CH631207A5 - Verfahren zur zellzuechtung in vitro und vorrichtung zur ausfuehrung des verfahrens. - Google Patents
Verfahren zur zellzuechtung in vitro und vorrichtung zur ausfuehrung des verfahrens. Download PDFInfo
- Publication number
- CH631207A5 CH631207A5 CH440377A CH440377A CH631207A5 CH 631207 A5 CH631207 A5 CH 631207A5 CH 440377 A CH440377 A CH 440377A CH 440377 A CH440377 A CH 440377A CH 631207 A5 CH631207 A5 CH 631207A5
- Authority
- CH
- Switzerland
- Prior art keywords
- fiber
- culture
- fibers
- medium
- cells
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 20
- 238000000338 in vitro Methods 0.000 title claims description 6
- 230000010261 cell growth Effects 0.000 title description 5
- 239000000835 fiber Substances 0.000 claims description 84
- 239000002609 medium Substances 0.000 claims description 39
- 238000004113 cell culture Methods 0.000 claims description 24
- 239000001963 growth medium Substances 0.000 claims description 20
- 239000002184 metal Substances 0.000 claims description 12
- 238000009826 distribution Methods 0.000 claims description 10
- 239000007789 gas Substances 0.000 claims description 10
- 239000012510 hollow fiber Substances 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 238000011081 inoculation Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000002503 metabolic effect Effects 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 102000008186 Collagen Human genes 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 229920001436 collagen Polymers 0.000 claims description 3
- 230000007423 decrease Effects 0.000 claims description 3
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- 239000010410 layer Substances 0.000 claims 11
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
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- 238000012136 culture method Methods 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 4
- 239000012894 fetal calf serum Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 229920002492 poly(sulfone) Polymers 0.000 description 3
- 229920002239 polyacrylonitrile Polymers 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
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- 238000010276 construction Methods 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 230000002706 hydrostatic effect Effects 0.000 description 2
- 210000003292 kidney cell Anatomy 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 238000009827 uniform distribution Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical class CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 101100273566 Humulus lupulus CCL10 gene Proteins 0.000 description 1
- 241000282560 Macaca mulatta Species 0.000 description 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920005372 Plexiglas® Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000007640 basal medium Substances 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 208000019065 cervical carcinoma Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229920000831 ionic polymer Polymers 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002991 molded plastic Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 244000144985 peep Species 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/04—Flat or tray type, drawers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/16—Hollow fibers
Landscapes
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/676,100 US4087327A (en) | 1976-04-12 | 1976-04-12 | Mammalion cell culture process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH631207A5 true CH631207A5 (de) | 1982-07-30 |
Family
ID=24713225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH440377A CH631207A5 (de) | 1976-04-12 | 1977-04-07 | Verfahren zur zellzuechtung in vitro und vorrichtung zur ausfuehrung des verfahrens. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4087327A (enExample) |
| JP (1) | JPS603474B2 (enExample) |
| AU (1) | AU514239B2 (enExample) |
| BE (1) | BE853416A (enExample) |
| CA (1) | CA1071556A (enExample) |
| CH (1) | CH631207A5 (enExample) |
| DE (1) | DE2715821C2 (enExample) |
| FR (1) | FR2348270A1 (enExample) |
| GB (1) | GB1514906A (enExample) |
| IL (1) | IL51858A (enExample) |
| IT (1) | IT1077765B (enExample) |
| NL (1) | NL188808C (enExample) |
| ZA (1) | ZA772208B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10023505A1 (de) * | 2000-05-13 | 2001-11-22 | Fraunhofer Ges Forschung | Reaktormodul mit Kapillarmembranen |
| DE102013113578A1 (de) | 2012-12-05 | 2014-06-05 | Japan Tobacco Inc. | Verfahren zur kontrollierten Versorgung einer oder mehrerer Zellkulturen in Zellkulturbehältern mit einem Medium |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4301814A (en) * | 1977-04-26 | 1981-11-24 | Meer Sneer | Cassette implant |
| JPS5642584A (en) * | 1979-09-18 | 1981-04-20 | Asahi Chem Ind Co Ltd | Cell cultivation method |
| DE2940446C2 (de) * | 1979-10-05 | 1982-07-08 | B. Braun Melsungen Ag, 3508 Melsungen | Züchtung von tierischen Zellen in Suspensions- und Monolayerkulturen in Fermentationsgefäßen |
| US4301249A (en) * | 1980-07-23 | 1981-11-17 | Merck & Co., Inc. | High titer production of hepatitis A virus |
| EP0052001B1 (en) * | 1980-11-06 | 1984-08-01 | Albright & Wilson Limited | Callus culture in nutrient flow |
| SE448881B (sv) * | 1981-03-12 | 1987-03-23 | Erik Walum | Apparat for genomforandet av perfusionsodling av en eller flera cellkulturer samt forfarande for perfusionsodling av en eller flera cellkulturer |
| EP0125303A4 (en) * | 1982-11-16 | 1985-03-06 | Univ California | RAPID PRODUCTION OF BIOLOGICALS BY FERMENTATION IN A DENSE-LINED MICROBIAL MEMBRANE REACTOR. |
| US4546083A (en) * | 1983-04-22 | 1985-10-08 | Stolle Research & Development Corporation | Method and device for cell culture growth |
| JPS60160881A (ja) * | 1984-01-03 | 1985-08-22 | イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− | 細胞培養室のための薄いフイルム |
| JPS613473U (ja) * | 1984-06-13 | 1986-01-10 | 昭和ア−ルアンドディ株式会社 | 低抵抗測定用接触子 |
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| US5160490A (en) * | 1986-04-18 | 1992-11-03 | Marrow-Tech Incorporated | Three-dimensional cell and tissue culture apparatus |
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| EP0268651A4 (en) * | 1986-05-14 | 1989-07-26 | Life Technologies Inc | SIEVE PLATES. |
| US4734373A (en) * | 1986-06-24 | 1988-03-29 | Bartal Arie H | Apparatus for enhancing cell growth, preservation and transport |
| DE3633891A1 (de) * | 1986-10-04 | 1988-04-07 | Akzo Gmbh | Verfahren und vorrichtung zum kultivieren von tierischen zellen |
| US5254471A (en) * | 1986-10-06 | 1993-10-19 | Toray Industries, Inc. | Carrier for cell culture |
| US4752284A (en) * | 1986-12-05 | 1988-06-21 | Biscar Jean P | Artificial gravity intracellular molecular extraction |
| JPS63105873U (enExample) * | 1986-12-26 | 1988-07-08 | ||
| US4839280A (en) * | 1987-05-04 | 1989-06-13 | Banes Albert J | Apparatus for applying stress to cell cultures |
| US4789601A (en) * | 1987-05-04 | 1988-12-06 | Banes Albert J | Biocompatible polyorganosiloxane composition for cell culture apparatus |
| WO1989000188A1 (en) * | 1987-06-30 | 1989-01-12 | Brunswick Corporation | Cell growth reactor with three compartments formed by hydrophobic and hydrophilic membranes |
| DE3729127A1 (de) * | 1987-09-01 | 1989-03-09 | Taetzner Wolfgang | Verfahren und vorrichtung zur biologischen reinigung von abwaessern von ihren phosphat-verunreinigungen |
| WO1989001967A1 (en) * | 1987-09-03 | 1989-03-09 | Brown University Research Foundation | Blood purification with cultured renal cells |
| US5015584A (en) * | 1987-10-14 | 1991-05-14 | Board Of Regents, The University Of Texas System | Epidermal graft system |
| US4824788A (en) * | 1987-11-09 | 1989-04-25 | Ferre Penelope J | Humidity chamber for immunoperoxidase staining |
| US5100775A (en) * | 1988-03-16 | 1992-03-31 | Smyczek Peter J | Method for conducting nucleic acid hybridization in chamber with precise fluid delivery |
| US4908319A (en) * | 1988-03-16 | 1990-03-13 | Smyczek Peter J | Laboratory apparatus |
| US5079168A (en) * | 1988-08-10 | 1992-01-07 | Endotronics, Inc. | Cell culture apparatus |
| US5068195A (en) * | 1988-11-02 | 1991-11-26 | Du Pont Merck Pharmaceutical Company | Dot matrix membrane cell expansion and maintenance vessel |
| US5162225A (en) * | 1989-03-17 | 1992-11-10 | The Dow Chemical Company | Growth of cells in hollow fibers in an agitated vessel |
| US4960706A (en) * | 1989-03-27 | 1990-10-02 | Baxter International, Inc. | Static oxygenator for suspension culture of animal cells |
| JPH02128963U (enExample) * | 1989-03-30 | 1990-10-24 | ||
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| US3821087A (en) * | 1972-05-18 | 1974-06-28 | Dedrick R | Cell culture on semi-permeable tubular membranes |
| US3843454A (en) * | 1972-07-31 | 1974-10-22 | Abbott Lab | Flow through tissue culture propagator |
| CH593339A5 (enExample) * | 1973-07-02 | 1977-11-30 | Monsanto Co |
-
1976
- 1976-04-12 US US05/676,100 patent/US4087327A/en not_active Expired - Lifetime
-
1977
- 1977-04-07 NL NLAANVRAGE7703847,A patent/NL188808C/xx not_active IP Right Cessation
- 1977-04-07 DE DE2715821A patent/DE2715821C2/de not_active Expired
- 1977-04-07 AU AU24112/77A patent/AU514239B2/en not_active Expired
- 1977-04-07 CA CA275,866A patent/CA1071556A/en not_active Expired
- 1977-04-07 CH CH440377A patent/CH631207A5/de not_active IP Right Cessation
- 1977-04-08 BE BE176562A patent/BE853416A/xx not_active IP Right Cessation
- 1977-04-08 FR FR7710860A patent/FR2348270A1/fr active Granted
- 1977-04-08 IT IT22327/77A patent/IT1077765B/it active
- 1977-04-11 IL IL51858A patent/IL51858A/xx unknown
- 1977-04-11 JP JP52041268A patent/JPS603474B2/ja not_active Expired
- 1977-04-12 GB GB14989/77A patent/GB1514906A/en not_active Expired
- 1977-04-12 ZA ZA00772208A patent/ZA772208B/xx unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10023505A1 (de) * | 2000-05-13 | 2001-11-22 | Fraunhofer Ges Forschung | Reaktormodul mit Kapillarmembranen |
| US6821762B2 (en) * | 2000-05-13 | 2004-11-23 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Reactor module with capillary membranes |
| DE102013113578A1 (de) | 2012-12-05 | 2014-06-05 | Japan Tobacco Inc. | Verfahren zur kontrollierten Versorgung einer oder mehrerer Zellkulturen in Zellkulturbehältern mit einem Medium |
Also Published As
| Publication number | Publication date |
|---|---|
| NL7703847A (nl) | 1977-10-14 |
| FR2348270A1 (fr) | 1977-11-10 |
| FR2348270B1 (enExample) | 1980-04-18 |
| AU2411277A (en) | 1978-10-12 |
| IL51858A (en) | 1979-11-30 |
| IT1077765B (it) | 1985-05-04 |
| JPS603474B2 (ja) | 1985-01-28 |
| ZA772208B (en) | 1978-03-29 |
| AU514239B2 (en) | 1981-01-29 |
| DE2715821C2 (de) | 1985-11-14 |
| IL51858A0 (en) | 1977-06-30 |
| NL188808C (nl) | 1992-10-01 |
| US4087327A (en) | 1978-05-02 |
| CA1071556A (en) | 1980-02-12 |
| DE2715821A1 (de) | 1977-10-20 |
| GB1514906A (en) | 1978-06-21 |
| BE853416A (fr) | 1977-10-10 |
| NL188808B (nl) | 1992-05-06 |
| JPS52125688A (en) | 1977-10-21 |
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