CH653556A5 - Arzneimittel mit antitumor-wirkung. - Google Patents
Arzneimittel mit antitumor-wirkung. Download PDFInfo
- Publication number
- CH653556A5 CH653556A5 CH1491/80A CH149180A CH653556A5 CH 653556 A5 CH653556 A5 CH 653556A5 CH 1491/80 A CH1491/80 A CH 1491/80A CH 149180 A CH149180 A CH 149180A CH 653556 A5 CH653556 A5 CH 653556A5
- Authority
- CH
- Switzerland
- Prior art keywords
- cells
- yit
- mouse
- tumor
- negative
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title description 22
- 239000003814 drug Substances 0.000 title description 5
- 229940079593 drug Drugs 0.000 title description 3
- 210000004027 cell Anatomy 0.000 description 30
- 241000699666 Mus <mouse, genus> Species 0.000 description 29
- 230000005764 inhibitory process Effects 0.000 description 16
- 238000002360 preparation method Methods 0.000 description 16
- 244000199866 Lactobacillus casei Species 0.000 description 15
- 208000006268 Sarcoma 180 Diseases 0.000 description 14
- 241000699670 Mus sp. Species 0.000 description 13
- 241000186660 Lactobacillus Species 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 11
- 239000000725 suspension Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 235000013958 Lactobacillus casei Nutrition 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 235000010633 broth Nutrition 0.000 description 6
- 229940039696 lactobacillus Drugs 0.000 description 6
- 229940017800 lactobacillus casei Drugs 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 230000002354 daily effect Effects 0.000 description 5
- 208000032839 leukemia Diseases 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000011780 sodium chloride Substances 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000007920 subcutaneous administration Methods 0.000 description 4
- 240000001046 Lactobacillus acidophilus Species 0.000 description 3
- 240000006024 Lactobacillus plantarum Species 0.000 description 3
- 241000186869 Lactobacillus salivarius Species 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000007912 intraperitoneal administration Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 244000199885 Lactobacillus bulgaricus Species 0.000 description 2
- 241000186673 Lactobacillus delbrueckii Species 0.000 description 2
- 241000186840 Lactobacillus fermentum Species 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 208000007093 Leukemia L1210 Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 229940041514 candida albicans extract Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 239000012138 yeast extract Substances 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 239000007836 KH2PO4 Substances 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 240000001929 Lactobacillus brevis Species 0.000 description 1
- 240000002605 Lactobacillus helveticus Species 0.000 description 1
- 241001561398 Lactobacillus jensenii Species 0.000 description 1
- 241001134654 Lactobacillus leichmannii Species 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 108700014839 Streptococcus SAGP Proteins 0.000 description 1
- 244000057717 Streptococcus lactis Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 description 1
- 229940089837 amygdalin Drugs 0.000 description 1
- YZLOSXFCSIDECK-UHFFFAOYSA-N amygdalin Natural products OCC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC(C#N)c3ccccc3 YZLOSXFCSIDECK-UHFFFAOYSA-N 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 235000014048 cultured milk product Nutrition 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- YGHHWSRCTPQFFC-UHFFFAOYSA-N eucalyptosin A Natural products OC1C(O)C(O)C(CO)OC1OC1C(OC(C#N)C=2C=CC=CC=2)OC(CO)C(O)C1O YGHHWSRCTPQFFC-UHFFFAOYSA-N 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- CEQFOVLGLXCDCX-WUKNDPDISA-N methyl red Chemical compound C1=CC(N(C)C)=CC=C1\N=N\C1=CC=CC=C1C(O)=O CEQFOVLGLXCDCX-WUKNDPDISA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000255 pathogenic effect Toxicity 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 1
- 229940120668 salicin Drugs 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- 230000005748 tumor development Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
- C12R2001/245—Lactobacillus casei
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2133979A JPS55113718A (en) | 1979-02-27 | 1979-02-27 | Antitumor agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH653556A5 true CH653556A5 (de) | 1986-01-15 |
Family
ID=12052351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1491/80A CH653556A5 (de) | 1979-02-27 | 1980-02-25 | Arzneimittel mit antitumor-wirkung. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4347240A (enExample) |
| JP (1) | JPS55113718A (enExample) |
| BR (1) | BR8001129A (enExample) |
| CA (1) | CA1124176A (enExample) |
| CH (1) | CH653556A5 (enExample) |
| DE (1) | DE3007412A1 (enExample) |
| FR (1) | FR2450108B1 (enExample) |
| HK (1) | HK23784A (enExample) |
| IT (1) | IT1129802B (enExample) |
| MY (1) | MY8500010A (enExample) |
| NL (1) | NL189999C (enExample) |
| SG (1) | SG38183G (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3125797A1 (de) * | 1981-06-30 | 1983-01-13 | Rudolf Dr. Schuler | Diaetetisches mittel |
| US5965414A (en) * | 1985-11-04 | 1999-10-12 | Microlife Technics, Inc. | Process for producing yeast and mold inhibiting products with lactobacillus |
| JPH0696538B2 (ja) * | 1985-12-19 | 1994-11-30 | 株式会社アドバンス | 抗発癌剤 |
| WO1991005851A1 (fr) * | 1989-10-10 | 1991-05-02 | Tartusky Gosudarstvenny Universitet | Souche de bacterie de lactobacillus casei subsp casei 37 de production d'une preparation biologique bacterienne |
| JPH0755908B2 (ja) * | 1992-11-24 | 1995-06-14 | 財団法人京都パストゥール研究所 | 免疫機能助長剤 |
| US5840318A (en) * | 1993-05-11 | 1998-11-24 | Immunom Technologies, Inc. | Methods and compositions for modulating immune systems of animals |
| WO1994026114A1 (en) * | 1993-05-11 | 1994-11-24 | Immunom Technologies, Inc. | Method of stimulating and modulating the immune system of animals with microbial compositions |
| US7189834B2 (en) * | 1993-05-11 | 2007-03-13 | Marshall William E | Oligoribonucleotides alert the immune system of animals to the imminence of microbial infection |
| US6180100B1 (en) * | 1994-09-30 | 2001-01-30 | Urex Biotech., Inc. | Lactobacillus compositions and methods for treating urinary tract infections |
| AUPN907296A0 (en) * | 1996-04-02 | 1996-04-26 | Commonwealth Scientific And Industrial Research Organisation | Biocontrol agents for use in treatment of opportunistic infections |
| EP0974666A4 (en) | 1996-06-26 | 2004-12-15 | Yakult Honsha Kk | METHODS OF GENTRANSFER IN CHROMOSOMES |
| ES2360341T3 (es) * | 1997-02-11 | 2011-06-03 | Enterprise Ireland (Trading As Bioresearch Ireland) | Cepas probióticas de lactobacillus salivarius y agentes antimicrobianos obtenidos a partir de las mismas. |
| US6645506B1 (en) * | 1997-04-18 | 2003-11-11 | Ganeden Biotech, Inc. | Topical compositions containing extracellular products of Pseudomonas lindbergii and Emu oil |
| ES2255730T3 (es) * | 1997-04-18 | 2006-07-01 | Ganeden Biotech, Inc. | Utilizacion topica de esporas de bacilos probioticos para prevenir o tratar las infecciones microbianas. |
| ID29150A (id) * | 1999-01-15 | 2001-08-02 | Entpr Ireland Cs | Penggunaan lactobacillus salivarius |
| PE20030283A1 (es) * | 2001-07-26 | 2003-05-01 | Alimentary Health Ltd | Cepas de lactobacillus casei |
| EP1631308B1 (en) * | 2003-05-30 | 2013-07-31 | Amylin Pharmaceuticals, LLC | Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins |
| AU2004261832B2 (en) * | 2003-07-30 | 2007-10-04 | Bhph Company Limited | Novel lactobacillus, living body activating lactobacillus preparation and preventive or therapeutic agent against living body infection |
| US20050112097A1 (en) * | 2003-11-26 | 2005-05-26 | Hinton Golden S. | Method for the treatment of cancer |
| WO2006084381A1 (en) * | 2005-02-11 | 2006-08-17 | Technologie Biolactis Inc. | Use of lactobacillus kefiranofaciens as a probiotic and a synbiotic |
| US8404823B2 (en) * | 2006-10-27 | 2013-03-26 | Kabushiki Kaisha Yakult Honsha | Cytokine production regulator gene and use thereof |
| KR20090080536A (ko) * | 2006-11-02 | 2009-07-24 | 가부시키가이샤 아우레오 | 생체 치유 촉진제 |
| KR20100008831A (ko) * | 2008-07-17 | 2010-01-27 | 주식회사 쎌바이오텍 | 락토바실러스 카제이 배양물을 유효성분으로 함유하는항암용 조성물 |
| WO2011058535A1 (en) | 2009-11-11 | 2011-05-19 | Alimentary Health Limited | Probiotic bifidobacterium strain |
| JP5600179B2 (ja) | 2009-11-11 | 2014-10-01 | アリメンタリー、ヘルス、リミテッド | ビフィズス菌株 |
| WO2018158309A1 (en) | 2017-02-28 | 2018-09-07 | Alimentary Health Limited | Bifidobacterium longum able to beneficially modulate immune response to respiratory virus infection |
| BR112019019734A2 (pt) | 2017-03-23 | 2020-04-14 | Ku Leuven Res & Development | cepa probiótica de lactobacillus casei e usos da mesma |
| US20230106819A1 (en) | 2020-03-13 | 2023-04-06 | Precisionbiotics Group Limited | Bifidobacterium longum |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1514949A (fr) * | 1965-06-01 | 1968-03-01 | Texim Entpr Economique D Etat | Procédé de fabrication d'une nouvelle substance à partir de culture de microorganisme du genre lactobacillus |
| US3632746A (en) * | 1967-08-30 | 1972-01-04 | Chugai Pharmaceutical Co Ltd | Dried stable anti-tumor preparations and process for preparing the same |
| FR2244464A1 (en) * | 1973-06-26 | 1975-04-18 | Serozym Laboratoires | Yeast, lacto- and colibacillus based compsns - used to modify intestinal flora, treat colitis and digestive disorders, etc. |
-
1979
- 1979-02-27 JP JP2133979A patent/JPS55113718A/ja active Granted
-
1980
- 1980-02-20 NL NLAANVRAGE8001045,A patent/NL189999C/xx not_active IP Right Cessation
- 1980-02-25 CA CA346,374A patent/CA1124176A/en not_active Expired
- 1980-02-25 CH CH1491/80A patent/CH653556A5/de not_active IP Right Cessation
- 1980-02-26 US US06/124,725 patent/US4347240A/en not_active Expired - Lifetime
- 1980-02-26 BR BR8001129A patent/BR8001129A/pt unknown
- 1980-02-26 FR FR8004213A patent/FR2450108B1/fr not_active Expired
- 1980-02-27 IT IT67302/80A patent/IT1129802B/it active
- 1980-02-27 DE DE19803007412 patent/DE3007412A1/de not_active Ceased
-
1983
- 1983-06-30 SG SG381/83A patent/SG38183G/en unknown
-
1984
- 1984-03-15 HK HK237/84A patent/HK23784A/xx not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY10/85A patent/MY8500010A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL189999B (nl) | 1993-05-03 |
| DE3007412A1 (de) | 1980-11-06 |
| MY8500010A (en) | 1985-12-31 |
| IT8067302A0 (it) | 1980-02-27 |
| JPS6234727B2 (enExample) | 1987-07-28 |
| FR2450108A1 (fr) | 1980-09-26 |
| NL8001045A (nl) | 1980-08-29 |
| US4347240A (en) | 1982-08-31 |
| JPS55113718A (en) | 1980-09-02 |
| NL189999C (nl) | 1993-10-01 |
| FR2450108B1 (fr) | 1988-10-28 |
| BR8001129A (pt) | 1980-11-04 |
| HK23784A (en) | 1984-03-23 |
| SG38183G (en) | 1984-07-20 |
| IT1129802B (it) | 1986-06-11 |
| CA1124176A (en) | 1982-05-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CH653556A5 (de) | Arzneimittel mit antitumor-wirkung. | |
| US4710379A (en) | Intestinal microflora-improving agent | |
| DE69930944T2 (de) | Bacillus coagulans-zusammensetzung und deren verwendung | |
| DE60125529T2 (de) | MIKROORGANISMEN FüR DIE BEHANDLUNG ODER VORBEUGUNG VON FETTLEIBIGKEIT UND DIABETES MELLITUS UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN, DIE DIESE ENTHALTEN | |
| DE3586744T2 (de) | Zusammensetzungen mit einem gehalt an mikroflora mit erhoehter adhaesion. | |
| WO2007073709A1 (de) | Neue lactobacillus stämme und deren verwendung gegen helicobacter pylori | |
| Ishihara et al. | Growth inhibition of Streptococcus mutans by cellular extracts of human intestinal lactic acid bacteria | |
| JP2002522393A (ja) | 共生乳酸産生細菌を使用する、栄養材料の溶解度を増大するための方法 | |
| Hinz | Beitrag zur differenzierung von haemophilus‐stämmen aus hühnern* I. mitteilung: Kulturelle und biochemische untersuchungen | |
| CN113164531B (zh) | 用于生发或防止脱发的外用剂 | |
| CH643459A5 (de) | Mikrobielles zellwandgeruest mit adjuvans- und antitumorwirkung enthaltende, verfestigte pharmazeutische zubereitung und ihre herstellung. | |
| CH661868A5 (de) | Ganzzellen- oder zellwandpraeparate fuer die radio- oder chemotherapie von tumoren. | |
| DE2738652B2 (de) | Lactobacillus-Präparat und seine Verwendung bei der Bekämpfung bakterieller Infektionen und Entzündungen | |
| DE69028520T2 (de) | Arzneimittelzubereitung bei der behandlung von tonsillitis | |
| CH639133A5 (de) | Verfahren zur herstellung einer antitumor wirksamen substanz mit immunostimulierender wirkung. | |
| DE2106154C3 (de) | Verfahren zur Herstellung eines Milchsäurebakterien-Präparates | |
| JP2969017B2 (ja) | 感染防御剤 | |
| DE2200376A1 (de) | Vaccine gegen Streptococcus equi. und Verfahren zu deren Herstellung | |
| GB2072502A (en) | Antitumour agent comprising lactobacillus casei | |
| DE3118148A1 (de) | Antiallergisches praeparat und verfahren zu seiner herstellung | |
| DE2921829C2 (enExample) | ||
| DE3686396T2 (de) | Impfstoff ohne hilfsmittel. | |
| CH543227A (de) | Verfahren zur Erhöhung der Antitumorwirksamkeit und Herabsetzung der pathogenen Wirkung von Streptococcus hemolyticus | |
| JPS6011686B2 (ja) | 新規な抗腫瘍剤 | |
| DE2431270A1 (de) | Antibiotische substanz, verfahren zu ihrer herstellung und verwendung dieser antibiotischen substanz als wachstumsfoerderndes mittel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |