID=27110869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1467/86A CH674309A5 (en, 2012) | 1985-04-16 | 1986-04-14 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4689214A (en, 2012) |
| AT (1) | AT389445B (en, 2012) |
| AU (1) | AU587241B2 (en, 2012) |
| BE (1) | BE904604A (en, 2012) |
| BR (1) | BR8601690A (en, 2012) |
| CA (1) | CA1283055C (en, 2012) |
| CH (1) | CH674309A5 (en, 2012) |
| DE (1) | DE3610179C2 (en, 2012) |
| DK (1) | DK167336B1 (en, 2012) |
| ES (1) | ES8706435A1 (en, 2012) |
| FI (1) | FI84313C (en, 2012) |
| FR (1) | FR2587209B1 (en, 2012) |
| GB (1) | GB2173701B (en, 2012) |
| GR (1) | GR860981B (en, 2012) |
| HK (1) | HK18492A (en, 2012) |
| IN (1) | IN165260B (en, 2012) |
| IT (1) | IT1214408B (en, 2012) |
| MX (1) | MX164084B (en, 2012) |
| MY (1) | MY100363A (en, 2012) |
| NL (1) | NL8600957A (en, 2012) |
| NO (1) | NO166391C (en, 2012) |
| NZ (1) | NZ215697A (en, 2012) |
| PH (1) | PH22873A (en, 2012) |
| PT (1) | PT82387B (en, 2012) |
| SE (1) | SE467609B (en, 2012) |
| SG (1) | SG4992G (en, 2012) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5095035A (en) * | 1981-07-31 | 1992-03-10 | Eby Iii George A | Flavor stable zinc acetate compositions for oral absorption |
| FR2586350B1 (fr) * | 1985-08-22 | 1992-05-15 | Colgate Palmolive Co | Composition pharmaceutique a base de peroxodiphosphate pour l'inhibition de la secretion d'hormone parathyroidienne |
| US4814163A (en) * | 1986-03-10 | 1989-03-21 | Colgate-Palmolive Company | Solid antitartar mouth deodorant |
| US4814164A (en) * | 1986-03-10 | 1989-03-21 | Colgate-Palmolive Company | Solid antitartar mouth deodorant composition |
| JPH0747531B2 (ja) * | 1986-06-27 | 1995-05-24 | ライオン株式会社 | 口腔用組成物 |
| US4937066A (en) * | 1989-06-22 | 1990-06-26 | David G. Vlock | Zinc containing oral compositions |
| US5188820A (en) * | 1989-10-05 | 1993-02-23 | Chesebrough-Pond's Usa Co., Dividion Of Conopco, Inc. | Method of inhibiting plaque on teeth by applying an oral composition |
| US5286479A (en) * | 1991-12-10 | 1994-02-15 | The Dow Chemical Company | Oral compositions for suppressing mouth odors |
| US5292527A (en) * | 1992-07-02 | 1994-03-08 | Bausch & Lomb Incorporated | Non-alcoholic aqueous mouthwash |
| US5405836A (en) * | 1993-03-02 | 1995-04-11 | Nabisco, Inc. | Pet foods with water-soluble zinc compound coating for controlling malodorous breath |
| US5833952A (en) * | 1993-09-16 | 1998-11-10 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Oral compositions |
| CN1066668C (zh) * | 1994-11-16 | 2001-06-06 | 住友化学工业株式会社 | 热可塑性弹性体粉末，使用它的成形方法和成形后的成形体 |
| WO1998011867A1 (en) * | 1996-09-20 | 1998-03-26 | Warner-Lambert Company | Oral compositions containing a zinc compound |
| NZ335780A (en) | 1996-10-23 | 2001-01-26 | Univ New York State Res Found | Compositions to control oral microbial oxidation-reduction (Eh) levels and treat gingivitis-periodontitis |
| US5833955A (en) * | 1996-11-14 | 1998-11-10 | The Research Foundation Of State University Of New York | Diagnostic tests to assess a persons oral malodor capacity and potential for developing periodontitis |
