DE3923279C2 - - Google Patents
Info
- Publication number
- DE3923279C2 DE3923279C2 DE3923279A DE3923279A DE3923279C2 DE 3923279 C2 DE3923279 C2 DE 3923279C2 DE 3923279 A DE3923279 A DE 3923279A DE 3923279 A DE3923279 A DE 3923279A DE 3923279 C2 DE3923279 C2 DE 3923279C2
- Authority
- DE
- Germany
- Prior art keywords
- cell
- cells
- carrier
- carriers
- cultivation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000004027 cell Anatomy 0.000 claims description 43
- 239000000969 carrier Substances 0.000 claims description 9
- 239000001963 growth medium Substances 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 230000001413 cellular effect Effects 0.000 claims description 2
- 210000000270 basal cell Anatomy 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012876 carrier material Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000010412 perfusion Effects 0.000 description 4
- 238000007789 sealing Methods 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102000007547 Laminin Human genes 0.000 description 1
- 108010085895 Laminin Proteins 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 229940050561 matrix product Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/44—Multiple separable units; Modules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/14—Scaffolds; Matrices
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Clinical Laboratory Science (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3923279A DE3923279A1 (de) | 1989-07-14 | 1989-07-14 | Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren |
| US07/627,729 US5190878A (en) | 1989-07-14 | 1990-12-14 | Apparatus for cultivating cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3923279A DE3923279A1 (de) | 1989-07-14 | 1989-07-14 | Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3923279A1 DE3923279A1 (de) | 1990-01-18 |
| DE3923279C2 true DE3923279C2 (enExample) | 1991-01-31 |
Family
ID=6385013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3923279A Granted DE3923279A1 (de) | 1989-07-14 | 1989-07-14 | Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US5190878A (enExample) |
| DE (1) | DE3923279A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19808055A1 (de) * | 1998-02-27 | 1999-09-02 | Adamietz | Verfahren und Apparatur zur Herstellung von dreidimensionalen Gewebezellkulturen |
| DE102010064098A1 (de) | 2010-12-23 | 2012-06-28 | Universität Rostock | Zellreaktor |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5763266A (en) * | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
| US5104804A (en) * | 1990-06-04 | 1992-04-14 | Molecular Devices Corporation | Cell assay device used in a microphysiometer |
| DE4116727C2 (de) * | 1991-05-17 | 1995-09-07 | Uwe Dr Marx | Verfahren und Vorrichtung zur gleichzeitigen Kultivierung unterschiedlicher Säugerzellen |
| US6066496A (en) * | 1991-09-17 | 2000-05-23 | Bridges; Michael Anthony | Apparatus for culturing mammalian respiratory epithelial |
| US5726060A (en) * | 1991-09-17 | 1998-03-10 | Bridges; Michael Anthony | Method for culturing mammalian respiratory epithelial cells |
| DE4305405C1 (de) * | 1993-02-22 | 1994-05-26 | Hering Steffen Dr Sc Med | Vorrichtung zum Untersuchen eines Objekts, das sich in einer ein Substrat bedeckenden Perfusionsflüssigkeit befindet |
| US5514555A (en) * | 1993-03-12 | 1996-05-07 | Center For Blood Research, Inc. | Assays and therapeutic methods based on lymphocyte chemoattractants |
| US5599688A (en) * | 1993-10-18 | 1997-02-04 | Precision Instrument Design | Device and method for circulating fluid over a membrane |
| US5591636A (en) * | 1993-10-18 | 1997-01-07 | Precision Instrument Design | Membrane holder |
| US5595866A (en) * | 1994-05-27 | 1997-01-21 | Methodist Hospital Of Indiana, Inc. | Step-wise method to remove cryoprotectant from sperm |
| US6054287A (en) * | 1994-05-27 | 2000-04-25 | Methodist Hospital Of Indiana, Inc. | Cell-type-specific methods and devices for the low temperature preservation of the cells of an animal species |
| DE4426315C1 (de) * | 1994-07-25 | 1996-03-21 | Gore W L & Ass Gmbh | Membran zur Regeneration von Körpergeweben und Verwendung der Membran als Wundabdeckung und Hautersatz |
| FR2735496B1 (fr) * | 1995-06-15 | 1997-08-29 | Chemodyne Sa | Nouveau dispositif de culture de cellules et les tissus ainsi recoltes |
| US5635396A (en) | 1995-08-30 | 1997-06-03 | Becton, Dickinson And Company | Coverslip holder |
| GB9700840D0 (en) * | 1997-01-16 | 1997-03-05 | Smith & Nephew | Cell-culture system |
| DE19721477A1 (de) * | 1997-05-23 | 1998-11-26 | Abb Patent Gmbh | Mikrobieller Membranreaktor zur Verwendung in Fließsystemen |
| DE19818425A1 (de) * | 1997-10-18 | 1999-07-15 | Malte Dr Med Boehm | Vorrichtung zur Handhabung von Proben für die membrangestützte Mikrodissektion |
| ATE246349T1 (de) * | 1997-10-18 | 2003-08-15 | Malte Dr Boehm | Vorrichtung zur handhabung von proben für die membrangestützte mikrodissektion |
| EP1064353B1 (en) * | 1998-03-18 | 2002-11-06 | Massachusetts Institute Of Technology | Vascularized perfused microtissue/micro-organ arrays |
| AT407047B (de) * | 1998-08-03 | 2000-11-27 | Pfaller Walter Dr | Zellkulturvorrichtung |
| US6146883A (en) * | 1998-09-14 | 2000-11-14 | Navicyte, Inc. | Packing device for transporting confluent cell monolayers |
| WO2000055297A1 (en) * | 1999-03-17 | 2000-09-21 | Biodiversity Limited | Biochemical synthesis apparatus |
| WO2000078920A1 (en) * | 1999-06-21 | 2000-12-28 | The General Hospital Corporation | Methods and devices for cell culturing and organ assist systems |
| ATE373079T1 (de) | 1999-06-21 | 2007-09-15 | Gen Hospital Corp | Zellkultursysteme und verfahren für einrichtungen zur organunterstützung |
| DE19932439C2 (de) * | 1999-07-12 | 2002-06-13 | Sefar Ag Rueschlikon | Bioreaktor |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US20030235908A1 (en) * | 2000-02-24 | 2003-12-25 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| US7572631B2 (en) * | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| BR0108545A (pt) | 2000-02-24 | 2004-06-29 | Xcyte Therapies Inc | Estimulação e concentração simultâneas das células |
| US20030119185A1 (en) * | 2000-02-24 | 2003-06-26 | Xcyte Therapies, Inc. | Activation and expansion of cells |
| FR2808283B1 (fr) * | 2000-04-27 | 2002-12-20 | Cell Tissue Progress | Unite de culture de cellules et tissus a configuration variable |
| US20020019048A1 (en) * | 2000-05-25 | 2002-02-14 | Ronald Berenson | Methods for restoring or enhancing T-cell immune surveillance following naturally or artificially induced immunosuppression |
| KR100394247B1 (ko) * | 2001-02-05 | 2003-08-06 | 주식회사 케이티앤지 | 세포 배양기 |
| WO2003060061A1 (en) * | 2001-12-21 | 2003-07-24 | Organogenesis Inc. | Chamber with adjustable volume for cell culture and organ assist |
| US7638326B2 (en) | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
| AU2003202908A1 (en) * | 2002-01-03 | 2003-07-24 | The Trustees Of The University Of Pennsylvania | Activation and expansion of t-cells using an engineered multivalent signaling platform |
| US7745140B2 (en) * | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| EP1490520A4 (en) * | 2002-03-12 | 2006-06-07 | Surface Logix Inc | TEST APPARATUS ANALYZING THE ABSORPTION, METABOLISM, PERMEABILITY AND / OR TOXICITY OF A CANDIDATE COMPOUND |
| US20040151704A1 (en) * | 2002-06-28 | 2004-08-05 | Xcyte Therapies, Inc. | Compositions and methods for restoring immune repertoire in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| US20050084967A1 (en) * | 2002-06-28 | 2005-04-21 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| US20040175373A1 (en) * | 2002-06-28 | 2004-09-09 | Xcyte Therapies, Inc. | Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation |
| WO2004076608A2 (en) * | 2003-02-26 | 2004-09-10 | Georgia Tech Research Corporation | Bioreactor and methods for tissue growth and conditioning |
| DE60334250D1 (de) * | 2003-05-08 | 2010-10-28 | Life Technologies Corp | Erzeugung und isolierung antigenspezifischer t-zellen |
| CA2539716A1 (en) * | 2003-09-22 | 2005-04-07 | Xcyte Therapies, Inc. | Compositions and methods to accelerate hematologic recovery |
| DE102004017476B4 (de) * | 2004-04-08 | 2009-03-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung einer Epithelzellen enthaltenden Zellzusammensetzung |
| DK1773978T3 (da) * | 2004-05-19 | 2014-05-26 | Univ Pittsburgh | Perfunderede, tredimensionelle celle/vævssygdomsmodeller |
| DE102004024834A1 (de) * | 2004-05-19 | 2006-01-12 | Universität Rostock | Vorrichtung zur Durchführung einer Liquid-Air-Kultur von Epithel |
| CA2568344C (en) | 2004-05-27 | 2016-01-19 | The Trustees Of The University Of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| US6987019B1 (en) * | 2004-09-03 | 2006-01-17 | Vitaly Rogalsky | Device for growing cells |
| US7368279B2 (en) * | 2004-11-24 | 2008-05-06 | The Regents Of The University Of Michigan | Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor |
| US7927867B2 (en) * | 2005-03-31 | 2011-04-19 | Cascade Life Sciences, Inc. | Device for evaluating in vitro cell migration under flow conditions, and methods of use thereof |
| EP1913126B1 (en) * | 2005-08-12 | 2019-09-25 | Clemson University Research Foundation | Co-culture bioreactor system |
| ZA200602094B (en) * | 2006-01-16 | 2007-11-28 | Reliance Life Sciences Pvt Ltd | Device for culturing and transporting cells |
| DE102007034935B4 (de) * | 2006-07-24 | 2014-07-17 | Biocer Entwicklungs Gmbh | Anordnung für Online-Messungen an Zellen |
| US9309491B2 (en) | 2007-05-29 | 2016-04-12 | Corning Incorporated | Cell culture apparatus for co-culture of cells |
| US8808541B2 (en) | 2008-03-03 | 2014-08-19 | Marwan Nasralla | Dialysis cell and tray for dialysis cells |
| AT506826B1 (de) * | 2008-05-23 | 2010-03-15 | Greiner Bio One Gmbh | Bioreaktor und verfahren zum kultivieren von zellen und geweben |
| US9226494B2 (en) * | 2008-09-19 | 2016-01-05 | University Of Louisville Research Foundation, Inc. | Bioreactors, systems, and methods for vascularizing tissue constructs |
| WO2010042072A1 (en) * | 2008-10-08 | 2010-04-15 | Agency For Science, Technology And Research | Apparatus for culturing anchorage dependent cells |
| JP2012506257A (ja) * | 2008-10-22 | 2012-03-15 | バイオベスト インターナショナル インコーポレイテッド | 細胞および細胞由来生成物の産生のための、灌流バイオリアクター、細胞培養システム、および方法 |
| EP2361302A4 (en) * | 2008-11-05 | 2013-10-16 | Nanopoint Inc | ACTIVE MICROFLUID SYSTEM FOR IN VITRO CULTURES |
| WO2010069320A2 (en) | 2008-12-19 | 2010-06-24 | Stobbe Tech A/S | Biopharmaceutical plant in a column |
| EP3936606A1 (en) | 2009-06-18 | 2022-01-12 | Kiyatec Inc. | Bioreactor system |
| ITTO20090798A1 (it) * | 2009-10-21 | 2011-04-22 | Techfab S R L | Dispositivo e metodo per la manipolazione di particelle in sospensione e tessuti cellulari |
| MX342017B (es) | 2010-03-26 | 2016-09-09 | Dartmouth College | Proteina mediadora de celula t regulatoria vista, agentes de enlace de vista y uso de los mismos. |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| DE102010023794B4 (de) | 2010-04-09 | 2016-07-21 | Stefan Neumeyer | Medizinisches, insbesondere zahnmedizinisches Substrat |
| KR20130109000A (ko) * | 2010-05-11 | 2013-10-07 | 아르텔리스 에스에이 | 세포 배양 장치 및 방법 |
| WO2012003465A2 (en) | 2010-07-01 | 2012-01-05 | The Regents Of The University Of Michigan | Scaffold-free three dimensional nerve fibroblast constructs |
| DE102011057045A1 (de) * | 2011-12-23 | 2013-06-27 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Monitoringzelle und Verfahren zur Analyse eines Zell- und Gewebewachstums |
| WO2017117229A1 (en) | 2015-12-30 | 2017-07-06 | Wake Forest University Health Sciences | Tissue-engineered gut-sphincter complexes and methods of making the same |
| US11311367B2 (en) | 2012-01-31 | 2022-04-26 | Wake Forest University Health Sciences | Tissue-engineered gut-sphincter complexes and methods of making the same |
| DE102012101078A1 (de) | 2012-02-09 | 2013-10-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Stimulationszelle und Verfahren zur in vitro Stimulation von Zellen oder Geweben |
| SG11201404769UA (en) | 2012-02-22 | 2014-11-27 | Univ Pennsylvania | Use of icos-based cars to enhance antitumor activity and car persistence |
| CN104619722B (zh) | 2012-06-22 | 2022-10-04 | 达特茅斯大学理事会 | 新型vista-ig构建体和vista-ig用于治疗自身免疫性、过敏性和炎性疾病的用途 |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| CA2884704C (en) | 2012-09-07 | 2023-04-04 | Randolph J. Noelle | Vista modulators for diagnosis and treatment of cancer |
| WO2014152906A2 (en) | 2013-03-14 | 2014-09-25 | Research Institute At Nationwide Children's Hospital, Inc. | Tissue engineered intestine |
| US20150147771A1 (en) * | 2013-11-22 | 2015-05-28 | Cleveland State University | Microperfusion tissue interrogator |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| EP4043493A1 (en) | 2013-12-24 | 2022-08-17 | Janssen Pharmaceutica NV | Anti-vista antibodies and fragments |
| CN108841728A (zh) | 2014-04-14 | 2018-11-20 | 株式会社岛津制作所 | 细胞培养用设备、细胞培养用系统及细胞培养方法 |
| DE102014106423A1 (de) * | 2014-05-08 | 2015-11-12 | Universitätsklinikum Jena | Verfahren und Vorrichtungen zur In-vitro-Herstellung von Anordnungen von Zellschichten |
| EP3154585B1 (en) | 2014-06-11 | 2022-02-23 | Kathy A. Green | Use of vista agonists and antagonists to suppress or enhance humoral immunity |
| US20170209492A1 (en) | 2014-07-31 | 2017-07-27 | Novartis Ag | Subset-optimized chimeric antigen receptor-containing t-cells |
| JP2018505911A (ja) | 2014-12-05 | 2018-03-01 | イミュネクスト,インコーポレーテッド | 推定上のvista受容体としてのvsig8の同定と、vista/vsig8調節剤を産生するためのその使用 |
| EP3722314A1 (en) | 2015-06-24 | 2020-10-14 | Janssen Pharmaceutica NV | Anti-vista antibodies and fragments |
| WO2017015123A1 (en) * | 2015-07-17 | 2017-01-26 | Boyd Lawrence M | Apparatus and method for sorting of cells |
| US10227556B2 (en) | 2015-09-04 | 2019-03-12 | Wayne State University | Cell culture devices for biomimetic and pathomimetic cell cultures |
| US20170158999A1 (en) * | 2015-12-03 | 2017-06-08 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Modular bioreactor for culture of biopaper based tissues |
| TW202216201A (zh) | 2016-02-12 | 2022-05-01 | 比利時商楊森製藥公司 | 抗vista抗體及片段、其用途及鑑定其之方法 |
| JP7184751B2 (ja) | 2016-04-15 | 2022-12-06 | イミュネクスト インコーポレイテッド | 抗ヒトvista抗体およびその使用 |
| EP3504315A4 (en) | 2016-08-27 | 2020-04-15 | 3D Biotek, LLC | BIOREACTOR |
| US10247724B1 (en) | 2017-09-28 | 2019-04-02 | Autobiologic Inc. | Optically clear sealable petri dish bioreactor |
| TWI865629B (zh) * | 2019-10-16 | 2024-12-11 | 日本國立研究開發法人理化學研究所 | 細胞層片製造裝置及細胞層片製造方法 |
| US20250136929A1 (en) * | 2022-02-08 | 2025-05-01 | Ivy Farm Technologies Limited | Bioreactor |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2761813A (en) * | 1953-01-21 | 1956-09-04 | Goetz Alexander | Means and method of producing and controlling cultures of microorganisms |
| US3839155A (en) * | 1972-07-27 | 1974-10-01 | Merck & Co Inc | Cell and vaccine production |
| US4087327A (en) * | 1976-04-12 | 1978-05-02 | Monsanto Company | Mammalion cell culture process |
| DE2624047C3 (de) * | 1976-05-28 | 1980-07-03 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Massenzüchtung von Zellen und Kammer-System zu ihrer Durchführung |
| DE2726313C3 (de) * | 1977-06-10 | 1980-02-07 | Battelle-Institut E.V., 6000 Frankfurt | Verfahren zur in-vitro-Biosynthese von Hormonen, insbesondere von Insulin |
| US4228243A (en) * | 1978-07-13 | 1980-10-14 | Toray Industries, Inc. | Cell culture propagation apparatus |
| US4242459A (en) * | 1978-11-02 | 1980-12-30 | Chick William L | Cell culture device |
| US4446234A (en) * | 1981-10-23 | 1984-05-01 | The United States Of America As Represented By The Department Of Health And Human Services | Vitro cellular interaction with amnion membrane substrate |
| DE3317550C2 (de) * | 1983-05-13 | 1985-08-22 | Stephan Priv.Doz.Dr.rer.nat.Dr.med.habil. 8000 München Nees | Verfahren zum Züchten einer lückenlosen Zellschicht und Vorrichtung zur Durchführung dieses Verfahrens |
| DE3317551A1 (de) * | 1983-05-13 | 1984-11-15 | Stephan Dipl.-Chem. Dr.rer.nat. 8000 München Nees | Perfusionseinrichtung zum "in vitro"-bespuelen verankerungsabhaengiger biologischer zellsysteme |
| US4661458A (en) * | 1983-08-31 | 1987-04-28 | Cell Environmental Systems, Ltd. | Cell culture system |
| US4748124A (en) * | 1984-10-30 | 1988-05-31 | E. I. Du Pont De Nemours And Company | Compartmentalized cell-culture device and method |
| US4656130A (en) * | 1985-03-14 | 1987-04-07 | Yissum Research Development Company | Collagen coated cell growth plates |
| US4681853A (en) * | 1985-10-23 | 1987-07-21 | Hardy Kenneth J | Perfusion slit chamber for filter-bound sample analyses |
| US4661455A (en) * | 1986-01-16 | 1987-04-28 | Dorr-Oliver Incorporated | Membrane cell culturing device |
| US4835102A (en) * | 1987-03-31 | 1989-05-30 | Eugene Bell | Tissue equivalent test systems |
| JPS6447372A (en) * | 1987-08-14 | 1989-02-21 | Mitsubishi Chem Ind | Cell culture film carrier |
| US4937196A (en) * | 1989-08-18 | 1990-06-26 | Brunswick Corporation | Membrane bioreactor system |
-
1989
- 1989-07-14 DE DE3923279A patent/DE3923279A1/de active Granted
-
1990
- 1990-12-14 US US07/627,729 patent/US5190878A/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19808055A1 (de) * | 1998-02-27 | 1999-09-02 | Adamietz | Verfahren und Apparatur zur Herstellung von dreidimensionalen Gewebezellkulturen |
| DE19808055B4 (de) * | 1998-02-27 | 2007-02-08 | Adamietz, Peter, Dr.rer.nat. | Verfahren und Apparatur zur Herstellung von dreidimensionalen Gewebezellkulturen |
| DE102010064098A1 (de) | 2010-12-23 | 2012-06-28 | Universität Rostock | Zellreaktor |
Also Published As
| Publication number | Publication date |
|---|---|
| US5190878A (en) | 1993-03-02 |
| DE3923279A1 (de) | 1990-01-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2715821C2 (de) | Verfahren zur in vitro-Zellkultur und Zellkultur-Reaktionsgefäß zur Durchführung dieses Verfahrens | |
| DE69126882T2 (de) | Kulturvorrichtung mit lösbarer aufwuchsfläche für zellen oder gewebe | |
| DE69109651T2 (de) | Zellkultureinsatz. | |
| EP0155237B1 (de) | Verfahren und Vorrichtung zum Kultivieren von humanen, tierischen, pflanzlichen sowie hybriden Zellen und Mikroorganismen | |
| DE4132379C2 (enExample) | ||
| DE69224383T2 (de) | Vorrichtung zur kultivierung und manipulierung von zellen | |
| DE69615655T2 (de) | Biologische analytische vorrichtung mit verbesserter verhinderung von kontamination | |
| DE68907153T2 (de) | Zellkultur-Gerät. | |
| DE3923279A1 (de) | Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren | |
| EP1718409B1 (de) | Vorrichtung für mikrofluiduntersuchungen | |
| DE10244859B4 (de) | Bioreaktor mit modularem Aufbau, insbesondere zur ex-vivo Zellvermehrung | |
| EP0983341A1 (de) | Vorrichtung zum züchten und/oder behandeln von zellen | |
| DE102013203306B4 (de) | Einsatz zur beidseitigen Kultivierung einer Poren aufweisenden Membran für Zellen und Gewebekulturen sowie Hefen und Bakterien als Objekte | |
| DE29913011U1 (de) | Zellkulturvorrichtung | |
| WO2009127647A2 (de) | Teilaktives mikrofluidisches system für die 3d-zellkultivierung sowie verfahren zu dessen perfusion | |
| DE69624483T2 (de) | Umkehrbarer membraneinsatz zur kultivierung von zellen | |
| DE3317550A1 (de) | Verfahren zum zuechten einer lueckenlosen zellschicht auf einer poroesen oder semipermeablen unterlage und vorrichtung zur durchfuehrung dieses verfahrens | |
| AT506826A1 (de) | Bioreaktor und verfahren zum kultivieren von zellen und geweben | |
| DE19725602C2 (de) | Verfahren und Vorrichtung zum Züchten von Zellen | |
| DE19844154C1 (de) | Vorrichtung zur Kultivierung und Konzentrierung nicht adhärenter Zellen sowie zur Kokultur zweier unterschiedlicher Zellsorten | |
| DE102016119391B3 (de) | Mikrobioreaktor-Modul | |
| EP3882335A1 (de) | Verfahren zur kultivierung von zellen | |
| EP2171036B1 (de) | Verfahren und vorrichtung zur kultivierung lebender zellen | |
| DE3541738A1 (de) | Verfahren und vorrichtung zum kultivieren von zellen | |
| DE102015216241A1 (de) | Behälter und Verfahren zur Filtration einer Suspension |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OAV | Publication of unexamined application with consent of applicant | ||
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8122 | Nonbinding interest in granting licences declared | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |