CH642637A5 - Benzylpyrimidines and process for their preparation - Google Patents

Benzylpyrimidines and process for their preparation Download PDF

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Publication number
CH642637A5
CH642637A5 CH265078A CH265078A CH642637A5 CH 642637 A5 CH642637 A5 CH 642637A5 CH 265078 A CH265078 A CH 265078A CH 265078 A CH265078 A CH 265078A CH 642637 A5 CH642637 A5 CH 642637A5
Authority
CH
Switzerland
Prior art keywords
formula
compound
diamino
pyrimidine
acid
Prior art date
Application number
CH265078A
Other languages
German (de)
English (en)
Inventor
Ivan Dr Kompis
Alexander Eduard Dr Wick
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CA301,705A priority Critical patent/CA1084498A/en
Priority to US05/900,357 priority patent/US4203980A/en
Priority to NZ187115A priority patent/NZ187115A/xx
Priority to IL54598A priority patent/IL54598A0/xx
Priority to FI781350A priority patent/FI781350A7/fi
Priority to MC781301A priority patent/MC1194A1/xx
Priority to DE19782819212 priority patent/DE2819212A1/de
Priority to FR7813130A priority patent/FR2389611B1/fr
Priority to NO781587A priority patent/NO781587L/no
Priority to AT320578A priority patent/ATA320578A/de
Priority to NL7804776A priority patent/NL7804776A/xx
Priority to DK195678A priority patent/DK143447C/da
Priority to ES469450A priority patent/ES469450A1/es
Priority to JP5284378A priority patent/JPS53137978A/ja
Priority to PT67994A priority patent/PT67994B/pt
Priority to GB17758/78A priority patent/GB1583817A/en
Priority to IT23093/78A priority patent/IT1096292B/it
Priority to BR787802834A priority patent/BR7802834A/pt
Priority to SE7805186A priority patent/SE7805186L/xx
Priority to ES474741A priority patent/ES474741A1/es
Priority to LU81031A priority patent/LU81031A1/de
Priority to US06/087,617 priority patent/US4254286A/en
Publication of CH642637A5 publication Critical patent/CH642637A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Multimedia (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CH265078A 1977-05-05 1978-03-10 Benzylpyrimidines and process for their preparation CH642637A5 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
CA301,705A CA1084498A (en) 1977-05-05 1978-04-21 Benzylpyrimidines and process for the preparation thereof
US05/900,357 US4203980A (en) 1977-05-05 1978-04-26 Benzylpyrimidine derivatives
NZ187115A NZ187115A (en) 1977-05-05 1978-04-28 2,4-diamino-5-(substituted benzyl)-pyrimidines and pharmaceutical compositions
IL54598A IL54598A0 (en) 1977-05-05 1978-04-30 Novel benzylpyrimidines, their manufacture and pharmaceutiical compositions containing them
FI781350A FI781350A7 (fi) 1977-05-05 1978-05-02 Benzylpyrimidiner och foerfarande foer deras framstaellning
MC781301A MC1194A1 (fr) 1977-05-05 1978-05-02 Benzylpyrimidines et procede pour leur preparation
DE19782819212 DE2819212A1 (de) 1977-05-05 1978-05-02 Benzylpyrimidine und verfahren zu deren herstellung
FR7813130A FR2389611B1 (enrdf_load_stackoverflow) 1977-05-05 1978-05-03
NO781587A NO781587L (no) 1977-05-05 1978-05-03 Benzylpyrimidiner og fremgangsmaate til fremstilling av disse
AT320578A ATA320578A (de) 1977-05-05 1978-05-03 Verfahren zur herstellung von neuen benzylpyrimidinen und deren salzen
NL7804776A NL7804776A (nl) 1977-05-05 1978-05-03 Benzylpyrimidinen en werkwijzen ter bereiding ervan.
DK195678A DK143447C (da) 1977-05-05 1978-05-03 Analogifremgangsmaade til fremstilling af 2,4-diamino-5-benzylpyrimidiner
ES469450A ES469450A1 (es) 1977-05-05 1978-05-04 Ÿun procedimiento para la preparacion de bencilpirimidinasŸ
JP5284378A JPS53137978A (en) 1977-05-05 1978-05-04 Benzylpyrimidine
PT67994A PT67994B (en) 1977-05-05 1978-05-04 Benzylpyrimidines and process for the preparation thereof
GB17758/78A GB1583817A (en) 1977-05-05 1978-05-04 Benzylpyrimidines
IT23093/78A IT1096292B (it) 1977-05-05 1978-05-05 Benzil-pirimidine e procedimento per la loro preparazione
BR787802834A BR7802834A (pt) 1977-05-05 1978-05-05 Processo para a preparacao de benzilpirimidinas,compostos assim obtidos,e aplicacao dos mesmos
SE7805186A SE7805186L (sv) 1977-05-05 1978-05-05 Bensylpyrimidiner och forfarande for framstellning derav
ES474741A ES474741A1 (es) 1978-03-10 1978-11-02 Ÿun procedimiento para la preparacion de bencilpirimidinasÿ
LU81031A LU81031A1 (de) 1978-03-10 1979-03-12 Benzylpyrimidine und verfahren zu deren herstellung
US06/087,617 US4254286A (en) 1977-05-05 1979-10-22 Benzaldehyde compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77269A LU77269A1 (enrdf_load_stackoverflow) 1977-05-05 1977-05-05

Publications (1)

Publication Number Publication Date
CH642637A5 true CH642637A5 (en) 1984-04-30

Family

ID=19728559

Family Applications (1)

Application Number Title Priority Date Filing Date
CH265078A CH642637A5 (en) 1977-05-05 1978-03-10 Benzylpyrimidines and process for their preparation

Country Status (6)

Country Link
AU (1) AU517426B2 (enrdf_load_stackoverflow)
BE (1) BE866653A (enrdf_load_stackoverflow)
CH (1) CH642637A5 (enrdf_load_stackoverflow)
ES (2) ES474740A1 (enrdf_load_stackoverflow)
LU (1) LU77269A1 (enrdf_load_stackoverflow)
ZA (1) ZA782459B (enrdf_load_stackoverflow)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07509215A (ja) * 1990-11-14 1995-10-12 カイロン　コーポレイション ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物

Also Published As

Publication number Publication date
AU517426B2 (en) 1981-07-30
ES474740A1 (es) 1979-04-01
ZA782459B (en) 1979-04-25
BE866653A (fr) 1978-11-03
AU3560178A (en) 1979-11-08
LU77269A1 (enrdf_load_stackoverflow) 1979-01-18
ES474739A1 (es) 1979-04-01

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