CH658597A5 - Selbsttragende polymere diffusionsmatrix und diese enthaltende vorrichtung zur transdermalen verarbreichung von medikamenten. - Google Patents
Selbsttragende polymere diffusionsmatrix und diese enthaltende vorrichtung zur transdermalen verarbreichung von medikamenten. Download PDFInfo
- Publication number
- CH658597A5 CH658597A5 CH1456/82A CH145682A CH658597A5 CH 658597 A5 CH658597 A5 CH 658597A5 CH 1456/82 A CH1456/82 A CH 1456/82A CH 145682 A CH145682 A CH 145682A CH 658597 A5 CH658597 A5 CH 658597A5
- Authority
- CH
- Switzerland
- Prior art keywords
- diffusion matrix
- matrix according
- molecular weight
- polymer diffusion
- polyvinyl alcohol
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title claims description 69
- 238000009792 diffusion process Methods 0.000 title claims description 62
- 239000003814 drug Substances 0.000 title claims description 32
- 229920000642 polymer Polymers 0.000 title claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 22
- 229940079593 drug Drugs 0.000 claims description 20
- 235000011187 glycerol Nutrition 0.000 claims description 20
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 18
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 18
- 239000004014 plasticizer Substances 0.000 claims description 15
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 14
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 14
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000002202 Polyethylene glycol Substances 0.000 claims description 11
- 229920001223 polyethylene glycol Polymers 0.000 claims description 11
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims description 8
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims description 8
- 229920000936 Agarose Polymers 0.000 claims description 8
- 229960000195 terbutaline Drugs 0.000 claims description 8
- 229920001817 Agar Polymers 0.000 claims description 6
- 239000008272 agar Substances 0.000 claims description 6
- 229930182833 estradiol Natural products 0.000 claims description 6
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims description 4
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims description 4
- 229960002896 clonidine Drugs 0.000 claims description 4
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 4
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 claims description 4
- 229960002179 ephedrine Drugs 0.000 claims description 4
- 150000002159 estradiols Chemical class 0.000 claims description 4
- 229960000395 phenylpropanolamine Drugs 0.000 claims description 4
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims description 4
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 3
- 230000003111 delayed effect Effects 0.000 claims description 2
- 229960001802 phenylephrine Drugs 0.000 claims description 2
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 239000008240 homogeneous mixture Substances 0.000 description 6
- 239000010410 layer Substances 0.000 description 5
- -1 phenylephedrine Chemical compound 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000005266 casting Methods 0.000 description 4
- 229960005309 estradiol Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000012790 adhesive layer Substances 0.000 description 2
- 230000003182 bronchodilatating effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229940046978 chlorpheniramine maleate Drugs 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000000850 decongestant Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 description 1
- 229920002799 BoPET Polymers 0.000 description 1
- 239000005041 Mylar™ Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- VQHQLBARMFAKSV-QIKJAYGVSA-N [(8r,9s,13s,14s)-3-acetyloxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1CC2=CC(OC(C)=O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CCC(OC(=O)C)[C@@]1(C)CC2 VQHQLBARMFAKSV-QIKJAYGVSA-N 0.000 description 1
- VQHQLBARMFAKSV-AANPDWTMSA-N [(8r,9s,13s,14s,17s)-3-acetyloxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1CC2=CC(OC(C)=O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)C)[C@@]1(C)CC2 VQHQLBARMFAKSV-AANPDWTMSA-N 0.000 description 1
- 230000001387 anti-histamine Effects 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16700880A | 1980-07-09 | 1980-07-09 | |
| US06/167,009 US4289749A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing phenylpropanolamine |
| US06/167,104 US4292302A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing terbutaline |
| US06/167,010 US4292301A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing ephedrine |
| US06/167,101 US4294820A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing phenylephrine |
| US06/167,106 US4292303A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing clonidine |
| US06/167,729 US4291014A (en) | 1979-01-11 | 1980-07-11 | Polymeric diffusion matrix containing estradiol diacetate |
| US06/217,400 US4321252A (en) | 1979-08-14 | 1980-12-17 | Polymeric diffusion matrix containing ester derivatives of estradiol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH658597A5 true CH658597A5 (de) | 1986-11-28 |
Family
ID=41698406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1456/82A CH658597A5 (de) | 1980-07-09 | 1981-06-26 | Selbsttragende polymere diffusionsmatrix und diese enthaltende vorrichtung zur transdermalen verarbreichung von medikamenten. |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS57500980A (fr) |
| AU (1) | AU7415181A (fr) |
| BE (1) | BE889549A (fr) |
| CA (1) | CA1163559A (fr) |
| CH (1) | CH658597A5 (fr) |
| DE (1) | DE3152182A1 (fr) |
| FR (1) | FR2486397A1 (fr) |
| GB (1) | GB2089210B (fr) |
| IT (1) | IT1237327B (fr) |
| NL (1) | NL8120270A (fr) |
| NO (1) | NO153638C (fr) |
| SE (1) | SE447448B (fr) |
| WO (1) | WO1982000099A1 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58206751A (ja) * | 1982-05-26 | 1983-12-02 | 日石三菱株式会社 | 創傷被覆材 |
| FR2532546B1 (fr) * | 1982-09-07 | 1985-12-27 | Biotrol Sa Lab | Pate pour la protection de la peau |
| FR2548021B1 (fr) * | 1983-06-29 | 1986-02-28 | Dick P R | Compositions pharmaceutiques dermiques a action prolongee et continue a base d'acides gras essentiels |
| DE3409079A1 (de) * | 1984-03-13 | 1985-09-19 | Bayer Ag, 5090 Leverkusen | Medizinische pflaster |
| SE457326B (sv) * | 1986-02-14 | 1988-12-19 | Lejus Medical Ab | Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa |
| US4860543A (en) * | 1986-08-08 | 1989-08-29 | Helix Technology Corporation | Vibration isolation system for a linear reciprocating machine |
| SU1705319A1 (ru) * | 1987-10-23 | 1992-01-15 | Всесоюзный Научно-Исследовательский Институт Биотехнологии | Состав полимерной диффузионной матрицы дл трансдермального введени лекарственных веществ |
| IT1261305B (it) * | 1993-06-22 | 1996-05-14 | Gevipi Ag | Dispositivo smorzatore di vibrazioni e di rumore, per impianti idraulici |
| DE4429667C2 (de) * | 1994-08-20 | 1996-07-11 | Lohmann Therapie Syst Lts | Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung |
| US6673363B2 (en) | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
| AU2727801A (en) * | 1999-12-16 | 2001-06-25 | Dermatrends, Inc. | Transdermal administration of phenylpropanolamine |
| US6602912B2 (en) | 2000-06-30 | 2003-08-05 | Dermatrends, Inc. | Transdermal administration of phenylpropanolamine |
| US6719997B2 (en) | 2000-06-30 | 2004-04-13 | Dermatrends, Inc. | Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2693438A (en) * | 1951-02-21 | 1954-11-02 | Norwich Pharma Co | Preformed, nonadherent films for application to open lesions |
| US2804073A (en) * | 1953-01-26 | 1957-08-27 | Protective Teatments Inc | Fluid surgical dressing |
| BE638231A (fr) * | 1962-03-16 | |||
| US3214338A (en) * | 1964-07-31 | 1965-10-26 | Ehrlich Joseph Ronald | Medicament releasing film-forming ointments and process of making |
| SU219116A1 (ru) * | 1965-11-26 | 1973-03-20 | А. А. Вишневский, Т. Т. Даурова, М. И. Долгина, И. А. Паников, Ф. П. Сидельковска , М. И. Шрайбер | Пленка для первичной обработки ожоговой поверхности |
| DE1617282A1 (de) * | 1965-11-30 | 1975-02-06 | Astra Pharma Prod | Vorrichtung zur lokalanaesthetisierung durch oertliche aufbringung und verfahren zur herstellung dieser vorrichtung |
| GB1213295A (en) * | 1967-04-27 | 1970-11-25 | Boots Pure Drug Co Ltd | Improvements in therapeutic compositions for topical application |
| FR2047874A6 (fr) * | 1969-06-10 | 1971-03-19 | Nouvel Lucien | |
| US3577516A (en) * | 1969-12-02 | 1971-05-04 | Nat Patent Dev Corp | Preparation of spray on bandage |
| DE2012775C3 (de) * | 1970-03-18 | 1973-10-04 | V.P. Variopharm Gmbh Herstellung Und Vertrieb Pharmazeutischer, Kosmetischer Und Chemischer Erzeugnisse, 6656 Einoed | Salbenfohe und Verfahren zu ihrer Herstellung |
| US3892905A (en) * | 1970-08-12 | 1975-07-01 | Du Pont | Cold water soluble plastic films |
| US4210633A (en) * | 1978-10-20 | 1980-07-01 | Eli Lilly And Company | Flurandrenolide film formulation |
| IL59063A (en) * | 1979-01-11 | 1983-12-30 | Key Pharma | Polymeric diffusion matrix for release of pharmaceutical dosage |
-
1981
- 1981-06-24 CA CA000380505A patent/CA1163559A/fr not_active Expired
- 1981-06-26 GB GB8206466A patent/GB2089210B/en not_active Expired
- 1981-06-26 CH CH1456/82A patent/CH658597A5/de not_active IP Right Cessation
- 1981-06-26 AU AU74151/81A patent/AU7415181A/en not_active Abandoned
- 1981-06-26 JP JP56502416A patent/JPS57500980A/ja active Pending
- 1981-06-26 NL NL8120270A patent/NL8120270A/nl unknown
- 1981-06-26 DE DE813152182T patent/DE3152182A1/de not_active Withdrawn
- 1981-06-26 WO PCT/US1981/000893 patent/WO1982000099A1/fr active Application Filing
- 1981-07-08 BE BE0/205347A patent/BE889549A/fr not_active IP Right Cessation
- 1981-07-09 FR FR8113518A patent/FR2486397A1/fr active Pending
-
1982
- 1982-02-24 IT IT8219833A patent/IT1237327B/it active
- 1982-03-04 SE SE8201337A patent/SE447448B/sv not_active IP Right Cessation
- 1982-03-08 NO NO820722A patent/NO153638C/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7415181A (en) | 1982-02-02 |
| BE889549A (fr) | 1981-11-03 |
| NO820722L (no) | 1982-03-08 |
| CA1163559A (fr) | 1984-03-13 |
| NO153638C (no) | 1986-05-07 |
| JPS57500980A (fr) | 1982-06-03 |
| NL8120270A (en) | 1982-06-01 |
| GB2089210B (en) | 1984-09-05 |
| SE8201337L (en) | 1982-03-04 |
| IT8219833A0 (it) | 1982-02-24 |
| IT1237327B (it) | 1993-05-31 |
| WO1982000099A1 (fr) | 1982-01-21 |
| SE447448B (sv) | 1986-11-17 |
| DE3152182A1 (de) | 1983-02-10 |
| NO153638B (no) | 1986-01-20 |
| FR2486397A1 (fr) | 1982-01-15 |
| GB2089210A (en) | 1982-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |