WO1982000099A1 - Matrice polymere de diffusion pour administrer des medicaments - Google Patents

Matrice polymere de diffusion pour administrer des medicaments Download PDF

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Publication number
WO1982000099A1
WO1982000099A1 PCT/US1981/000893 US8100893W WO8200099A1 WO 1982000099 A1 WO1982000099 A1 WO 1982000099A1 US 8100893 W US8100893 W US 8100893W WO 8200099 A1 WO8200099 A1 WO 8200099A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
patient
diffusion matrix
sustained release
polyvinylalcohol
Prior art date
Application number
PCT/US1981/000893
Other languages
English (en)
Inventor
Pharma Inc Key
A Keith
W Snipes
Original Assignee
Key Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/167,010 external-priority patent/US4292301A/en
Priority claimed from US06/167,729 external-priority patent/US4291014A/en
Application filed by Key Pharma filed Critical Key Pharma
Priority to AU74151/81A priority Critical patent/AU7415181A/en
Priority to NL8120270A priority patent/NL8120270A/nl
Priority to JP56502416A priority patent/JPS57500980A/ja
Priority to DE813152182T priority patent/DE3152182A1/de
Priority to PCT/US1981/000893 priority patent/WO1982000099A1/fr
Priority to GB8206466A priority patent/GB2089210B/en
Publication of WO1982000099A1 publication Critical patent/WO1982000099A1/fr
Priority to IT8219833A priority patent/IT1237327B/it
Priority to SE8201337A priority patent/SE447448B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Definitions

  • the following methods may be used for preparing the diffusion matrix of the present invention.
  • estradiol ester derivatives suitable for use according to this invention are pharmacologically acceptable esters particularly the 3-benzoate and 3-valerate esters of estradiol.
  • Estradiol diacetate and other esters of a pharmocologically active type small enough to pass through the skin may also be used.
  • the esters suitable for this invention provide a source of pharmacologically active estradiol in the bloodstream. It must also be understood that the estradiol esters contemplated herein may be administered in admixture with other drugs which are not incompatible with the desired therapeutic objective.
  • EXAMPLE III In place of the glycerol of Example I, there is substituted 5 gm. polyethylene glycol (mw. 1,000), 4 gm. glycerol and 21 ml. water. The resultant diffusion matrix shares the improved rigidity of the diffusion matrix of Example II, while providing contact with the skin characteristic of the glycerol in this type of diffusion matrix.

Abstract

Une matrice polymere de diffusion pour administrer un medicament se compose d'environ 2 a 60% d'un plastifiant polaire, par exemple du glycerol, environ 6 a 20% d'alcool polyvinylique, d'environ 2 a 10% de pyrrolidone polyvinylique, et une quantite pharmaceutiquement effective d'un medicament, resultant en une matrice capable de liberer de maniere soutenue un medicament vasodilateur disperse a l'interieur de cette matrice, et le solde etant constitue par de l'eau, les pourcentages etant ponderes. Les medicaments consistent en terbutaline, ephedrine, clonidine, phenylephrine, des esters d'espradiol, la phenylepropanolamine et le maleate de chlorpheniramine.
PCT/US1981/000893 1980-07-09 1981-06-26 Matrice polymere de diffusion pour administrer des medicaments WO1982000099A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU74151/81A AU7415181A (en) 1980-07-09 1981-06-26 Polymeric diffusion matrix for administration of drugs
NL8120270A NL8120270A (en) 1980-07-09 1981-06-26 Self-supporting polymeric diffusion matrix contg. terbutaline - comprising polar plasticiser, polyvinyl alcohol and polyvinyl pyrrolidone
JP56502416A JPS57500980A (fr) 1980-07-09 1981-06-26
DE813152182T DE3152182A1 (de) 1980-07-09 1981-06-26 Polymere diffusionsmatrix zur verabreichung von medikamenten
PCT/US1981/000893 WO1982000099A1 (fr) 1980-07-09 1981-06-26 Matrice polymere de diffusion pour administrer des medicaments
GB8206466A GB2089210B (en) 1980-07-09 1981-06-26 Polymeric diffusion matrix for administration of drugs
IT8219833A IT1237327B (it) 1980-07-09 1982-02-24 Matrice polimerica di diffusione per la somministrazione di farmaci.
SE8201337A SE447448B (sv) 1980-07-09 1982-03-04 Polymer diffusionsmatris for transdermal administrering av lekemedel

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US16700880A 1980-07-09 1980-07-09
US167104 1980-07-09
US06/167,010 US4292301A (en) 1979-08-14 1980-07-09 Polymeric diffusion matrix containing ephedrine
US06/167,104 US4292302A (en) 1979-08-14 1980-07-09 Polymeric diffusion matrix containing terbutaline
US06/167,106 US4292303A (en) 1979-08-14 1980-07-09 Polymeric diffusion matrix containing clonidine
US167106 1980-07-09
US167101 1980-07-09
US06/167,009 US4289749A (en) 1979-08-14 1980-07-09 Polymeric diffusion matrix containing phenylpropanolamine
US06/167,101 US4294820A (en) 1979-08-14 1980-07-09 Polymeric diffusion matrix containing phenylephrine
US167008800709 1980-07-09
US167729 1980-07-11
US06/167,729 US4291014A (en) 1979-01-11 1980-07-11 Polymeric diffusion matrix containing estradiol diacetate
US06/217,400 US4321252A (en) 1979-08-14 1980-12-17 Polymeric diffusion matrix containing ester derivatives of estradiol
US217400 1980-12-17
PCT/US1981/000893 WO1982000099A1 (fr) 1980-07-09 1981-06-26 Matrice polymere de diffusion pour administrer des medicaments
US167010 1993-12-16
US167009 1998-10-06

Publications (1)

Publication Number Publication Date
WO1982000099A1 true WO1982000099A1 (fr) 1982-01-21

Family

ID=41698406

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1981/000893 WO1982000099A1 (fr) 1980-07-09 1981-06-26 Matrice polymere de diffusion pour administrer des medicaments

Country Status (13)

Country Link
JP (1) JPS57500980A (fr)
AU (1) AU7415181A (fr)
BE (1) BE889549A (fr)
CA (1) CA1163559A (fr)
CH (1) CH658597A5 (fr)
DE (1) DE3152182A1 (fr)
FR (1) FR2486397A1 (fr)
GB (1) GB2089210B (fr)
IT (1) IT1237327B (fr)
NL (1) NL8120270A (fr)
NO (1) NO153638C (fr)
SE (1) SE447448B (fr)
WO (1) WO1982000099A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0095892A1 (fr) * 1982-05-26 1983-12-07 Nippon Oil Co. Ltd. Moyens de recouvrement de blessure
FR2532546A1 (fr) * 1982-09-07 1984-03-09 Biotrol Sa Lab Pate pour la protection de la peau
EP0154907A2 (fr) * 1984-03-13 1985-09-18 Bayer Ag Pansement médical
EP0237506A1 (fr) * 1986-02-14 1987-09-16 Lejus Medical Aktiebolag Composition pharmaceutique
WO1989003859A1 (fr) * 1987-10-23 1989-05-05 Vsesojuzny Nauchno-Issledovatelsky Institut Biotek Composition de matrice de diffusion polymere pour introduire par voie transcutanee des substances pharmaceutiques
US4860543A (en) * 1986-08-08 1989-08-29 Helix Technology Corporation Vibration isolation system for a linear reciprocating machine
DE4429667A1 (de) * 1994-08-20 1996-02-22 Lohmann Therapie Syst Lts Estradiol-TTS mit wasserbindenden Zusätzen
WO2001043734A2 (fr) * 1999-12-16 2001-06-21 Dermatrends, Inc. Administration transdermique de phenylpropanolamine
US6602912B2 (en) 2000-06-30 2003-08-05 Dermatrends, Inc. Transdermal administration of phenylpropanolamine
US6673363B2 (en) 1999-12-16 2004-01-06 Dermatrends, Inc. Transdermal and topical administration of local anesthetic agents using basic enhancers
US6719997B2 (en) 2000-06-30 2004-04-13 Dermatrends, Inc. Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548021B1 (fr) * 1983-06-29 1986-02-28 Dick P R Compositions pharmaceutiques dermiques a action prolongee et continue a base d'acides gras essentiels
IT1261305B (it) * 1993-06-22 1996-05-14 Gevipi Ag Dispositivo smorzatore di vibrazioni e di rumore, per impianti idraulici

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2693438A (en) * 1951-02-21 1954-11-02 Norwich Pharma Co Preformed, nonadherent films for application to open lesions
US2804073A (en) * 1953-01-26 1957-08-27 Protective Teatments Inc Fluid surgical dressing
US3214338A (en) * 1964-07-31 1965-10-26 Ehrlich Joseph Ronald Medicament releasing film-forming ointments and process of making
US3287222A (en) * 1962-03-16 1966-11-22 Roussel Uclaf Method for preparation of synthetic fiber medical dressing impregnated with therapeutic
GB1108837A (en) * 1965-11-30 1968-04-03 Astra Pharma Prod Improvements in material for causing local anaesthesia
US3577516A (en) * 1969-12-02 1971-05-04 Nat Patent Dev Corp Preparation of spray on bandage
US3608070A (en) * 1969-06-10 1971-09-21 Lucien Nouvel New surgical dressing
US3627871A (en) * 1967-04-27 1971-12-14 Boots Pure Drug Co Ltd Therapeutic compositions for topical application
SU219116A1 (ru) * 1965-11-26 1973-03-20 А. А. Вишневский, Т. Т. Даурова, М. И. Долгина, И. А. Паников, Ф. П. Сидельковска , М. И. Шрайбер Пленка для первичной обработки ожоговой поверхности
US3803300A (en) * 1970-03-18 1974-04-09 H Pospischil Ointment foil and method of preparing the same
US3892905A (en) * 1970-08-12 1975-07-01 Du Pont Cold water soluble plastic films
US4210633A (en) * 1978-10-20 1980-07-01 Eli Lilly And Company Flurandrenolide film formulation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59063A (en) * 1979-01-11 1983-12-30 Key Pharma Polymeric diffusion matrix for release of pharmaceutical dosage

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2693438A (en) * 1951-02-21 1954-11-02 Norwich Pharma Co Preformed, nonadherent films for application to open lesions
US2804073A (en) * 1953-01-26 1957-08-27 Protective Teatments Inc Fluid surgical dressing
US3287222A (en) * 1962-03-16 1966-11-22 Roussel Uclaf Method for preparation of synthetic fiber medical dressing impregnated with therapeutic
US3214338A (en) * 1964-07-31 1965-10-26 Ehrlich Joseph Ronald Medicament releasing film-forming ointments and process of making
SU219116A1 (ru) * 1965-11-26 1973-03-20 А. А. Вишневский, Т. Т. Даурова, М. И. Долгина, И. А. Паников, Ф. П. Сидельковска , М. И. Шрайбер Пленка для первичной обработки ожоговой поверхности
GB1108837A (en) * 1965-11-30 1968-04-03 Astra Pharma Prod Improvements in material for causing local anaesthesia
US3627871A (en) * 1967-04-27 1971-12-14 Boots Pure Drug Co Ltd Therapeutic compositions for topical application
US3608070A (en) * 1969-06-10 1971-09-21 Lucien Nouvel New surgical dressing
US3577516A (en) * 1969-12-02 1971-05-04 Nat Patent Dev Corp Preparation of spray on bandage
US3803300A (en) * 1970-03-18 1974-04-09 H Pospischil Ointment foil and method of preparing the same
US3892905A (en) * 1970-08-12 1975-07-01 Du Pont Cold water soluble plastic films
US4210633A (en) * 1978-10-20 1980-07-01 Eli Lilly And Company Flurandrenolide film formulation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, Volume 79, No. 8, Issued 27 August 1973 (Columbus, Ohio, USA) A.A. Vishnevski et al; PROTECTIVE AND MEDICATED FILM FOR THE INITIAL TREATMENT OF SCALDS, Page 215, column 2, the abstract No. 45845b; & SU-A-219 116 20 March 1973 *
Vishnevski, A.A., et al; & SU-A-219 116, 20 March 1973, from OTKRYTIYA IZOBRET, PROM. OBRAZTSY, TOVARNY ZNAKI 1973 50(15), 170. *

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0095892A1 (fr) * 1982-05-26 1983-12-07 Nippon Oil Co. Ltd. Moyens de recouvrement de blessure
FR2532546A1 (fr) * 1982-09-07 1984-03-09 Biotrol Sa Lab Pate pour la protection de la peau
EP0107526A1 (fr) * 1982-09-07 1984-05-02 Laboratoires Biotrol S.A. Pâte pour la protection de la peau
US4503034A (en) * 1982-09-07 1985-03-05 Laboratoires Biotrol S.A Paste for protecting the skin
EP0154907A2 (fr) * 1984-03-13 1985-09-18 Bayer Ag Pansement médical
EP0154907A3 (fr) * 1984-03-13 1986-02-12 Bayer Ag Pansement médical
US4738670A (en) * 1984-03-13 1988-04-19 Bayer Aktiengesellschaft Medicinal plasters
EP0237506A1 (fr) * 1986-02-14 1987-09-16 Lejus Medical Aktiebolag Composition pharmaceutique
US4860543A (en) * 1986-08-08 1989-08-29 Helix Technology Corporation Vibration isolation system for a linear reciprocating machine
WO1989003859A1 (fr) * 1987-10-23 1989-05-05 Vsesojuzny Nauchno-Issledovatelsky Institut Biotek Composition de matrice de diffusion polymere pour introduire par voie transcutanee des substances pharmaceutiques
DE4429667A1 (de) * 1994-08-20 1996-02-22 Lohmann Therapie Syst Lts Estradiol-TTS mit wasserbindenden Zusätzen
WO2001043734A2 (fr) * 1999-12-16 2001-06-21 Dermatrends, Inc. Administration transdermique de phenylpropanolamine
WO2001043734A3 (fr) * 1999-12-16 2002-01-03 Dermatrends Inc Administration transdermique de phenylpropanolamine
US6673363B2 (en) 1999-12-16 2004-01-06 Dermatrends, Inc. Transdermal and topical administration of local anesthetic agents using basic enhancers
US6602912B2 (en) 2000-06-30 2003-08-05 Dermatrends, Inc. Transdermal administration of phenylpropanolamine
US6719997B2 (en) 2000-06-30 2004-04-13 Dermatrends, Inc. Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers

Also Published As

Publication number Publication date
IT1237327B (it) 1993-05-31
CH658597A5 (de) 1986-11-28
CA1163559A (fr) 1984-03-13
SE447448B (sv) 1986-11-17
NL8120270A (en) 1982-06-01
GB2089210B (en) 1984-09-05
FR2486397A1 (fr) 1982-01-15
IT8219833A0 (it) 1982-02-24
NO820722L (no) 1982-03-08
GB2089210A (en) 1982-06-23
AU7415181A (en) 1982-02-02
JPS57500980A (fr) 1982-06-03
DE3152182A1 (de) 1983-02-10
NO153638C (no) 1986-05-07
NO153638B (no) 1986-01-20
SE8201337L (en) 1982-03-04
BE889549A (fr) 1981-11-03

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