| US5780015A (en) * | 1997-05-14 | 1998-07-14 | Colgate Palmolive Company | Dentifrice for the treatment of dentinal hypersensitivity having limited astringency |
| DE19735126C1 (de) * | 1997-08-13 | 1999-01-21 | Infectopharm Arzneimittel Und | Verfahren zur Herstellung einer eine Zinkverbindung enthaltenden oralen Zusammensetzung und deren Verwendung zur Behandlung von Erkältungskrankheiten |
| US5948390A (en) * | 1997-08-25 | 1999-09-07 | Pfizer Inc. | Stable zinc/citrate/CPC oral rinse formulations |
| DK176196B1 (da) | 1997-10-07 | 2007-01-08 | Ejvind Jersie Pedersen | Mundhygejnepræparat til behandling af halitosis samt anvendelse af et chelat omfattende en metaliondel og en aminosyredel som en komponent i præparatet |
| US6174514B1 (en) | 1999-04-12 | 2001-01-16 | Fuisz Technologies Ltd. | Breath Freshening chewing gum with encapsulations |
| NO307168B1 (no) * | 1999-03-01 | 2000-02-21 | Orix As | Oralt preparat som er effektivt mot halitose |
| US6306372B1 (en) * | 2000-06-21 | 2001-10-23 | Noville Inc. | Oral hygiene compositions which mask the burn sensation and the astringency of eucalyptol and zinc |
| US6723305B2 (en) * | 2002-03-04 | 2004-04-20 | Colgate Palmolive Company | Anti-microbial breath freshening mouthrinse |
| GB0303678D0 (en) * | 2003-02-18 | 2003-03-19 | Quest Int | Improvements in or relating to flavour compositions |
| GB0303676D0 (en) * | 2003-02-18 | 2003-03-19 | Quest Int | Improvements in or relating to flavour compositions |
| GB0303675D0 (en) * | 2003-02-18 | 2003-03-19 | Quest Int | Improvements in or relating to flavour compositions |
| WO2004098566A2 (en) * | 2003-04-30 | 2004-11-18 | Zicam, Llc | Chewable lozenge cold remedy composition and method for making same |
| US20070092583A1 (en) * | 2003-04-30 | 2007-04-26 | Tim Clarot | Cold remedy composition comprising zinc salts |
| ATE373468T1 (de) * | 2003-04-30 | 2007-10-15 | Zicam Llc | Orales spray gegen erkältungssymptome und deren dauer |
| US20050239019A1 (en) * | 2004-04-21 | 2005-10-27 | Hall Teena V | Method of applying an antiseptic to an oral appliance |
| US20100226998A1 (en) * | 2009-03-05 | 2010-09-09 | Ultradent Products, Inc. | Anti-viral and anti-microbial dental operative material and methods |
| EP2575740A4 (en) * | 2010-06-01 | 2015-09-30 | Belle Aire Fragrances Inc | METHOD AND PRODUCT FOR COMBATTING ORAL ODORS |
| US10736612B2 (en) * | 2016-12-14 | 2020-08-11 | Boka Sciences, Inc. | Salvia assessing method, device, and system |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2180932A (en) * | 1939-06-30 | 1939-11-21 | Frits E Stockelbach | Flavoring solution |
| AU463173B2 (en) * | 1971-01-20 | 1975-07-17 | Warner-Lambert Company | Reodorant compositions |
| US3988432A (en) * | 1971-03-18 | 1976-10-26 | Colgate-Palmolive Company | Flavor and fragrant compositions |
| IL39553A0 (en) * | 1971-06-18 | 1972-07-26 | Beecham Inc | Dental cleaning compositions comprising organic metal complexes |
| GB1429774A (en) * | 1972-07-28 | 1976-03-24 | Unilever Ltd | Oral compositions |
| US4100269A (en) * | 1973-06-28 | 1978-07-11 | Lever Brothers Company | Anticalculus dentifrice |
| US4022880A (en) * | 1973-09-26 | 1977-05-10 | Lever Brothers Company | Anticalculus composition |
| SE393532B (sv) * | 1974-05-02 | 1977-05-16 | Draco Ab | Sett att framstella en farmaceutisk zinkberedning for astadkommande av en smaklig, fordragbar, peroral zinklosning innehallande ett zinkkomplex |
| US4082841A (en) * | 1975-10-10 | 1978-04-04 | Lever Brothers Company | Dentifrice |
| US4138477A (en) * | 1976-05-28 | 1979-02-06 | Colgate Palmolive Company | Composition to control mouth odor |
| US4144323A (en) * | 1978-06-15 | 1979-03-13 | Lever Brothers Company | Novel anticalculus compositions |
| CH633692A5 (fr) * | 1978-06-15 | 1982-12-31 | Firmenich & Cie | Utilisation d'alpha-dihydroionone en tant qu'ingredient aromatisant. |
| US4390556A (en) * | 1978-11-24 | 1983-06-28 | Givaudan Corporation | Microbiological transformations of alpha-ionone |
| US4311860A (en) * | 1978-11-24 | 1982-01-19 | Givaudan Corporation | Microbiological transformations of ionone compounds |
| US4325939A (en) * | 1980-09-22 | 1982-04-20 | Richardson-Vicks Inc. | Zinc derivatives and their use in dental compositions |
| US4289754A (en) * | 1980-11-03 | 1981-09-15 | Richardson-Vicks Inc. | Zinc derivatives and their use in mouthwash compositions |
| US4289755A (en) * | 1980-11-03 | 1981-09-15 | Richardson-Vicks Inc. | Stable mouthwash compositions containing zinc and fluoride compounds |
| US4814164A (en) * | 1986-03-10 | 1989-03-21 | Colgate-Palmolive Company | Solid antitartar mouth deodorant composition |
-
1986
- 1986-03-10 US US06/836,671 patent/US4689214A/en not_active Expired - Lifetime
- 1986-03-24 IN IN275/DEL/86A patent/IN165260B/en unknown
- 1986-03-25 FI FI861281A patent/FI84313C/fi not_active IP Right Cessation
- 1986-03-26 AU AU55379/86A patent/AU587241B2/en not_active Expired
- 1986-03-26 DE DE3610179A patent/DE3610179C2/de not_active Expired - Lifetime
- 1986-04-03 AT AT0087786A patent/AT389445B/de not_active IP Right Cessation
- 1986-04-03 NZ NZ215697A patent/NZ215697A/xx unknown
- 1986-04-09 MX MX2116A patent/MX164084B/es unknown
- 1986-04-10 IT IT8647870A patent/IT1214408B/it active
- 1986-04-10 FR FR868605142A patent/FR2587209B1/fr not_active Expired - Lifetime
- 1986-04-14 PH PH33652A patent/PH22873A/en unknown
- 1986-04-14 PT PT82387A patent/PT82387B/pt not_active IP Right Cessation
- 1986-04-14 SE SE8601655A patent/SE467609B/sv not_active IP Right Cessation
- 1986-04-14 GR GR860981A patent/GR860981B/el unknown
- 1986-04-14 CH CH1467/86A patent/CH674309A5/de not_active IP Right Cessation
- 1986-04-14 CA CA000506527A patent/CA1283055C/en not_active Expired - Lifetime
- 1986-04-15 NO NO861469A patent/NO166391C/no unknown
- 1986-04-15 BR BR8601690A patent/BR8601690A/pt unknown
- 1986-04-15 ES ES553977A patent/ES8706435A1/es not_active Expired
- 1986-04-16 NL NL8600957A patent/NL8600957A/nl not_active Application Discontinuation
- 1986-04-16 GB GB08609252A patent/GB2173701B/en not_active Expired
- 1986-04-16 BE BE0/216536A patent/BE904604A/fr not_active IP Right Cessation
- 1986-04-16 DK DK173586A patent/DK167336B1/da active IP Right Grant
-
1987
- 1987-09-28 MY MYPI87002050A patent/MY100363A/en unknown
-
1992
- 1992-01-20 SG SG49/92A patent/SG4992G/en unknown
- 1992-03-05 HK HK184/92A patent/HK18492A/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |